The Division of Clinical and Translational Research (DoCTR) is the home for patient-oriented research in the Department of Anesthesiology. Numerous translational and clinical research projects are currently led by faculty members in the division, in a wide variety of research areas. These include perioperative outcomes; postoperative delirium; functional neuroimaging of anesthesia and drug disposition; cognitive dysfunction and chronic pain; novel treatments for neuropathic pain, including for pain associated with cancer and anticancer chemotherapy;; postoperative patient reported outcomes; perioperative mental health; machine learning and artificial intelligence; human factors; telemedicine; persistent post-surgical pain, perioperative and peripartum sleep apnea; and integration of electronic health information to optimize safety and outcomes. All investigators have clinical research programs, and some also have laboratory-based translational programs. DoCTR has several full-time faculty members as well as affiliated faculty. It employs full-time research coordinators and nurses, as well as regulatory/QA specialists for human subjects research. DoCTR offers support for all aspects of clinical research, from study design, protocol development, IRB and regulatory document preparation and submission, recruitment, monitoring, data management and analysis. The Division is led by Michael Avidan, MBBCh, Dr. Seymour and Rose T. Brown Professor of Anesthesiology, an experienced clinical and translational scientist in the field of clinical trials and perioperative outcomes. Simon Haroutounian, PhD, is the Chief of Clinical Pain Research, and provides a robust research bridge between DoCTR and the Washington University Pain Center. Robert Gereau, PhD, Dr. Seymour and Rose T. Brown Professor of Anesthesiology, leads the Division of Basic Science Research as well as the Washington University Pain Center. Gereau and Avidan jointly provide research oversight for the Department, and are committed to team science and vibrant intra as well as inter departmental collaborations.