First Annual C.R. Stephen Lecture – March 12, 1988
Leroy D. Vandam, M.D.
Professor of Anesthesiology, Emeritus
Harvard Medical School
Brigham and Women’s Hospital
Boston, Massachusetts
Topic: “Schools of Anesthesia”

Second Annual C.R. Stephen Lecture – March 11, 1989
M.T. Jenkins, M.D.
McDermott Professor Emeritus
Department of Anesthesiology
The University of Texas
Southwestern Medical Center – Dallas
Topic: “Archeology of Fluid Balance in Infants, Birds, Sharks, and Other Strange Milieus”

Third Annual C.R. Stephen Lecture – March 17, 1990
James E. Eckenhoff, M.D., D.Sc.
Professor Emeritus
Department of Anesthesiology
Northwestern University Medical Center
Chicago, Illinois
Topic: “Random Thoughts About the Practice of Anesthesiology: A Half Century Perspective”

Fourth Annual C.R. Stephen Lecture – March 16, 1991
Robert K. Stoelting, M.D.
Professor and Chairman
Department of Anesthesiology
Indiana University School of Medicine
Indianapolis, Indiana
Topic: “Pharmacology of Anesthetic Drugs – Past Problems and Future Promises”

Fifth Annual C. R. Stephen Lecture – April 18, 1992
Nicholas M. Greene, M.D.
Professor Emeritus
Department of Anesthesiology
Yale University School of Medicine
New Haven, Connecticut
Topic: “The ASA’s East African Anesthesia Program”

The Sixth Annual C. R. Stephen Lecture – March 10, 1994
Warren M. Zapol, M.D.
Professor, Department of Anesthesiology
Harvard Medical School
Massachusetts General Hospital
Boston, Massachusetts
Topic: “Inhaled Nitric Oxide:  A Selective Pulmonary Vasodilator”

The Seventh Annual C. R. Stephen Lecture – March 30, 1995
Howard L. Fields, M.D., Ph.D.
Professor, Department of Neurology and Physiology
Vice Chairman, Department of Neurology
University of California – San Francisco
San Francisco, California
Topic: “Neural Circuits Underlying Opioid Analgesia”

The Eighth Annual C.R. Stephen Lecture – March 21, 1996
Marcus E. Raichle, M.D.
Professor of Radiology, Neurology and Anatomy and Neurobiology
Washington University School of Medicine
St. Louis, Missouri
Topic: “An Expanded View of Human Memory Systems”

The Ninth Annual C.R. Stephen Lecture – March 6, 1997
Steven E. Hyman, M.D.
Director, National Institute of Mental Health
Topic: “How Dopamine and Psychostimulant Drugs Regulate Gene Expression in the Striatum: Implications for Behavior”

The Tenth Annual C.R. Stephen Lecture – March 5, 1998
Clifford J. Woolf, Ph.D.
Professor of Anesthesia Research
Neurobiologist, Massachusetts General Hospital
Harvard Medical School
Topic: “Pain and Plasticity”

The Eleventh Annual C.R. Stephen Lecture – March 18, 1999
David A. McCormick, Ph.D.
Professor, Section of Neurobiology
Yale University School of Medicine
Topic: “General Activating Systems and Their Role in Sleep, Arousal, and Anesthesia”

The Twelfth Annual C.R. Stephen Lecture – March 23, 2000
Allan I. Basbaum, Ph.D.
Professor and Chairman, Department of Anatomy
University of California, San Francisco
Topic: “The Neurochemistry of Acute and Persistent Pain”

The Thirteenth Annual C.R. Stephen Lecture – March 15, 2001
Nicholas P. Franks, Ph.D.
Professor of Biophysics and Anaesthetics
Head of Biophysics Section
Imperial College, London University
United Kingdom
Topic: “How Do General Anesthetics Work? – Light at the End of the Tunnel”

The Fourteenth Annual C.R. Stephen Lecture – March 14, 2002
Eric R. Kandel, M.D.
Professor, Department of Biochemistry and Molecular Biophysics
Senior Investigator, Howard Hughes Medical Institute
College of Physicians and Surgeons of Columbia University
Topic: “Genes, Synapses and Long-Term Memory”

The Fifteenth Annual C.R. Stephen Lecture – March 20, 2003
Erwin Neher, PhD
Professor of Biophysics
Director, Department of Membrane Biophysics
Max-Planck-Institut für biophysikalische Chemie
Topic: “Ca++ signals controlling neurotransmitter release and short term synaptic plasticity”

The Sixteenth Annual C.R. Stephen Lecture – April 15, 2004
Mervyn Maze, M.B., Ch.B., F.R.C.P.
Sir Ivan Magill Professor of Anaesthetics
Head, Department of Anesthesiology
Imperial College, Chelsea and Westminster Hospital
London, England
Topic: “Molecular Mechanisms and Neural Substrates for the Behavioral Effects of General Anesthetics: Clinical Implications”

The Seventeenth Annual C.R. Stephen Lecture – April 28, 2005
David Julius, Ph.D.
Professor and Vice-Chair
Department of Cellular and Molecular Pharmacology
University of California, San Francisco
Topic: “From Peppers to Peppermints: Molecular Insights into Thermosensation and Pain”

The Eighteenth Annual C.R. Stephen Lecture – April 27, 2006
Kevin J. Tracey, M.D.
Director and Chief Executive Officer
The Feinstein Institute for Medical Research
Manhassett, New York
Topic: “HMGB1 and the Inflammatory Reflex”

The Nineteenth Annual C.R. Stephen Lecture – March 29, 2007
Clifford B. Saper, M.D., Ph.D.
James Jackson Putnam Professor of Neurology and Neuroscience
Harvard Medical School
Chairman, Department of Neurology
Beth Israel Deaconess Medical Center
Boston, MA
Topic: “Relationship of Sleep and Anesthesia”

The Twentieth Annual C.R. Stephen Lecture – April 2, 2008
Jeffrey R. Balser M.D., Ph.D.
Associate Vice Chancellor for Research
The James Tayloe Gwathmey Professor of Anesthesiology,
Medicine, and Pharmacology
Vanderbilt University Medical Center
Nashville, Tennessee
Topic: “Personalized Healthcare – The Next Manhattan Project”

The Twenty-First Annual C.R. Stephen Lecture
Gregg L. Semenza, M.D., Ph.D.
Director, Vascular Program, Institute for Cell Engineering
Professor, Departments of Pediatrics, Medicine, Oncology, Radiation Oncology,
and McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine
Topic: “Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1”

The Twenty-Second Annual C.R. Stephen Lecture
Irene Tracey, Ph.D.
Nuffield Professor of Anaesthetic Science &
Director FMRIB Centre
University of Oxford
Topic: “Imaging Pain and Its Relief in Controls and Chronic Pain Patients”

The Twenty-Third Annual C.R. Stephen Lecture
James C. Eisenach, M.D.
FM James, III Professor of Anesthesiology
Wake Forest University Medical Center
Department of Anesthesiology
Section on Obstetric and Gynecologic Anesthesiology
Topic: “Can We Prevent Chronic Pain After Injury?”

The Twenty-Fourth Annual C.R. Stephen Lecture
Giulio Tononi, M.D., Ph.D.
David P. White Chair in Sleep Medicine
University of Wisconsin
Topic: “Consciousness, Sleep and Anesthesia”

The Twenty-Fifth Annual C.R. Stephen Lecture
Beverley Orser, MD, PhD, FRCPC
Professor of Anesthesia and Physiology
University of Toronto
Topic: “Memory Loss and Anesthesia:  The Good, The Bad, and The Ugly”

The Twenty-Sixth Annual C.R. Stephen Lecture
Albert Dahan, M.D., Ph.D.
Professor of Anesthesiology
Leiden University Medical Center
POBox 9600 – 2300 RC Leiden
The Netherlands
Topic: “Ketamine’s Second and ….. Third Life”

The Twenty-Seventh Annual C.R. Stephen Lecture
Emery N. Brown, M.D., Ph.D.
Edward Hood Taplin Professor of Medical Engineering
Institute for Medical Engineering and Science
Professor of Computational Neuroscience
Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology
and Warren M. Zapol Professor of Anaesthesia
Harvard Medical School
Department of Anesthesia, Critical Care and Pain Medicine
Massachusetts General Hospital
55 Fruit Street, Gray-Bigelow 444
Boston, MA 02114
Topic: “Unlocking the Mysteries of the Brain Under General Anesthesia”

The Twenty-Eighth Annual C.R. Stephen Lecture
Paul Myles, MBBS, MPH, MD
Professor and Chair
Department of Anaesthesia
and Perioperative Medicine
Alfred Hospital and Monash University
Melbourne, Australia
Topic: “The Special Value and Importance of Large Trials in Perioperative Medicine”

The Twenty-Ninth Annual C.R. Stephen Lecture
E. Wesley Ely, M.D., M.P.H.
Department of Medicine
Vanderbilt University School of Medicine
Topic: “A New Frontier in Critical Care:  Saving the Injured Brain”

The Thirtieth Annual C.R. Stephen Lecture
Vamsi Mootha, M.D.
Howard Hughes Medical Institute
Professor of Systems Biology
Harvard Medical School
Professor of Medicine
Massachusetts General Hospital
Topic: “Mitochondrial Systems Biology: Understanding the Whole from the Parts”