Dr. Yarimar Carrasquillo
National Center for Complementary and Integrative Health
Divi
sion of Intramural Research-Section on Behavioral Neurocircuitry and Cellul
ar Plasticity
This in-depth scientific r esearch presentation and discussion on the featured speaker's latest findin gs will provide scholars with an experience of how faculty members share an d teach about novel knowledge in their fields.
This portion of the seminar is accessible to both scholars and Department of Anesthesiol ogy members\, and all will be given the opportunity to ask questions after the talk if desired.
Dr. Carrasquillo received her B.S. in Biology from the University of Puerto Rico\, Rio Piedras and her Ph.D. in Neuroscience from Baylor College of Me dicine. Her graduate work in the lab of Dr. Robert W. Gereau revealed criti cal roles for the amygdala in the modulation of persistent pain and also de monstrated that the extracellular signal regulated kinase (ERK) plays a rol e in this process. Her postdoctoral studies in the lab of Dr. Jeanne Nerbon ne at Washington University School of Medicine revealed previously unapprec iated molecular and functional diversity of repolarizing voltage-gated\, A- type\, (IA) K+ currents in central neurons. Dr. Carrasquillo joined the PAI N Branch at NCCIH as an investigator in 2014 where she directs a multifacet ed\, multidisciplinary research program focused on delineating the anatomic al\, molecular and cellular mechanisms that underlie pain perception and mo dulation.
The main goal of her lab is to identify anatomical\, molecu lar and cellular mechanisms that underlie pathological pain states. Her res earch focuses on the amygdala\, a structure in the limbic brain system that plays critical roles in the modulation of tactile hypersensitivity\, pain- related aversion learning and pain-induced changes in anxiety-related behav iors in rodent models of persistent pain.
Studies in her lab use a co mbination of anatomical\, behavioral\, electrophysiological and optogenetic approaches to define how alterations in the excitability of amygdala neuro ns affect function at a circuit-level. These studies focus on evaluating th e physiological impact of the modulation of neuronal excitability in distin ct anatomical pathways to and from the amygdala on different components of persistent pain\, including the sensory\, affective and cognitive component s.
Dr. Carrasquillo is also strongly committed to and invested in fos tering the career development of students and trainees of all backgrounds\, particularly underrepresented minorities\, trainees with underprivileged a nd disadvantageous backgrounds and women in science. She is also strongly c ommitted to promoting scientific rigor\, transparency and reproducibility i n research and in training scientists that understand\, value\, and exercis e scientific integrity throughout their work.
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