Laura Cavallone, MD

Research Interests

Since 1989. as a medical student at the Universita’ degli Studi in Milan, Dr. Cavallone had an interest in research in the field of nociception, and was involved in a series of studies in rats, aimed to characterize neuronal clusters in selected mesencephalic nuclei and identify their connections within nociceptive pathways. Since 2004, as a Faculty of the Department of Anesthesiology at Washington University, she has been involved in a basic science research project on the molecular basis of nociception and neuroplasticity of CNS in mice. Currently Dr. Cavallone is focusing on a research project aimed to translate in human the results of a series of pre-clinical studies in mice on the possible role of glutamate metabotropic receptor 5 antagonists in the treatment of inflammatory pain (PI Dr. Robert Gereau). As a clinical researcher Dr. Cavallone also has an interest in perioperative management and anesthesia for ENT and Head and Neck surgery, and in difficult airway management. In 2009 she worked on a study aimed to evaluate the incidence of postoperative cardiovascular events in the ENT/Head and Neck surgical population after major resective surgery (PI Dr. Peter Nagele), now awaiting publication. Recently she has been involved in a multicenter project aimed to establish a set of guidelines for the clinical management of the threatened airway in the hospital setting.

Selected Publications

Peer-reviewed manuscripts:

  • Montana MC, Cavallone LF, Stubbert KK, Stefanescu AD, Kharasch ED, Gereau RW. The mGlu5 antagonist fenobam is analgesic and has improved in vivo selectivity as compared to the prototypical antagonist MPEP. J Pharmacol Exp Ther. 2009 Sep;330(3):834-43. Epub 2009 Jun 10.
  • Iapichino G., RadrizzaniD., Veschi G., Biondi A.,Cambisano M., Cavallone L.,Colombo A., Pasetti G., Codazzi D., Russo R. Bilancio azotato corporeo,muscolare e viscerale in pazienti catabolici – Modificazioni del trattamento metabolico . [Body, muscle, and visceral nitrogen balance in catabolic patients. Modification with metabolic treatment] Minerva Anestesiol 1993; 59:79 – 86.
  • G. Ronzoni, R. Cesari, E. Quarenghi, E. Gregnanin, L.Vento, G. Pasetti, A. Bordone, C. Ruffini, L. Cavallone, G.Iapichino. Livelli plasmatici di carnitina durante rigetto acuto d’organo in pazienti sottoposti a trapianto di fegato [Carnitine plasmatic levels during acute organ rejection in patients who have undergone liver transplantation]. Anest Rianim Intens, 1992 vol. 3, 32 -34.

Invited publications:

  • L.F .Cavallone
    Dreaming of patients’ satisfaction 
    Editorial – Minerva Anestesiol. 2009 Jun;75(6):355-6. Epub 2009 Feb 10.
  • F. Zucco, L. Cavallone
    Ischemia, neuropatie e dolore 
    [Ischemia, neuropathies and pain] in “Contro il dolore” – Stato dell’Arte – vol 1, pp 105-135, Excerpta Medica, 2002
  • F. Zucco, L. Cavallone
    Considerazioni relative all’equilibrio economico di una Unità di Cure Palliative 
    [Considerations on economic equilibrium in a Palliative Care Unit] in “Contro il dolore” – Stato dell’Arte – vol 2, pp 71-124, Excerpta Medica, 2002
  • Croci M., Cavallone L., Fumagalli M., Maestri M., Palandi A., Pelosi P. and GILap Lung function in laparoscopic surgery. In: A. Gullo ed. Atti del 9O Congresso A.P.I.C.E., Trieste 1994, pag 555-63.