Ben Palanca, MD, PhD

Research Interests

Dr. Palanca is interested in characterizing the mechanisms whereby anesthetic agents alter intracortical and subcortical neural networks and impair cognitive processes to generate unconsciousness. The question of how anesthetic agents induce reversible states of unconsciousness is of central importance in the science of anesthesiology. The answers to this question have obvious importance for understanding the neural circuitry underlying cognitive function and developing safer and better approaches to administering and monitoring general anesthesia.

In 2010, Dr. Palanca was awarded a two year Mentored Research Training Grant from the Foundation for Anesthesia Education and Research (FAER) to investigate the neural correlates of anesthetic-induced unconsciousness in functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) signals. This project combines his background in primate neurophysiology and clinical anesthesiology with training in EEG and fMRI toward the conduct of translational research studies involving anesthetized human volunteers. He will assess the states of cortical connectivity at anesthetic gas concentrations flanking the important point of loss of responsiveness. As different brain monitors designed for preventing unintended return of consciousness function via analysis of either spontaneous or evoked neural activity, he will assess cortical connectivity both in the context of a resting state and in the context of individuals performing a task. This project should clarify the relationships among networks of critical cortical and subcortical areas, impairment of cognitive functions induced by anesthetics, and surface electrical activity.


Honors and Awards

2010 Mentored Research Training Grant, Foundation for Anesthesia Education and Research (FAER)
2010 Postdoctoral Scholar, Washington University Clinical Research Training Center (K30)
2010 Election to Alpha Omega Alpha Honor Medical Society, Washington University Chapter
2007 Foundation for Anesthesia Education and Research (FAER) Scholar Award
2001-2003 National Eye Institute Vision Sciences Predoctoral Training Grant
1997 University of Washington President’s Medal (most distinguished record at graduation)
1996 Barry M. Goldwater Scholarship for Excellence in Education
1996 Election to Washington Alpha Chapter, Phi Beta Kappa
1996 Howard Hughes Undergraduate Summer Research Internship
1995 University of Washington Junior Medal for High Scholarship
1995 University of Washington Undergraduate Research Stipend
1994 National Academy of Science, Space, and Technology Scholarship

Research Team

Marcus Raichle, MD — Primary Mentor
Evan Kharasch, MD, PhD — Secondary Mentor

Jane Blood, RN — Nurse Coordinator

Alex Evers, MD — Collaborator
Michael Avidan, MBBCh — Collaborator
Biyu He, PhD — Collaborator
Eric Leuthardt, MD — Collaborator


Publications

PEER REVIEWED PUBLICATIONS
Kertai, M.D., Pal, N., Palanca, B.J.A., Lin, N., Searleman, S.A., Zhang, L., Burnside, B.A.,

Finkel, K.J., Avidan, M.S; on behalf of the B-Unaware Study Group. Association of perioperative risk factors and cumulative duration of low bispectral index with intermediate- term mortality following cardiac surgery in the B-Unaware Trial. Anesthesiology. 2010: 112(5).

Palanca, B.J.A., DeAngelis, G.C. Does neuronal synchrony underlie visual feature grouping? Neuron. 2005: 46(2): 333-46.

Palanca, B.J.A., DeAngelis, G.C. Macaque middle temporal neurons signal depth in the absence of motion. J. Neurosci. 2003; 23(20):7647-58.

Potter, A.J., Gollahon, K.A., Palanca B.J., Harbert, M.J., Choi, Y.M., Moskovitz, A.H., Potter, J.D., Rabinovitch, P.S. Flow cytometric analysis of cell cycle phase specificity of DNA damage induced by radiation. Carcinogenesis 2002; 23(3): 389-401.

Brown, M.G., Scalzo, A.A., Stone L.R., Clark P.Y., Du Y., Palanca B., Yokoyama W.M. Natural killer gene complex (Nkc) allelic variability in inbred mice: evidence for Nkc haplotypes. Immunogenetics 2001; 53(7): 584-91.

Xu, C., Mao, D., Holers, V.M., Palanca, B., Cheng, A.M., Molina, H. A critical role for murine complement regulator crry in fetomaternal tolerance. Science 2000; 287(5452): 498-501.

Glogovac, J.K., Pierce, R., Palanca, B.J.A., Rabinovitch, P.S. Cytokeratin immunoflourescence in DNA analysis of paraffin extracted cells. Clin. Immunol. Newsletter 1996; 16(12): 157-61.

NON-PEER REVIEWED PUBLICATIONS

Avidan, M.S., Palanca, B.J., Glick, D., Jacobsohn, E., Villafranca A., O’Connor, M., Mashour, G.A., and Study Group BAG-RECALL. Protocol for the BAG-RECALL Clinical Trial: A prospective, multi-center, randomized, controlled trial to determine whether a bispectral index- guided protocol is superior to an anesthesia gas-guided protocol in reducing intraoperative awareness with explicit recall in high risk surgical patients. BMC Anesthesiol. 2009: 9(1): 8.

Palanca, B.J.A., Mashour, G.A., and Avidan M.S. Processed EEG in depth of anesthesia monitoring: controversies and future prospects. Curr Opin Anaesthesiol. 2009: 22(5): 553-9.

BOOKS AND BOOK CHAPTERS

Palanca, B.J.A., Searleman, A, and Avidan, M.S. “Current Controversies in Intraoperative Awareness II.” Consciousness, Awareness, and Anesthesia. Ed. George A. Mashour. Cambridge University. 2010.

Palanca, B.J.A. Neuronal synchrony fails as a general mechanism underlying feature binding. Doctoral Dissertation. 2005