Publications

1. Ablordeppey EA, Drewry AM, Anderson AL, Casali D, Wallace LA, Kane DS, Tian L, House SL, Fuller BM, Griffey RT, Theodoro DL.  Point-of-care Ultrasound-guided Central Venous Catheter Confirmation in Ultrasound Nonexperts. AEM Educ Train. 2021 Oct 13;5(3):e10530. doi: 10.1002/aet2.10530.PMID: 34124497 
2. Abraham, J., King, C.R., Meng, A. (2021). Ascertaining Design Requirements for Postoperative Care Transition Interventions. Applied Clinical Informatics. 12(1):107-115. PMID: 33626584.
3. Abraham, J., Meng, A., Brawer, L., Casarella, A., Holzer, K., Avidan, M., Politi, M. (2021). Exploring Patient Perspectives on Telemedicine Monitoring within the Operating Room. International Journal of Medical Informatics. PMID: 34627112.
4. Abraham, J., Meng, A., Sona, C., Wildes, T., Avidan, M., Kannampallil, T., (2021). An Observational Study of Postoperative Handoff Standardization Failures. International Journal of Medical Informatics. 151, 104458. PMID: 33932762.
5. Abraham, J., Meng, A., Tripathy, S., Avidan, M.S., & Kannampallil, T.G. (2021). A Systematic Review and Meta-analysis of Interventions for Operating Room to Intensive Care Unit Handoffs, BMJ Quality & Safety. PMID: 33563791.
6. Abraham, J., Pfeifer, E., Doering, M., Avidan, M., Kannampallil, T. (2021). Systematic Review of Intraoperative Anesthesia Handoffs and Handoff Tools. Anesthesia and Analgesia. 10-1213.
7. Arcario MJ, Lou S, Taylor P, Gregory SH. 2021. Sinus of Valsalva aneurysms: a review with perioperative considerations. J Cardiothorac Vasc Anesth. 35(11): 3340-3349 
8. Arnold WR, Carnevale LN, Xie Z, Baylon JL, Tajkhorshid E, Hu H, Das A, Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel. Nat Commun 2021: 12(1): 926.  
9. Athiraman U, Lele A, Karanikolas M, Dhulipala V, Jayaraman K, Fong C, Kentner R, Sheolal R, Vellimana A, Gidday J, Dhar R, Zipfel GJ. Inhalational versus Intravenous anesthetic conditioning for subarachnoid hemorrhage induced delayed cerebral ischemia. Stroke. 2021 Nov 4: STROKEAHA121035075. PMID: 34732071.
10. Athiraman U, Liu M, Jayaraman K, Yuan J, Mehla J, Zipfel GJ. Anesthetic and subanesthetic doses of isoflurane conditioning provides strong protection against delayed cerebral ischemia in a mouse model of subarachnoid hemorrhage. Brain Res. 2021 Jan 1; 1750:147169. PMID: 33132166.
11. Athiraman U, Zipfel GJ. Role of anesthetics and their adjuvants in neurovascular protection in secondary brain injury after aneurysmal subarachnoid hemorrhage. Int J Mol Sci. 2021 Jun 18;22(12):6550. PMID: 34207292.
12. Azevedo K, Wessman BT.  Pneumomediastinum Diagnosed From A Remote Tele-ICU Center?  Crit Care & Shock. 2021. 24 (1): 1-7. 
13. BA Matikainen-Ankney, T. Earnest, M Ali, E. Casey, AK Sutton, A. Legaria, K. Barclay, LB Murdaugh, MR Norris, YH Chang, KP Nguyen E. Lin, A.Reichenback, RE Clark, R. Stark, SM Conway, F. Carvalho, R. Al-Hasani, JG McCall, MC Creed, V. Cazares, MW Buczynski, MJ Krashes, Z. Andrews, AV Kravitz.  Feeding Experimentation Device Version 3 (FED#): An open-source home-cage compatible device for measuring food intake and operant behavior. eLife 2021; 10; 366173 DOI: 107554/eLife.66173.  
14. Bakir NH, Khiabani AJ, MacGregor RM, Kelly MO, Sinn LA, Schuessler RB, Maniar HS, Melby SJ, Helwani MA, Damiano RJ Jr.. Concomitant surgical ablation for atrial fibrillation is associated with increased risk of acute kidney injury but improved late survival. J Thorac Cardiovasc Surg. 2021 Jan 23:S0022-5223(21)00118-5.  
15. Benhardt AC, Kodali BS. All epidural needle bevels are not the same. Indian J Anaesth. 2021 Apr; 65(4):328-330.
16. Biccard BM, du Toit L, Lesosky M, et al. Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial. The Lancet Global Health. 2021 Oct 1;9(10):e1391-401.
17. Bombardieri AM, Tsui B, Yaeger L, Athiraman U, Singh P, Singh PM. The effect on cerebral oxygen saturation of vasopressors administered to treat intraoperative hypotension: a Bayesian network meta-analysis. J Neurosurg Anesthesiol. 2021 Jun 10. PMID: 34116546.
18. Burton, S., Valenta, A.L., Starren, J., Abraham, J., Nelson, T., Kochendorfer, K., Hughes, A., Harris, B., Boyd, A. (2021). Examining Perspectives on the Adoption and Use of Computer-Based Patient-Reported Outcomes among Clinicians and Health Professionals: A Q Methodology Study. Journal of American Medical Informatics. PMID: 34871423.
19. Cao L, Yue X, Zhao Y, Du L, Xie Z, Yuan Y, Zhang S, Li F, Feng J, Hu H, Mechanisms of broad-band ultraviolet B irradiation-induced itch in mice. J Invest Dermatol 2021: S0022-202X (21)01129-5. doi: 10.1016/j.jid.2021.03.015. 
20. Carbone, J. T., Jackson, D. B., Holzer, K. J., & Vaughn, M. V. (2021). Childhood adversity, suicidality, and non-suicidal self-injury among children and adolescents admitted to emergency departments. Annals of Epidemiology, 60, 21-27.
21. Cazares, M.W. Buczynski, M.J. Krashes, Z. Andrews, A.V. Kravitz. Feeding Experimentation: Characteristics of U.S. Acute Care Hospitals That Have Implemented Telemedicine Critical Care.
22. Chumakov K, Avidan MS, Benn CS, Bertozzi SM, Blatt L, Chang AY, Jamison DT, Khader SA, Kottilil S, Netea MG, Sparrow A, Gallo RC.  Old vaccines for new infections: exploiting innate immunity to control COVID-19 and prevent future pandemics.  Proc Natl Acad Sci USA. 2021 May 25; 118(21): e2101718118. Doi: 10.1073/pnas.210718118. PMID: 34006644.
23. Charshafian S, Wessman BT. Critical Care Medicine Ocular Emergency Presentation: Can you see it?  Crit Care & Shock. 2021. 24 (1):8-12. 
24. Chen, H., Deng, J., Cui, Q., Chanda, B., Henzler-Wildman, K. (2021) Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K+ channel. Proceedings of the National Academy of Sciences (USA). 118 (14) e2017280118
25. Chiang MD, Frey K, Lee C, Kharasch ED, Tallchief D, Sawyer C, Blood J, Back H, Kagan L, Haroutounian S. Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans.  Br J Clin Pharmacol. 2021 Feb;87(2):516-526. PMID: 32495990
26. Cowgill, J., Chanda, B. (2021) Mapping electromechanical coupling pathways in voltage-gated ion channels: Challenges and the way forward. Journal of Molecular Biology doi: 10.1016/j.jmb.2021.167104
27. Cottler LB, Lasopa SO, Striley CW, Cicero TJ, Fitzgerald ND, Ben Abdallah A. Prescription stimulant brand name recognition among a national sample of 10-to-18-year-old youth. Int. J. Methods Psychiatr. Res. 2021; e1884; 10 July 2021.
28. Deng Z, Zhao y, Feng J, Zhang J, Zhao Y, Rau MJ, Fitzpatrick J, Hu H, Yuan P, Cryo-EM structure of a proton-activated chloride channel TMEM206. Sci Adv 2021: 7(9): eabe5983. 
29. Devarajan J, Balasubramian S; Nazarnia S, Lin C, Subramaniam K. Regional Analgesia for Cardiac Surgery Part 1. Current Status of Neuraxial and paravertebral blocks for adult cardiac surgery. Seminars in Cardiothoracic and Vascular Anesthesia 2021 25(4): 252-264.
30. Devarajan J, Balasubramian S; Shariat AN, Bhatt HV. Regional Analgesia for Cardiac Surgery Part 2. Peripheral Regional Analgesia for Cardiac Surgery. Seminars in Cardiothoracic and Vascular Anesthesia 2021 25(4): 252-264.
31. Duclos C, Maschke C, Mahdid Y, Berkun K, Castanheira JDS, Tarnal V, Picton P, Vanini G, Golmirzaie G, Janke, E, Avidan MS, Kelz MB, Liuzzi L, Brookes MJ, Mashour GA, Blain-Moraes S. Differential classification of states of consciousness using envelope-and phase-based functional connectivity. Neuroimage. 2021 Aug 15; 237:118171. Doi: 10.1016/j.neuroimage.2021.118171. PMID: 34000405.
32. Duclos C, Nadin D, Mahdid Y, Tarnal V, Picton P, Vanini G, Colmirzaie G, Janke E, Avidan MS, Kelz MB, Mashour GA, Blain-Moraes S.  Brain network motifs are markers of loss and recovery of consciousness. Sci Rep 2021 Feb 16;11(1): 3892. Doi:10.1038/s41598-021-03482-9. PMID: 33594110
33. Emerson NE, Nahman-Averbuch H, Coghill RC. Pain sensitivity does not differ between obese and healthy weight individuals. Pain Reports. 2021;6(3):e942.
34. Emerson NE, Nahman-Averbuch H, Coghill RC. Pain sensitivity does not differ between obese and healthy weight individuals. Pain Reports. 2021;6(3):e942.
35. Evers AS: Anaesthetic-induced developmental neurotoxicity on (neuro)steroids. Br J Anaesth. 2021. 126:34-37 PMID: 32891411
36. Finn DP, Haroutounian S, Hohmann AG, Krane E, Soliman N, Rice ASC. Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies.   Pain. 2021 Jul 1;162(Suppl 1):S5-S25. PMID: 33729211
37. Fisher E, Moore RA, Fogarty AE, Finn DP, Finnerup NB, Gilron I, Haroutounian S, Krane E, Rice ASC, Rowbotham M, Wallace M, Eccleston C. Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials.   Pain. 2021 Jul 1;162(Suppl 1):S45-S66. PMID: 32804836
38. Flowers KM, Beck M, Colebaugh C, Haroutounian S, Edwards RR, Schreiber KL. Pain, numbness, or both? Distinguishing the longitudinal course and predictors of positive, painful neuropathic features vs numbness after breast cancer surgery.  Pain Rep. 2021 Nov 22;6(4):e976. PMID: 34841183 Free PMC article.
39. Fritz BA, King CR, Mickle TS, Budelier TP, Oberhaus J, … Palanca BJ, Stevens TW, Stark SL, Lenze EJ, Avidan MS; ENGAGES Research Group. Br J Anaesth. Effect of electroencephalogram-guided anaesthesia administration on 1-yr mortality: follow-up of a randomised clinical trial. 2021 Sep; 127(3): 386-395. Doi: 10.1016/j.bja.2021.04.036. PMID: 34243940.
40. Germann A, Pierce S, Tateiwa H, Sugasawa Y, Reichert D, Evers AS, Steinbach JH and Akk G.  Intrasubunit and intersubunit steroid binding sites independently and energetically additively mediate α1β2γ2L GABAA receptor potentiation by the endogenous neurosteroid allopregnanolone. Mol Pharmacol 2021. 100:19-31 PMID:33958479
41. Germann Al, Pierce SR, Evers AS, Steinbach JH and Akk G. Perspective on the relationship between GABAA receptor activity and the apparent potency of an inhibitor. Curr Neuropharmacol 2021. doi: 10.2174/1570159X19666211104142433. PMID: 34784870 
42. Gonzalez-Perez V, Martinez-Espinosa PL, Sala-Rabanal M, Bharadwaj N, Xia XM, Chen AC, Alvarado D, Gustafsson JK, Hu H, Ciorba MA, Lingle CJ, Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice. Proc Natl Acad Sci USA 2021: 118(3): e2019149118. 
43. Grajales-Reyes, J.G., Copits, B.A., Lie, F., Yu, Y.,  Avila, R., Vogt, S.K., Huang, Y., Banks, A.R, Rogers, J.A., Gereau IV, R.W., and Golden, J.P. Surgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice. Nature Protocols, 2021 16:3072.
44. Gregory SH, King CR, Ben Abdallah A, Kronzer A, Wildes TS. 2021. The epidemiology of abnormal preoperative cognitive screening in aged surgical patients: a retrospective cohort analysis. Br J Anaesth. 126(1):230-237. 
45. Guay CS, Labonte AK, Montana MC, Landsness EC, Lucey BP, Kafashan M, Haroutounian S, Avidan MS, Brown EN, Palanca BJA. Closed-Loop Acoustic Stimulation During Sedation with Dexmedetomidine (CLASS-D): Protocol for a Within-Subject, Crossover, Controlled, Interventional Trial with Healthy Volunteers.   Nat Sci Sleep. 2021 Mar 4;13:303-313.  PMID: 33692642 
46. Guffey R, Abuirqeba A, Wolfson M, Fingerman ME, Liu Q, Ohman JW, Thompson RW. Erector Spinae Plane Block versus Continuous Perineural Local Anesthetic Infusion for Postoperative Pain Control After Supraclavicular Decompression for Neurogenic Thoracic Outlet Syndrome: A Matched Case-Control Comparison.  Ann Vasc Surg  2021 Nov;77:236-242.    PMID: 34455047
47. Haroutounian S, Arendt-Nielsen L, Belton J, Blyth FM, Degenhardt L, Di Forti M, Eccleston C, Finn DP, Finnerup NB, Fisher E, Fogarty AE, Gilron I, Hohmann AG, Kalso E, Krane E, Mohiuddin M, Moore RA, Rowbotham M, Soliman N, Wallace M, Zinboonyahgoon N, Rice ASC. International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia: research agenda on the use of cannabinoids, cannabis, and cannabis-based medicines for pain management.   Pain. 2021 Jul 1;162(Suppl 1):S117-S124. PMID: 34138827
48. Haroutounian S, Gilron I, Belton J, Degenhardt L, Di Forti M, Finn DP, Fogarty A, Kalso E, Krane E, Moore RA, Rowbotham M, Wallace M, Rice ASC. Societal issues and policy implications related to the use of cannabinoids, cannabis, and cannabis-based medicines for pain management.   Pain. 2021 Jul 1;162(Suppl 1):S110-S116. PMID: 33009248
49. Haroutounian S, Todorovic MS, Leinders M, Campagnolo M, Gewandter JS, Dworkin RH, Freeman R. Diagnostic criteria for idiopathic small fiber neuropathy: A systematic review.  Muscle Nerve. 2021 Feb;63(2):170-177. doi: 10.1002/mus.27070.   PMID: 32989823
50. Hickman LB, Kafashan M, Labonte AK, Chan CW, Huels ER, Guay C, Guan M, Ching S, Lenze EJ, Farber NB, Avidan MS, Hogan RE, Palanca BJA. Generalized Electroencephalographic Suppression Following Electroconvulsive Therapy: Temporal Characteristics and Impact of Anesthetic Regimen. Clin Neurophysiol. 2021. Apr; 132(4): 977-983. 132(4): 977-983. PMID: 33652270.
51. Hincker A, Nadler J, Karan S, Carter E, Porat S, Warner B, Ju YS, Ben Abdallah A, Wilson E, Lockhart EM, Ginosar Y. Sleep Apnea and Fetal Growth Restriction (SAFER) study: protocol for a pragmatic randomised clinical trial of positive airway pressure as an antenatal therapy for fetal growth restriction in maternal obstructive sleep apnoea. BMJ Open. 2021 Jun 29;11(6):e049120. doi: 10.1136/bmjopen-2021-049120. PMID: 34187829
52. Holzer, K. J., Lou, S., Goss, C. W., Strickland, J., Evanoff, B. A., Duncan, J., & Kannampallil, T. (2021). Impact of Changes in EHR Use during COVID-19 on Physician Trainee Mental Health. Applied Clinical Informatics, 12, 507-517.
53. Holzer, K. J., Vaughn, M. G., Fearn, N. E., Loux, T. M, & Mancini, M. A. (2021). Age bias in the criteria for antisocial personality disorder. Journal of Psychiatric Research, 137, 444-451.
54. Jaffer D, Singh PM, Aslam A, Cahill AG, Palanisamy A, Monks DT. Preventing postpartum hemorrhage after cesarean delivery: a network meta-analysis of available pharmacologic agents. Am J Obstet Gynecol.2021 Sep 14;. doi: 10.1016/j.ajog.2021.08.060.  PMID: 34534498. 
55. Jayaraman K, Liu M, Zipfel GJ, Athiraman U. Sevoflurane and Desflurane Exposures Following Aneurysmal Subarachnoid Hemorrhage confer multifaceted protection against Delayed Cerebral Ischemia. Biomedicines 2021, 9(7), 820. PMID: 34356884.
56. Kafashan M, Hyche O, Nguyen T, Smith SK, Guay CS, Wilson E, Labonte AK, Guan MJ, Lucey BP, Ju YS, Palanca BJA. Perioperative sleep in geriatric cardiac surgical patients: a feasibility study using wireless wearable devices. Br J Anaesth. 2021 June; 126(6): e205-e208. PMID: 33812667.
57. Kafashan M, Jaffe A, Chettih S, Nogueira R, Arandia-Romero, Harvey CD, Moreno-Bote R, Drugowitsch J. Scaling of sensory information in large neural populations shows signatures of information-limiting correlations, Nature Communications. 2021 Jan; 12(1):473. PMID: 33473113.
58. Kaiser HA, Knapp J, Sligh J, Avidan MS, Stuber F, Hight D. The quantitative EEG in electroencephalogram-based brain monitoring during general anesthesia.  Anaesthesist 2021 Jun; 70 (6): 531-547.  Doi:10.1007/s00101-021-00960-5. PMID: 33970302. German
59. Kannampallil T, Holzer KJ, Abraham J, Naim U, Lenze EJ, Haroutounian S, Avidan MS. Surgical Complications in Older Adults Predict Decline in Self-Perceived Cognitive Function in the Ensuing Year: A Cohort Study.    Am J Geriatr Psychiatry. 2021 Apr;29(4):352-361. PMID: 32981851
60. Kim Y, Wang Z, Li C, Kidd K, Wang Y, Johnson BG, Kmoch S, Morrissey JJ, Bleyer AJ, Duffield JS, Singamaneni S, Chen YM. Ultrabright plasmonic-fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease. Am J Physiol Renal Physiol. 2021 Aug1;321(2):F236-F244. doi: 10.1152/ajprenal.00231.2021. PMID:34251273; PMCID: PMC8424663.
61. King, C.R., Abraham, J., Fritz, B., Cui, Z., Galanter, W.L., Chen, Y., & Kannampallil, T.G. (2021). Predicting Self-Intercepted Medication Ordering Errors using Machine Learning, PLOS One. 16.7. PMID: 34260662.
62. Krishnan K, Qian M, Feltes M, Chen ZW, Gale, Wang L, Sugasawa Y,  Reichert DE, Schaffer JE, Ory DS, Evers AS, Covey DF. Validation of trifluoromethylphenyl diazirine cholesterol analogues as cholesterol mimetics and photolabeling reagents. ACS Chem Biol 2021. 16:1493-1507. PMID: 34355883
63. Ladha KS, McLaren-Blades A, Goel A, Buys MJ, Farquhar-Smith P, Haroutounian S, Kotteeswaran Y, Kwofie K, Le Foll B, Lightfoot NJ, Loiselle J, Mace H, Nicholls J, Regev A, Rosseland LA, Shanthanna H, Sinha A, Sutherland A, Tanguay R, Yafai S, Glenny M, Choi P, Ladak SSJ, Leroux TS, Kawpeng I, Samman B, Singh R, Clarke H. Perioperative Pain and Addiction Interdisciplinary Network (PAIN): consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users by a modified Delphi process.   Br J Anaesth. 2021 Jan;126(1):304-318. PMID: 33129489
64. Lan Z, Chen L, Feng J, Xie Z, Liu Z, Wang F, Liu P, Yue X, Du L, Zhao Y, Yang p, Luo J, Zhu Z, Hu X, Cao L, Lu P, Sah R, Lavine K, Kim BS, Hu H, The mechanosensitive TRPV4 is required for crystal-induced inflammation. Ann Rheum Dis. 2021 Oct 18; annrheumdis-2021-220295. doi: 10.1136/annrheumdis-2021-220295
65. Lan Z, Chen L, Feng J, Xie Z, Liu Z, Wang F, Liu P, Yue X, Du L, Zhao Y, Yang p, Luo J, Zhu Z, Hu X, Cao L, Lu P, Sah R, Lavine K, Kim BS, Hu H, The mechanosensitive TRPV4 is required for crystal-induced inflammation. Ann Rheum Dis. 2021 Oct 18; annrheumdis-2021-220295. doi: 10.1136/annrheumdis-2021-220295
66. Larsen EG, Cho TS, McBride ML, Feng J, Manivannan B, Madura C, Klein NE, Wright EB, Wickstead ES, Garcia-Verdugo HD, Jarvis C, Khanna R, Hu H, Largent-Milnes TM, Bhattacharya MRC. Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch. Pain 2021 Aug 18. doi: 10.1097/j.pain.0000000000002452. 
67. Larsen EG, Cho TS, McBride ML, Feng J, Manivannan B, Madura C, Klein NE, Wright EB, Wickstead ES, Garcia-Verdugo HD, Jarvis C, Khanna R, Hu H, Largent-Milnes TM, Bhattacharya MRC. Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch. Pain 2021 Aug 18. doi: 10.1097/j.pain.0000000000002452. 
68. Lele AV, Takala R, Athiraman U, Schloemerkemper N, Gollapudy S, Vagnerova K, Vincent A, Wahlster S, Vavilala MS.  Implementation of an Online External Ventricular Drain Training: An Educational Initiative to Improve Proficiency of Perioperative Clinicians: Results of a Retrospective Study. J Neurosurg Anesthesiol. 2021 Oct 11. PMID: 34881561.
69. Li KM, Baddigam R, Bethel B, Guay C, Song Z, Sullivan S, Gregory SH.  2021. Anesthetic considerations for transcatheter mitral and aortic valve procedures: An introduction and overview of current literature. Curr Anesthesiol Rep. 11:284-291 
70. Liang C, Luan J, Wang Z, Jiang Q, Gupta R, Cao S, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S. Gold Nanorod Size-Dependent Fluorescence Enhancement for Ultrasensitive Fluoroimmunoassays. ACS Appl Mater Interfaces. 2021 Mar 10;13(9):11414-11423. doi: 10.1021/acsami.0c20303. PMID: 33620204.
71. Linda B. Cottler, Sonam O. Lasopa, Catherine W. Striley, Theodore J. Cicero, Nicole D. Fitzgerald, Arbi Ben Abdallah. Prescription stimulant brand name recognition among a national sample of 10- to 18-year-old youth. Int. J. Methods Psychiatr. Res. 2021;e1884. https://doi.org/10.1002/mpr.1884. 
72. Liu L, Wang Z, Wang Y, Luan J, Morrissey JJ, Naik RR, Singamaneni S. Plasmonically Enhanced CRISPR/Cas13a-Based Bioassay for Amplification-Free Detection of Cancer-Associated RNA. Adv Health Mater. 2021 Aug 8:e2100956. doi:10.1002/adhm.202100956. PMID: 34369102.
73. Liu M, Jayaraman K, Giri T, Zipfel GJ, Athiraman U. Role of SIRT1 in Isoflurane conditioning-induced neurovascular protection against delayed cerebral ischemia secondary to subarachnoid hemorrhage. Int J Mol Sci. 2021 Apr 20;22(8):4291. PMID: 33924243.
74. Lou S, Bethel M, Reidy AB, Helwani MA. Tracheobronchial Trauma From Double-Lumen Tube Placement in Patients Undergoing Lung Transplantation. J. Cardiothorac Vasc Anesth. 2021 Apr 20:S1053-0770(21) 00346-3
75. Maranhao B, Liu M, Palanisamy A, Monks DT, Singh PM. The association between post-dural puncture headache and needle type during spinal anaesthesia: a systematic review and network meta-analysis.Anaesthesia. 2021 Aug;76(8):1098-1110. doi: 10.1111/anae.15320. PMID: 33332606.
76. Mashour GA, Palanca BJ, Basner M, Li D, Wang W, Blain-Moraes S…Golmirzaie G, Picton P, McKinstry-Wu AR, Avidan MS, Kelz MB. Recovery of consciousness and cognition after general anesthesia in humans. Elife. 2021 May 10; 10:e59525. doi: 10.7554/eLife.59525. PMID: 33970101.
77. Mazer MB, C Caldwell C, Hanson J, Mannion D, Turnbull IR, Drewry A, Osborne D, Walton A, Blood T, Moldawer LL, Brakenridge S, Remy KE, Hotchkiss RS. A Whole Blood Enzyme-linked Immunospit Assay for Functional Immune Endotyping of Septic Patients. J Immunol. 2021 Jan 1;206(1):23-36. doi: 10.4049/jimmunol.2001088. PMID: 33239423
78. Mohiuddin M, Blyth, FM, Degenhardt L, Di Forti M, Eccleston C, Haroutounian S, Moore A, Rice ASC, Wallace M, Park R, Gilron I. General risks of harm with cannabinoids, cannabis, and cannabis-based medicine possibly relevant to patients receiving these for pain management: an overview of systematic reviews.    Pain. 2021 Jul 1;162(Suppl 1):S80-S96. PMID: 32941319.
79. Mohr NM, Harland KK, Okoro UE, Fuller BM, Campbell K, Swanson MB, Simpson SQ, Parker EA, Mack LJ, Bell A, DeJong K, Faine B, Zepeski A, Mueller K, Chrischilles E, Carpenter CR, Jones MP, Ward MM. TELEmedicine as an intervention for sepsis in emergency departments: a multicenter comparative effectiveness study (TELEvISED Study).J Comp Eff Res. 2021 Feb;10(2):77-91. doi: 10.2217/cer-2020-0141. PMID: 33470848
80. Monks DT, Palanisamy A. Oxytocin: at birth and beyond. A systematic review of the long-term effects of peripartum oxytocin. Anaesthesia. 2021 Nov;76(11):1526-1537. doi: 10.1111/anae.15553.    PMID: 34389972.
81. Moore RA, Fisher E, Finn DP, Finnerup NB, Gilron I, Haroutounian S, Krane E, Rice ASC, Rowbotham M, Wallace M, Eccleston C.  Cannabinoids, cannabis, and cannabis-based medicines for pain management: an overview of systematic reviews.  Pain. 2021 Jul 1;162(Suppl 1):S67-S79. PMID: 32804833
82. Moquin, R. (2021). [Review of Classroom talk for social change: Critical conversations in English Language Arts, by M. Schieble, A. Vetter, & K. Monét Martin]. The Wabash Center Journal on Teaching 2(2).
83. Moquin, R. (2021). [Review of The craft of college teaching: A practical guide, by R. DiYanni & A. Borst]. Teachers College Record, Date Published: July 26, 2021.
84. Moquin, R. (2021). [Review of The department chair primer: What chairs need to know and do to make a difference, 2nd Edition, by D. Chu]. The Wabash Center Journal on Teaching 2(1).
85. Moy HP, Olvera D, Nayman BD, Pappal RD, Hayes JM, Mohr NM, Kollef MH, Palmer CM, Ablordeppey E, Faine B, Roberts BW, Fuller BM.  The AIR-SED Study: A multicenter Cohor Study of SEDation Practices, Deep Sedation and Coma Among Mechanically Venilated AIR Transport Patients. Crit Care Explor 2021 Dec 9;3(12) e0597 PMID: 34909700.
86. Murugan, V., Holzer, K. J., Termos, M., Vaughn, M.G. (2021). Intimate partner violence among pregnant women reporting to the emergency department: Findings from a nationwide sample. BMJ Sexual & Reproductive Health, 47, e7.
87. Murugan, V., Holzer, K. J., Vaughn, M. G., Carbone, J. T., Jackson, D. B., & Bitter, C. (2021). Coding of sexual assault by emergency physicians: A nationally representative study. Western Journal of Emergency Medicine, 22, 291-296.
88. Myers, M. A., Smith, A. P., Lane, L. C., Moquin, D. J., Vogel, P., Woolard, S., & Smith, A. M. (2021). Dynamically Linking Influenza Virus Infection with Lung Injury, Inflammation, and Disease Severity. eLife 2021;10:e68864. 
89. Nagele P, Palanca BJ, Gott B, Brown F, Barnes L, Nguyen T, Xiong W, Salloum NC, Espejo GD, Lessov-Schlaggar CN, Jain N, Cheng WWL, Komen H, Yee B, Bolzenius JD, Janski A, Gibbons R, Zorumski CF, Conway CR. A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med. 2021 June 9; 13: eabe1376. PMID: 34108247.
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74. Lee H, Golkowski D, Jordan D, Berger S, Ilg R, Lee J, Mashour GA, Lee U; ReCCognition Study Group. Relationship of critical dynamics, functional connectivity, and states of consciousness in large-scale human brain networks. Neuroimage. 2019 Mar;188:228-238.

75. Lele AV, Mills B, Qiu Q, Schloemerkemper N, Naik BI, Williams J, Venkat-Raghavan L, Vavilala MS; EVD Aware Study Collaborators. International Multicenter Survey
of Perioperative Management of External Ventricular Drains: Results of the EVD Aware Study. J Neurosurg Anesthesiol. 2020 Apr;32(2):132-139.

76. Lenze EJ, Bowie CR, Avidan MS. Cognitive Training for Optimizing Perioperative Brain Health. Am J Geriatr Psychiatry. 2019 Nov;27(11):1228-1231.

77. Lenze EJ, Avidan MS. Pride and Prejudice in the Treatment of Depression and Anxiety in Acutely Ill Older Adults. Am J Geriatr Psychiatry. 2019 Apr;27(4):391-394.

78. Li D, Vlisides PE, Kelz MB, Avidan MS, Mashour GA; ReCCognition Study Group. Dynamic Cortical Connectivity during General Anesthesia in Healthy Volunteers.
Anesthesiology. 2019 Jun;130(6):870-884.

79. Li F, Yang W, Jiang H, Guo C, Huang AJW, Hu H, Liu Q. TRPV1 activity and substance P release are required for corneal cold nociception. Nat Commun. 2019 Dec 12;10(1):5678.

80. Liang M, Guo Q, Huang F, Han G, Song K, Luo J, Cheng H, Hu H, Peden EK, Chen C, Mitch WE, Du J, Fu X, Truong L, Cheng J. Notch signaling in bone marrow-derived
FSP-1 cells initiates neointima formation in arteriovenous fistulas. Kidney Int. 2019 Jun;95(6):1347-1358.

81. Lingle CJ, Martinez-Espinosa PL, Yang-Hood A, Boero LE, Payne S, Persic D, V-Ghaffari B, Xiao M, Zhou Y, Xia XM, Pyott SJ, Rutherford MA. LRRC52 regulates
BK channel function and localization in mouse cochlear inner hair cells. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18397-18403.

82. Liu F, Dai S, Feng D, Peng X, Qin Z, Kearns AC, Huang W, Chen Y, Ergün S, Wang H, Rappaport J, Bryda EC, Chandrasekhar A, Aktas B, Hu H, Chang SL, Gao B, Qin X. Versatile cell ablation tools and their applications to study loss of cell functions. Cell Mol Life Sci. 2019 Dec;76(23):4725-4743.

83. Liu XY, Ginosar Y, Yazdi J, Hincker A, Chen ZF. Cross-talk between Human Spinal Cord μ-opioid Receptor 1Y Isoform and Gastrin-releasing Peptide Receptor Mediates Opioid-induced Scratching Behavior. Anesthesiology. 2019 Aug;131(2):381-391.

84. Lockhart EM, Hincker A, Klumpner TT, Hofer J, Cahill AG, Palanisamy A, Boyle W, Ginosar Y. Consultation, Surveillance, Monitoring, and Intensive Care (COSMIC): A
Novel 4-Tier Program to Identify and Monitor High-Risk Obstetric Patients From the Clinic to Critical Care. Anesth Analg. 2019 Jun;128(6):1354-1360.

85. Makkar JK, Jain K, Kuberan A, Balasubramanian M, Bhatia N, Singh PM. Pre-emptive multimodal analgesic regimen reduces post-operative epidural demand boluses in
traumatic shaft of femur fracture – A randomised controlled trial. Indian J Anaesth. 2019 Nov;63(11):895-899.

86. Makkar JK, Gourav KKP, Jain K, Singh PM, Dhatt SS, Sachdeva N, Bhadada S. Transforaminal Versus Lateral Parasagittal Versus Midline Interlaminar Lumbar Epidural Steroid Injection for Management of Unilateral Radicular Lumbar Pain: A Randomized Double-Blind Trial. Pain Physician. 2019 Nov;22(6):561-573.

87. Maloney SE, Rieger MA, Al-Hasani R, Bruchas MR, Wozniak DF, Dougherty JD. Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning. Genes Brain Behav. 2019 Sep;18(7):e12593.

88. Massaly N, Copits BA, Wilson-Poe AR, Hipólito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klaas A, Walker BM, Neve R, Cahill CM, Shoghi KI, Gereau RW 4th, McCall JG, Al-Hasani R, Bruchas MR, Morón JA. Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System. Neuron. 2019 May 8;102(3):564-573.e6.

89. Massaly N, Morón JA. Pain And Opioid Systems, Implications In The Opioid Epidemic. Curr Opin Behav Sci. 2019 Apr;26:69-74.

90. Maybrier HR, King CR, Crawford AE, Mickle AM, Emmert DA, Wildes TS, Avidan MS, Palanca BJA; ENGAGES Study Investigators. Early Postoperative Actigraphy Poorly Predicts Hypoactive Delirium. J Clin Sleep Med. 2019 Jan 15;15(1):79-87.

91. Mazer M, Unsinger J, Drewry A, Walton A, Osborne D, Blood T, Hotchkiss R, Remy KE. IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients. J Immunol. 2019 Oct 15;203(8):2088-2099.

92. McCall JG. Parsing Pain From Anxiety Within the Locus Coeruleus Noradrenergic System. Biol Psychiatry. 2019 Jun 15;85(12):983-985.

93. Meador K, Wysoczynski CL, Norris AJ, Aoto J, Bruchas MR, Tucker CL. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res. 2019 Sep 26;47(17):e97.

94. Meshik X, O’Neill PR, Gautam N. Physical Plasma Membrane Perturbation Using Subcellular Optogenetics Drives Integrin-Activated Cell Migration. ACS Synth Biol. 2019 Mar 15;8(3):498-510.

95. Meyer J, Del Vecchio G, Seitz V, Massaly N, Stein C. Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue. Br J Pharmacol. 2019 Dec;176(23):4510-4520.

96. Mickle AD, Won SM, Noh KN, Yoon J, Meacham KW, Xue Y, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Payne MA, Zhang J, Jang H, Li Y, Lai HH, Huang Y, et al. A wireless closed-loop system for optogenetic peripheral neuromodulation. Nature. 2019 Jan;565(7739):361-365.

97. Mohiuddin MM, Mizubuti G, Haroutounian S, Smith S, Campbell F, Park R, Gilron I. Adherence to Consolidated Standards of Reporting Trials (CONSORT) Guidelines for
Reporting Safety Outcomes in Trials of Cannabinoids for Chronic Pain: Protocol for a Systematic Review. JMIR Res Protoc. 2019 Jan 28;8(1):e11637.

98. Monks DT, Palanisamy A. Intrapartum oxytocin: time to focus on longer term consequences? Anaesthesia. 2019 Oct;74(10):1219-1222.

99. Montana MC. Where’s the Beef Indeed! Anesthesiology. 2019 Aug;131(2):449-450.

100. Montana MC, Juriga L, Sharma A, Kharasch ED. Opioid Sensitivity in Children with and without Obstructive Sleep Apnea. Anesthesiology. 2019 Jun;130(6):936-945.

101. Moore RP, Liu CJ, George P, Welch TP, AuBuchon JD, Jiao Y, Drobish JK. Early experiences with the use of continuous erector spinae plane blockade for the provision of perioperative analgesia for pediatric liver transplant recipients. Reg Anesth Pain Med. 2019 Apr 16. pii: rapm-2018-100253.

102. Murray DJ. Adding Science to the Decision to Extubate Children. Anesthesiology. 2019 Oct;131(4):769-770.

103. Murray-Torres T, Casarella A, Bollini M, Wallace F, Avidan MS, Politi MC. Anesthesiology Control Tower-Feasibility Assessment to Support Translation (ACTFAST): Mixed-Methods Study of a Novel Telemedicine-Based Support System for the Operating Room. JMIR Hum Factors. 2019 Apr 23;6(2):e12155.

104. Musch G. A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease. Contrast Media Mol Imaging. 2019 Aug 25;2019:1510507.

105. Nelson J, Hansen C, Scupp T, Brainard J. Implications of Procalcitonin Testing in Critically Ill Patients with Sepsis. Am J Respir Crit Care Med. 2019 Jan 15;199(2):232-234.

106. Onwochei DN, Van Ross J, Singh PM, Salter A, Monks DT. Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. Int J Obstet Anesth. 2019 Nov;40:14-23.

107. Oster AS, Reina E, Fehr JJ, Moore RP, Cox TE, George P. Massive Fetal Transfusion During an Emergency Ex Utero Intrapartum Treatment for a Congenital Infantile Fibrosarcoma: A Case Report. A A Pract. 2019 Oct 1;13(7):267-270.

108. Palanisamy A, Kinsella SM. Spinal tranexamic acid – a new killer in town. Anaesthesia. 2019 Jul;74(7):831-833.

109. Palanisamy A, Lopez J, Frolova A, Macones G, Cahill AG. Association between Uterine Tachysystole during the Last Hour of Labor and Cord Blood Lactate in Parturients at Term Gestation. Am J Perinatol. 2019 Sep;36(11):1171-1178.

110. Pappal RD, Roberts BW, Mohr NM, Ablordeppey E, Wessman BT, Drewry AM, Yan Y, Kollef MH, Avidan MS, Fuller BM. Protocol for a prospective, observational cohort
study of awareness in mechanically ventilated patients admitted from the emergency department: the ED-AWARENESS study. BMJ Open. 2019 Oct 7;9(10):e033379.

111. Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou
T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR. A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward. Cell. 2019 Jul 25;178(3):653-671.e19.

112. Pierce SR, Senneff TC, Germann AL, Akk G. Steady-state activation of the high-affinity isoform of the α4β2δ GABA(A) receptor. Sci Rep. 2019 Nov 5;9(1):15997.

113. Pollard K, Wessman BT. Development of a Standardized Communication Intervention Bundle for Use at a Medical Training Hospital Intensive Care Unit. Indian J Crit Care Med. 2019 May;23(5):234-235.

114. Ramirez-Zamora A, Giordano J, Boyden ES, Gradinaru V, Gunduz A, Starr PA, Sheth SA, McIntyre CC, Fox MD, Vitek J, Vedam-Mai V, Akbar U, Almeida L, Bronte-Stewart HM, Mayberg HS, Pouratian N, Gittis AH, Singer AC, Creed MC, Lazaro-Munoz G, Richardson M, Rossi MA, et al. Proceedings of the Sixth Deep Brain Stimulation
Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics. Front Neurosci. 2019 Sep 12;13:936.

115. Reijntjes DOJ, Lee JH, Park S, Schubert NMA, van Tuinen M, Vijayakumar S, Jones TA, Jones SM, Gratton MA, Xia XM, Yamoah EN, Pyott SJ. Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice. Sci Rep. 2019 Feb 22;9(1):2573.

116. Ristvedt S, Trinkaus K, Waters E, James A. Threat sensitivity is associated with the healthcare source used most often: doctor’s office, emergency room, or none at all. Heliyon. 2019 May 30;5(5):e01685.

117. Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Shea L, Donnino M, Jones C, Fuller BM, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S. Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest: Results From a Multicenter Prospective Cohort Study. Crit Care Med. 2019 Jan;47(1):93-100.

118. Roberts KL, Shuster JE, Britt NS, Balsara KR, Graetz TJ, Helwani M, Itoh A, Tellor BR. Evaluation of Clinical Outcomes with Phosphodiesterase-5 Inhibitor Therapy for Right Ventricular Dysfunction After Left Ventricular Assist Device Implantation. ASAIO J. 2019 Mar/Apr;65(3):264-269.

119. Sabapathi P, Roberts MB, Fuller BM, Puskarich MA, Jones CW, Kilgannon JH, Braz V, Creel-Bulos C, Scott N, Tester KL, Mazzarelli A, Trzeciak S, Roberts BW. Validation of a 5-item tool to measure patient assessment of clinician compassion in the emergency department. BMC Emerg Med. 2019 Nov 4;19(1):63.

120. Samaha E, Avila A, Helwani MA, Ben Abdallah A, Jaffe AS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2019 Mar 19;8(6):e008626.

121. Samineni VK, Grajales-Reyes JG, Sundaram SS, Yoo JJ, Gereau RW 4th. Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray. Nat Commun. 2019 Sep 25;10(1):4356.

122. Schoenfeldt J, Guffey R, Fingerman M. Cadaveric study investigating the mechanism of action of erector spinae blockade. Reg Anesth Pain Med. 2019 Jan 11. pii: rapm-2018-100190.

123. Shah AS, Yahanda AT, Athiraman U, Tempelhoff R, Chicoine MR. Spinal cord infarction with resultant paraplegia after Chiari I decompression: case report. J Neurosurg Spine. 2019 Dec 20:1-7.

124. Shea K, Choi L, Jagannathan D, Elterman K, Robinson J, Kodali B, Huang CC, Palanisamy A. Accidental dural puncture during labor analgesia and obstetric outcomes in nulliparous women. Int J Obstet Anesth. 2019 May;38:46-51.

125. Shin DJ, Germann AL, Covey DF, Steinbach JH, Akk G. Analysis of GABA(A) Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites. Mol Pharmacol. 2019 Jan;95(1):70-81.

126. Shortal BP, Hickman LB, Mak-McCully RA, Wang W, Brennan C, Ung H, Litt B, Tarnal V, Janke E, Picton P, Blain-Moraes S, Maybrier HR, Muench MR, Lin N, Avidan MS, Mashour GA, McKinstry-Wu AR, Kelz MB, Palanca BJ, Proekt A; ReCCognition Study Group. Duration of EEG suppression does not predict recovery time or degree of
cognitive impairment after general anaesthesia in human volunteers. Br J Anaesth. 2019 Aug;123(2):206-218.

127. Simkins M, Iqbal A, Gronemeyer A, Konzen L, White J, Koenig M, Palmer C, Kerby P, Buckman S, Despotovic V, Hoehner C, Boyle W. Inter-Rater Reliability and Impact
of Disagreements on Acute Physiology and Chronic Health Evaluation IV Mortality Predictions. Crit Care Explor. 2019 Oct 30;1(10):e0059.

128. Sindhar S, Kallogjeri D, Wildes TS, Avidan MS, Piccirillo JF. Association of Preoperative Functional Performance With Outcomes After Surgical Treatment of Head and Neck Cancer: A Clinical Severity Staging System. JAMA Otolaryngol Head Neck Surg. 2019 May 2.

129. Singh S, Lumbreras-Marquez MI, Farber MK, Xu X, Singh P, Gorman T, Palanisamy A. Transient Tachypnea of Newborns Is Associated With Maternal Spinal Hypotension During Elective Cesarean Delivery: A Retrospective Cohort Study. Anesth Analg. 2019 Jul;129(1):162-167.

130. Soliman N, Hohmann AG, Haroutounian S, Wever K, Rice ASC, Finn DP. A protocol for the systematic review and meta-analysis of studies in which cannabinoids were
tested for antinociceptive effects in animal models of pathological or injury-related persistent pain. Pain Rep. 2019 Jul 22;4(4):e766.

131. Song JB, Morrissey JJ, Mobley JM, Figenshau KG, Vetter JM, Bhayani SB, Kharasch ED, Figenshau RS. Urinary aquaporin 1 and perilipin 2: Can these novel markers accurately characterize small renal masses and help guide patient management? Int J Urol. 2019 Feb;26(2):260-265.

132. Spencer NJ, Hibberd T, Feng J, Hu H. Optogenetic control of the enteric nervous system and gastrointestinal transit. Expert Rev Gastroenterol Hepatol. 2019 Apr;13(4):281-284.

133. Stamenkovic DM, Laycock H, Karanikolas M, Ladjevic NG, Neskovic V, Bantel C. Chronic Pain and Chronic Opioid Use After Intensive Care Discharge – Is It Time to Change Practice? Front Pharmacol. 2019 Feb 22;10:23.

134. Steinbach JH, Akk G. Applying the Monod-Wyman-Changeux Allosteric Activation Model to Pseudo-Steady-State Responses from GABA(A) Receptors. Mol Pharmacol. 2019 Jan;95(1):106-119.

135. Stephens RJ, Siegler JE, Fuller BM. Mechanical Ventilation in the Prehospital and Emergency Department Environment. Respir Care. 2019 May;64(5):595-603.

136. Stewart KA, Ristvedt S, Brown KM, Waters EA, Trinkaus K, McCray N, James AS. Giving Voice to Black Men: Guidance for Increasing the Likelihood of Having a Usual Source of Care. Am J Mens Health. 2019 May-Jun;13(3):1557988319856738.

137. Strutz PK, Kronzer V, Tzeng W, Arrington B, McKinnon SL, Ben Abdallah A, Haroutounian S, Avidan MS. The relationship between obstructive sleep apnoea and postoperative delirium and pain: an observational study of a surgical cohort. Anaesthesia. 2019 Dec;74(12):1542-1550.

138. Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL. The molecular determinants of neurosteroid binding
in the GABA(A) receptor. J Steroid Biochem Mol Biol. 2019 Sep;192:105383.

139. Sun MY, Ziolkowski L, Lambert P, Shu HJ, Keiser M, Rensing N, Warikoo N, Martinek M, Platnick C, Benz A, Bracamontes J, Akk G, Steinbach JH, Zorumski CF, Wong M, Mennerick S. Mild chronic perturbation of inhibition severely alters hippocampal function. Sci Rep. 2019 Nov 11;9(1):16431.

140. Szabari MV, Takahashi K, Feng Y, Locascio JJ, Chao W, Carter EA, Vidal Melo MF, Musch G. Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation. Am J Respir Cell Mol Biol. 2019 Feb;60(2):179-188.

141. Taylor BK, Sinha GP, Donahue RR, Grachen CM, Morón JA, Doolen S. Opioid receptors inhibit the spinal AMPA receptor Ca(2+) permeability that mediates latent pain
sensitization. Exp Neurol. 2019 Apr;314:58-66.

142. Tisherman SA, Spevetz A, Blosser SA, Brown D, Chang C, Efron PA, O’Connor M, Sevransky JE, Wessman BT. The authors reply. Crit Care Med. 2019 May;47(5):e429.

143. Tolly BT, Helwani MA. Intraoperative Diagnosis of Atrial Flutter Using Left Atrial Appendage Doppler Profiling. J Cardiothorac Vasc Anesth. 2019 Feb;33(2):588-590.

144. Tong A, Petroff JT 2nd, Hsu FF, Schmidpeter PA, Nimigean CM, Sharp L, Brannigan G, Cheng WW. Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel. Elife. 2019 Nov 14;8. pii: e50766.

145. Turnbull IR, Hotchkiss RS. An Aspirin a Day Keeps the Intensivist Away? Crit Care Med. 2019 Apr;47(4):603-604.

146. Velissaris D, Karamouzos V, Pantzaris ND, Kyriakopoulou O, Gogos C, Karanikolas M. Relation Between Central Venous, Peripheral Venous and Arterial Lactate Levels
in Patients With Sepsis in the Emergency Department. J Clin Med Res. 2019 Sep;11(9):629-634.

147. Villafranca A, Hiebert B, Hamlin C, Young A, Parveen D, Arora RC, Avidan M, Jacobsohn E. Prevalence and predictors of exposure to disruptive behaviour in the operating room. Can J Anaesth. 2019 Jul;66(7):781-794.

148. Vlisides PE, Avidan MS, Mashour GA. Uncovering covert stroke in surgical patients. Lancet. 2019 Sep 21;394(10203):982-984.

149. Vlisides PE, Ioannidis JPA, Avidan MS. Hypnotic depth and postoperative death: a Bayesian perspective and an Independent Discussion of a clinical trial. Br J
Anaesth. 2019 Apr;122(4):421-427.

150. Vlisides PE, Thompson A, Kunkler BS, Maybrier HR, Avidan MS, Mashour GA; PODCAST Research Group. Perioperative Epidural Use and Risk of Delirium in Surgical
Patients: A Secondary Analysis of the PODCAST Trial. Anesth Analg. 2019 May;128(5):944-952.

151. Washburn ML, Wang Z, Walton AH, Goedegebuure SP, Figueroa DJ, Van Horn S, Grossman J, Remlinger K, Madsen H, Brown J, Srinivasan R, Wolf AI, Berger SB, Yi
VN, Hawkins WG, Fields RC, Hotchkiss RS. T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer. J Immunol. 2019 Oct 1;203(7):1897-1908.

152. Whitlock EL, Diaz-Ramirez LG, Smith AK, Boscardin WJ, Avidan MS, Glymour MM. Cognitive Change After Cardiac Surgery Versus Cardiac Catheterization: A Population-Based Study. Ann Thorac Surg. 2019 Apr;107(4):1119-1125.

153. Wildes TS, Mickle AM, Avidan MS. Electroencephalography-Guided Anesthetic Administration and Postoperative Delirium-Reply. JAMA. 2019 Jun 25;321(24):2471-2472.

154. Wildes TS, Mickle AM, Ben Abdallah A, Maybrier HR, Oberhaus J, Budelier TP, Kronzer A, McKinnon SL, Park D, Torres BA, Graetz TJ, Emmert DA, Palanca BJ, Goswami S, Jordan K, Lin N, Fritz BA, Stevens TW, Jacobsohn E, Schmitt EM, Inouye SK, Stark S, et al. Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial. JAMA. 2019 Feb 5;321(5):473-483.

155. Wulff AB, Tooley J, Marconi LJ, Creed MC. Ventral pallidal modulation of aversion processing. Brain Res. 2019 Jun 15;1713:62-69.

156. Yu Y, Liang Q, Liu H, Luo Z, Hu H, Perlmutter JS, Tu Z. Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain. Org Biomol Chem. 2019 Jun 5;17(22):5586-5594.

157. Zhang H, Gutruf P, Meacham K, Montana MC, Zhao X, Chiarelli AM, Vázquez-Guardado A, Norris A, Lu L, Guo Q, Xu C, Wu Y, Zhao H, Ning X, Bai W, Kandela I, Haney CR, Chanda D, Gereau RW 4th, Rogers JA. Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry. Sci Adv. 2019 Mar 8;5(3):eaaw0873.

158. Zhang Y, Mickle AD, Gutruf P, McIlvried LA, Guo H, Wu Y, Golden JP, Xue Y, Grajales-Reyes JG, Wang X, Krishnan S, Xie Y, Peng D, Su CJ, Zhang F, Reeder JT, Vogt SK, Huang Y, Rogers JA, Gereau RW 4th. Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. Sci Adv. 2019 Jul 5;5(7):eaaw5296.

159. Zoller JK, Gregory SH, Stevens TW, Sanchez LA, Hueneke R. Anesthetic Considerations for Aortic Arch Stenting. J Cardiothorac Vasc Anesth. 2019 Nov;33(11):3163-3175.

Department Publications 2018

1. Abbott TEF, Ahmad T, Phull MK, Fowler AJ, Hewson R, Biccard BM, Chew MS, Gillies M, Pearse RM: The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis. British journal of anaesthesia 2018, 120(1):146-155.

2. Abraham J, Ihianle I, Ward CE, Arora VM, Kannampallil TG: Comparative assessment of content overlap between written documentation and verbal communication: An observational study of resident sign-outs. JAMIA Open 2018, 1(2):210-217.

3. Abraham J, Kannampallil TG, Jarman A, Sharma S, Rash C, Schiff G, Galanter W: Reasons for computerised provider order entry (CPOE)-based inpatient medication ordering errors: an observational study of voided orders. BMJ quality & safety 2018, 27(4):299-307.

4. Abraham J, Kannampallil TG, Ward CE, Bogan C, Hyderi A: Effect of Handoff Training on Resident Communication Quality: An Observational Study (Refereed Conference Papers). 2018.

5. Akk G, Shin DJ, Germann AL, Steinbach JH: GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC50 and Basal Activity. Molecular pharmacology 2018, 93(2):90-100.

6. Al-Hasani R, Wong JT, Mabrouk OS, McCall JG, Schmitz GP, Porter-Stransky KA, Aragona BJ, Kennedy RT, Bruchas MR: In vivo detection of optically-evoked opioid peptide release. eLife 2018, 7.

7. Aranake-Chrisinger A, Cheng JZ, Muench MR, Tang R, Mickle A, Maybrier H, Lin N, Wildes T, Lenze E, Avidan MS: Ability of postoperative delirium to predict intermediate-term postoperative cognitive function in patients undergoing elective surgery at an academic medical centre: protocol for a prospective cohort study. BMJ open 2018, 8(3):e017079.

8. Aranake-Chrisinger A, Whitlock EL, Avidan MS: We may be Homo sapiens, but anaesthetists are merely apes when evaluating risk. British journal of anaesthesia 2018, 121(4):702-705.

9. AS O, E R, JJ F, RP M, TE C, P. G: Massive Transfusion During Emergency Ex-Utero Intrapartum Treatment Procedure for Delivery of Infant with Congenital Infantile Fibrosarcoma: A Case Report. A&A Practice 2018.

10. Aslan NA, Vural C, Yilmaz AA, Alanoglu Z: Propofol Versus Thiopental for Rapid-Sequence Induction in Isolated Systolic Hypertensive Patients: A Factorial Randomized Double-Blind Clinical Trial. Turkish journal of anaesthesiology and reanimation 2018, 46(5):367-372.

11. Athiraman U, Abdallah AB, Kansagra A, Tempelhoff R: Endovascular treatment of acute ischaemic stroke under conscious sedation: Predictors of poor outcomes. Indian journal of anaesthesia 2018, 62(12):951-957.

12. Avidan MS, Graetz TJ: Monitoring the brain strikes a discordant note for anesthesiologists. Canadian journal of anaesthesia = Journal canadien d’anesthesie 2018, 65(5):501-506.

13. Avidan MS, Myles PS: Auditing the national audit projects: impact and implementation. British journal of anaesthesia 2018, 121(1):107-111.

14. Balci D, Ozcelik M, Kirimker EO, Cetinkaya A, Ustuner E, Cakici M, Inan B, Alanoglu Z, Bilgic S, Akar AR: Extended left hepatectomy for intrahepatic cholangiocarcinoma: hepatic vein reconstruction with in-situ hypothermic perfusion and extracorporeal membrane oxygenation. BMC surgery 2018, 18(1):7.

15. Barry DM, Munanairi A, Chen ZF: Spinal Mechanisms of Itch Transmission. Neuroscience bulletin 2018, 34(1):156-164.

16. Basnet S, Zhang M, Lesser M, Wolf-Klein G, Qiu G, Williams M, Pekmezaris R, DiMarzio P: Thirty-day hospital readmission rate amongst older adults correlates with an increased number of medications, but not with Beers medications. Geriatrics & gerontology international 2018, 18(10):1513-1518.

17. Bombardieri AM, Beckman J, Urban M, Go G, De Gaudio AR, Girardi FP, Ma Y, Memtsoudis SG: An Observational Study of Cerebral Blood Flow Velocity Evaluation in the Prone Position During Posterior Lumbar Surgery. Anesthesia and analgesia 2018.

18. Boyle WA, Murray DJ, Beyatte MB, Knittel JG, Kerby PW, Woodhouse J, Boulet JR: Simulation-Based Assessment of Critical Care “Front-Line” Providers. Crit Care Med 2018, 46(6):e516-e522.

19. Burden DL, Kim D, Cheng W, Chandler Lawler E, Dreyer DR, Keranen Burden LM: Mechanically Enhancing Planar Lipid Bilayers with a Minimal Actin Cortex. Langmuir : the ACS journal of surfaces and colloids 2018, 34(37):10847-10855.

20. BW R, NM M, E A, AM D, IT F, S T, MH K, BM F: Association between arterial pressure of arterial carbon dioxide and survival to hospital discharge among patients diagosed with sepsis in the emergency department. Crit care Med 2018, 46(3):e213-e220.

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129. Spencer NJ, Hibberd TJ, Travis L, Wiklendt L, Costa M, Hu H, Brookes SJ, Wattchow DA, Dinning PG, Keating DJ et al: Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle. The Journal of neuroscience : the official journal of the Society for Neuroscience 2018, 38(24):5507-5522.

130. Stephens RJ, Dettmer MR, Roberts BW, Ablordeppey E, Fowler SA, Kollef MH, Fuller BM: Practice Patterns and Outcomes Associated With Early Sedation Depth in Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis. Crit Care Med 2018, 46(3):471-479.

131. Strutz P, Tzeng W, Arrington B, Kronzer V, McKinnon S, Ben Abdallah A, Haroutounian S, Avidan MS: Obstructive sleep apnea as an independent predictor of postoperative delirium and pain: protocol for an observational study of a surgical cohort. F1000Research 2018, 7:328.

132. Sun MY, Shu HJ, Benz A, Bracamontes J, Akk G, Zorumski CF, Steinbach JH, Mennerick SJ: Chemogenetic Isolation Reveals Synaptic Contribution of delta GABAA Receptors in Mouse Dentate Granule Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 2018, 38(38):8128-8145.

133. Swarm RA, Dans M: NCCN Frameworks for Resource Stratification of NCCN Guidelines: Adult Cancer Pain and Palliative Care. Journal of the National Comprehensive Cancer Network : JNCCN 2018, 16(5s):628-631.

134. Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ: Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. The pharmacogenomics journal 2018, 18(1):136-143.

135. Thampy LK, Remy KE, Walton AH, Hong Z, Liu K, Liu R, Yi V, Burnham CD, Hotchkiss RS: Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration. PloS one 2018, 13(6):e0199497.

136. Tisherman SA, Spevetz A, Blosser SA, Brown D, Chang C, Efron PA, O’Connor M, Sevransky JE, Wessman BT: A Case for Change in Adult Critical Care Training for Physicians in the United States: A White Paper Developed by the Critical Care as a Specialty Task Force of the Society of Critical Care Medicine. Crit Care Med 2018, 46(10):1577-1584.

137. Tooley J, Marconi L, Alipio JB, Matikainen-Ankney B, Georgiou P, Kravitz AV, Creed MC: Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula-Tegmental Circuitry and Constrain Reward Seeking. Biological psychiatry 2018, 83(12):1012-1023.

138. Townsend M, Liou T, Kallogjeri D, Schoer M, Scott-Wittenborn N, Lindburg M, Bottros M, Jackson RS, Nussenbaum B, Piccirillo JF: Effect of Perioperative Gabapentin Use on Postsurgical Pain in Patients Undergoing Head and Neck Mucosal Surgery: A Randomized Clinical Trial. JAMA otolaryngology– head & neck surgery 2018, 144(11):959-966.

139. Vannucci A, Kallogjeri D, Helsten DL, Cavallone LF: In Response. Anesthesia and analgesia 2018, 127(5):e82-e83.

140. Vannucci A, Rossi IT, Prifti K, Kallogjeri D, Rangrass G, DeCresce D, Brenner D, Lakshman N, Helsten DL, Cavallone LF: Modifiable and Nonmodifiable Factors Associated With Perioperative Failure of Extraglottic Airway Devices. Anesthesia and analgesia 2018, 126(6):1959-1967.

141. Varaday SS, (Raghu) MR, Press CD: Subarachnoid Spinal Block. Medscape 2018.

142. Venkata C, Kasal J: Cardiac Dysfunction in Adult Patients with Traumatic Brain Injury: A Prospective Cohort Study. Clinical medicine & research 2018, 16(3-4):57-65.

143. Vlisides PE, Avidan MS, Mashour GA: Reconceptualising stroke research to inform the question of anaesthetic neurotoxicity. British journal of anaesthesia 2018, 120(3):430-435.

144. Wang C, Sudlow G, Wang Z, Cao S, Jiang Q, Neiner A, Morrissey JJ, Kharasch ED, Achilefu S, Singamaneni S: Metal-Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics. Advanced healthcare materials 2018, 7(22):e1800950.

145. Wang C, Sun H, Luan J, Jiang Q, Tadepalli S, Morrissey JJ, Kharasch ED, Singamaneni S: Metal-Organic Framework Encapsulation for Biospecimen Preservation. Chem Mater 2018, 30:1291-1300.

146. Wang C, Wang L, Tadepalli S, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S: Ultrarobust Biochips with Metal-Organic Framework Coating for Point-of-Care Diagnosis. ACS sensors 2018, 3(2):342-351.

147. Wang H, Cui Z, Chen Y, Avidan M, Abdallah AB, Kronzer A: Predicting Hospital Readmission via Cost-Sensitive Deep Learning. IEEE/ACM transactions on computational biology and bioinformatics 2018, 15(6):1968-1978.

148. Wessman B: Member Spotlight: Supporting Chromosome 18 Research. Critical Connections SCCM 2018, 17(6).

149. Whitlock EL, Diaz-Ramirez LG, Smith AK, Boscardin WJ, Avidan MS, Glymour MM: Cognitive Change After Cardiac Surgery Versus Cardiac Catheterization: A Population-Based Study. The Annals of thoracic surgery 2018.

150. Wolfman SL, Gill DF, Bogdanic F, Long K, Al-Hasani R, McCall JG, Bruchas MR, McGehee DS: Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum. Nature communications 2018, 9(1):2710.

151. Wulff AB, Tooley J, Marconi LJ, Creed MC: Ventral pallidal modulation of aversion processing. Brain Res 2018.

152. Xie Z, Hu H: TRP Channels as Drug Targets to Relieve Itch. Pharmaceuticals (Basel, Switzerland) 2018, 11(4).

153. Zhou Y, Xia XM, Lingle CJ: BK channel inhibition by strong extracellular acidification. eLife 2018, 7.

Department Publications 2017

1. Ablordeppey EA, Drewry AM, Beyer AB, Theodoro DL, Fowler SA, Fuller BM, Carpenter CR. Diagnostic Accuracy of Central Venous Catheter Confirmation by Bedside Ultrasound Versus Chest Radiography in Critically Ill Patients: A Systematic Review and Meta-Analysis. Critical care medicine 2017;45:715-24.
2. Ablordeppey EA, Drewry AM, Beyer AB, Theodoro DL, Fuller BM, Carpenter CR. The authors reply. Critical care medicine 2017;45:e1190-e1.
3. Aranake-Chrisinger A, Avidan MS. Postoperative delirium portends descent to dementia. British journal of anaesthesia 2017;119:285-8.
4. Aretha D, Fligou F, Kiekkas P, Messini C, Panteli E, Zintzaras E, Karanikolas M. Safety and effectiveness of alveolar recruitment maneuvers and positive end-expiratory pressure during general anesthesia for cesarean section: a prospective, randomized trial. International journal of obstetric anesthesia 2017;30:30-8.
5. Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO, Veselis RA, Grocott HP, Emmert DA, Rogers EM, Downey RJ, Yulico H, Noh GJ, Lee YH, Waszynski CM, Arya VK, Pagel PS, Hudetz JA, Muench MR, Fritz BA, Waberski W, Inouye SK, Mashour GA. Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. Lancet (London, England) 2017;390:267-75.
6. Backer CL, Hardy CA. Preoperative labs: Less is more. The Journal of thoracic and cardiovascular surgery 2017;153:677.
7. Balderman J, Holzem K, Field BJ, Bottros MM, Abuirqeba AA, Vemuri C, Thompson RW. Associations between clinical diagnostic criteria and pretreatment patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome. Journal of vascular surgery 2017;66:533-44.e2.
8. Barry DM, Yu YQ, Hao Y, Liu XT, Chen ZF. Response to Comment on “Molecular and neural basis of contagious itch behavior in mice”. Science (New York, NY) 2017;357.
9. Beyer A, Rees R, Palmer C, Wessman BT, Fuller BM. Blood product transfusion in emergency department patients: a case-control study of practice patterns and impact on outcome. International journal of emergency medicine 2017;10:5.
10. Blain-Moraes S, Tarnal V, Vanini G, Bel-Behar T, Janke E, Picton P, Golmirzaie G, Palanca BJA, Avidan MS, Kelz MB, Mashour GA. Network Efficiency and Posterior Alpha Patterns Are Markers of Recovery from General Anesthesia: A High-Density Electroencephalography Study in Healthy Volunteers. Frontiers in human neuroscience 2017;11:328.
11. Bottros MM, AuBuchon JD, McLaughlin LN, Altchek DW, Illig KA, Thompson RW. Exercise-Enhanced, Ultrasound-Guided Anterior Scalene Muscle/Pectoralis Minor Muscle Blocks Can Facilitate the Diagnosis of Neurogenic Thoracic Outlet Syndrome in the High-Performance Overhead Athlete. The American journal of sports medicine 2017;45:189-94.
12. Bouzia A, Tassoudis V, Karanikolas M, Vretzakis G, Petsiti A, Tsilimingas N, Arnaoutoglou E. Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery. Anesthesiology research and practice 2017;2017:2753962.
13. Brown JC, Samaha E, Rao S, Helwani MA, Duma A, Brown F, Gage BF, Miller JP, Jaffe AS, Apple FS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI. Anesthesia and analgesia 2017;125:1455-62.
14. Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS. Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins. Analytical chemistry 2017;89:2636-44.
15. Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. The Journal of biological chemistry 2017;292:9294-304.
16. Bullock WM, Yalamuri SM, Gregory SH, Auyong DB, Grant SA. Ultrasound-Guided Suprainguinal Fascia Iliaca Technique Provides Benefit as an Analgesic Adjunct for Patients Undergoing Total Hip Arthroplasty. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2017;36:433-8.
17. C W, R H, JJ M, ED K, S S. Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction. Small (Weinheim an der Bergstrasse, Germany) 2017.
18. Cavallone LF. Airway management and the unstable cervical spine: it is time to assess outcomes that matter to patients. Minerva anestesiologica 2017;83:781-3.
19. CC L, R X, B. Z. Preoperative Drinking and Enhanced Recovery After Surgery (ERAS) in Chinese. Chinese Journal Of Current Advances in General Surgery 2017;20:876-81.
20. Chalmers PN, Salazar D, Fingerman ME, Keener JD, Chamberlain A. Continuous interscalene brachial plexus blockade is associated with reduced length of stay after shoulder arthroplasty. Orthopaedics & traumatology, surgery & research : OTSR 2017;103:847-52.
21. Chen J, Xia L, Bruchas MR, Solnica-Krezel L. Imaging early embryonic calcium activity with GCaMP6s transgenic zebrafish. Developmental biology 2017;430:385-96.
22. Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, Chan DW, Gibson BW, Gingras AC, Held JM, Hirayama-Kurogi M, Hou G, Krisp C, Larsen B, Lin L, Liu S, Molloy MP, Moritz RL, Ohtsuki S, Schlapbach R, Selevsek N, Thomas SN, Tzeng SC, Zhang H, Aebersold R. Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nature communications 2017;8:291.
23. Crouser ED, Hotchkiss RS. Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis. Critical care medicine 2017;45:145-7.
24. Cui V, Tedeschi CM, Kronzer VL, McKinnon SL, Avidan MS. Protocol for an observational study of delirium in the post-anaesthesia care unit (PACU) as a potential predictor of subsequent postoperative delirium. BMJ open 2017;7:e016402.
25. Dahl AB, Ben Abdallah A, Maniar H, Avidan MS, Bollini ML, Patterson GA, Steinberg A, Scaggs K, Dribin BV, Ridley CH. Building a collaborative culture in cardiothoracic operating rooms: pre and postintervention study protocol for evaluation of the implementation of teamSTEPPS training and the impact on perceived psychological safety. BMJ open 2017;7:e017389.
26. De Tina A, Palanisamy A. General Anesthesia During the Third Trimester: Any Link to Neurocognitive Outcomes? Anesthesiology clinics 2017;35:69-80.
27. Dong P, Guo C, Huang S, Ma M, Liu Q, Luo W. TRPC3 Is Dispensable for beta-Alanine Triggered Acute Itch. Scientific reports 2017;7:13869.
28. Drewry AM, Ablordeppey EA, Murray ET, Stoll CRT, Izadi SR, Dalton CM, Hardi AC, Fowler SA, Fuller BM, Colditz GA. Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis. Critical care medicine 2017;45:806-13.
29. Drzymalski DM, Tsen LC, Palanisamy A, Zhou J, Huang CC, Kodali BS. A Randomized Controlled Trial of Music Use During Epidural Catheter Placement on Laboring Parturient Anxiety, Pain, and Satisfaction. Anesthesia and analgesia 2017;124:542-7.
30. Duma A, Pal S, Johnston J, Helwani MA, Bhat A, Gill B, Rosenkvist J, Cartmill C, Brown F, Miller JP, Scott MG, Sanchez-Conde F, Jarvis M, Farber NB, Zorumski CF, Conway C, Nagele P. High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy: A Prospective, Observational Cohort Study. Anesthesiology 2017;126:643-52.
31. Fehr JJ, McBride ME, Boulet JR, Murray DJ. The Simulation-Based Assessment of Pediatric Rapid Response Teams. The Journal of pediatrics 2017;188:258-62.e1.
32. Feng J, Luo J, Mack MR, Yang P, Zhang F, Wang G, Gong X, Cai T, Mei Z, Kim BS, Yin S, Hu H. The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice. The Journal of allergy and clinical immunology 2017;140:885-8.e6.
33. Feng J, Yang P, Mack MR, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Yin S, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nature communications 2017;8:980.
34. Fick DM, Auerbach AD, Avidan MS, Busby-Whitehead J, Ely EW, Jones RN, Marcantonio ER, Needham DM, Pandharipande P, Robinson TN, Schmitt EM, Travison TG, Inouye SK. Network for Investigation of Delirium Across the U.S. (NIDUS): Advancing the Field of Delirium with a New Interdisciplinary Research Network. Journal of gerontological nursing 2017;43:4-6.
35. Fuller B. The importance of mechanical ventilation in the emergency department: an interview with Brian Fuller, MD. ACEP Critical Care Medicine Newsletter 2017.
36. Fuller BM, Carpenter CR. Pooled RCTs: Early goal-directed therapy does not reduce mortality more than usual care in early septic shock. Annals of internal medicine 2017;167:Jc6.
37. Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH. Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial. Annals of emergency medicine 2017;70:406-18.e4.
38. Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH. A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome. Critical care medicine 2017;45:645-52.
39. Fuller BM, Mohr NM, Drewry AM, Ferguson IT, Trzeciak S, Kollef MH, Roberts BW. Partial pressure of arterial carbon dioxide and survival to hospital discharge among patients requiring acute mechanical ventilation: A cohort study. Journal of critical care 2017;41:29-35.
40. Gaudilliere B, Angst MS, Hotchkiss RS. Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go! Critical care medicine 2017;45:1577-8.
41. Girard T, Palanisamy A. The obstetric difficult airway: if we can’t predict it, can we prevent it? Anaesthesia 2017;72:143-7.
42. Gomez AM, Bruchas MR. A Molecular Code for Imprinting Drug-Cue Associations. Neuron 2017;96:3-5.
43. Graetz TJ, Hotchkiss RS. Sepsis: Preventing organ failure in sepsis – the search continues. Nature reviews Nephrology 2017;13:5-6.
44. Gregory SH, Yalamuri SM, McCartney SL, Shah SA, Sosa JA, Roman S, Colin BJ, Lentschener C, Munroe R, Patel S, Feinman JW, Augoustides JG. Perioperative Management of Adrenalectomy and Inferior Vena Cava Reconstruction in a Patient With a Large, Malignant Pheochromocytoma With Vena Caval Extension. Journal of cardiothoracic and vascular anesthesia 2017;31:365-77.
45. Gregory SH, Zoller JK, Lakshminarasimhachar A. A New Regional Wall Motion Abnormality After Aortic Dissection Repair: What is the Next Step? Journal of cardiothoracic and vascular anesthesia 2017;31:2131-3.
46. Grimaldi D, Pradier O, Hotchkiss RS, Vincent JL. Nivolumab plus interferon-gamma in the treatment of intractable mucormycosis. The Lancet Infectious diseases 2017;17:18.
47. H W, Z C, Y C, M A, A BA, A K. Cost-sensitive Deep Learning for Early Readmission Prediction at A Major Hospital. In Proceedings of KDD, Halifax, Canada 2017;(KDD’17):9.
48. Hibberd TJ, Costa M, Travis L, Brookes SJH, Wattchow DA, Feng J, Hu H, Spencer NJ. Neurogenic and myogenic patterns of electrical activity in isolated intact mouse colon. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2017;29:1-12.
49. Hincker A, Ben Abdallah A, Avidan M, Candelario P, Helsten D. Electronic medical record interventions and recurrent perioperative antibiotic administration: a before-and-after study. Canadian journal of anaesthesia = Journal canadien d’anesthesie 2017;64:716-23.
50. Hu R, Luan J, Kharasch ED, Singamaneni S, Morrissey JJ. Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors. ACS applied materials & interfaces 2017;9:145-51.
51. Huang KL, Li S, Mertins P, Cao S, Gunawardena HP, Ruggles KV, Mani DR, Clauser KR, Tanioka M, Usary J, Kavuri SM, Xie L, Yoon C, Qiao JW, Wrobel J, Wyczalkowski MA, Erdmann-Gilmore P, Snider JE, Hoog J, Singh P, Niu B, Guo Z, Sun SQ, Sanati S, Kawaler E, Wang X, Scott A, Ye K, McLellan MD, Wendl MC, Malovannaya A, Held JM, Gillette MA, Fenyo D, Kinsinger CR, Mesri M, Rodriguez H, Davies SR, Perou CM, Ma C, Reid Townsend R, Chen X, Carr SA, Ellis MJ, Ding L. Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nature communications 2017;8:14864.
52. Hueneke R, Adenwala A, Mellor RL, Seidman JG, Seidman CE, Nerbonne JM. Early remodeling of repolarizing K(+) currents in the alphaMHC(403/+) mouse model of familial hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology 2017;103:93-101.
53. Jin X, Germann AL, Shin DJ, Akk G, Steinbach JH. Determination of the Residues in the Extracellular Domain of the Nicotinic alpha Subunit Required for the Actions of Physostigmine on Neuronal Nicotinic Receptors. Molecular pharmacology 2017;92:318-26.
54. Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH. The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic alpha4beta2 Receptors. Molecular pharmacology 2017;91:100-9.
55. JK M, DJ M, A S, KN R, A N. Tertiary Referrals for Fractures in Children. Journal of PeriAnesthesia Nursing 32 2017.
56. Juang J, Gabriel RA, Dutton RP, Palanisamy A, Urman RD. Choice of Anesthesia for Cesarean Delivery: An Analysis of the National Anesthesia Clinical Outcomes Registry. Anesthesia and analgesia 2017;124:1914-7.
57. Juriga LL, Murray DJ, Boulet JR, Fehr JJ. Simulation and the diagnostic process: a pilot study of trauma and rapid response teams. Diagnosis (Berlin, Germany) 2017;4:241-9.
58. Kahan BC, Koulenti D, Arvaniti K, Beavis V, Campbell D, Chan M, Moreno R, Pearse RM. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries. Intensive care medicine 2017;43:971-9.
59. Kharasch ED. Current Concepts in Methadone Metabolism and Transport. Clinical pharmacology in drug development 2017;6:125-34.
60. Kharasch ED. Editor’s Note: ANESTHESIOLOGY 2017: Expanding the Richness and Reach. Anesthesiology 2017;127:1-2.
61. Kharasch ED, Houle TT. Errors and Integrity in Seeking and Reporting Apparent Research Misconduct. Anesthesiology 2017;127:733-7.
62. Kopec M, Duma A, Helwani MA, Brown J, Brown F, Gage BF, Gibson DW, Miller JP, Novak E, Jaffe AS, Apple FS, Scott MG, Nagele P. Improving Prediction of Postoperative Myocardial Infarction With High-Sensitivity Cardiac Troponin T and NT-proBNP. Anesthesia and analgesia 2017;124:398-405.
63. Kremer JC, Prudner BC, Lange SES, Bean GR, Schultze MB, Brashears CB, Radyk MD, Redlich N, Tzeng SC, Kami K, Shelton L, Li A, Morgan Z, Bomalaski JS, Tsukamoto T, McConathy J, Michel LS, Held JM, Van Tine BA. Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers. Cell reports 2017;18:991-1004.
64. Krom AJ, Cohen Y, Ezri T, Halpern SH, Miller JP, Ginosar Y. Category-1 caesarean section, airways and Julius Caesar. A reply. Anaesthesia 2017;72:1154-5.
65. Krom AJ, Cohen Y, Miller JP, Ezri T, Halpern SH, Ginosar Y. Choice of anaesthesia for category-1 caesarean section in women with anticipated difficult tracheal intubation: the use of decision analysis. Anaesthesia 2017;72:156-71.
66. Kronzer VL, Jerry MR, Ben Abdallah A, Wildes TS, McKinnon SL, Sharma A, Avidan MS. Changes in quality of life after elective surgery: an observational study comparing two measures. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2017;26:2093-102.
67. Lai HH, Jemielita T, Sutcliffe S, Bradley CS, Naliboff B, Williams DA, Gereau RWt, Kreder K, Clemens JQ, Rodriguez LV, Krieger JN, Farrar JT, Robinson N, Landis JR. Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study. The Journal of urology 2017;198:622-31.
68. Lai HH, Shen B, Vijairania P, Zhang X, Vogt SK, Gereau RWt. Anti-vascular endothelial growth factor treatment decreases bladder pain in cyclophosphamide cystitis: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network animal model study. BJU international 2017;120:576-83.
69. Lee LO, Bateman BT, Kheterpal S, Klumpner TT, Housey M, Aziz MF, Hand KW, MacEachern M, Goodier CG, Bernstein J, Bauer ME. Risk of Epidural Hematoma after Neuraxial Techniques in Thrombocytopenic Parturients: A Report from the Multicenter Perioperative Outcomes Group. Anesthesiology 2017;126:1053-63.
70. Lenze EJ, Stark S, Avidan MS. Alternative Facts? Antidepressants and Falls in Older Adults. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2017;25:1337-8.
71. Luan J, Hu R, Tadepalli S, Morrissey JJ, Kharasch ED. Amplification of Refractometric Biosensor Response through Biomineralization of Metal-Organic Framework Nanocrystals. Advanced Materials Technologies 2017;2.
72. Luo J, Abaci Turk E, Bibbo C, Gagoski B, Roberts DJ, Vangel M, Tempany-Afdhal CM, Barnewolt C, Estroff J, Palanisamy A, Barth WH, Zera C, Malpica N, Golland P, Adalsteinsson E, Robinson JN, Grant PE. In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study. Scientific reports 2017;7:3713.
73. M B, I M, MM B. A Gathering Storm: Are Perioperative Opioids Problematic? Perspectives from the Next Generation of Pain Practitioners. PAINWeek Journal 2017;Q1:26-33.
74. Maier KL, McKinstry-Wu AR, Palanca BJA, Tarnal V, Blain-Moraes S, Basner M, Avidan MS, Mashour GA, Kelz MB. Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Frontiers in human neuroscience 2017;11:284.
75. Matkovich SJ, Al Khiami B, Efimov IR, Evans S, Vader J, Jain A, Brownstein BH, Hotchkiss RS, Mann DL. Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis. Critical care medicine 2017;45:407-14.
76. McCall JG, Jeong JW. Minimally invasive probes for programmed microfluidic delivery of molecules in vivo. Current opinion in pharmacology 2017;36:78-85.
77. McCall JG, Qazi R, Shin G, Li S, Ikram MH, Jang KI, Liu Y, Al-Hasani R, Bruchas MR, Jeong JW, Rogers JA. Preparation and implementation of optofluidic neural probes for in vivo wireless pharmacology and optogenetics. Nature protocols 2017;12:219-37.
78. McCall JG, Siuda ER, Bhatti DL, Lawson LA, McElligott ZA, Stuber GD, Bruchas MR. Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior. eLife 2017;6.
79. McCartney SL, Cooter M, Samad Z, Sivak J, Castleberry A, Gregory S, Haney J, Hartwig M, Swaminathan M. Mitral Regurgitation After Orthotopic Lung Transplantation: Natural History and Impact on Outcomes. Journal of cardiothoracic and vascular anesthesia 2017;31:924-30.
80. Meacham K, Shepherd A, Mohapatra DP, Haroutounian S. Neuropathic Pain: Central vs. Peripheral Mechanisms. Current pain and headache reports 2017;21:28.
81. Mohr NM, Harland KK, Shane DM, Ahmed A, Fuller BM, Ward MM, Torner JC. Rural Patients With Severe Sepsis or Septic Shock Who Bypass Rural Hospitals Have Increased Mortality: An Instrumental Variables Approach. Critical care medicine 2017;45:85-93.
82. Montana MC, Evers AS. Anesthetic Neurotoxicity: New Findings and Future Directions. The Journal of pediatrics 2017;181:279-85.
83. Mooradian AD, Held JM, Naegle KM. Using ProteomeScout: A Resource of Post-Translational Modifications, Their Experiments, and the Proteins That They Annotate. Current protocols in bioinformatics 2017;59:13.32.1-13.32.27.
84. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O’Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nature immunology 2017;18:826-31.
85. Odom EB, Mehta N, Parikh RP, Guffey R, Myckatyn TM. Paravertebral Blocks Reduce Narcotic Use Without Affecting Perfusion in Patients Undergoing Autologous Breast Reconstruction. Annals of surgical oncology 2017;24:3180-7.
86. Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RWt, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell 2017;171:217-28.e13.
87. Olsen MC, Anderson MJ, Fehr JJ, Christensen JL, Shepard MP, Poe JB, Eghtesady P. ECMO for Pediatric Lung Transplantation. ASAIO journal (American Society for Artificial Internal Organs : 1992) 2017;63:e77-e80.
88. Padilla C, Palanisamy A. Managing Maternal Sepsis: Early Warning Criteria to ECMO. Clinical obstetrics and gynecology 2017;60:418-24.
89. Palanca BJA, Avidan MS, Mashour GA. Human neural correlates of sevoflurane-induced unconsciousness. British journal of anaesthesia 2017;119:573-82.
90. Palanca BJA, Wildes TS, Ju YS, Ching S, Avidan MS. Electroencephalography and delirium in the postoperative period. British journal of anaesthesia 2017;119:294-307.
91. Palanisamy A, Crosby G, Culley DJ. EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats. Behavioral and brain functions : BBF 2017;13:14.
92. Puyo CA, Peruzzi D, Earhart A, Roller E, Karanikolas M, Kollef MH, Krupnick AS, Kreisel D, Ibrahim M, Gelman AE. Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA. Molecular pain 2017;13:1744806917731696.
93. Ridley C, Sohmer B, Vallabhajosyula P, Augoustides JGT. Aortic Leaflet Billowing as a Risk Factor for Repair Failure After Aortic Valve Repair. Journal of cardiothoracic and vascular anesthesia 2017;31:1001-6.
94. Ross F, Latham G, Joffe D, Richards M, Geiduschek J, Eisses M, Thompson D, Radman M. Preoperative malnutrition is associated with increased mortality and adverse outcomes after paediatric cardiac surgery. Cardiology in the young 2017;27:1716-25.
95. Saied NN, Helwani MA, Weavind LM, Shi Y, Shotwell MS, Pandharipande PP. Effect of anaesthesia type on postoperative mortality and morbidities: a matched analysis of the NSQIP database. British journal of anaesthesia 2017;118:105-11.
96. Samineni VK, Grajales-Reyes JG, Copits BA, O’Brien DE, Trigg SL, Gomez AM, Bruchas MR, Gereau RWt. Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray. eNeuro 2017;4.
97. Samineni VK, Mickle AD, Yoon J, Grajales-Reyes JG, Pullen MY, Crawford KE, Noh KN, Gereau GB, Vogt SK, Lai HH, Rogers JA, Gereau RWt. Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain. Scientific reports 2017;7:15865.
98. Samineni VK, Yoon J, Crawford KE, Jeong YR, McKenzie KC, Shin G, Xie Z, Sundaram SS, Li Y, Yang MY, Kim J, Wu D, Xue Y, Feng X, Huang Y, Mickle AD, Banks A, Ha JS, Golden JP, Rogers JA, Gereau RWt. Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics. Pain 2017;158:2108-16.
99. Seo DO, Bruchas MR. Polymorphic computation in locus coeruleus networks. Nature neuroscience 2017;20:1517-9.
100. Sheahan TD, Siuda ER, Bruchas MR, Shepherd AJ, Mohapatra DP, Gereau RWt, Golden JP. Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain. Neurobiology of pain (Elsevier) 2017;2:1-12.
101. Shin DJ, Germann AL, Steinbach JH, Akk G. The Actions of Drug Combinations on the GABAA Receptor Manifest as Curvilinear Isoboles of Additivity. Molecular pharmacology 2017;92:556-63.
102. Shin G, Gomez AM, Al-Hasani R, Jeong YR, Kim J, Xie Z, Banks A, Lee SM, Han SY, Yoo CJ, Lee JL, Lee SH, Kurniawan J, Tureb J, Guo Z, Yoon J, Park SI, Bang SY, Nam Y, Walicki MC, Samineni VK, Mickle AD, Lee K, Heo SY, McCall JG, Pan T, Wang L, Feng X, Kim TI, Kim JK, Li Y, Huang Y, Gereau RWt, Ha JS, Bruchas MR, Rogers JA. Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics. Neuron 2017;93:509-21.e3.
103. Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS. Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia. Journal of leukocyte biology 2017;101:543-54.
104. Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS. Anti-PD-L1 peptide improves survival in sepsis. The Journal of surgical research 2017;208:33-9.
105. Sim JY, Haney MP, Park SI, McCall JG, Jeong JW. Microfluidic neural probes: in vivo tools for advancing neuroscience. Lab on a chip 2017;17:1406-35.
106. Spangler S, Bruchas MR. Tuning Biased GPCR Signaling for Physiological Gain. Cell 2017;171:989-91.
107. Spangler SM, Bruchas MR. Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits. Current opinion in pharmacology 2017;32:56-70.
108. Stephens RJ, Ablordeppey E, Drewry AM, Palmer C, Wessman BT, Mohr NM, Roberts BW, Liang SY, Kollef MH, Fuller BM. Analgosedation Practices and the Impact of Sedation Depth on Clinical Outcomes Among Patients Requiring Mechanical Ventilation in the ED: A Cohort Study. Chest 2017;152:963-71.
109. Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord. Neuron 2017;93:840-53.e5.
110. Ten Hoope W, Hollmann MW, Atchabahian A, Rigaud M, Kerkhoffs GM, Lirk P, Baumann HM. Minimum local anesthetic volumes for a selective saphenous nerve block: a dose-finding study. Minerva anestesiologica 2017;83:183-90.
111. Velissaris D, Karanikolas M, Pantzaris N, Kipourgos G, Bampalis V, Karanikola K, Fafliora E, Apostolopoulou C, Gogos C. Acute Abdominal Pain Assessment in the Emergency Department: The Experience of a Greek University Hospital. Journal of clinical medicine research 2017;9:987-93.
112. Wan L, Jin H, Liu XY, Jeffry J, Barry DM, Shen KF, Peng JH, Liu XT, Jin JH, Sun Y, Kim R, Meng QT, Mo P, Yin J, Tao A, Bardoni R, Chen ZF. Distinct roles of NMB and GRP in itch transmission. Scientific reports 2017;7:15466.
113. Wang C, Hu R, Morrissey JJ, Kharasch ED, Singamaneni S. Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction. Small (Weinheim an der Bergstrasse, Germany) 2017;13.
114. Wang C, Tadepalli S, Luan J, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S. Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips. Advanced materials (Deerfield Beach, Fla) 2017;29.
115. Wang X, Mooradian AD, Erdmann-Gilmore P, Zhang Q, Viner R, Davies SR, Huang KL, Bomgarden R, Van Tine BA, Shao J, Ding L, Li S, Ellis MJ, Rogers JC, Townsend RR, Fenyo D, Held JM. Breast tumors educate the proteome of stromal tissue in an individualized but coordinated manner. Science signaling 2017;10.
116. Wessman BT, Sona C, Schallom M. A Novel ICU Hand-Over Tool: The Glass Door of the Patient Room. Journal of intensive care medicine 2017;32:514-9.
117. Wessman BT, Sona C, Schallom M. Improving Caregivers’ Perceptions Regarding Patient Goals of Care/End-of-Life Issues for the Multidisciplinary Critical Care Team. Journal of intensive care medicine 2017;32:68-76.
118. Willingham MD, Avidan MS. Triple low, double low: it’s time to deal Achilles heel a single deadly blow. British journal of anaesthesia 2017;119:1-4.
119. Wilson-Poe AR, Jeong HJ, Vaughan CW. Chronic morphine reduces the readily releasable pool of GABA, a presynaptic mechanism of opioid tolerance. The Journal of physiology 2017;595:6541-55.
120. Wirtz MR, Baumann HM, Klinkspoor JH, Goslings JC, Juffermans NP. Viscoelastic Testing in Trauma. Seminars in thrombosis and hemostasis 2017;43:375-85.
121. Xia L, Nygard SK, Sobczak GG, Hourguettes NJ, Bruchas MR. Dorsal-CA1 Hippocampal Neuronal Ensembles Encode Nicotine-Reward Contextual Associations. Cell reports 2017;19:2143-56.
122. Yang C, Gonzalez-Perez V, Mukaibo T, Melvin JE, Xia XM, Lingle CJ. Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 2017;114:E3739-e47.
123. Yang JM, Li F, Liu Q, Ruedi M, Wei ET, Lentsman M, Lee HS, Choi W, Kim SJ, Yoon KC. A novel TRPM8 agonist relieves dry eye discomfort. BMC ophthalmology 2017;17:101.
124. Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. Molecular and neural basis of contagious itch behavior in mice. Science (New York, NY) 2017;355:1072-6.
125. Zhou Y, Yang H, Cui J, Lingle CJ. Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel. The Journal of general physiology 2017;149:985-1007.
126. Zoller JK, He J, Ballew AT, Orr WN, Flynn BC. Novel use of a noninvasive hemodynamic monitor in a personalized, active learning simulation. Advances in physiology education 2017;41:266-9.

Department Publications 2016

1. Asehnoune K, Hotchkiss RS, Monneret G. Understanding Why Clinicians Should Care About Danger-Associated Molecular Patterns. Intensive care medicine 2016;42:611-4.
2. Asehnoune K, Villadangos J, Hotchkiss RS. Understanding Host-Pathogen Interaction. Intensive care medicine 2016;42:2084-6.
3. Avidan MS, Evers AS. The Fallacy of Persistent Postoperative Cognitive Decline. Anesthesiology 2016;124:255-8.
4. Avidan MS, Evers AS. In Reply: Eckenhoff RG, Hogan KJ, Evered L. Fallacy…Really? Anesthesiology. 2016;125(2):426-8. Anesthesiology 2016;125:428-9.
5. Barry DM, Li H, Liu XY, Shen KF, Liu XT, Wu ZY, Munanairi A, Chen XJ, Yin J, Sun YG, Li YQ, Chen ZF. Critical Evaluation of the Expression of Gastrin-Releasing Peptide in Dorsal Root Ganglia and Spinal Cord. Molecular pain 2016;12.
6. Bjelanovic Z, Draskovic M, Veljovic M, Lekovic I, Karanikolas M, Stamenkovic D. Transanal Hemorrhoid Dearterialization is a Safe and Effective Outpatient Procedure for the Treatment df Hemorrhoidal Disease. Cirugia espanola 2016;94:588-94.
7. Blain-Moraes S, Boshra R, Ma HK, Mah R, Ruiter K, Avidan M, Connolly JF, Mashour GA. Normal Brain Response to Propofol in Advance of Recovery from Unresponsive Wakefulness Syndrome. Frontiers in human neuroscience 2016;10:248. eCollection 2016.
8. Bottiger BW, Bernhard M, Knapp J, Nagele P. Influence of EMS-Physician Presence on Survival after Out-of-Hospital Cardiopulmonary Resuscitation: Systematic Review and Meta-Analysis. Critical care (London, England) 2016;20:4.
9. Bracamontes JR, Akk G, Steinbach JH. Introduced Amino Terminal Epitopes Can Reduce Surface Expression of Neuronal Nicotinic Receptors. PloS one 2016;11:e0151071.
10. Bruchas MR, Roth BL. New Technologies for Elucidating Opioid Receptor Function. Trends in pharmacological sciences 2016;37:279-89.
11. Cabanero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PH, Caterina MJ, Rice FL, Moron JA. Identification of an Epidermal Keratinocyte AMPA Glutamate Reception Iinvolved in Dermatopathies Associated with Sensory Abnormalities. PAIN Rep 2016;9:e573.
12. Cavallone LF, Vannucci A. Percutaneous Tracheostomy in Animal Models: it’s the Year of the Sheep! Minerva anestesiologica 2016;82:151-3.
13. Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G. Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed alpha1beta2gamma2L GABA(A) Receptors. Molecular pharmacology 2016;89:399-406.
14. Chen Y, Cai A, Dexter F, Pryor KO, Jacobsohn EM, Glick DB, Willingham MD, Escallier K, Winter A, Avidan MS. Amnesia of the Operating Room in the B-Unaware and BAG-RECALL Clinical Trials. Anesthesia and analgesia 2016;122:1158-68.
15. Chen Y, Pryor KO, Avidan MS. In Response to: McHugh SM, Ibinson JW, Murty VP. Disruption of Memory Consolidation May Explain Patterns of Memory Netter Than Emotion-Induced Retrograde Amnesia in Study by Chen et al. Anesth Analg. 2016;123(6):1638-9. Anesthesia and analgesia 2016;123:1639.
16. Copits BA, Pullen MY, Gereau RW, 4th. Spotlight on Pain: Optogenetic Approaches for Interrogating Somatosensory Circuits. Pain 2016;157:2424-33.
17. Cristancho P, Lenze EJ, Avidan MS, Rawson KS. Trajectories of Depressive Symptoms after Hip Fracture. Psychological medicine 2016;46:1413-25.
18. Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell reports 2016;14:2774-83.
19. Davidson EM, Haroutounian S, Kagan L, Naveh M, Aharon A, Ginosar Y. A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs. Anesthesia and analgesia 2016;122:1663-72.
20. Davidson S, Golden JP, Copits BA, Ray PR, Vogt SK, Valtcheva MV, Schmidt RE, Ghetti A, Price TJ, Gereau RW, 4th. Group II mGluRs Suppress Hyperexcitability in Mouse and Human Nociceptors. Pain 2016;157:2081-8.
21. Doerflinger M, Glab J, Nedeva C, Jose I, Lin A, O’Reilly L, Allison C, Pellegrini M, Hotchkiss RS, Puthalakath H. Chemical Chaperone TUDCA Prevents Apoptosis and Improves Survival during Polymicrobial Sepsis in Mice. Scientific reports 2016;6:34702.
22. Dominguez JE, Lockhart EM, Miskovic A, Bullough AS. Recognition of Obstructive Sleep Apnea in Pregnancy Survey. International journal of obstetric anesthesia 2016;26:85-7.
23. Drewry AM, Ablordeppey EA, Murray ET, Beiter ER, Walton AH, Hall MW, Hotchkiss RS. Comparison of Monocyte Human Leukocyte Antigen-DR Expression and Stimulated Tumor Necrosis Factor Alpha Production as Outcome Predictors in Severe Sepsis: A Prospective Observational Study. Critical care (London, England) 2016;20:334.
24. Duma A, Pal S, Helsten D, Stein PK, Miller JP, Nagele P. High-Fidelity Analysis of Perioperative QTc Prolongation. Anesthesia and analgesia 2016;122:439-48.
25. Dussor G, Cao YQ. TRPM8 and Migraine. Headache 2016;56:1406-17.
26. Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G. Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol. Current neuropharmacology 2016;14:772-80.
27. Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice AS, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D. Patient Phenotyping in Clinical Trials of Chronic Pain Treatments: IMMPACT Recommendations. Pain 2016;157:1851-71.
28. Fakira AK, Massaly N, Cohensedgh O, Berman A, Moron JA. Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons. Neuropsychopharmacology 2016;41:2668-78.
29. Fehr JJ, Chao J, Kuan C, Zhong J. The Important Role of Simulation in Sedation. Current opinion in anaesthesiology 2016;29 Suppl 1:S14-20.
30. Fehr JJ, Kuan C. Summer Camp, Boot Camp, and the Formation of a New Fellow. Paediatric anaesthesia 2016;26:466-7.
31. Fehr JJ, Shepard M, McBride ME, Mehegan M, Reddy K, Murray DJ, Boulet JR. Simulation-Based Assessment of ECMO Clinical Specialists. Simulation in healthcare : journal of the Society for Simulation in Healthcare 2016;11:194-9.
32. Ferschl MB, Moon-Grady AJ, Rollins MD, Gilliss B, Schulman SR, Tulzer G, Stohl S, Ginosar Y. CASE 8-2016 Percutaneous Fetal Cardiac Intervention for Severe Aortic Stenosis and Evolving Hypoplastic Left-Heart Syndrome. Journal of cardiothoracic and vascular anesthesia 2016;30:1118-28.
33. Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DL, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice AS, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic Pain: An Updated Grading System for Research and Clinical Practice. Pain 2016;157:1599-606.
34. Friederich P PH, Nagele P, Crotti L. Anaesthesia Recommendations for Patients Suffering from: Long QT Syndrome. Anasthesiologie und Intensivmedizin 2016;57:S590-6.
35. Fritz BA, Escallier KE, Ben Abdallah A, Oberhaus J, Becker J, Geczi K, McKinnon S, Helsten DL, Sharma A, Wildes TS, Avidan MS. Convergent Validity of Three Methods for Measuring Postoperative Complications. Anesthesiology 2016;124:1265-76.
36. Fritz BA, Kalarickal PL, Maybrier HR, Muench MR, Dearth D, Chen Y, Escallier KE, Ben Abdallah A, Lin N, Avidan MS. Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium. Anesthesia and analgesia 2016;122:234-42.
37. Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH. Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Study Protocol for a Quasi-Experimental, Before-After Trial Aimed at Reducing Pulmonary Complications. BMJ open 2016;6:e010991.
38. Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G. Activation and Modulation of Recombinant Glycine and GABAA Receptors by 4-Halogenated Analogues of Propofol. British journal of pharmacology 2016;173:3110-20.
39. Ginosar Y, Haroutounian S, Kagan L, Naveh M, Aharon A, Davidson EM. Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data after Subcutaneous Administration in Volunteers. Anesthesia and analgesia 2016;122:1673-80.
40. Gu QD, Moss CR, 2nd, Kettelhut KL, Gilbert CA, Hu H. Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons. Frontiers in physiology 2016;7:65.
41. Gupte RP, Kadunganattil S, Shepherd AJ, Merrill R, Planer W, Bruchas MR, Strack S, Mohapatra DP. Convergent Phosphomodulation of the Major Neuronal Dendritic Potassium Channel Kv4.2 by Pituitary Adenylate Cyclase-Activating Polypeptide. Neuropharmacology 2016;101:291-308.
42. Haroutounian S. Somatosensory Phenotyping for Better Translation in Neuropathic Pain? Pain 2016;157:995-6.
43. Haroutounian S, Ratz Y, Ginosar Y, Furmanov K, Saifi F, Meidan R, Davidson E. The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study. The Clinical journal of pain 2016;32:1036-43.
44. Helsten DL, Ben Abdallah A, Avidan MS, Wildes TS, Winter A, McKinnon S, Bollini M, Candelario P, Burnside BA, Sharma A. Methodologic Considerations for Collecting Patient-reported Outcomes from Unselected Surgical Patients. Anesthesiology 2016;125:495-504.
45. Helwani MA, Donnelly JE, Makan M, De Wet CJ. A Pregnant Woman in the Third Trimester Diagnosed with Acute Respiratory Failure and Severe Lower-Extremity Edema. Chest 2016;150:e105-e7.
46. Helwani MA, Saied NN. Automated Pulse Pressure Variation Display in the Operating Room and in the Intensive Care Unit. Journal of clinical anesthesia 2016;33:502-4.
47. Horst J, Frei-Jones M, Deych E, Shannon W, Kharasch ED. Pharmacokinetics and Analgesic Effects of Methadone in Children and Adults with Sickle Cell Disease. Pediatric blood & cancer 2016;63:2123-30.
48. Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Sepsis and Septic Shock. Nature reviews Disease primers 2016;2:16045.
49. Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y. Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction. Cell reports 2016;16:106-19.
50. Huang D, Ren L, Qiu CS, Liu P, Peterson J, Yanagawa Y, Cao YQ. Characterization of a Mouse Model of Headache. Pain 2016;157:1744-60.
51. Ibrahim M, Menna C, Andreetti C, Puyo C, Maurizi G, D’Andrilli A, Ciccone AM, Massullo D, Vanni C, Berardi G, Baldini R, Rendina EA. Does a Multimodal No-Compression Suture Technique of the Intercostal Space Reduce Chronic Postthoracotomy Pain? A Prospective Randomized Study. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2016;11:1460-8.
52. Ishag S, Thakar CV. Stratification and Risk Reduction of Perioperative Acute Kidney Injury. Anesthesiology clinics 2016;34:89-99.
53. Kafashan M, Ching S, Palanca BJ. Sevoflurane Alters Spatiotemporal Functional Connectivity Motifs That Link Resting-State Networks during Wakefulness. Frontiers in neural circuits 2016;10:107. eCollection 2016.
54. Kaplan KJ, Rao LK. Selection and Implementation of New Information Systems. Clinics in laboratory medicine 2016;36:113-31.
55. Karan S, Ginosar Y. Gestational Sleep Apnea: Have We Been Caught Napping? International journal of obstetric anesthesia 2016;26:1-3.
56. Karlsson P HS, Polydefkis M, Nyengaard JR, Jensen TS. Structural and Functional Characterization of Nerve Fibres in Plyneuropathy and Healthy Subjects. Scandinavian J Pain 2016;10:28-35.
57. Kharasch ED. Changes: Handing Off and the Future of ANESTHESIOLOGY. Anesthesiology 2016;125:4-6.
58. Kharasch ED, Brunt LM. Perioperative Opioids and Public Health. Anesthesiology 2016;124:960-5.
59. Kharasch ED, Eisenach JC. Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment? Anesthesiology 2016;124:10-2.
60. Kharasch ED, Tedeschi V, Kendall G. Changes: Thank You, Dr. Eisenach. Anesthesiology 2016;125:1-3.
61. Kiekkas P, Stefanopoulos N, Bakalis N, Kefaliakos A, Karanikolas M. Agreement of Infrared Temporal Artery Thermometry with Other Thermometry Methods in Adults: Systematic Review. Journal of clinical nursing 2016;25:894-905.
62. Kim S, Barry DM, Liu XY, Yin S, Munanairi A, Meng QT, Cheng W, Mo P, Wan L, Liu SB, Ratnayake K, Zhao ZQ, Gautam N, Zheng J, Karunarathne WK, Chen ZF. Facilitation of TRPV4 by TRPV1 is Required for Itch Transmission in Some Sensory Neuron Populations. Science signaling 2016;9:ra71.
63. Knittel JG, Wildes TS. Preoperative Assessment of Geriatric Patients. Anesthesiology clinics 2016;34:171-83.
64. Kronzer VL, Avidan MS. Preventing Postoperative Delirium: All That Glisters is Not Gold. Lancet (London, England) 2016;388:1854-6.
65. Kronzer VL, Ben Abdallah A, McKinnon SL, Wildes TS, Avidan MS. Ability of Preoperative Falls to Predict Postsurgical Outcomes in Non-Selected Patients Undergoing Elective Surgery at an Academic Medical Centre: Protocol for a Prospective Cohort Study. BMJ open 2016;6:e011570.
66. Kronzer VL, Jerry MR, Avidan MS. Assessing Change in Patient-Reported Quality of Life After Elective Surgery: Protocol for an Observational Comparison Study. F1000Research 2016;5:976. eCollection 2016.
67. Kronzer VL, Jerry MR, Ben Abdallah A, Wildes TS, Stark SL, McKinnon SL, Helsten DL, Sharma A, Avidan MS. Preoperative Falls Predict Postoperative Falls, Functional Decline, and Surgical Complications. EBioMedicine 2016;12:302-8.
68. Kronzer VL, Tang RD, Schelble AP, Ben Abdallah A, Wildes TS, McKinnon SL, Sadiq F, Lin N, Helsten DL, Sharma A, Stark SL, Avidan MS. Preoperative Falls and Their Association with Functional Dependence and Quality of Life. Anesthesiology 2016;125:322-32.
69. Kronzer VL, Wildes TM, Stark SL, Avidan MS. Review of Perioperative Falls. British journal of anaesthesia 2016;117:720-32.
70. Lakshminarasimhachar A, Smetana GW. Preoperative Evaluation: Estimation of Pulmonary Risk. Anesthesiology clinics 2016;34:71-88.
71. Lenze EJ, Farber NB, Kharasch E, Schweiger J, Yingling M, Olney J, Newcomer JW. Ninety-Six Hour Ketamine Infusion with Co-Administered Clonidine for Treatment-Resistant Depression: A Pilot Randomised Controlled Trial. World J Biol Psychiatry 2016;17:230-8.
72. Liu S, Feng J, Luo J, Yang P, Brett TJ, Hu H. Eact, a Small Molecule Activator of TMEM16A, Activates TRPV1 and Elicits Pain- and Itch-Related Behaviours. British journal of pharmacology 2016;173:1208-18.
73. Luan J, Liu KK, Tadepalli S, Jiang Q, Morrissey JJ, Kharasch ED, Singamaneni S. PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity. ACS applied materials & interfaces 2016;8:23509-16.
74. Maniar HS, Lindman BR, Escallier K, Avidan M, Novak E, Melby SJ, Damiano MS, Lasala J, Quader N, Rao RS, Lawton J, Moon MR, Helsten D, Pasque MK, Damiano RJ, Jr., Zajarias A. Delirium after Surgical and Transcatheter Aortic Valve Replacement is Associated with Increased Mortality. The Journal of thoracic and cardiovascular surgery 2016;151:815-23.e1-2.
75. Massaly N, Moron JA, Al-Hasani R. A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System. Frontiers in neuroscience 2016;10:480. eCollection 2016.
76. McKenzie H, Pulley DD. The Pregnant Patient: Assessment and Perioperative Management. Anesthesiology clinics 2016;34:213-22.
77. Meng QT, Cao C, Liu HM, Xia ZY, Li W, Tang LH, Chen R, Jiang M, Wu Y, Leng Y, Lee CC. Safety and Efficacy of Etomidate and Propofol Anesthesia in Elderly Patients Undergoing Gastroscopy: A Double-Blind Randomized Clinical Study. Exp Ther Med 2016;12:1515-24.
78. Mickle AD, Shepherd AJ, Mohapatra DP. Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies. Pharmaceuticals (Basel, Switzerland) 2016;9.
79. Mohr NM, Harland KK, Shane DM, Ahmed A, Fuller BM, Torner JC. Inter-hospital Transfer is Associated with Increased Mortality and Costs in Severe Sepsis and Septic Shock: An Instrumental Variables Approach. Journal of critical care 2016;36:187-94.
80. Nagele P. The Case for a Revised Definition of Myocardial Infarction-Resolving the Ambiguity of Type 2 Myocardial Infarction. JAMA cardiology 2016;1:247-8.
81. Namburi P, Al-Hasani R, Calhoon GG, Bruchas MR, Tye KM. Architectural Representation of Valence in the Limbic System. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016;41:1697-715.
82. Nygard SK, Hourguettes NJ, Sobczak GG, Carlezon WA, Bruchas MR. Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience 2016;36:9937-48.
83. Oetjen LK, Noti M, Kim BS. New Insights into Basophil Heterogeneity. Seminars in immunopathology 2016;38:549-61.
84. O’Neill PR, Kalyanaraman V, Gautam N. Subcellular Optogenetic Activation of Cdc42 Controls Local and Distal Signaling to Drive Immune Cell Migration. Molecular biology of the cell 2016;27:1442-50.
85. Orser BA, Evers AS, Suresh S, Hertz S. The GAS trial. Lancet (London, England) 2016;387:1613-4.
86. Park SI, Shin G, McCall JG, Al-Hasani R, Norris A, Xia L, Brenner DS, Noh KN, Bang SY, Bhatti DL, Jang KI, Kang SK, Mickle AD, Dussor G, Price TJ, Gereau RW, 4th, Bruchas MR, Rogers JA. Stretchable Multichannel Antennas in Soft Wireless Optoelectronic Implants for Optogenetics. Proceedings of the National Academy of Sciences of the United States of America 2016;113:E8169-e77.
87. Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS. Frontline Science: Defects in Immune Function in Patients with Sepsis are Associated with PD-1 or PD-L1 Expression and Can be Restored by Antibodies Targeting PD-1 or PD-L1. Journal of leukocyte biology 2016;100:1239-54.
88. Pene F, Pickkers P, Hotchkiss RS. Erratum to: Is This Critically Ill Patient Immunocompromised? Intensive care medicine 2016;42:1106.
89. Pene F, Pickkers P, Hotchkiss RS. Is This Critically Ill Patient Immunocompromised? Intensive care medicine 2016;42:1051-4.
90. Pesenti A, Musch G, Lichtenstein D, Mojoli F, Amato MB, Cinnella G, Gattinoni L, Quintel M. Imaging in Acute Respiratory Distress Syndrome. Intensive care medicine 2016;42:686-98.
91. Pulley DD. Preoperative Evaluation of the Patient with Substance Use Disorder and Perioperative Considerations. Anesthesiology clinics 2016;34:201-11.
92. Rao LK, Flaker AM, Friedel CC, Kharasch ED. Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance. Anesthesiology 2016;125:1103-12.
93. Reis Rodrigues P, Kaul TK, Ho JH, Lucanic M, Burkewitz K, Mair WB, Held JM, Bohn LM, Gill MS. Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans. G3 (Bethesda, Md) 2016;6:1695-705.
94. Ridley CH, Vallabhajosyula P, Bavaria JE, Patel PA, Gutsche JT, Shah R, Feinman JW, Weiss SJ, Augoustides JG. The Sievers Classification of the Bicuspid Aortic Valve for the Perioperative Echocardiographer: The Importance of Valve Phenotype for Aortic Valve Repair in the Era of the Functional Aortic Annulus. Journal of cardiothoracic and vascular anesthesia 2016;30:1142-51.
95. Rossi HL, Broadhurst KA, Luu AS, Lara O, Kothari SD, Mohapatra DP, Recober A. Abnormal Trigeminal Sensory Processing in Obese Mice. Pain 2016;157:235-46.
96. Saana SB, Ablordeppey E, Mensah NJ, Karikari TK. Academic Dishonesty in Higher Education: Students’ Perceptions and Involvement in an African Institution. BMC research notes 2016;9:234.
97. Saettele AK, Christensen JL, Chilson KL, Murray DJ. Children with Heart Disease: Risk Stratification for Non-Cardiac Surgery. Journal of clinical anesthesia 2016;35:479-84.
98. Santos CA, Hotchkiss RS, Chapman WC, Olsen MA. Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients. Transplantation direct 2016;2:e67. eCollection 2016 Mar.
99. Seo DO, Funderburk SC, Bhatti DL, Motard LE, Newbold D, Girven KS, McCall JG, Krashes M, Sparta DR, Bruchas MR. A GABAergic Projection from the Centromedial Nuclei of the Amygdala to Ventromedial Prefrontal Cortex Modulates Reward Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience 2016;36:10831-42.
100. Shutov LP, Warwick CA, Shi X, Gnanasekaran A, Shepherd AJ, Mohapatra DP, Woodruff TM, Clark JD, Usachev YM. The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1. The Journal of neuroscience : the official journal of the Society for Neuroscience 2016;36:5055-70.
101. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Jama 2016;315:801-10.
102. Siuda ER, Al-Hasani R, McCall JG, Bhatti DL, Bruchas MR. Chemogenetic and Optogenetic Activation of Galphas Signaling in the Basolateral Amygdala Induces Acute and Social Anxiety-Like States. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016;41:2011-23.
103. Spangler SM, Bruchas MR. Optogenetic Approaches for Dissecting Neuromodulation and GPCR Signaling in Neural Circuits. Current opinion in pharmacology 2016;32:56-70.
104. Spec A, Shindo Y, Burnham CA, Wilson S, Ablordeppey EA, Beiter ER, Chang K, Drewry AM, Hotchkiss RS. T Cells from Patients with Candida Sepsis Display a Suppressive Immunophenotype. Critical care (London, England) 2016;20:15.
105. Spehar B, Tye-Murray N, Myerson J, Murray DJ. Real-Time Captioning for Improving Informed Consent: Patient and Physician Benefits. Regional anesthesia and pain medicine 2016;41:65-8.
106. Tassoudis V, Ieropoulos H, Karanikolas M, Vretzakis G, Bouzia A, Mantoudis E, Petsiti A. Bronchospasm in Obese Patients Undergoing Elective Laparoscopic Surgery under General Anesthesia. SpringerPlus 2016;5:435. eCollection 2016.
107. Teitelbaum AM, Flaker AM, Kharasch ED. Development, Validation and Application of a Comprehensive Stereoselective LC/MS-MS Assay for Bupropion and Oxidative, Reductive, and Glucuronide Metabolites in Human Urine. Journal of chromatography B, Analytical technologies in the biomedical and life sciences 2016;1027:239-53.
108. Teitelbaum AM, Flaker AM, Kharasch ED. Development and Validation of a High-Throughput Stereoselective LC-MS/MS Assay for Bupropion, Hydroxybupropion, Erythrohydrobupropion, and Threohydrobupropion in Human Plasma. Journal of chromatography B, Analytical technologies in the biomedical and life sciences 2016;1017-1018:101-13.
109. Teitelbaum AM, Kharasch ED. Misidentification of Bupropion Glucuronide Metabolites and Re-evaluation of Metabolite Pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals 2016;44:1851.
110. Toll L, Bruchas MR, Calo G, Cox BM, Zaveri NT. Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems. Pharmacological reviews 2016;68:419-57.
111. Tsung A WB. MRSA Pneumonia Mucus Plug Burden and the Difficult Airway. Crit Care Shock 2016;19:54-8.
112. Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW, 4th. Surgical Extraction of Human Dorsal Root Ganglia from Organ Donors and Preparation of Primary Sensory Neuron Cultures. Nature protocols 2016;11:1877-88.
113. Vannucci A, Cavallone LF. Bedside Predictors of Difficult Intubation: A Systematic Review. Minerva anestesiologica 2016;82:69-83.
114. Velissaris D, Karamouzos V, Kotroni I, Pierrakos C, Karanikolas M. The Use of Pulmonary Artery Catheter in Sepsis Patients: A Literature Review. Journal of clinical medicine research 2016;8:769-76.
115. Velissaris D, Karamouzos V, Pierrakos C, Koniari I, Apostolopoulou C, Karanikolas M. Use of Sodium Bicarbonate in Cardiac Arrest: Current Guidelines and Literature Review. Journal of clinical medicine research 2016;8:277-83.
116. Wang C, Luan J, Tadepalli S, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S. Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability. ACS applied materials & interfaces 2016;8:26493-500.
117. Welch TP, Wallendorf MJ, Kharasch ED, Leonard JR, Doctor A, Pineda JA. Fentanyl and Midazolam are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury. Critical care medicine 2016;44:809-18.
118. Wellman TJ, de Prost N, Tucci M, Winkler T, Baron RM, Filipczak P, Raby B, Chu JH, Harris RS, Musch G, Dos Reis Falcao LF, Capelozzi V, Venegas JG, Vidal Melo MF. Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity. Anesthesiology 2016;125:992-1004.
119. Whitman CB, Ablordeppey E, Taylor B. Levodopa Withdrawal Presenting as Fever in a Critically Ill Patient Receiving Concomitant Enteral Nutrition. Journal of pharmacy practice 2016;29:574-8.
120. Wildes TS, Avidan MS. The Suffering and Satisfaction of Schrodinger’s Cat. British journal of anaesthesia 2016;117:691-2.
121. Wildes TS, Winter AC, Maybrier HR, Mickle AM, Lenze EJ, Stark S, Lin N, Inouye SK, Schmitt EM, McKinnon SL, Muench MR, Murphy MR, Upadhyayula RT, Fritz BA, Escallier KE, Apakama GP, Emmert DA, Graetz TJ, Stevens TW, Palanca BJ, Hueneke RL, Melby S, Torres B, Leung J, Jacobsohn E, Avidan MS. Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) Study: A Pragmatic, Randomised Clinical Trial. BMJ open 2016;6:e011505.
122. Willingham MD, Kheterpal S, Avidan MS. In Reply: Carette R, Struys MM, De Wolf AM, Hendrickx JF. Not Really Triple Low? Anesthesiology. 2016;124(6):1410-1. Anesthesiology 2016;124:1411-2.
123. Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K. Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning. Anesthesiology 2016;124:1065-76.
124. Wong T, Schlichting AB, Stoltze AJ, Fuller BM, Peacock A, Harland KK, Ahmed A, Mohr N. No Decrease in Early Ventilator-Associated Pneumonia after Early use of Chlorhexidine. American journal of critical care : an official publication, American Association of Critical-Care Nurses 2016;25:173-7.
125. Xu AZ, Tripathi SV, Kau AL, Schaffer A, Kim BS. Immune Dysregulation Underlies a Subset of Patients with Chronic Idiopathic Pruritus. Journal of the American Academy of Dermatology 2016;74:1017-20.
126. Zhou Y LC. Engineering Differential Charge Selectivity from a Single Structural Template. PNAS 2016;113:12610-2.

Department Publications 2015

1. Abbatiello, S. E., B. Schilling, D. R. Mani, L. J. Zimmerman, S. C. Hall, B. MacLean, M. Albertolle, S. Allen, M. Burgess, M. P. Cusack, M. Gosh, V. Hedrick, J. M. Held, H. D. Inerowicz, A. Jackson, H. Keshishian, C. R. Kinsinger, J. Lyssand, L. Makowski, M. Mesri, H. Rodriguez, P. Rudnick, P. Sadowski, N. Sedransk, K. Shaddox, S. J. Skates, E. Kuhn, D. Smith, J. R. Whiteaker, C. Whitwell, S. Zhang, C. H. Borchers, S. J. Fisher, B. W. Gibson, D. C. Liebler, M. J. MacCoss, T. A. Neubert, A. G. Paulovich, F. E. Regnier, P. Tempst and S. A. Carr (2015). “Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.” Mol Cell Proteomics 14(9): 2357-2374.
2. Al-Hasani, R., J. G. McCall, G. Shin, A. M. Gomez, G. P. Schmitz, J. M. Bernardi, C. O. Pyo, S. I. Park, C. M. Marcinkiewcz, N. A. Crowley, M. J. Krashes, B. B. Lowell, T. L. Kash, J. A. Rogers and M. R. Bruchas (2015). “Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward.” Neuron 87(5): 1063-1077.
3. Al-Hasani, R., G. Shin, S. Il Park, M. J. Schmidt, S. L. Anderson, W. J. Planer, J. A. Rogers and M. R. Bruchas Nat Commun.
4. Avidan, M. S. and T. W. Stevens (2015). “The diving bell and the butterfly.” Br J Anaesth 115 Suppl 1: i8-i10.
5. Avidan, M. S. and T. S. Wildes (2015). “Power of negative thinking.” Br J Anaesth 114(1): 3-5.
6. Bharat, A., S. A. Cunningham, G. R. Scott Budinger, D. Kreisel, C. J. DeWet, A. E. Gelman, K. Waites, D. Crabb, L. Xiao, S. Bhorade, N. Ambalavanan, D. F. Dilling, E. M. Lowery, T. Astor, R. Hachem, A. S. Krupnick, M. M. DeCamp, M. G. Ison and R. Patel (2015). “Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans.” Sci Transl Med 7(284): 284re283.
7. Bottiger, B. W., M. Bernhard, J. Knapp and P. Nagele (2016). “Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis.” Crit Care 20(1): 4.
8. Brenner, D. S., J. P. Golden, S. K. Vogt and R. W. t. Gereau (2015). “A simple and inexpensive method for determining cold sensitivity and adaptation in mice.” J Vis Exp(97).
9. Brier, M. R., Q. Wu, A. B. Tanenbaum, E. T. Westerhaus, E. D. Kharasch and B. M. Ances (2015). “Effect of HAART on Brain Organization and Function in HIV-Negative Subjects.” J Neuroimmune Pharmacol 10(4): 517-521.
10. Campbell, S. D., S. Gadel, C. Friedel, A. Crafford, K. J. Regina and E. D. Kharasch (2015). “Influence of HIV antiretrovirals on methadone N-demethylation and transport.” Biochem Pharmacol 95(2): 115-125.
11. Canet, J., S. Sabate, V. Mazo, L. Gallart, M. G. de Abreu, J. Belda, O. Langeron, A. Hoeft and P. Pelosi (2015). “Development and validation of a score to predict postoperative respiratory failure in a multicentre European cohort: A prospective, observational study.” Eur J Anaesthesiol 32(7): 458-470.
12. Cavallone, L. F. and A. Vannucci (2015). “Percutaneous tracheostomy in animal models: it’s the year of the sheep!” Minerva Anestesiol.
13. Chang, S. D., L. E. Brieaddy, J. D. Harvey, A. H. Lewin, S. W. Mascarella, H. H. Seltzman, P. A. Reddy, A. M. Decker, C. J. McElhinny, Jr., D. Zhong, E. E. Peterson, H. A. Navarro, M. R. Bruchas and F. I. Carroll (2015). “Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4 .5]decan-4-one (Ro 64-6198).” ACS Chem Neurosci 6(12): 1956-1964.
14. Chinta, S. S., C. R. Schrock, J. D. McAllister, D. M. Jaffe, J. Liu and R. M. Kennedy (2015). “Rapid administration technique of ketamine for pediatric forearm fracture reduction: a dose-finding study.” Ann Emerg Med 65(6): 640-648.e642.
15. Christensen, J. L., G. K. Singh, J. Aubuchon and A. Sharma (2015). “Echocardiography of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery.” Anesth Analg 121(5): 1143-1146.
16. Copits, B. A., H. U. Chung, M. Y. Pullen, K. N. Noh, S. Davidson and S. J. Oh.
17. Crock, L. W., B. J. Kolber, C. D. Morgan, K. E. Sadler, S. K. Vogt, M. R. Bruchas and R. W. t. Gereau (2012). “Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain.” J Neurosci 32(41): 14217-14226.
18. Dettmer, M., C. V. Holthaus and B. M. Fuller (2015). “The impact of serial lactate monitoring on emergency department resuscitation interventions and clinical outcomes in severe sepsis and septic shock: an observational cohort study.” Shock 43(1): 55-61.
19. Dettmer, M. R., N. M. Mohr and B. M. Fuller (2015). “Sepsis-associated pulmonary complications in emergency department patients monitored with serial lactate: An observational cohort study.” J Crit Care 30(6): 1163-1168.
20. Doshi, T. L., I. Kangrga and A. Vannucci (2015). “Hyperostosis frontalis interna as a potential source of cerebral oximetry signal interference: A case report.” Eur J Anaesthesiol 32(6): 448-450.
21. Drewry, A. M., B. M. Fuller, L. P. Skrupky and R. S. Hotchkiss (2015). “The authors reply.” Crit Care Med 43(11): e529-530.
22. Drewry, A. M., B. M. Fuller, L. P. Skrupky and R. S. Hotchkiss (2015). “The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia.” Crit Care Med 43(6): 1165-1169.
23. Drewry, A. M. and R. S. Hotchkiss (2015). “Sepsis: Revising definitions of sepsis.” Nat Rev Nephrol 11(6): 326-328.
24. Duma, A., C. Cartmill, J. Blood, A. Sharma, E. D. Kharasch and P. Nagele (2015). “The hematological effects of nitrous oxide anesthesia in pediatric patients.” Anesth Analg 120(6): 1325-1330.
25. Duma, A., S. Pal, D. Helsten, P. K. Stein, J. P. Miller and P. Nagele (2015). “High-Fidelity Analysis of Perioperative QTc Prolongation.” Anesth Analg.
26. Eaton, M. M., L. Q. Cao, Z. Chen, N. P. Franks, A. S. Evers and G. Akk (2015). “Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human beta3 Homomeric GABAA Receptors.” Mol Pharmacol 88(4): 736-745.
27. Ehrich, J. M., D. I. Messinger, C. R. Knakal, J. R. Kuhar, S. S. Schattauer, M. R. Bruchas, L. S. Zweifel, B. L. Kieffer, P. E. Phillips and C. Chavkin (2015). “Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons.” J Neurosci 35(37): 12917-12931.
28. Faine, B., N. Mohr, K. K. Harland, K. Rolfes, B. Porter and B. M. Fuller (2015). “Importance of Decision Support Implementation in Emergency Department Vancomycin Dosing.” West J Emerg Med 16(4): 557-564.
29. Faine, B. A., J. M. Noack, T. Wong, J. T. Messerly, A. Ahmed, B. M. Fuller and N. M. Mohr (2015). “Interhospital Transfer Delays Appropriate Treatment for Patients With Severe Sepsis and Septic Shock: A Retrospective Cohort Study.” Crit Care Med 43(12): 2589-2596.
30. Fatourou, E., J. Koskinas, D. Karandrea, M. Palaiologou, T. Syminelaki, M. Karanikolas, E. Felekouras, E. Antoniou, E. K. Manesis, J. Delladetsima and D. Tiniakos (2015). “Keratin 19 protein expression is an independent predictor of survival in human hepatocellular carcinoma.” Eur J Gastroenterol Hepatol 27(9): 1094-1102.
31. Feng, J., W. Yang, Z. Xie, F. Xiang, Z. Cao, W. Li, H. Hu, Z. Chen and Y. Wu (2015). “Kv Channel S1-S2 Linker Working as a Binding Site of Human beta-Defensin 2 for Channel Activation Modulation.” J Biol Chem 290(25): 15487-15495.
32. Finnerup, N. B., N. Attal, S. Haroutounian, E. McNicol, R. Baron, R. H. Dworkin, I. Gilron, M. Haanpaa, P. Hansson, T. S. Jensen, P. R. Kamerman, K. Lund, A. Moore, S. N. Raja, A. S. Rice, M. Rowbotham, E. Sena, P. Siddall, B. H. Smith and M. Wallace (2015). “Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.” Lancet Neurol 14(2): 162-173.
33. Fritz, B. A., P. L. Kalarickal, H. R. Maybrier, M. R. Muench, D. Dearth, Y. Chen, K. E. Escallier, A. Ben Abdallah, N. Lin and M. S. Avidan (2016). “Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium.” Anesth Analg 122(1): 234-242.
34. Fuller, B. M. (2015). “The adrenal gland and corticosteroid therapy in sepsis: I certainly remain uncertain.” Crit Care Med 43(3): 702-703.
35. Fuller, B. M. (2015). “What’s New in Shock? August 2015.” Shock 44(2): 99-100.
36. Fuller, B. M., N. M. Mohr, T. J. Graetz, I. P. Lynch, M. Dettmer, K. Cullison, T. Coney, S. Gogineni and R. Gregory (2015). “The impact of cardiac dysfunction on acute respiratory distress syndrome and mortality in mechanically ventilated patients with severe sepsis and septic shock: an observational study.” J Crit Care 30(1): 65-70.
37. Fuller, B. M., N. M. Mohr, C. N. Miller, A. R. Deitchman, B. J. Levine, N. Castagno, E. C. Hassebroek, A. Dhedhi, N. Scott-Wittenborn, E. Grace, C. Lehew and M. H. Kollef (2015). “Mechanical Ventilation and ARDS in the ED: A Multicenter, Observational, Prospective, Cross-sectional Study.” Chest 148(2): 365-374.
38. Fuller, B. M., N. M. Mohr, L. Skrupky, S. Fowler, M. H. Kollef and C. R. Carpenter (2015). “The use of inhaled prostaglandins in patients with ARDS: a systematic review and meta-analysis.” Chest 147(6): 1510-1522.
39. Gadel, S., C. Friedel and E. D. Kharasch (2015). “Differences in Methadone Metabolism by CYP2B6 Variants.” Drug Metab Dispos 43(7): 994-1001.
40. Ganeli, G. and M. Karanikolas Anesthesiol Res Pract.
41. Gereau, G. B., J. A. Demaro, 3rd, G. E. Landreth, J. P. Golden and R. W. t. Gereau.
42. Gonzalez-Perez, V., X. M. Xia and C. J. Lingle (2015). “Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating.” Nat Commun 6: 8341.
43. Gonzalez-Romero, J., L. Virag, R. Whittington, S. D. Comer, S. M. Carlton, B. M. Walker, M. R. Bruchas and J. A. Moron J Neurosci.
44. Graboyes, E. M., J. P. Bradley, D. Kallogjeri, L. F. Cavallone and B. Nussenbaum (2015). “Prognosis and patterns of failure for the extubation of patients who remain intubated after head and neck surgery.” Ann Otol Rhinol Laryngol 124(3): 179-186.
45. Gradwohl, S. C., A. Aranake, A. B. Abdallah, P. McNair, N. Lin, B. A. Fritz, A. Villafranca, D. Glick, E. Jacobsohn, G. A. Mashour and M. S. Avidan (2015). “Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study.” Can J Anaesth 62(4): 345-355.
46. Gupte, R. P., S. Kadunganattil, A. J. Shepherd, R. Merrill, W. Planer, M. R. Bruchas, S. Strack and D. P. Mohapatra (2016). “Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.” Neuropharmacology 101: 291-308.
47. Haroutounian, S., L. Nikolajsen, N. B. Finnerup and T. S. Jensen (2015). “Topical capsaicin response as a phenotypic measure in patients with pain.” Pain Med 16(4): 823-825.
48. Helwani, M. A. (2015). “When should cilostazol (pletal) and dipyridamole be discontinued before neuroaxial block?” Reg Anesth Pain Med 40(3): 295-296.
49. Helwani, M. A., M. S. Avidan, A. Ben Abdallah, D. J. Kaiser, J. C. Clohisy, B. L. Hall and H. A. Kaiser (2015). “Effects of regional versus general anesthesia on outcomes after total hip arthroplasty: a retrospective propensity-matched cohort study.” J Bone Joint Surg Am 97(3): 186-193.
50. Helwani, M. A. and J. R. Gillihan (2015). “Mortality and ratio of blood products used in patients with severe trauma.” Jama 313(20): 2078.
51. Helwani, M. A. and N. N. Saied (2015). “Automated pulse pressure variation display in the operating room and in the intensive care unit.” J Clin Anesth.
52. Helwani, M. A. and N. N. Saied (2015). “End-tidal anesthetic concentration audible alert setup to minimize intraoperative awareness.” J Clin Anesth 27(1): 87-89.
53. Hipolito, L., A. Wilson-Poe, Y. Campos-Jurado and E. Zhong (2015). “Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area mu Opioid Receptors.”  35(35): 12217-12231.
54. Huang, C. C., Y. S. Kim, W. P. Olson, F. Li, C. Guo, W. Luo, A. J. Huang and Q. Liu (2015). “A histamine-independent itch pathway is required for allergic ocular itch.” J Allergy Clin Immunol.
55. Jeong, J. W., J. G. McCall, G. Shin, Y. Zhang, R. Al-Hasani, M. Kim, S. Li, J. Y. Sim, K. I. Jang, Y. Shi, D. Y. Hong, Y. Liu, G. P. Schmitz, L. Xia, Z. He, P. Gamble, W. Z. Ray, Y. Huang, M. R. Bruchas and J. A. Rogers (2015). “Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics.” Cell 162(3): 662-674.
56. Jin, X. and J. H. Steinbach (2015). “Potentiation of Neuronal Nicotinic Receptors by 17beta-Estradiol: Roles of the Carboxy-Terminal and the Amino-Terminal Extracellular Domains.” PLoS One 10(12): e0144631.
57. Karunarathne, W. K., P. R. O’Neill and N. Gautam (2015). “Subcellular optogenetics – controlling signaling and single-cell behavior.” J Cell Sci 128(1): 15-25.
58. Kharasch, E. D. (2015). “Opioid Half-lives and Hemlines: The Long and Short of Fashion.” Anesthesiology 122(5): 969-970.
59. Kharasch, E. D. and M. W. Hollmann (2015). “Steroid Anesthesia Revisited: Again.” Anesth Analg 120(5): 983-984.
60. Kharasch, E. D., K. J. Regina, J. Blood and C. Friedel (2015). “Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.” Anesthesiology 123(5): 1142-1153.
61. Kim, T. I., Y. Huang, M. C. Montana, J. P. Golden, M. R. Bruchas and R. W. t. Gereau.
62. Kimball, C., J. Luo, S. Yin, H. Hu and A. Dhaka (2015). “The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane.” Mol Pharmacol 88(1): 131-138.
63. Kumar, V. R., U. K. Athiraman, S. M. Jahagirdar, R. Sripriya, S. Parthasarathy and M. Ravishankar (2015). “Comparison of efficacy of three subanesthetic doses of ketamine in allaying procedural discomfort during establishment of subarachnoid block: A randomized double-blind trial.” Saudi J Anaesth 9(1): 55-59.
64. Kutcher, M. E., B. M. Howard, J. L. Sperry, A. E. Hubbard, A. L. Decker, J. Cuschieri, J. P. Minei, E. E. Moore, B. H. Brownstein, R. V. Maier and M. J. Cohen (2015). “Evolving beyond the vicious triad: Differential mediation of traumatic coagulopathy by injury, shock, and resuscitation.” J Trauma Acute Care Surg 78(3): 516-523.
65. Lai, H., R. W. t. Gereau, Y. Luo, M. O’Donnell, C. N. Rudick, M. Pontari, C. Mullins and D. J. Klumpp (2015). “Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network.” Urology 85(6): 1454-1465.
66. Langenhan, T., M. M. Barr, M. R. Bruchas, J. Ewer, L. C. Griffith, I. Maiellaro, P. H. Taghert, B. H. White and K. R. Monk (2015). “Model Organisms in G Protein-Coupled Receptor Research.” Mol Pharmacol 88(3): 596-603.
67. Li, F., C. J. Guo, C. C. Huang, G. Yu, S. M. Brown, S. Xu and Q. Liu (2015). “Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice.” Anesthesiology 122(4): 768-775.
68. Li, P. and G. Akk (2015). “Synaptic-type alpha1beta2gamma2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs.” Mol Pharmacol 87(5): 776-781.
69. Lingle, C. J. (2015). “NAVigating a transition from single action potential firing to bursting in chromaffin cells.” J Physiol 593(4): 761-762.
70. Liu, C., N. Vachharajani, S. Song, R. Cooke, I. Kangrga, W. C. Chapman and B. J. Grossman (2015). “A quantitative model to predict blood use in adult orthotopic liver transplantation.” Transfus Apher Sci 53(3): 386-392.
71. Liu, Q. and X. Dong (2015). “The role of the Mrgpr receptor family in itch.” Handb Exp Pharmacol 226: 71-88.
72. Lockhart, E. M., A. Ben Abdallah, M. G. Tuuli and B. L. Leighton (2015). “Obstructive Sleep Apnea in Pregnancy: Assessment of Current Screening Tools.” Obstet Gynecol 126(1): 93-102.
73. Luo, J., J. Feng, S. Liu, E. T. Walters and H. Hu (2015). “Molecular and cellular mechanisms that initiate pain and itch.” Cell Mol Life Sci 72(17): 3201-3223.
74. Martinez-Espinosa, P. L., J. Wu, C. Yang, V. Gonzalez-Perez, H. Zhou, H. Liang, X. M. Xia and C. J. Lingle (2015). “Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.” Elife 4.
75. McCall, J. G., R. Al-Hasani, E. R. Siuda, D. Y. Hong, A. J. Norris, C. P. Ford and M. R. Bruchas (2015). “CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety.” Neuron 87(3): 605-620.
76. Mickle, A. D., A. J. Shepherd, L. Loo and D. P. Mohapatra (2015). “Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.” Pain 156(9): 1620-1636.
77. Mickle, A. D., A. J. Shepherd and D. P. Mohapatra (2015). “Sensory TRP channels: the key transducers of nociception and pain.” Prog Mol Biol Transl Sci 131: 73-118.
78. Moore, R. A., P. J. Wiffen, C. Eccleston, S. Derry, R. Baron, R. F. Bell, A. D. Furlan, I. Gilron, S. Haroutounian, N. P. Katz, A. G. Lipman, S. Morley, P. M. Peloso, S. N. Quessy, K. Seers, S. A. Strassels and S. Straube (2015). “Systematic review of enriched enrolment, randomised withdrawal trial designs in chronic pain: a new framework for design and reporting.” Pain 156(8): 1382-1395.
79. Morrissey, J. J., V. M. Mellnick, J. Luo, M. J. Siegel, R. S. Figenshau, S. Bhayani and E. D. Kharasch (2015). “Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study.” JAMA Oncol 1(2): 204-212.
80. Morrissey, J. J., J. Mobley, R. S. Figenshau, J. Vetter, S. Bhayani and E. D. Kharasch (2015). “Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer.” Mayo Clin Proc 90(1): 35-42.
81. Mueller, K., C. McCammon, L. Skrupky and B. M. Fuller (2015). “Vancomycin Use in Patients Discharged From the Emergency Department: A Retrospective Observational Cohort Study.” J Emerg Med 49(1): 50-57.
82. Murray, D. J., B. D. Freeman, J. R. Boulet, J. Woodhouse, J. J. Fehr and M. E. Klingensmith (2015). “Decision making in trauma settings: simulation to improve diagnostic skills.” Simul Healthc 10(3): 139-145.
83. Nagele, P., A. Duma, M. Kopec, M. A. Gebara, A. Parsoei, M. Walker, A. Janski, V. N. Panagopoulos, P. Cristancho, J. P. Miller, C. F. Zorumski and C. R. Conway (2015). “Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.” Biol Psychiatry 78(1): 10-18.
84. Nykiel-Bailey, S. M., J. D. McAllister, C. R. Schrock, D. W. Molter, J. K. Marsh and D. J. Murray (2015). “Difficult airway consultation service for children: steps to implement and preliminary results.” Paediatr Anaesth 25(4): 363-371.
85. O’Brien, D. E. and B. J. Alter (2015). “ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.”  35(25): 9491-9507.
86. O’Neill, P. R. and N. Gautam (2015). “Optimizing optogenetic constructs for control over signaling and cell behaviours.” Photochem Photobiol Sci 14(9): 1578-1585.
87. Palanca, B. J., A. Mitra, L. Larson-Prior, A. Z. Snyder, M. S. Avidan and M. E. Raichle (2015). “Resting-state Functional Magnetic Resonance Imaging Correlates of Sevoflurane-induced Unconsciousness.” Anesthesiology 123(2): 346-356.
88. Park, S. I., D. S. Brenner, G. Shin and C. D. Morgan (2015). “Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.”  33(12): 1280-1286.
89. Park, S. I., G. Shin, A. Banks, J. G. McCall, E. R. Siuda, M. J. Schmidt, H. U. Chung, K. N. Noh, J. G. Mun, J. Rhodes, M. R. Bruchas and J. A. Rogers (2015). “Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics.” J Neural Eng 12(5): 056002.
90. Petsiti, A., V. Tassoudis and G. Vretzakis (2015). “Depth of Anesthesia as a Risk Factor for Perioperative Morbidity.”  2015: 829151.
91. Ren, L., A. Dhaka and Y. Q. Cao (2015). “Function and postnatal changes of dural afferent fibers expressing TRPM8 channels.” Mol Pain 11: 37.
92. Rogers, J. A. Nat Biotechnol.
93. Saied, N., M. A. Helwani and P. P. Pandharipande (2015). “Intraoperative protective ventilation: too early to redefine management parameters?” Bmj 351: h5126.
94. Satomoto, M., C. D. Morgan, S. Davidson, S. K. Vogt and M. E. Norman.
95. Schilling, B., B. MacLean, J. M. Held, A. K. Sahu, M. J. Rardin, D. J. Sorensen, T. Peters, A. J. Wolfe, C. L. Hunter, M. J. MacCoss and B. W. Gibson (2015). “Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows.” Anal Chem 87(20): 10222-10229.
96. Schindler, S. E., J. G. McCall, P. Yan, K. L. Hyrc, M. Li, C. L. Tucker, J. M. Lee, M. R. Bruchas and M. I. Diamond (2015). “Photo-activatable Cre recombinase regulates gene expression in vivo.” Sci Rep 5: 13627.
97. Sheahan, T. D., B. A. Copits, J. P. Golden and R. W. t. Gereau (2015). “Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.” PLoS One 10(7): e0133191.
98. Sheth, T., M. Chan, C. Butler, B. Chow, V. Tandon, P. Nagele, A. Mitha, M. Mrkobrada, W. Szczeklik, Y. Faridah, B. Biccard, L. K. Stewart, D. Heels-Ansdell and P. J. Devereaux (2015). “Prognostic capabilities of coronary computed tomographic angiography before non-cardiac surgery: prospective cohort study.” Bmj 350: h1907.
99. Siuda, E. R., B. A. Copits, M. J. Schmidt, M. A. Baird, R. Al-Hasani, W. J. Planer, S. C. Funderburk, J. G. McCall, R. W. t. Gereau and M. R. Bruchas (2015). “Spatiotemporal control of opioid signaling and behavior.” Neuron 86(4): 923-935.
100. Siuda, E. R. and J. G. McCall (2015). “Optodynamic simulation of beta-adrenergic receptor signalling.”  6: 8480.
101. Skrupky, L. P., A. M. Drewry, B. Wessman, R. R. Field, R. E. Fagley, L. Varghese, A. Lieu, J. Olatunde, S. T. Micek, M. H. Kollef and W. A. Boyle (2015). “Clinical effectiveness of a sedation protocol minimizing benzodiazepine infusions and favoring early dexmedetomidine: a before-after study.” Crit Care 19: 136.
102. Stoltze, A. J., T. S. Wong, K. K. Harland, A. Ahmed, B. M. Fuller and N. M. Mohr (2015). “Prehospital tidal volume influences hospital tidal volume: A cohort study.” J Crit Care 30(3): 495-501.
103. Tadepalli, S., Z. Kuang, Q. Jiang, K. K. Liu, M. A. Fisher, J. J. Morrissey, E. D. Kharasch, J. M. Slocik, R. R. Naik and S. Singamaneni (2015). “Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.” Sci Rep 5: 16206.
104. Tellor, B., N. Shin, T. J. Graetz and M. S. Avidan (2015). “Ketamine infusion for patients receiving extracorporeal membrane oxygenation support: a case series.” F1000Res 4: 16.
105. Tian, L., M. Fei, S. Tadepalli, J. J. Morrissey, E. D. Kharasch and S. Singamaneni (2015). “Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots.” Adv Healthc Mater 4(10): 1502-1509, 1423.
106. Tran, L., U. Athiraman, K. M. Rich and R. Tempelhoff (2015). “Hyperventilation, Sympathetic and Metabolic Derangements After Endoscopic Third Ventriculostomy.” J Neurosurg Anesthesiol.
107. Valtcheva, M. V., S. Davidson, C. Zhao, M. Leitges and R. W. t. Gereau (2015). “Protein kinase Cdelta mediates histamine-evoked itch and responses in pruriceptors.” Mol Pain 11: 1.
108. Valtcheva, M. V., V. K. Samineni, J. P. Golden, R. W. t. Gereau and S. Davidson (2015). “Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.” J Pain 16(4): 346-356.
109. van Unen, J., J. Woolard, A. Rinken, C. Hoffmann, S. J. Hill, J. Goedhart, M. R. Bruchas, M. Bouvier and M. J. Adjobo-Hermans (2015). “A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms.” Mol Pharmacol 88(3): 589-595.
110. Vannucci, A. and L. F. Cavallone (2015). “Bedside predictors of difficult intubation: a systematic review.” Minerva Anestesiol.
111. Velissaris, D., V. Karamouzos, N. Ktenopoulos, C. Pierrakos and M. Karanikolas (2015). “The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate.” Crit Care Res Pract 2015: 605830.
112. Velissaris, D., V. Karamouzos, C. Pierrakos, D. Aretha and M. Karanikolas (2015). “Hypomagnesemia in Critically Ill Sepsis Patients.” J Clin Med Res 7(12): 911-918.
113. Wang, C., Z. Wang, Y. Yang, C. Zhu, G. Wu, G. Yu, T. Jian, N. Yang, H. Shi, M. Tang, Q. He, L. Lan, Q. Liu, Y. Guan, X. Dong, J. Duan and Z. Tang (2015). “Pirt contributes to uterine contraction-induced pain in mice.” Mol Pain 11: 57.
114. Wessman, B. and B. Fuller (2015). “Emergency Medicine: An Integral Component of the Continuum of Critical Care That is Devalued by Fellowship Programs.” J Emerg Med 49(3): 342-344.
115. Wessman, B. T., M. Schallom and C. Sona (2015). “”Just Ask” for the ABCDEFG Campaign.” Crit Care Med 43(12): e600-601.
116. Wessman, B. T., C. Sona and M. Schallom (2015). “Improving Caregivers’ Perceptions Regarding Patient Goals of Care/End-of-Life Issues for the Multidisciplinary Critical Care Team.” J Intensive Care Med.
117. Whitlock, E. L., T. L. Rodebaugh, A. L. Hassett, A. M. Shanks, E. Kolarik, J. Houghtby, H. M. West, B. A. Burnside, E. Shumaker, A. Villafranca, W. A. Edwards, C. A. Levinson, J. K. Langer, K. C. Fernandez, R. El-Gabalawy, E. Y. Zhou, J. Sareen, E. Jacobsohn, G. A. Mashour and M. S. Avidan (2015). “Psychological sequelae of surgery in a prospective cohort of patients from three intraoperative awareness prevention trials.” Anesth Analg 120(1): 87-95.
118. Wildes, T. M., P. Dua, S. A. Fowler, J. P. Miller, C. R. Carpenter, M. S. Avidan and S. Stark (2015). “Systematic review of falls in older adults with cancer.” J Geriatr Oncol 6(1): 70-83.
119. Willingham, M. D., E. Karren, A. M. Shanks, M. F. O’Connor, E. Jacobsohn, S. Kheterpal and M. S. Avidan (2015). “Concurrence of Intraoperative Hypotension, Low Minimum Alveolar Concentration, and Low Bispectral Index Is Associated with Postoperative Death.” Anesthesiology 123(4): 775-785.
120. Wu, H. C., G. Yamankurt, J. Luo, J. Subramaniam, S. S. Hashmi, H. Hu and S. R. Cunha (2015). “Identification and characterization of two ankyrin-B isoforms in mammalian heart.” Cardiovasc Res 107(4): 466-477.
121. Yoon, J., K. I. Jang, V. K. Samineni, M. Norman, J. G. Grajales-Reyes, S. K. Vogt, S. S. Sundaram, K. M. Wilson, J. S. Ha, R. Xu and T. Pan.
122. Zeng, X. H., C. Yang, X. M. Xia, M. Liu and C. J. Lingle (2015). “SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.” Proc Natl Acad Sci U S A 112(8): 2599-2604.
123. Zhou, J. Y., M. Isaacson-Schmid, E. C. Utterson, E. M. Todd, M. McFarland, J. Sivapalan, J. M. Niehoff, C. A. Burnham and S. C. Morley (2015). “Prevalence of nasopharyngeal pneumococcal colonization in children and antimicrobial susceptibility profiles of carriage isolates.” Int J Infect Dis 39: 50-52.
124. Zhou, Y., C. O. Wong, K. J. Cho, D. van der Hoeven, H. Liang, D. P. Thakur, J. Luo, M. Babic, K. E. Zinsmaier, M. X. Zhu, H. Hu, K. Venkatachalam and J. F. Hancock (2015). “SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.” Science 349(6250): 873-876.
125. Zhou, Y., X. M. Xia and C. J. Lingle (2015). “Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications.” Proc Natl Acad Sci U S A 112(16): 5237-5242.
126. Zimick, N. C., U. Athiraman and R. Tempelhoff (2015). “Intraparenchymal Temperature Probe on Intraoperative Magnetic Resonance Imaging.” Anesthesiology.
127. Zorumski, C. F., P. Nagele, S. Mennerick and C. R. Conway (2015). “Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy.” Front Psychiatry 6: 172.

Department Publications 2014

1. Abdelmalak BB, Knittel J, Abdelmalak JB, Dalton JE, Christiansen E, Foss J, Argalious M, Zimmerman R, Van den Berghe G. Preoperative blood glucose concentrations and postoperative outcomes after elective non-cardiac surgery: an observational study. Br J Anaesth 2014;112:79-88.
2. Avidan MS, Evers AS. Surgical safety checklists in ontario, Canada. N Engl J Med 2014;370:2350-1.
3. Avidan MS, Fritz BA, Maybrier HR, Muench MR, Escallier KE, Chen Y, Ben Abdallah A, Veselis RA, Hudetz JA, Pagel PS, Noh G, Pryor K, Kaiser H, Arya VK, Pong R, Jacobsohn E, Grocott HP, Choi S, Downey RJ, Inouye SK, Mashour GA. The Prevention of Delirium and Complications Associated with Surgical Treatments (PODCAST) study: protocol for an international multicentre randomised controlled trial. BMJ Open 2014;4:e005651.
4. Avidan MS, Mashour GA. Mind the gap: attitudes towards intraoperative brain monitoring. Anesth Analg 2014;119:1022-5.
5. Avidan MS, Sleigh JW. Beware the Boojum: the NAP5 audit of accidental awareness during intended general anaesthesia. Anaesthesia 2014;69:1065-8.
6. Avidan MS, Wildes TS. Power of negative thinking. Br J Anaesth 2015;114:3-5.
7. Beirowski B, Babetto E, Golden JP, Chen YJ, Yang K. Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance. 2014;17:1351-61.
8. Bendtsen TF, Pedersen EM, Haroutounian S, Soballe K, Moriggl B, Nikolajsen L, Hasselstrom JB, Fisker AK, Strid JM, Iversen B, Borglum J. The suprasacral parallel shift vs lumbar plexus blockade with ultrasound guidance in healthy volunteers–a randomised controlled trial. Anaesthesia 2014;69:1227-40.
9. Bo L, Li J, Tao T, Bai Y, Ye X, Hotchkiss RS, Kollef MH, Crooks NH, Deng X. Probiotics for preventing ventilator-associated pneumonia. Cochrane Database Syst Rev 2014;10:Cd009066.
10. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schunemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O’Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O’Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortes OL, Chaparro MS, Vasquez S, Castaneda A, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schunemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin, II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santalo M, Gonzalez R, Font A, Martinez C, Pelaez X, De Antonio M, Villamor JM, Garcia JA, Ferre MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernandez C, Palencia M, Diaz S, Del Castillo T, Varela A, de Miguel A, Munoz M, Pineiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology 2014;120:564-78.
11. Bottros MM, Christo PJ. Current perspectives on intrathecal drug delivery. J Pain Res 2014;7:615-26.
12. Bracamontes JR, Li P, Akk G, Steinbach JH. Mutations in the main cytoplasmic loop of the GABA(A) receptor alpha4 and delta subunits have opposite effects on surface expression. Mol Pharmacol 2014;86:20-7.
13. Brenker C, Zhou Y, Muller A, Echeverry FA, Trotschel C, Poetsch A, Xia XM, Bonigk W, Lingle CJ, Kaupp UB, Strunker T. The Ca2+-activated K+ current of human sperm is mediated by Slo3. Elife 2014;3:e01438.
14. Brenner DS, Golden JP, Vogt SK, Dhaka A, Story GM, Gereau Iv RW. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain 2014;155:2124-33.
15. Brenner DS, Vogt SK, Gereau RWt. A technique to measure cold adaptation in freely behaving mice. J Neurosci Methods 2014;236:86-91.
16. Campbell SD, Regina KJ, Kharasch ED. Significance of lipid composition in a blood-brain barrier-mimetic PAMPA assay. J Biomol Screen 2014;19:437-44.
17. Carpenter CR, Avidan MS, Wildes T, Stark S, Fowler SA, Lo AX. Predicting geriatric falls following an episode of emergency department care: a systematic review. Acad Emerg Med 2014;21:1069-82.
18. Chang SD, Bruchas MR. Functional selectivity at GPCRs: new opportunities in psychiatric drug discovery. Neuropsychopharmacology 2014;39:248-9.
19. Chen SY, Lin PL, Yang YH, Yang YM, Lee CN, Fan SZ, Chen LK. The effects of different epidural analgesia formulas on labor and mode of delivery in nulliparous women. Taiwan J Obstet Gynecol 2014;53:8-11.
20. Chen SY, Liu FL, Cherng YG, Fan SZ, Leighton BL, Chang HC, Chen LK. Patient-controlled epidural levobupivacaine with or without fentanyl for post-cesarean section pain relief. Biomed Res Int 2014;2014:965152.
21. Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RWt, Wang F, Liedtke W. TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain 2014;155:2662-72.
22. Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS. 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology (Berl) 2014;231:3479-91.
23. Davidson S, Copits BA, Zhang J, Page G, Ghetti A, Gereau RWt. Human sensory neurons: Membrane properties and sensitization by inflammatory mediators. Pain 2014;155:1861-70.
24. Dettmer M, Holthaus CV, Fuller BM. The impact of serial lactate monitoring on emergency department resuscitation interventions and clinical outcomes in severe sepsis and septic shock: an observational cohort study. Shock 2015;43:55-61.
25. Drewry AM, Samra N, Skrupky LP, Fuller BM, Compton SM, Hotchkiss RS. Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock 2014;42:383-91.
26. Duma A, Helsten D, Brown F, Bottros MM, Nagele P. The effect of nitrous oxide anesthesia on early postoperative opioid consumption and pain. Reg Anesth Pain Med 2014;39:31-6.
27. Eaton MM, Bracamontes J, Shu HJ, Li P, Mennerick S, Steinbach JH, Akk G. gamma-aminobutyric acid type A alpha4, beta2, and delta subunits assemble to produce more than one functionally distinct receptor type. Mol Pharmacol 2014;86:647-56.
28. Eaton MM, Lim YB, Covey DF, Akk G. Modulation of the human rho1 GABAA receptor by inhibitory steroids. Psychopharmacology (Berl) 2014;231:3467-78.
29. Escallier KE, Nadelson MR, Zhou D, Avidan MS. Monitoring the brain: processed electroencephalogram and peri-operative outcomes. Anaesthesia 2014;69:899-910.
30. Fuller BM. Response to “regarding the benefits and harms of blood transfusion in septic patients”. J Emerg Med 2014;47:694-5.
31. Fuller BM, Mohr NM. Limiting acute respiratory distress syndrome in the emergency department: a survey of US academic emergency medicine physicians. Eur J Emerg Med 2014;21:387-8.
32. Fuller BM, Mohr NM, Graetz TJ, Lynch IP, Dettmer M, Cullison K, Coney T, Gogineni S, Gregory R. The impact of cardiac dysfunction on acute respiratory distress syndrome and mortality in mechanically ventilated patients with severe sepsis and septic shock: An observational study. J Crit Care 2015;30:65-70.
33. Fuller BM, Mohr NM, Hotchkiss RS, Kollef MH. Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department. Shock 2014;41:378-87.
34. Fuzaylov G, Anderson R, Knittel J, Driscoll DN. Global Health: Burn Outreach Program. J Burn Care Res 2014.
35. Fuzaylov G, Murthy S, Dunaev A, Savchyn V, Knittel J, Zabolotina O, Dylewski ML, Driscoll DN. Improving burn care and preventing burns by establishing a burn database in Ukraine. Burns 2014;40:1007-12.
36. Gaut JP, Crimmins DL, Ohlendorf MF, Lockwood CM, Griest TA, Brada NA, Hoshi M, Sato B, Hotchkiss RS, Jain S, Ladenson JH. Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem 2014;60:747-57.
37. Gereau RWt, Sluka KA, Maixner W, Savage SR, Price TJ, Murinson BB, Sullivan MD, Fillingim RB. A pain research agenda for the 21st century. J Pain 2014;15:1203-14.
38. Gonzalez-Perez V, Xia XM, Lingle CJ. Functional regulation of BK potassium channels by gamma1 auxiliary subunits. Proc Natl Acad Sci U S A 2014;111:4868-73.
39. Gross RW, Patti GJ, Milbrandt J. Nat Neurosci.
40. Guo Z, Cao YQ. Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors. PLoS One 2014;9:e87029.
41. Guo Z, Liu P, Ren F, Cao YQ. Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons. J Neurophysiol 2014;112:568-79.
42. Haller G, Li P, Esch C, Hsu S, Goate AM, Steinbach JH. Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. PLoS One 2014;9:e96753.
43. Haroutiunian S, Kagan L, Yifrach-Damari I, Davidson E, Ratz Y, Hoffman A. Enhanced antinociceptive efficacy of epidural compared with i.v. methadone in a rat model of thermal nociception. Br J Anaesth 2014;112:150-8.
44. Haroutounian S, Nikolajsen L, Bendtsen TF, Finnerup NB, Kristensen AD, Hasselstrom JB, Jensen TS. Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain 2014;155:1272-9.
45. Haroutounian S, Nikolajsen L, Finnerup NB, Jensen TS. Topical Capsaicin Response as a Phenotypic Measure in Patients with Pain. Pain Med 2014.
46. He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain. Pain 2014;155:534-44.
47. Helwani MA, Saied NN. End-tidal anesthetic concentration audible alert setup to minimize intraoperative awareness. J Clin Anesth 2014.
48. Hotchkiss RS, Moldawer LL. Parallels between cancer and infectious disease. N Engl J Med 2014;371:380-3.
49. Hutchins NA, Unsinger J, Hotchkiss RS, Ayala A. The new normal: immunomodulatory agents against sepsis immune suppression. Trends Mol Med 2014;20:224-33.
50. Ibrahim M, Wang X, Puyo CA, Montecalvo A, Huang HJ, Hachem RR, Andreetti C, Menna C, Chen R, Krupnick AS, Kreisel D, Rendina EA, Gelman AE. Human recombinant apyrase therapy protects against canine pulmonary ischemia-reperfusion injury. J Heart Lung Transplant 2014.
51. Kaiser HA, Ben Abdallah A, Lin N, Tellor BR, Helwani M, Smith JR, Moon MR, Avidan MS. Contaminated heparin and outcomes after cardiac surgery: a retrospective propensity-matched cohort study. PLoS One 2014;9:e106096.
52. Karunarathne WK, O’Neill PR, Gautam N. Subcellular optogenetics – controlling signaling and single-cell behavior. J Cell Sci 2015;128:15-25.
53. Kaspera R, Kirby BJ, Sahele T, Collier AC, Kharasch ED, Unadkat JD, Totah RA. Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. Biochem Pharmacol 2014;91:109-18.
54. Lai HH, Gardner V, Ness TJ, Gereau RWt. Segmental hyperalgesia to mechanical stimulus in interstitial cystitis/bladder pain syndrome: evidence of central sensitization. J Urol 2014;191:1294-9.
55. Lai HH, Vetter J, Jain S, Gereau RWt, Andriole GL. The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder: a questionnaire based analysis. J Urol 2014;192:1679-85.
56. Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol 2014;86:760-72.
57. Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G. The neurosteroid 5beta-pregnan-3alpha-ol-20-one enhances actions of etomidate as a positive allosteric modulator of alpha1beta2gamma2L GABAA receptors. Br J Pharmacol 2014;171:5446-57.
58. Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu YX, Wang Y, Hin N, Tsukamoto T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain 2014;155:1613-21.
59. London DA, Stepan JG, Lalchandani GR, Okoroafor UC, Wildes TS, Calfee RP. The impact of obesity on complications of elbow, forearm, and hand surgeries. J Hand Surg Am 2014;39:1578-84.
60. Luo J, Hu H. Thermally activated TRPV3 channels. Curr Top Membr 2014;74:325-64.
61. Martinez-Espinosa PL, Yang C, Gonzalez-Perez V, Xia XM, Lingle CJ. Knockout of the BK beta2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. J Gen Physiol 2014;144:275-95.
62. Mashour GA, Avidan MS. Psychological trajectories after intraoperative awareness with explicit recall. Anesth Analg 2014;119:1-3.
63. Mashour GA, Avidan MS. Postoperative delirium: disconnecting the network? Anesthesiology 2014;121:214-6.
64. Mashour GA, Avidan MS. Dementia and sensitivity to anesthetics. Can J Anaesth 2014;61:599-604.
65. Mashour GA, Woodrum DT, Avidan MS. Neurological complications of surgery and anaesthesia. Br J Anaesth 2015;114:194-203.
66. McNicol ED, Schumann R, Haroutounian S. A systematic review and meta-analysis of ketamine for the prevention of persistent post-surgical pain. Acta Anaesthesiol Scand 2014;58:1199-213.
67. Micek ST, Lang A, Fuller BM, Hampton NB, Kollef MH. Clinical implications for patients treated inappropriately for community-acquired pneumonia in the emergency department. BMC Infect Dis 2014;14:61.
68. Morrissey JJ, Mobley J, Song J, Vetter J, Luo J, Bhayani S, Figenshau RS, Kharasch ED. Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade. Urology 2014;83:256.e9-14.
69. Nadelson MR, Sanders RD, Avidan MS. Perioperative cognitive trajectory in adults. Br J Anaesth 2014;112:440-51.
70. O’Neill PR, Gautam N. Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Mol Biol Cell 2014;25:2305-14.
71. O’Neill PR, Giri L, Karunarathne WK, Patel AK, Venkatesh KV, Gautam N. The structure of dynamic GPCR signaling networks. Wiley Interdiscip Rev Syst Biol Med 2014;6:115-23.
72. Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH. Abandon the mouse research ship? Not just yet! Shock 2014;41:463-75.
73. Pierrakos C, Velissaris D, Franchi F, Muzzi L, Karanikolas M, Scolletta S. Levosimendan in critical illness: a literature review. J Clin Med Res 2014;6:75-85.
74. Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Moron JA. Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference. J Neurosci 2014;34:527-38.
75. Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of gamma-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. J Med Chem 2014;57:171-90.
76. Rao S, Huverserian AR, Ben Abdallah A, Lees K, Willingham MD, Burnside BA, Villafranca AJ, Glick DB, Jacobsohn E, Avidan MS. Impact of right-handedness on anaesthetic sensitivity, intra-operative awareness and postoperative mortality. Anaesthesia 2014;69:840-6.
77. Ruger JP, Abdallah AB, Ng NY, Luekens C, Cottler L. Cost-effectiveness of interventions to prevent HIV and STDs among women: a randomized controlled trial. AIDS Behav 2014;18:1913-23.
78. Sai KK, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [(1)(1)C]l-alpha-acetylmethadol ([(1)(1)C]LAAM). Appl Radiat Isot 2014;91:135-40.
79. Shanks AM, Avidan MS, Kheterpal S, Tremper KK, Vandervest JC, Cavanaugh JM, Mashour GA. Alerting thresholds for the prevention of intraoperative awareness with explicit recall: A secondary analysis of the Michigan Awareness Control Study. Eur J Anaesthesiol 2014.
80. Tian L, Tadepalli S, Park SH, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S. Bioplasmonic calligraphy for multiplexed label-free biodetection. Biosens Bioelectron 2014;59:208-15.
81. Vannucci A, Rathor R, Vachharajani N, Chapman W, Kangrga I. Atrial fibrillation in patients undergoing liver transplantation-a single-center experience. Transplant Proc 2014;46:1432-7.
82. Velissaris D, Karamouzos V, Marangos M, Pierrakos C, Karanikolas M. Pharmacokinetic changes and dosing modification of aminoglycosides in critically ill obese patients: a literature review. J Clin Med Res 2014;6:227-33.
83. Walton AH, Muenzer JT, Rasche D, Boomer JS, Sato B, Brownstein BH, Pachot A, Brooks TL, Deych E, Shannon WD, Green JM, Storch GA, Hotchkiss RS. Reactivation of multiple viruses in patients with sepsis. PLoS One 2014;9:e98819.
84. Wessman BT, Fuller BM. Training emergency physicians to meet the critical care needs in the United States: a consensus of two. Crit Care Med 2014;42:e677-8.
85. Whitlock EL, Rodebaugh TL, Hassett AL, Shanks AM, Kolarik E, Houghtby J, West HM, Burnside BA, Shumaker E, Villafranca A, Edwards WA, Levinson CA, Langer JK, Fernandez KC, El-Gabalawy R, Zhou EY, Sareen J, Jacobsohn E, Mashour GA, Avidan MS. Psychological Sequelae of Surgery in a Prospective Cohort of Patients from Three Intraoperative Awareness Prevention Trials. Anesth Analg 2014.
86. Whitlock EL, Torres BA, Lin N, Helsten DL, Nadelson MR, Mashour GA, Avidan MS. Postoperative delirium in a substudy of cardiothoracic surgical patients in the BAG-RECALL clinical trial. Anesth Analg 2014;118:809-17.
87. Wildes TM, Dua P, Fowler SA, Miller JP, Carpenter CR, Avidan MS, Stark S. Systematic review of falls in older adults with cancer. J Geriatr Oncol 2015;6:70-83.
88. Willingham M, Ben Abdallah A, Gradwohl S, Helsten D, Lin N, Villafranca A, Jacobsohn E, Avidan M, Kaiser H. Association between intraoperative electroencephalographic suppression and postoperative mortality. Br J Anaesth 2014;113:1001-8.
89. Wilson-Edell KA, Kehasse A, Scott GK, Yau C, Rothschild DE, Schilling B, Gabriel BS, Yevtushenko MA, Hanson IM, Held JM, Gibson BW, Benz CC. RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. Oncotarget 2014;5:5165-76.
90. Yin S, Luo J, Qian A, Yu W, Hu H. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. Br J Pharmacol 2014;171:1510-20.
91. Young JL, Lockhart EM, Baysinger CL. Anesthetic and obstetric management of the opioid-dependent parturient. Int Anesthesiol Clin 2014;52:67-85.
92. Zammataro M, Sortino MA, Parenti C, Gereau RWt, Chiechio S. HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors. Mol Pain 2014;10:68.
93. Zawadzka AM, Schilling B, Held JM, Sahu AK, Cusack MP, Drake PM, Fisher SJ, Gibson BW. Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition. Electrophoresis 2014;35:3487-97.
94. Zhao ZQ, Liu XY, Jeffry J, Karunarathne WK, Li JL, Munanairi A, Zhou XY, Li H, Sun YG, Wan L, Wu ZY, Kim S, Huo FQ, Mo P, Barry DM, Zhang CK, Kim JY, Gautam N, Renner KJ, Li YQ, Chen ZF. Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron 2014;84:821-34.
95. Zhou Y, Lingle CJ. Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. J Gen Physiol 2014;144:415-40.

Department Publications 2013

1. Abbas A, Tian L, Morrissey JJ, Kharasch ED, Singamaneni S. Hot Spot-Localized Artificial Antibodies for Label-Free Plasmonic Biosensing. Adv Funct Mater 2013;23:1789-97.
2. Akk G, Eaton M, Li P, Zheng S, Lo J, Steinbach JH. Energetic contributions to channel gating of residues in the muscle nicotinic receptor beta1 subunit. PLoS One 2013;8:e78539.
3. Al-Hasani R, McCall JG, Bruchas MR. Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference. Front Pharmacol 2013;4:96.
4. Al-Hasani R, McCall JG, Foshage AM, Bruchas MR. Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism. Neuropsychopharmacology 2013;38:2484-97.
5. Aranake A, Gradwohl S, Ben-Abdallah A, Lin N, Shanks A, Helsten DL, Glick DB, Jacobsohn E, Villafranca AJ, Evers AS, Avidan MS, Mashour GA. Increased risk of intraoperative awareness in patients with a history of awareness. Anesthesiology 2013;119:1275-83.
6. Aranake A, Mashour GA, Avidan MS. Minimum alveolar concentration: ongoing relevance and clinical utility. Anaesthesia 2013;68:512-22.
7. Aubuchon J, Maynard E, Lakshminarasimhachar A, Chapman W, Kangrga I. Intraoperative transesophageal echocardiography reveals thrombotic stenosis of inferior vena cava during orthotopic liver transplantation. Liver Transpl 2013;19:232-4.
8. Avidan MS, Mashour GA. Prevention of intraoperative awareness with explicit recall: making sense of the evidence. Anesthesiology 2013;118:449-56.
9. Avidan MS, Mashour GA. The incidence of intra-operative awareness in the UK: under the rate or under the radar? Anaesthesia 2013;68:334-8.
10. Blake CM, Kharasch ED, Schwab M, Nagele P. A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics. Clin Pharmacol Ther 2013;94:394-9.
11. Boston US, Fehr J, Gazit AZ, Eghtesady P. Paracorporeal lung assist device: an innovative surgical strategy for bridging to lung transplant in an infant with severe pulmonary hypertension caused by alveolar capillary dysplasia. J Thorac Cardiovasc Surg 2013;146:e42-3.
12. Burns TL, DeBaun MR, Boulet JR, Murray GM, Murray DJ, Fehr JJ. Acute care of pediatric patients with sickle cell disease: a simulation performance assessment. Pediatr Blood Cancer 2013;60:1492-8.
13. Cavallone LF, Frey K, Montana MC, Joyal J, Regina KJ, Petersen KL, Gereau RWt. Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers. J Pain Res 2013;6:771-84.
14. Cavallone LF, Hantler CB. A move in the right direction? Minerva Anestesiol 2013;79:1103-4.
15. Cavallone LF, Vannucci A. Review article: Extubation of the difficult airway and extubation failure. Anesth Analg 2013;116:368-83.
16. Chen LK, Chen SS, Huang CH, Yang HJ, Lin CJ, Chien KL, Fan SZ. Polymorphism of mu-Opioid Receptor Gene (OPRM1:c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting. Pain Res Treat 2013;2013:259306.
17. Chen Y, Williams SH, McNulty AL, Hong JH, Lee SH, Rothfusz NE, Parekh PK, Moore C, Gereau RWt, Taylor AB, Wang F, Guilak F, Liedtke W. Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. Pain 2013;154:1295-304.
18. Davis CG, Chang K, Osborne D, Walton AH, Ghosh S, Dunne WM, Hotchkiss RS, Muenzer JT. TLR3 agonist improves survival to secondary pneumonia in a double injury model. J Surg Res 2013;182:270-6.
19. Drewry AM, Fuller BM, Bailey TC, Hotchkiss RS. Body temperature patterns as a predictor of hospital-acquired sepsis in afebrile adult intensive care unit patients: a case-control study. Crit Care 2013;17:R200.
20. Drewry AM, Hotchkiss RS. Counterpoint: Should antipyretic therapy be given routinely to febrile patients in septic shock? No. Chest 2013;144:1098-101; discussion 101-3.
21. Duma A, Helsten D, Brown F, Bottros MM, Nagele P. The effect of nitrous oxide anesthesia on early postoperative opioid consumption and pain. Reg Anesth Pain Med 2014;39:31-6.
22. Fritz BA, Rao P, Mashour GA, Abdallah AB, Burnside BA, Jacobsohn E, Zhang L, Avidan MS. Postoperative recovery with bispectral index versus anesthetic concentration-guided protocols. Anesthesiology 2013;118:1113-22.
23. Fuller BM. Treatment of pulmonary embolism is all about relieving obstruction? N.o., it is not! Crit Care Med 2013;41:1828-9.
24. Fuller BM, Mohr N, Skrupky L, Mueller K, McCammon C. Emergency Department vancomycin use: dosing practices and associated outcomes. J Emerg Med 2013;44:910-8.
25. Fuller BM, Mohr NM, Carpenter CR. Protective ventilation for patients without acute respiratory distress syndrome. Jama 2013;309:654-5.
26. Fuller BM, Mohr NM, Dettmer M, Kennedy S, Cullison K, Bavolek R, Rathert N, McCammon C. Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock: an observational study. Acad Emerg Med 2013;20:659-69.
27. Fuller BM, Mohr NM, Drewry AM, Carpenter CR. Lower tidal volume at initiation of mechanical ventilation may reduce progression to acute respiratory distress syndrome: a systematic review. Crit Care 2013;17:R11.
28. Golden JP, Demaro JA, 3rd, Knoten A, Hoshi M, Pehek E, Johnson EM, Jr., Gereau RWt, Jain S. Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. J Neurosci 2013;33:17095-107.
29. Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte R, Dong X. A subpopulation of nociceptors specifically linked to itch. Nat Neurosci 2013;16:174-82.
30. Hotchkiss RS, Levy JH, Levi M. Sepsis-induced disseminated intravascular coagulation, symmetrical peripheral gangrene, and amputations. Crit Care Med 2013;41:e290-1.
31. Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013;13:862-74.
32. Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013;13:260-8.
33. Johnston J, Pal S, Nagele P. Perioperative torsade de pointes: a systematic review of published case reports. Anesth Analg 2013;117:559-64.
34. Jung E, Perrone EE, Brahmamdan P, McDonough JS, Leathersich AM, Dominguez JA, Clark AT, Fox AC, Dunne WM, Hotchkiss RS, Coopersmith CM. Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury. PLoS One 2013;8:e77203.
35. Karunarathne WK, Giri L, Kalyanaraman V, Gautam N. Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension. Proc Natl Acad Sci U S A 2013;110:E1565-74.
36. Karunarathne WKA, Giri L, Patel AK, Venkatesh KV, Gautam N. Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proc Natl Acad Sci U S A 2013;110:E1575-83.
37. Kim TI, McCall JG, Jung YH, Huang X, Siuda ER, Li Y, Song J, Song YM, Pao HA, Kim RH, Lu C, Lee SD, Song IS, Shin G, Al-Hasani R, Kim S, Tan MP, Huang Y, Omenetto FG, Rogers JA, Bruchas MR. Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science 2013;340:211-6.
38. Lai HH, Gardner V, Ness TJ, Gereau RWt. Segmental Hyperalgesia to Mechanical Stimulus in Interstitial Cystitis/Bladder Pain Syndrome – Evidence of Central Sensitization. J Urol 2013.
39. Li P, Eaton MM, Steinbach JH, Akk G. The benzodiazepine diazepam potentiates responses of alpha1beta2gamma2L gamma-aminobutyric acid type A receptors activated by either gamma-aminobutyric acid or allosteric agonists. Anesthesiology 2013;118:1417-25.
40. Li Y, Shi X, Song J, Lu C, Kim TI, McCall JG, Bruchas MR, Rogers JA, Huang Y. Erratum: Thermal analysis of injectable, cellular-scale optoelectronics with pulsed power. Proc Math Phys Eng Sci 2013;469:20130398.
41. Liu P, Xiao Z, Ren F, Guo Z, Chen Z, Zhao H, Cao YQ. Functional analysis of a migraine-associated TRESK K+ channel mutation. J Neurosci 2013;33:12810-24.
42. Lockhart EM, Willingham MD, Abdallah AB, Helsten DL, Bedair BA, Thomas J, Duntley S, Avidan MS. Obstructive sleep apnea screening and postoperative mortality in a large surgical cohort. Sleep Med 2013;14:407-15.
43. Mashour GA, Avidan MS. Capturing covert consciousness. Lancet 2013;381:271-2.
44. Mashour GA, Kent C, Picton P, Ramachandran SK, Tremper KK, Turner CR, Shanks A, Avidan MS. Assessment of intraoperative awareness with explicit recall: a comparison of 2 methods. Anesth Analg 2013;116:889-91.
45. McCall JG, Kim TI, Shin G, Huang X, Jung YH, Al-Hasani R, Omenetto FG, Bruchas MR, Rogers JA. Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics. Nat Protoc 2013;8:2413-28.
46. Mohr NM, Wessman B. Continuous capnography should be used for every emergency department procedural sedation. Ann Emerg Med 2013;61:697-8.
47. Moore RP, Wester T, Sunder R, Schrock C, Park TS. Peri-operative pain management in children with cerebral palsy: comparative efficacy of epidural vs systemic analgesia protocols. Paediatr Anaesth 2013;23:720-5.
48. Morrissey JJ, Kharasch ED. The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma. J Urol 2013;189:1913-20.
49. Nagele P. Exome sequencing: one small step for malignant hyperthermia, one giant step for our specialty–why exome sequencing matters to all of us, not just the experts. Anesthesiology 2013;119:1006-8.
50. Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP. Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial. Anesthesiology 2013;119:19-28.
51. Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery. Am Heart J 2013;166:325-32.e1.
52. Nattkemper LA, Zhao ZQ, Nichols AJ, Papoiu AD, Shively CA, Chen ZF, Yosipovitch G. Overexpression of the gastrin-releasing peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch. J Invest Dermatol 2013;133:2489-92.
53. Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. Incidence, predictors and outcomes of postoperative coma: an observational study of 858,606 patients. Eur J Anaesthesiol 2013;30:476-82.
54. O’Brien DE, Brenner DS, Gutmann DH, Gereau RWt. Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. J Pain 2013;14:628-37.
55. O’Neill PR, Karunarathne WK, Kalyanaraman V, Silvius JR, Gautam N. G-protein signaling leverages subunit-dependent membrane affinity to differentially control betagamma translocation to intracellular membranes. Proc Natl Acad Sci U S A 2012;109:E3568-77.
56. Parvizi D, Kamolz LP, Giretzlehner M, Haller HL, Trop M, Selig H, Nagele P, Lumenta DB. The potential impact of wrong TBSA estimations on fluid resuscitation in patients suffering from burns: Things to keep in mind. Burns 2013.
57. Saettele AK, Sharma A, Murray DJ. Case scenario: Hypotonia in infancy: anesthetic dilemma. Anesthesiology 2013;119:443-6.
58. Sanders RD, Avidan MS. Postoperative cognitive trajectories in adults: the role of inflammatory processes. Anesthesiology 2013;118:484-6.
59. Scott B, Sun CL, Mao X, Yu C, Vohra BP, Milbrandt J, Crowder CM. Role of oxygen consumption in hypoxia protection by translation factor depletion. J Exp Biol 2013;216:2283-92.
60. Selig HF, Nagele P, Lumenta DB, Voelckel WG, Trimmel H, Hupfl M, Kamolz LP. [Thermal injuries in the OEAMTC air rescue service : Epidemiological characteristics of burns/scalds in children and adults.]. Unfallchirurg 2013.
61. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, Lopez CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 2013;110:3507-12.
62. Slavkovic Z, Stamenkovic DM, Geric V, Veljovic M, Ivanovic N, Todorovic S, Maric P, Karanikolas M. Combined spinal-epidural technique: single-space vs double distant space technique. Vojnosanit Pregl 2013;70:953-8.
63. Slavkovic Z, Stamenkovic DM, Geric V, Veljovic M, Ivanoviic N, Tomic A, Randjelovic T, Raskovic J, Karanikolas M. Comparison of analgesic effect of intrathecal morphine alone or in combination with bupivacaine and fentanyl in patients undergoing total gastrectomy: a prospective randomized, double blind clinical trial. Vojnosanit Pregl 2013;70:541-7.
64. Slavkovic Z, Stamenkovic DM, Romic P, Tomic A, Milovic N, Jovanovic M, Karanikolas M. The present and future of fiberoptic intubation. Vojnosanit Pregl 2013;70:61-7.
65. Stemler KM, Crock LW, Lai HH, Mills JC, Gereau RWt, Mysorekar IU. Protamine sulfate induced bladder injury protects from distention induced bladder pain. J Urol 2013;189:343-51.
66. Sun CL, Kim E, Crowder CM. Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans. Cell Death Differ 2013.
67. Sykes KT, Yi X. Intracranial hypotension headache caused by a massive cerebrospinal fluid leak successfully treated with a targeted c2 epidural blood patch: a case report. Pain Physician 2013;16:399-404.
68. Takasu O, Gaut JP, Swanson PE, Hotchkiss RS. Reply: The role of arrhythmias in defining cardiac dysfunction during sepsis. Am J Respir Crit Care Med 2013;188:751.
69. Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, Hotchkiss RS. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med 2013;187:509-17.
70. Tan JA, Helsten D. Intraoperative handoffs. Int Anesthesiol Clin 2013;51:31-42.
71. Vannucci A. Sugammadex can be part of the solution. Let’s not make it part of the problem! Minerva Anestesiol 2013;79:587-9.
72. Vannucci A, Jeffcoat A, Ifune C, Salinas C, Duncan JR, Wall M. Special article: retained guidewires after intraoperative placement of central venous catheters. Anesth Analg 2013;117:102-8.
73. Vannucci A, Kras JF. Decision making, situation awareness, and communication skills in the operating room. Int Anesthesiol Clin 2013;51:105-27.
74. Villafranca A, Thomson IA, Grocott HP, Avidan MS, Kahn S, Jacobsohn E. The impact of bispectral index versus end-tidal anesthetic concentration-guided anesthesia on time to tracheal extubation in fast-track cardiac surgery. Anesth Analg 2013;116:541-8.
75. Villafranca AJ, Arenson BG, Avidan MS, Glick D, Mashour GA, Jacobsohn E. Case report: Volitional delay of self-reported outcomes: insights from a case of intraoperative awareness with explicit recall. Anesth Analg 2013;116:365-7.
76. Vretzakis G, Bareka M, Aretha D, Karanikolas M. Regional anesthesia for laparoscopic surgery: a narrative review. J Anesth 2013.
77. Vretzakis G, Georgopoulou S, Stamoulis K, Tassoudis V, Mikroulis D, Giannoukas A, Tsilimingas N, Karanikolas M. Monitoring of brain oxygen saturation (INVOS) in a protocol to direct blood transfusions during cardiac surgery: a prospective randomized clinical trial. J Cardiothorac Surg 2013;8:145.
78. Wang JC, Spiegel N, Bertelsen S, Le N, McKenna N, Budde JP, Harari O, Kapoor M, Brooks A, Hancock D, Tischfield J, Foroud T, Bierut LJ, Steinbach JH, Edenberg HJ, Traynor BJ, Goate AM. Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry. PLoS One 2013;8:e80204.
79. Yee BE, Wissler RN, Zanghi CN, Feng C, Eaton MP. The effective concentration of tranexamic acid for inhibition of fibrinolysis in neonatal plasma in vitro. Anesth Analg 2013;117:767-72.
80. Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP. A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nat Chem Biol 2013;9:715-20.
81. Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol 2013;142:305-13.
82. Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey JF, Jr., Zhong J, Chen ZF. Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest 2013.

Department Publications 2012

1. Group TPVLS. Risk factors associated with ischemic optic neuropathy after spinal fusion surgery. Anesthesiology 2012;116:15-24.
2. Ajith Karunarathne WK, O’Neill PR, Martinez-Espinosa PL, Kalyanaraman V, Gautam N. All G protein betagamma complexes are capable of translocation on receptor activation. Biochem Biophys Res Commun 2012;421:605-11.
3. Aubuchon J, Maynard E, Lakshminarasimhachar A, Chapman W, Kangrga I. Intraoperative transesophageal echocardiography reveals thrombotic stenosis of inferior vena cava during orthotopic liver transplantation. Liver Transpl 2012.
4. Avidan MS, Benzinger TL. Surgery and the plastic brain. Anesthesiology 2012;116:510-2.
5. Avidan MS, Kheterpal S. Perioperative mortality in developed and developing countries. Lancet 2012;380:1038-9.
6. Avidan MS, Mashour GA. Prevention of Intraoperative Awareness with Explicit Recall: Making Sense of the Evidence. Anesthesiology 2013;118:449-56.
7. Bezmarevic M, Mirkovic D, Soldatovic I, Stamenkovic D, Mitrovic N, Perisic N, Marjanovic I, Mickovic S, Karanikolas M. Correlation between procalcitonin and intra-abdominal pressure and their role in prediction of the severity of acute pancreatitis. Pancreatology 2012;12:337-43.
8. Boomer JS, Shuherk-Shaffer J, Hotchkiss RS, Green JM. A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care 2012;16:R112.
9. Boulet JR, Murray D. Review article: assessment in anesthesiology education. Can J Anaesth 2012;59:182-92.
10. Bracamontes JR, Li P, Akk G, Steinbach JH. A neurosteroid potentiation site can be moved among GABAA receptor subunits. J Physiol 2012;590:5739-47.
11. Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Martin LD, Dissen GA, Creeley CE, Olney JW. Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain. Anesthesiology 2012;116:372-84.
12. Brenner DS, Golden JP, Gereau RWt. A novel behavioral assay for measuring cold sensation in mice. PLoS One 2012;7:e39765.
13. Brown SM, Campbell SD, Crafford A, Regina KJ, Holtzman MJ, Kharasch ED. P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception. J Pharmacol Exp Ther 2012;343:53-61.
14. Chen ZW, Chen LH, Akentieva N, Lichti CF, Darbandi R, Hastings R, Covey DF, Reichert DE, Townsend RR, Evers AS. A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis 2012;33:666-74.
15. Chen ZW, Fuchs K, Sieghart W, Townsend RR, Evers AS. Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry. Mol Cell Proteomics 2012;11:M111 011445.
16. Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the beta3 subunit of the GABA(A) receptor. Mol Pharmacol 2012;82:408-19.
17. Crews KR, Gaedigk A, Dunnenberger HM, Klein TE, Shen DD, Callaghan JT, Kharasch ED, Skaar TC. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther 2012;91:321-6.
18. Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RWt. Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. J Neurosci 2012;32:14217-26.
19. Crock LW, Stemler KM, Song DG, Abbosh P, Vogt SK, Qiu CS, Lai HH, Mysorekar IU, Gereau RWt. Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Mol Pain 2012;8:20.
20. Davis CG, Chang K, Osborne D, Walton AH, Ghosh S, Dunne WM, Hotchkiss RS, Muenzer JT. TLR3 agonist improves survival to secondary pneumonia in a double injury model. J Surg Res 2012.
21. Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI, Jacka MJ, Sigamani A, Srinathan S, Biccard BM, Chow CK, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G, Heels-Ansdell D, Sessler DI, Thorlund K, Garg AX, Mrkobrada M, Thomas S, Rodseth RN, Pearse RM, Thabane L, McQueen MJ, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA 2012;307:2295-304.
22. Eaton MM, Lim YB, Bracamontes J, Steinbach JH, Akk G. Agonist-specific conformational changes in the alpha1-gamma2 subunit interface of the GABA A receptor. Mol Pharmacol 2012;82:255-63.
23. Fehr JJ, Honkanen A, Murray DJ. Simulation in pediatric anesthesiology. Paediatr Anaesth 2012;22:988-94.
24. Ferraris VA, Saha SP, Oestreich JH, Song HK, Rosengart T, Reece TB, Mazer CD, Bridges CR, Despotis GJ, Jointer K, Clough ER. 2012 update to the Society of Thoracic Surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations. Ann Thorac Surg 2012;94:1761-81.
25. Fleisher LA, Evers AS, Wiener-Kronish J, Ulatowski JA. What are we looking for? The question of resident selection. Anesthesiology 2012;117:230-1.
26. Fuller BM, Dellinger RP. Lactate as a hemodynamic marker in the critically ill. Curr Opin Crit Care 2012;18:267-72.
27. Fuller BM, Gajera M, Schorr C, Gerber D, Dellinger RP, Parrillo J, Zanotti S. Transfusion of packed red blood cells is not associated with improved central venous oxygen saturation or organ function in patients with septic shock. J Emerg Med 2012;43:593-8.
28. Fuller BM, Gajera M, Schorr C, Gerber D, Dellinger RP, Zanotti S. The association of prior statin use in septic shock treated with early goal directed therapy. Eur J Emerg Med 2012;19:226-30.
29. Fuller BM, Mohr N, Skrupky L, Mueller K, McCammon C. Emergency Department Vancomycin Use: Dosing Practices and Associated Outcomes. J Emerg Med 2012.
30. Gonzalez-Perez V, Zeng XH, Henzler-Wildman K, Lingle CJ. Stereospecific binding of a disordered peptide segment mediates BK channel inactivation. Nature 2012;485:133-6.
31. Gurnaney H, Ambardekar A, Schwartz AJ. Is simulation the best way to assess pediatric anesthesia skills? Anesthesiology 2012;117:219-20; author reply 20.
32. Helwani MA, Saied NN, Asaad B, Rasmussen S, Fingerman ME. The current role of ultrasound use in teaching regional anesthesia: a survey of residency programs in the United States. Pain Med 2012;13:1342-6.
33. Hill LL, Evers AS. Perspective: Hospital support for anesthesiology departments: aligning incentives and improving productivity. Acad Med 2012;87:348-55.
34. Huang D, Li S, Dhaka A, Story GM, Cao YQ. Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura. Mol Pain 2012;8:66.
35. Hughes JP, Chessell I, Malamut R, Perkins M, Backonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, Segerdahl M, Seminowicz DA, Watkins LR, Waxman SG, Wiech K, Woolf C. Understanding chronic inflammatory and neuropathic pain. Ann N Y Acad Sci 2012;1255:30-44.
36. Ingelmo, II, Julia NF, Rama-Maceiras P, Romero RR, Quiles RB, Sola LV, Krauchi OR, Honorato C, Palazon JH, Ledesma MJ. [Questionnaire on the anaesthesiology treatment of patients subjected to posterior fossa neurosurgery]. Rev Esp Anestesiol Reanim 2012;59:118-26.
37. Joyal JJ, Vannucci A, Kangrga I. High end-expiratory airway pressures caused by internal obstruction of the Draeger Apollo(R) scavenger system that is not detected by the workstation self-test and visual inspection. Anesthesiology 2012;116:1162-4; discussion 4-6.
38. Kertai MD, Whitlock EL, Avidan MS. Brain monitoring with electroencephalography and the electroencephalogram-derived bispectral index during cardiac surgery. Anesth Analg 2012;114:533-46.
39. Kharasch ED. Getting oil and water to mix. Anesthesiology 2012;116:504-6.
40. Kharasch ED, Bedynek PS, Hoffer C, Walker A, Whittington D. Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). Anesthesiology 2012;116:432-47.
41. Kharasch ED, Whittington D, Ensign D, Hoffer C, Bedynek PS, Campbell S, Stubbert K, Crafford A, London A, Kim T. Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 2012;91:673-84.
42. Kheterpal S, Avidan MS. “Triple low”: murderer, mediator, or mirror. Anesthesiology 2012;116:1176-8.
43. Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. Drug Metab Dispos 2012;40:610-6.
44. Krishnan K, Manion BD, Taylor A, Bracamontes J, Steinbach JH, Reichert DE, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on gamma-aminobutyric acid type A receptors. J Med Chem 2012;55:1334-45.
45. Mashour GA, Avidan MS. Variability indices of processed electroencephalography and electromyography. Anesth Analg 2012;114:713-4.
46. Mashour GA, Shanks A, Tremper KK, Kheterpal S, Turner CR, Ramachandran SK, Picton P, Schueller C, Morris M, Vandervest JC, Lin N, Avidan MS. Prevention of intraoperative awareness with explicit recall in an unselected surgical population: a randomized comparative effectiveness trial. Anesthesiology 2012;117:717-25.
47. Mijuskovic D, Stamenkovic DM, Borovic S, Karanikolas M. Successful resuscitation from two cardiac arrests in a female patient with critical aortic stenosis, severe mitral regurgitation and coronary artery disease. Vojnosanit Pregl 2012;69:714-6.
48. Misharin AV, Haines GK, 3rd, Rose S, Gierut AK, Hotchkiss RS, Perlman H. Development of a new humanized mouse model to study acute inflammatory arthritis. J Transl Med 2012;10:190.
49. Mohr NM, Fuller BM. Low tidal volume ventilation should be the routine ventilation strategy of choice for all emergency department patients. Ann Emerg Med 2012;60:215-6.
50. Morrissey JJ, Kharasch ED. The Specificity of Urinary Aquaporin 1 and Perilipin 2 to Screen for Renal Cell Carcinoma. J Urol 2012.
51. Murray DJ. The simulation-derived algorithm: a better method to achieve a performance consensus. Anesthesiology 2012;117:701-2.
52. Nagele P. Notorious oxide. Anesthesiology 2012;117:3-5.
53. Nagele P, Pal S, Brown F, Blood J, Miller JP, Johnston J. Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia. Anesthesiology 2012;117:321-8.
54. Olofsen E, Noppers I, Niesters M, Kharasch E, Aarts L, Sarton E, Dahan A. Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers. Anesthesiology 2012;117:353-64.
55. Palaiologou M, Koskinas J, Karanikolas M, Fatourou E, Tiniakos DG. E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma. Virchows Arch 2012;460:439-46.
56. Papadopoulos G, Karanikolas M, Liarmakopoulou A, Papathanakos G, Korre M, Beris A. Cerebral oximetry and cognitive dysfunction in elderly patients undergoing surgery for hip fractures: a prospective observational study. Open Orthop J 2012;6:400-5.
57. Pierrakos C, Karanikolas M, Scolletta S, Karamouzos V, Velissaris D. Acute respiratory distress syndrome: pathophysiology and therapeutic options. J Clin Med Res 2012;4:7-16.
58. Selig HF, Hupfl M, Trimmel H, Voelckel WG, Nagele P. Pediatric trauma in the Austrian Alps: the epidemiology of sport-related injuries in helicopter emergency medical service. High Alt Med Biol 2012;13:112-7.
59. Sharkey AM, Sharma A. Tetralogy of Fallot: anatomic variants and their impact on surgical management. Semin Cardiothorac Vasc Anesth 2012;16:88-96.
60. Sheth T, Butler C, Chow B, Chan MT, Mitha A, Nagele P, Tandon V, Stewart L, Graham M, Choi GY, Kisten T, Woodard PK, Crean A, Abdul Aziz YF, Karthikeyan G, Chow CK, Szczeklik W, Markobrada M, Mastracci T, Devereaux PJ. The coronary CT angiography vision protocol: a prospective observational imaging cohort study in patients undergoing non-cardiac surgery. BMJ Open 2012;2.
61. Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S. Characteristics of concatemeric GABA(A) receptors containing alpha4/delta subunits expressed in Xenopus oocytes. Br J Pharmacol 2012;165:2228-43.
62. Southard R, Ghosh S, Hilliard J, Davis C, Mazuski C, Walton A, Hotchkiss R. Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model. Shock 2012;37:629-33.
63. Stemler KM, Crock LW, Lai HH, Mills JC, Gereau RWt, Mysorekar IU. Protamine sulfate induced bladder injury protects from distention induced bladder pain. J Urol 2013;189:343-51.
64. Sunder RA, Haile DT, Farrell PT, Sharma A. Pediatric airway management: current practices and future directions. Paediatr Anaesth 2012;22:1008-15.
65. Sunshine J, Deem S, Weiss N, Yanez ND, Daniel S, Keech K, Brown M, Treggiari M. Etomidate, Adrenal Function and Mortality in Critically Ill Patients. Respir Care 2012.
66. Tang S, Mullins ME, Braun BM, Hock KG, Scott MG, Guarino AH, Brasington RD. Can tapentadol cause a false-positive urine drug screen result for amphetamine? Clin Toxicol (Phila) 2012;50:1174-5.
67. Tao J, Liu P, Xiao Z, Zhao H, Gerber BR, Cao YQ. Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons. J Neurophysiol 2012;107:1666-80.
68. Tian L, Morrissey JJ, Kattumenu R, Gandra N, Kharasch ED, Singamaneni S. Bioplasmonic paper as a platform for detection of kidney cancer biomarkers. Anal Chem 2012;84:9928-34.
69. Unsinger J, Burnham CA, McDonough J, Morre M, Prakash PS, Caldwell CC, Dunne WM, Jr., Hotchkiss RS. Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. J Infect Dis 2012;206:606-16.
70. Vannucci A. Sugammadex can be part of the solution. Let’s not make it part of the problem! Minerva Anestesiol 2012.
71. Vannucci A, Burykin A, Krejci V, Peck T, Buchman TG, Kangrga IM. Postreperfusion cardiac arrest and resuscitation during orthotopic liver transplantation: dynamic visualization and analysis of physiologic recordings. Shock 2012;37:34-8.
72. Vannucci A, Jeffcoat A, Ifune C, Salinas C, Duncan JR, Wall M. Retained Guidewires After Intraoperative Placement of Central Venous Catheters. Anesth Analg 2012.
73. Varaday SS, Leighton BL. A first step in determining appropriate amounts of obstetric anesthesia work. Isr J Health Policy Res 2012;1:49.
74. Velissaris D, Karanikolas M, Flaris N, Fligou F, Marangos M, Filos KS. Commonly used severity scores are not good predictors of mortality in sepsis from severe leptospirosis: a series of ten patients. Crit Care Res Pract 2012;2012:532376.
75. Weng Y, Batista-Schepman PA, Barabas ME, Harris EQ, Dinsmore TB, Kossyreva EA, Foshage AM, Wang MH, Schwab MJ, Wang VM, Stucky CL, Story GM. Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. Mol Pain 2012;8:75.
76. Werner J, Hartwig W, Hackert T, Kaiser H, Schmidt J, Gebhard MM, Buchler MW, Klar E. Multidrug strategies are effective in the treatment of severe experimental pancreatitis. Surgery 2012;151:372-81.
77. Zhang NR, Planer W, Siuda ER, Zhao HC, Stickler L, Chang SD, Baird MA, Cao YQ, Bruchas MR. Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling. J Biol Chem 2012;287:42019-30.
78. Zhou Y, Zeng XH, Lingle CJ. Barium ions selectively activate BK channels via the Ca2+-bowl site. Proc Natl Acad Sci U S A 2012;109:11413-8.
79. Zhurav L, Wildes TS. Pro: topical hypothermia should be used during deep hypothermic circulatory arrest. J Cardiothorac Vasc Anesth 2012;26:333-6.

Department Publications 2011

1. Akk G, Li P, Bracamontes J, Wang M, Steinbach JH. Pharmacology of structural changes at the GABA(A) receptor transmitter binding site. Br J Pharmacol 2011;162:840-50.
2. Akk G, Steinbach JH. Structural studies of the actions of anesthetic drugs on the gamma-aminobutyric acid type A receptor. Anesthesiology 2011;115:1338-48.
3. Al-Hasani R, Bruchas MR. Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology 2011;115:1363-81.
4. Asaad BO, Helwani M, Wheeler DM, O’Connor MS. Use of non-partitioned ventilator tubing results in dead-space ventilation hypercarbia. Respir Care 2011;56:698-701.
5. AuBuchon J, Krucylak C, Murray DJ. Subglottic airway foreign body: a near miss. Anesthesiology 2011;115:1300.
6. Avidan MS, Evers AS. Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia. J Alzheimers Dis 2011;24:201-16.
7. Avidan MS, Jacobsohn E, Glick D, Burnside BA, Zhang L, Villafranca A, Karl L, Kamal S, Torres B, O’Connor M, Evers AS, Gradwohl S, Lin N, Palanca BJ, Mashour GA. Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med 2011;365:591-600.
8. Avidan MS, Kheterpal S. Perioperative mortality in developed and developing countries. Lancet 2012;380:1038-9.
9. Avidan MS, Mashour GA. Prevention of Intraoperative Awareness with Explicit Recall: Making Sense of the Evidence. Anesthesiology 2013;118:449-56.
10. Avidan MS, Smith JR, Skrupky LP, Hill L, Jacobsohn E, Burnside B, Tymkew H, Eby C, Damiano R, Despotis GJ. The occurrence of antibodies to heparin-platelet factor 4 in cardiac and thoracic surgical patients receiving desirudin or heparin for postoperative venous thrombosis prophylaxis. Thromb Res 2011;128:524-9.
11. Baikoussis NG, Apostolakis EE, Katsanos K, Koletsis EN, Karanikolas M, Dougenis D. Huge expanding extrapleural haematoma in a coronary artery disease patient: conservative or surgical treatment? Eur Rev Med Pharmacol Sci 2011;15:978-9.
12. Baysinger CL, Pope JE, Lockhart EM, Mercaldo ND. The management of accidental dural puncture and postdural puncture headache: a North American survey. J Clin Anesth 2011;23:349-60.
13. Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michan S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A 2011;108:E952-61.
14. Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE. The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenet Genomics 2011;21:403-16.
15. Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD, 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011;306:2594-605.
16. Bottros MM, Palanca BJ, Mashour GA, Patel A, Butler C, Taylor A, Lin N, Avidan MS. Estimation of the bispectral index by anesthesiologists: an inverse turing test. Anesthesiology 2011;114:1093-101.
17. Bracamontes J, McCollum M, Esch C, Li P, Ann J, Steinbach JH, Akk G. Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site. Mol Pharmacol 2011;80:79-86.
18. Bracamontes JR, Li P, Akk G, Steinbach JH. A neurosteroid potentiation site can be moved among GABAA receptor subunits. J Physiol 2012;590:5739-47.
19. Brown SM, Holtzman M, Kim T, Kharasch ED. Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. Anesthesiology 2011;115:1251-60.
20. Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C. Selective p38alpha MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron 2011;71:498-511.
21. Burykin A, Peck T, Krejci V, Vannucci A, Kangrga I, Buchman TG. Toward optimal display of physiologic status in critical care: I. Recreating bedside displays from archived physiologic data. J Crit Care 2011;26:105 e1-9.
22. Caldwell CC, Hotchkiss RS. The first step in utilizing immune-modulating therapies: immune status determination. Crit Care 2011;15:108.
23. Chen DL, Zhou D, Chu W, Herrbrich P, Engle JT, Griffin E, Jones LA, Rothfuss JM, Geraci M, Hotchkiss RS, Mach RH. Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nucl Med Biol 2012;39:137-44.
24. Cho JH, Saini DK, Karunarathne WK, Kalyanaraman V, Gautam N. Alteration of Golgi structure in senescent cells and its regulation by a G protein gamma subunit. Cell Signal 2011;23:785-93.
25. Christo PJ, Manchikanti L, Ruan X, Bottros M, Hansen H, Solanki DR, Jordan AE, Colson J. Urine drug testing in chronic pain. Pain Physician 2011;14:123-43.
26. Culverhouse RC, Saccone NL, Stitzel JA, Wang JC, Steinbach JH, Goate AM, Schwantes-An TH, Grucza RA, Stevens VL, Bierut LJ. Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Hum Genet 2011;129:177-88.
27. Dallas J, Brown SM, Hock K, Scott MG, Skrupky LP, Boyle WA, 3rd, Kollef MH. Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the intensive care unit setting. Respir Care 2011;56:412-9.
28. Dallas J, Skrupky L, Abebe N, Boyle WA, 3rd, Kollef MH. Ventilator-associated tracheobronchitis in a mixed surgical and medical ICU population. Chest 2011;139:513-8.
29. Evers AS, Owens WD. Memories and dreams: building an academic department at Washington University in St. Louis. Anesthesiology 2011;115:1147-8.
30. Evers AS, Van Aken H. Congratulations from the IARS! Anesthesiology 2011;115:679-80.
31. Fan J, Brown SM, Tu Z, Kharasch ED. Chemical and enzyme-assisted syntheses of norbuprenorphine-3-beta-D-glucuronide. Bioconjug Chem 2011;22:752-8.
32. Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, Tu Z. Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot 2011;69:431-5.
33. Fehr JJ, Boulet JR, Waldrop WB, Snider R, Brockel M, Murray DJ. Simulation-based assessment of pediatric anesthesia skills. Anesthesiology 2011;115:1308-15.
34. Fingerman M. Regional anesthesia for outpatient hand surgery: ultrasound-guided peripheral nerve block. J Hand Surg Am 2011;36:532-4; quiz 4.
35. Fuller BM, Gajera M, Schorr C, Gerber D, Dellinger RP, Zanotti S. The association of prior statin use in septic shock treated with early goal directed therapy. Eur J Emerg Med 2011.
36. Garg R, Sunder RA. Valproate-induced hyperammonemia and seizures: perioperative concerns. Paediatr Anaesth 2011;21:1084-5.
37. Gazit AZ, Fehr J. Perioperative management of the pediatric cardiac transplantation patient. Curr Treat Options Cardiovasc Med 2011;13:425-43.
38. Graetz TJ, Tellor BR, Smith JR, Avidan MS. Desirudin: a review of the pharmacology and clinical application for the prevention of deep vein thrombosis. Expert Rev Cardiovasc Ther 2011;9:1101-9.
39. Hinrichs AL, Murphy SE, Wang JC, Saccone S, Saccone N, Steinbach JH, Goate A, Stevens VL, Bierut LJ. Common polymorphisms in FMO1 are associated with nicotine dependence. Pharmacogenet Genomics 2011;21:397-402.
40. Hu HJ, Gereau RWt. Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K channels primarily in excitatory neurons of the spinal dorsal horn. J Neurophysiol 2011;105:3010-21.
41. Inoue S, Bo L, Bian J, Unsinger J, Chang K, Hotchkiss RS. Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock 2011;36:38-44.
42. Jeffry J, Kim S, Chen ZF. Itch signaling in the nervous system. Physiology (Bethesda) 2011;26:286-92.
43. Jin X, Steinbach JH. A portable site: a binding element for 17beta-estradiol can be placed on any subunit of a nicotinic alpha4beta2 receptor. J Neurosci 2011;31:5045-54.
44. Karanikolas M, Aretha D, Tsolakis I, Monantera G, Kiekkas P, Papadoulas S, Swarm RA, Filos KS. Optimized perioperative analgesia reduces chronic phantom limb pain intensity, prevalence, and frequency: a prospective, randomized, clinical trial. Anesthesiology 2011;114:1144-54.
45. Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ, Hill SA, Thomas S, Mrkobrada M, Alonso-Coello P, Berwanger O, Biccard BM, Cembrowski G, Chan MT, Chow CK, de Miguel A, Garcia M, Graham MM, Jacka MJ, Kueh JH, Li SC, Lit LC, Martinez-Bru C, Naidoo P, Nagele P, Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier D, Devereaux PJ. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study. Clin Biochem 2011;44:1021-4.
46. Kertai MD, Pal N, Palanca BJ, Lin N, Searleman SA, Zhang L, Burnside BA, Finkel KJ, Avidan MS. Association of perioperative risk factors and cumulative duration of low bispectral index with intermediate-term mortality after cardiac surgery in the B-Unaware Trial. Anesthesiology 2010;112:1116-27.
47. Kertai MD, Palanca BJ, Pal N, Burnside BA, Zhang L, Sadiq F, Finkel KJ, Avidan MS. Bispectral index monitoring, duration of bispectral index below 45, patient risk factors, and intermediate-term mortality after noncardiac surgery in the B-Unaware Trial. Anesthesiology 2011;114:545-56.
48. Kharasch ED. Intraoperative methadone: rediscovery, reappraisal, and reinvigoration? Anesth Analg 2011;112:13-6.
49. Kharasch ED, Francis A, London A, Frey K, Kim T, Blood J. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. Clin Pharmacol Ther 2011;90:100-8.
50. Kharasch ED, Vangveravong S, Buck N, London A, Kim T, Blood J, Mach RH. Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. Clin Pharmacol Ther 2011;89:562-70.
51. Kiekkas P, Karga M, Lemonidou C, Aretha D, Karanikolas M. Medication errors in critically ill adults: a review of direct observation evidence. Am J Crit Care 2011;20:36-44.
52. Kim T, London A, Kharasch ED. Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry. J Pharm Biomed Anal 2011;55:487-93.
53. Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug Metab Dispos 2011;39:1070-8.
54. Koniari I, Mavrilas D, Papadaki H, Karanikolas M, Mandellou M, Papalois A, Koletsis E, Dougenis D, Apostolakis E. Structural and biomechanical alterations in rabbit thoracic aortas are associated with the progression of atherosclerosis. Lipids Health Dis 2011;10:125.
55. Lai HH, Qiu CS, Crock LW, Morales ME, Ness TJ, Gereau RWt. Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder. Pain 2011;152:2117-24.
56. Lakshminarasimhachar A, Wildes TS, Pal N, Graetz TJ. Lung transplantation on extracorporeal membrane oxygenation with iatrogenic aortic dissection. J Cardiothorac Vasc Anesth 2011;25:1121-4.
57. Leighton BL, Wall MH, Lockhart EM, Phillips LE, Zatta AJ. Use of recombinant factor VIIa in patients with amniotic fluid embolism: a systematic review of case reports. Anesthesiology 2011;115:1201-8.
58. Leuthardt EC, Lim CC, Shah MN, Evans JA, Rich KM, Dacey RG, Tempelhoff R, Chicoine MR. Use of movable high-field-strength intraoperative magnetic resonance imaging with awake craniotomies for resection of gliomas: preliminary experience. Neurosurgery 2011;69:194-205; discussion -6.
59. Li P, Ann J, Akk G. Activation and modulation of human alpha4beta2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid. J Neurosci Res 2011;89:1295-301.
60. Li P, McCollum M, Bracamontes J, Steinbach JH, Akk G. Functional characterization of the alpha5(Asn398) variant associated with risk for nicotine dependence in the alpha3beta4alpha5 nicotinic receptor. Mol Pharmacol 2011;80:818-27.
61. Liu XY, Liu ZC, Sun YG, Ross M, Kim S, Tsai FF, Li QF, Jeffry J, Kim JY, Loh HH, Chen ZF. Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids. Cell 2011;147:447-58.
62. Liu Y, Jiang Y, Si Y, Kim JY, Chen ZF, Rao Y. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature 2011;472:95-9.
63. Mashour GA, Avidan MS. Pharmacologic approaches to the prevention of intraoperative awareness. Expert Rev Neurother 2011;11:611-3.
64. Mashour GA, Orser BA, Avidan MS. Intraoperative awareness: from neurobiology to clinical practice. Anesthesiology 2011;114:1218-33.
65. McBride ME, Waldrop WB, Fehr JJ, Boulet JR, Murray DJ. Simulation in pediatrics: the reliability and validity of a multiscenario assessment. Pediatrics 2011;128:335-43.
66. McGreevy K, Bottros MM, Raja SN. Preventing Chronic Pain following Acute Pain: Risk Factors, Preventive Strategies, and their Efficacy. Eur J Pain Suppl 2011;5:365-72.
67. Mohr NM, Fuller BM, Skrupky LP, Moy H, Alunday R, Micek ST, Fagley RE. Clinical and demographic factors associated with antipyretic use in gram-negative severe sepsis and septic shock. Ann Pharmacother 2011;45:1207-16.
68. Mohr NM, Hotchkiss RS, Micek ST, Durrani S, Fuller BM. Change in temperature profile may precede fever and be an early indicator of sepsis: a case report. Shock 2011;36:318-20; discussion 20-1.
69. Montana MC, Conrardy BA, Cavallone LF, Kolber BJ, Rao LK, Greco SC, Gereau RWt. Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice. Anesthesiology 2011;115:1239-50.
70. Morrissey JJ, London AN, Lambert MC, Kharasch ED. Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma. Am J Nephrol 2011;34:391-8.
71. Murray DJ. Current trends in simulation training in anesthesia: a review. Minerva Anestesiol 2011;77:528-33.
72. Nagele P. Augmented CPR: rescue after the ResQ trial. Lancet 2011;377:276-8.
73. Nagele P. Perioperative genomics. Best Pract Res Clin Anaesthesiol 2011;25:549-55.
74. Nagele P, Liggett SB. Genetic variation, beta-blockers, and perioperative myocardial infarction. Anesthesiology 2011;115:1316-27.
75. Nagele P, Meissner K, Francis A, Fodinger M, Saccone NL. Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. Pharmacogenet Genomics 2011;21:426-31.
76. Nagele P, Rao LK, Penta M, Kallogjeri D, Spitznagel EL, Cavallone LF, Nussenbaum B, Piccirillo JF. Postoperative myocardial injury after major head and neck cancer surgery. Head Neck 2011;33:1085-91.
77. Nagele P, Tallchief D, Blood J, Sharma A, Kharasch ED. Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesth Analg 2011;113:843-8.
78. Nissman KW, Nissman DB, Leighton BL, Varaday SS, Lockhart EM. Necrotizing fasciitis after cesarean delivery. Anesthesiology 2011;115:1301.
79. Noppers I, Olofsen E, Niesters M, Aarts L, Mooren R, Dahan A, Kharasch E, Sarton E. Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration. Anesthesiology 2011;114:1435-45.
80. Papadopoulos G, Karanikolas M, Liarmakopoulou A, Berris A. Baseline cerebral oximetry values in elderly patients with hip fractures: a prospective observational study. Injury 2011;42:1328-32.
81. Qiu CS, Lash-Van Wyhe L, Sasaki M, Sakai R, Swanson GT, Gereau RWt. Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor. Pain 2011;152:1052-60.
82. Saifee O, Metz LB, Nonet ML, Crowder CM. A gain-of-function mutation in adenylate cyclase confers isoflurane resistance in Caenorhabditis elegans. Anesthesiology 2011;115:1162-71.
83. Schwedt TJ, Gereau RW, Frey K, Kharasch ED. Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis. Cephalalgia 2011;31:1082-9.
84. Schwedt TJ, Krauss MJ, Frey K, Gereau RWt. Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks. Cephalalgia 2011;31:6-12.
85. Selig HF, Trimmel H, Voelckel WG, Hupfl M, Trittenwein G, Nagele P. Prehospital pediatric emergencies in Austrian helicopter emergency medical service – a nationwide, population-based cohort study. Wien Klin Wochenschr 2011;123:552-8.
86. Sharkey AM, Sharma A. Tetralogy of Fallot: Anatomic Variants and Their Impact on Surgical Management. Semin Cardiothorac Vasc Anesth 2012.
87. Sharma A, Tallchief D, Blood J, Kim T, London A, Kharasch ED. Perioperative pharmacokinetics of methadone in adolescents. Anesthesiology 2011;115:1153-61.
88. Skrupky LP, Kerby PW, Hotchkiss RS. Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology 2011;115:1349-62.
89. Spitzer D, Simon PO, Jr., Kashiwagi H, Xu J, Zeng C, Vangveravong S, Zhou D, Chang K, McDunn JE, Hornick JR, Goedegebuure P, Hotchkiss RS, Mach RH, Hawkins WG. Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer Res 2012;72:201-9.
90. Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of delta(16)-alphaxalone and identification of a delta(17(20)) analogue with potent anesthetic activity. J Med Chem 2011;54:3926-34.
91. Steinbach JH. Flapping loops: roles for hinges in a ligand-binding domain of the nicotinic receptor. Mol Pharmacol 2011;79:337-9.
92. Steinbach JH, Akk G. Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation. Anesthesiology 2011;115:1328-37.
93. Tivener D, Vannucci A, Fagley RE, Doyle M, Shenoy S, Chapman W, Kangrga I. Atrial laceration caused by removal of a transjugular intrahepatic portosystemic shunt necessitates emergent cardiopulmonary bypass during liver transplant: a case report. Transplant Proc 2011;43:2810-3.
94. Toma O, Suntrup P, Stefanescu A, London A, Mutch M, Kharasch E. Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection. Anesth Analg 2011;113:730-7.
95. Vannucci A, Burykin A, Krejci V, Peck T, Buchman TG, Kangrga IM. Postreperfusion cardiac arrest and resuscitation during orthotopic liver transplantation: dynamic visualization and analysis of physiologic recordings. Shock 2012;37:34-8.
96. Vannucci A, Johnston J, Earl TM, Doyle M, Kangrga IM. Intraoperative transesophageal echocardiography guides liver transplant surgery in a patient with thrombosed transjugular intrahepatic portosystemic shunt. Anesthesiology 2011;115:1389-91.
97. Vannucci A, Tran LC, Kangrga IM. Inflammatory myofibroblastic tumor within intrahepatic inferior vena cava. Anesthesiology 2011;115:1299.
98. Viader A, Golden JP, Baloh RH, Schmidt RE, Hunter DA, Milbrandt J. Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 2011;31:10128-40.
99. Vretzakis G, Kleitsaki A, Aretha D, Karanikolas M. Management of intraoperative fluid balance and blood conservation techniques in adult cardiac surgery. Heart Surg Forum 2011;14:E28-39.
100. Werner J, Hartwig W, Hackert T, Kaiser H, Schmidt J, Gebhard MM, Buchler MW, Klar E. Multidrug strategies are effective in the treatment of severe experimental pancreatitis. Surgery 2011.
101. Whitlock EL, Vannucci A, Avidan MS. Postoperative delirium. Minerva Anestesiol 2011;77:448-56.
102. Whitlock EL, Villafranca AJ, Lin N, Palanca BJ, Jacobsohn E, Finkel KJ, Zhang L, Burnside BA, Kaiser HA, Evers AS, Avidan MS. Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial. Anesthesiology 2011;115:1209-18.
103. Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, Johnston F, Spitzer D, Chang KC, Hotchkiss RS, Hawkins WG, Wheeler KT, Mach RH. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun 2011;2:380.
104. Yang C, Zeng XH, Zhou Y, Xia XM, Lingle CJ. LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Proc Natl Acad Sci U S A 2011;108:19419-24.
105. Yi X, AuBuchon J, Zeltwanger S, Kirby JP. Necrotic arachnidism and intractable pain from recluse spider bites treated with lumbar sympathetic block: a case report and review of literature. Clin J Pain 2011;27:457-60.
106. Zammataro M, Chiechio S, Montana MC, Traficante A, Copani A, Nicoletti F, Gereau RWt. mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists. Mol Pain 2011;7:6.
107. Zeng C, Vangveravong S, Jones LA, Hyrc K, Chang KC, Xu J, Rothfuss JM, Goldberg MP, Hotchkiss RS, Mach RH. Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Mol Imaging 2011;10:420-33.
108. Zeng XH, Yang C, Kim ST, Lingle CJ, Xia XM. Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proc Natl Acad Sci U S A 2011;108:5879-84.
109. Zhao C, Leitges M, Gereau RWt. Isozyme-specific effects of protein kinase C in pain modulation. Anesthesiology 2011;115:1261-70.
110. Zhou Y, Xia XM, Lingle CJ. Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region. Proc Natl Acad Sci U S A 2011;108:12161-6.

Department Publications 2010

1. Ahmed I, Rawat JD, Singh S, Sharma A, Pandey A, Goel M. Neurothekeoma: a rare sacrococcygeal tumor in a child. J Pediatr Surg 2010;45:1037-9.
2. Akk G. EDITORIAL: Molecular Pharmacology of the GABA(A) Receptor. Curr Neuropharmacol 2010;8:1.
3. Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH. Kinetic and Structural Determinants for GABA-A Receptor Potentiation by Neuroactive Steroids. Curr Neuropharmacol 2010;8:18-25.
4. Akk G, Li P, Bracamontes J, Wang M, Steinbach JH. Pharmacology of structural changes at the GABA(A) receptor transmitter binding site. Br J Pharmacol 2011;162:840-50.
5. Aleksic P, Bancevic V, Milovic N, Kosevic B, Stamenkovic DM, Karanikolas M, Campara ZM, Jovanovic M. Short ileal segment for orthotopic neobladder: a feasibility study. Int J Urol 2010;17:768-73.
6. Alter BJ, Zhao C, Karim F, Landreth GE, Gereau RWt. Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. J Neurosci 2010;30:11537-47.
7. Apostolakis EE, Baikoussis NG, Kalogeropoulou C, Koletsis E, Koniari I, Karnabatidis D, Karanikolas M. Remnant of a non-patent ductus arteriosus mimicking traumatic thoracic aorta transection: a case report. J Cardiothorac Surg 2010;5:24.
8. Apostolakis EE, Baikoussis NG, Katsanos K, Karanikolas M. Postoperative peri-axillary seroma following axillary artery cannulation for surgical treatment of acute type A aortic dissection. J Cardiothorac Surg 2010;5:43.
9. Avidan MS, Xiong C, Evers AS. Postoperative cognitive decline: the unsubstantiated phenotype. Anesthesiology 2010;113:1246-8; author reply 8-50.
10. Baikoussis NG, Karanikolas M, Siminelakis S, Matsagas M, Papadopoulos G. Baseline cerebral oximetry values in cardiac and vascular surgery patients: a prospective observational study. J Cardiothorac Surg 2010;5:41.
11. Bandyopadhyaya AK, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Delta16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorg Med Chem Lett 2010;20:6680-4.
12. Batista PA, Werner MF, Oliveira EC, Burgos L, Pereira P, Brum LF, Story GM, Santos AR. The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice. J Pain 2010;11:1222-9.
13. Boulet JR, Murray DJ. Simulation-based assessment in anesthesiology: requirements for practical implementation. Anesthesiology 2010;112:1041-52.
14. Bradfute SB, Swanson PE, Smith MA, Watanabe E, McDunn JE, Hotchkiss RS, Bavari S. Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis. J Immunol 2010;184:327-35.
15. Brahmamdam P, Inoue S, Unsinger J, Chang KC, McDunn JE, Hotchkiss RS. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol 2010;88:233-40.
16. Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Zhang X, Dissen GA, Creeley CE, Olney JW. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 2010;112:834-41.
17. Breshears JD, Roland JL, Sharma M, Gaona CM, Freudenburg ZV, Tempelhoff R, Avidan MS, Leuthardt EC. Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia. Proc Natl Acad Sci U S A 2010;107:21170-5.
18. Burykin A, Peck T, Krejci V, Vannucci A, Kangrga I, Buchman TG. Toward optimal display of physiologic status in critical care: I. Recreating bedside displays from archived physiologic data. J Crit Care 2010.
19. Cao YQ, Tsien RW. Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses. J Neurosci 2010;30:4536-46.
20. Cattano D, Cavallone L. Airway Management and Patient Positioning: A Clinical Perspective. . Anesthesiology News 2010:35-40.
21. Cattano D, Altamirano A, Vannucci A, Melnikov V, Cone C, Hagberg CA. Preoperative use of incentive spirometry does not affect postoperative lung function in bariatric surgery. Transl Res 2010;156:265-72.
22. Chen B, Ge Q, Xia XM, Liu P, Wang SJ, Zhan H, Eipper BA, Wang ZW. A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. J Neurosci 2010;30:16651-61.
23. Chiechio S, Copani A, Zammataro M, Battaglia G, Gereau RWt, Nicoletti F. Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain. Trends Pharmacol Sci 2010;31:153-60.
24. Chisari M, Shu HJ, Taylor A, Steinbach JH, Zorumski CF, Mennerick S. Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions. Br J Pharmacol 2010;160:130-41.
25. Cooper JB, Murray D. Simulation training and assessment: a more efficient method to develop expertise than apprenticeship. Anesthesiology 2010;112:8-9.
26. Cox TE, Evers AS, Murray DJ. Leadership in postgraduate medical education. Anesthesiology 2010;113:754; author reply -5.
27. Culverhouse RC, Saccone NL, Stitzel JA, Wang JC, Steinbach JH, Goate AM, Schwantes-An TH, Grucza RA, Stevens VL, Bierut LJ. Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Hum Genet 2011;129:177-88.
28. Dabrowska DM, Gore C, Griffiths S, Mudzingwa M, Varaday S. Anaesthetic management of a pregnant patient with multiple myeloma. Int J Obstet Anesth 2010;19:336-9.
29. Dallas J, Skrupky L, Abebe N, Boyle WA, 3rd, Kollef MH. VENTILATOR-ASSOCIATED TRACHEOBRONCHITIS (VAT) IN A MIXED SURGICAL AND MEDICAL ICU POPULATION. Chest 2010.
30. Despotis GJ, Avidan MS. Plasma exchange for heparin-induced thrombocytopenia: is there enough evidence? Anesth Analg 2010;110:7-10.
31. Dilger JP, Steinbach JH. Inhibition of muscle acetylcholine receptors by nondepolarizing drugs: humans are not unique. Anesthesiology 2010;112:247-9; author reply 9-50.
32. Donados C, M. Karanikolas, P. Kaspis, A. Saridis, C. Matzaroglou. Monıtorıng Anaesthesıa Control Durıng Kyphoplastıes. The Internet Journal of Minimally Invasive Spinal Technology 2010;3.
33. Dooley J, Fingerman M, Melton S, Klein SM. Contralateral local anesthetic spread from an outpatient interscalene catheter. Can J Anaesth 2010;57:936-9.
34. Duncan JR, Katherine Henderson, Mandie Street, Amy Richmond, Mary Klingensmith, Elio Beta, Andrea Vannucci, David Murray. Creating and evaluating a data-driven curriculum for central venous catheter placement. Journal of Graduate Medical Education 2010;2:389-97.
35. Evers AS, Chen ZW, Manion BD, Han M, Jiang X, Darbandi-Tonkabon R, Kable T, Bracamontes J, Zorumski CF, Mennerick S, Steinbach JH, Covey DF. A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. J Pharmacol Exp Ther 2010;333:404-13.
36. Ezaru CS, Murray AW, Oravitz TM, Ibinson JW, Mangine MP. When ultrasound is not enough. J Ultrasound Med 2010;29:505; discussion 6-8.
37. Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, Tu Z. Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot 2011;69:431-5.
38. Fehr J, Brockel M. Mucopolysaccharidoses. Essence of Anesthesia Practice 2010;3.
39. Fox AC, Robertson CM, Belt B, Clark AT, Chang KC, Leathersich AM, Dominguez JA, Perrone EE, Dunne WM, Hotchkiss RS, Buchman TG, Linehan DC, Coopersmith CM. Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med 2010;38:886-93.
40. Fuller B, Rivers, E. Should early goal directed therapy be the standard for sepsis? -pro: research supports it. Emergency Physicians Monthly 2010.
41. Garvin S, FitzGerald DC, Despotis G, Shekar P, Body SC. Heparin concentration-based anticoagulation for cardiac surgery fails to reliably predict heparin bolus dose requirements. Anesth Analg 2010;111:849-55.
42. Gazit AZ, Huddleston CB, Checchia PA, Fehr J, Pezzella AT. Care of the pediatric cardiac surgery patient–part 1. Curr Probl Surg 2010;47:185-250.
43. Gazit AZ, Huddleston CB, Checchia PA, Fehr J, Pezzella AT. Care of the pediatric cardiac surgery patient–part 2. Curr Probl Surg 2010;47:261-376.
44. Goepfert CE, Ifune C, Tempelhoff R. Ischemic optic neuropathy: are we any further? Curr Opin Anaesthesiol 2010;23:582-7.
45. Golden JP, Hoshi M, Nassar MA, Enomoto H, Wood JN, Milbrandt J, Gereau RWt, Johnson EM, Jr., Jain S. RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci 2010;30:3983-94.
46. Gupta A, Chandra N, Sharma A, Husain N, Kureel SN. Renal leiomyoma in a child: a rare renal tumor. J Pediatr Surg 2010;45:1900-3.
47. Holzki JF, Laschat M, Puder C. The pediatric larynx: a complicated organ. Anesth Analg 2010;110:1509-10; author reply 11.
48. Hupfl M, Selig HF, Nagele P. Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis. Lancet 2010;376:1552-7.
49. Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF, Clark AT, Coopersmith CM, McDunn JE, Hotchkiss RS. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol 2010;184:1401-9.
50. Jacobs B, Duncan JR, Street M, Murray D. Audio and video recording system for routine documentation of fluoroscopic procedures. J Vasc Interv Radiol 2010;21:725-9.
51. Joy MS, Frye RF, Stubbert K, Brouwer KR, Falk RJ, Kharasch ED. Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases. J Clin Pharmacol 2010;50:714-20.
52. Karanikolas M, Aretha D, Kiekkas P, Monantera G, Tsolakis I, Filos KS. Case report. Intravenous fentanyl patient-controlled analgesia for perioperative treatment of neuropathic/ischaemic pain in haemodialysis patients: a case series. J Clin Pharm Ther 2010;35:603-8.
53. Karanikolas M, Velissaris D, Marangos M, Karamouzos V, Fligou F, Filos KS. Prolonged high-dose intravenous magnesium therapy for severe tetanus in the intensive care unit: a case series. J Med Case Reports 2010;4:100.
54. Kasten KR, Prakash PS, Unsinger J, Goetzman HS, England LG, Cave CM, Seitz AP, Mazuski CN, Zhou TT, Morre M, Hotchkiss RS, Hildeman DA, Caldwell CC. Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun 2010;78:4714-22.
55. Kertai MD, Pal N, Palanca BJ, Lin N, Searleman SA, Zhang L, Burnside BA, Finkel KJ, Avidan MS. Association of perioperative risk factors and cumulative duration of low bispectral index with intermediate-term mortality after cardiac surgery in the B-Unaware Trial. Anesthesiology 2010;112:1116-27.
56. Khanna P, Garg R, Sunder RA. Rosai-Dorfman disease–perianaesthetic concerns. Acta Anaesthesiol Belg 2010;61:1-3.
57. Kiekkas P, Karga M, Lemonidou C, Aretha D, Karanikolas M. Medication errors in critically ill adults: a review of direct observation evidence. Am J Crit Care 2011;20:36-44.
58. Kiekkas P, Velissaris D, Karanikolas M, Aretha D, Samios A, Skartsani C, Baltopoulos GI, Filos KS. Peak body temperature predicts mortality in critically ill patients without cerebral damage. Heart Lung 2010;39:208-16.
59. Kolber BJ, Montana MC, Carrasquillo Y, Xu J, Heinemann SF, Muglia LJ, Gereau RWt. Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci 2010;30:8203-13.
60. Krejci V, Vannucci A, Abbas A, Chapman W, Kangrga IM. Comparison of calibrated and uncalibrated arterial pressure-based cardiac output monitors during orthotopic liver transplantation. Liver Transpl 2010;16:773-82.
61. Kuhn CM. The innovative anesthesiology curriculum: a challenge and hope for the future. Anesthesiology 2010;112:267-8.
62. Lagerstrom MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallen-Mackenzie A, Kullander K. VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron 2010;68:529-42.
63. Lawrence KL, White PH, Morris GP, Jennemann J, Phelan DL, Hotchkiss RS, Kollef MH. CD4+ lymphocyte adenosine triphosphate determination in sepsis: a cohort study. Crit Care 2010;14:R110.
64. Lennerz JK, Hurov JB, White LS, Lewandowski KT, Prior JL, Planer GJ, Gereau RWt, Piwnica-Worms D, Schmidt RE, Piwnica-Worms H. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Mol Cell Biol 2010;30:5043-56.
65. Li P, Khatri A, Bracamontes J, Weiss DS, Steinbach JH, Akk G. Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids. Mol Pharmacol 2010;77:539-46.
66. Li P, Steinbach JH. The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open. Br J Pharmacol 2010;160:1906-15.
67. Lobato RL, Despotis GJ, Levy JH, Shore-Lesserson LJ, Carlson MO, Bennett-Guerrero E. Anticoagulation management during cardiopulmonary bypass: a survey of 54 North American institutions. J Thorac Cardiovasc Surg 2010;139:1665-6.
68. Mao XR, Crowder CM. Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Mol Cell Biol 2010;30:5033-42.
69. Matzaroglou C, Bougas P, Panagiotopoulos E, Saridis A, Karanikolas M, Kouzoudis D. Ninety-degree chevron osteotomy for correction of hallux valgus deformity: clinical data and finite element analysis. Open Orthop J 2010;4:152-6.
70. Mazoit JX, Roulleau P, Baujard C. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain: isoflurane or ischemia-reperfusion? Anesthesiology 2010;113:1245; author reply -6.
71. McConnell KW, McDunn JE, Clark AT, Dunne WM, Dixon DJ, Turnbull IR, Dipasco PJ, Osberghaus WF, Sherman B, Martin JR, Walter MJ, Cobb JP, Buchman TG, Hotchkiss RS, Coopersmith CM. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med 2010;38:223-41.
72. Meissner K, Ding M, Göpfert CE, Toma O, Buck N, Blood J, Kharasch ED. Variabilität von Wirkung und Nebenwirkungen von intravenösem Morphin und Hydromorphon zur postoperativen Schmerztherapie – eine Vergleichsstudie an gesunden Probanden (varaiability of effects and side effects of intravenous morphine and hydromorphone for postopertive pain therapy – a comparative study in healthy subjects). . DAC Nürnberg 2010.
73. Melby SJ, Larue SJ, Lasala JM, Pal N, Lakshminarasimhachar A, Trulock EP, Kreisel D, Pasque MK, Puri V, Patterson GA, Krupnick AS. Anatomic distortion of the right coronary artery as a complication of lung transplantation. Ann Thorac Surg 2010;89:2000-1.
74. Mizobuchi M, Nakamura H, Tokumoto M, Finch J, Morrissey J, Liapis H, Slatopolsky E. Myocardial effects of VDR activators in renal failure. J Steroid Biochem Mol Biol 2010;121:188-92.
75. Morrell MR, Despotis GJ, Lublin DM, Patterson GA, Trulock EP, Hachem RR. The efficacy of photopheresis for bronchiolitis obliterans syndrome after lung transplantation. J Heart Lung Transplant 2010;29:424-31.
76. Morrissey JJ, London AN, Luo J, Kharasch ED. Urinary biomarkers for the early diagnosis of kidney cancer. Mayo Clin Proc 2010;85:413-21.
77. Muenzer JT, Davis CG, Chang K, Schmidt RE, Dunne WM, Coopersmith CM, Hotchkiss RS. Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun 2010;78:1582-92.
78. Nagele P, Rao LK, Penta M, Kallogjeri D, Spitznagel EL, Cavallone LF, Nussenbaum B, Piccirillo JF. Postoperative myocardial injury after major head and neck cancer surgery. Head Neck 2010.
79. Nykiel S, Schrock CR, Murray DJ. Images in anesthesiology: transient paraplegia after anesthesia for magnetic resonance imaging. Anesthesiology 2010;113:687.
80. Pal N, Kertai MD, Lakshminarasimhachar A, Avidan MS. Pharmacology and clinical applications of human recombinant antithrombin. Expert Opin Biol Ther 2010;10:1155-68.
81. Papadopoulos G, Baikoussis NG, Tzimas P, Siminelakis SN, Karanikolas M. Intravenous levosimendan-norepinephrine combination during off-pump coronary artery bypass grafting in a hemodialysis patient with severe myocardial dysfunction. J Cardiothorac Surg 2010;5:9.
82. Pehbock D, Wenzel V, Voelckel W, Jonsson K, Herff H, Mittlbock M, Nagele P. Effects of preoxygenation on desaturation time during hemorrhagic shock in pigs. Anesthesiology 2010;113:593-9.
83. Rao LK, Francis AM, Wilcox U, Miller JP, Nagele P. Pre-operative vitamin B infusion and prevention of nitrous oxide-induced homocysteine increase. Anaesthesia 2010;65:710-5.
84. Rastogi R, Patel T, Swarm RA. Vertebral augmentation for compression fractures caused by malignant disease. J Natl Compr Canc Netw 2010;8:1095-102.
85. Saini DK, Gautam N. Live cell imaging for studying g protein-coupled receptor activation in single cells. Methods Mol Biol 2010;617:191-207.
86. Saini DK, Karunarathne WK, Angaswamy N, Saini D, Cho JH, Kalyanaraman V, Gautam N. Regulation of Golgi structure and secretion by receptor-induced G protein betagamma complex translocation. Proc Natl Acad Sci U S A 2010;107:11417-22.
87. Sanders RD, Avidan MS. Evidence is lacking for interventions proposed to prevent unintended awareness during general anesthesia for cesarean delivery. Anesth Analg 2010;110:972-3; author reply 3-4.
88. Scatizzi JC, Hutcheson J, Pope RM, Firestein GS, Koch AE, Mavers M, Smason A, Agrawal H, Haines GK, 3rd, Chandel NS, Hotchkiss RS, Perlman H. Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum 2010;62:441-51.
89. Silbert BS, Evered LA, Scott DA. Cognitive decline after surgery and illness. Anesthesiology 2010;112:1282; author reply 3-5.
90. Southard RE, Boyle WA. Corticosteroids and the original vasopressin and septic shock trial subgroups. Crit Care Med 2010;38:338; authore reply -9.
91. Spinos P, Matzaroglou C, Partheni M, Deli A, Karanikolas M, Konstantinou D. Surgical management of cervical spondyloarthropathy in hemodialysis patients. Open Orthop J 2010;4:39-43.
92. Spitzer D, McDunn JE, Plambeck-Suess S, Goedegebuure PS, Hotchkiss RS, Hawkins WG. A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther 2010;9:2142-51.
93. Stock E, Vannucci A, Doyle M, Patterson GA, Chapman W, Kangrga I. Combined liver-kidney transplantation complicated by intraoperative discovery of a bronchobiliary fistula. Transplant Proc 2010;42:2800-3.
94. Swarm R, Abernethy AP, Anghelescu DL, Benedetti C, Blinderman CD, Boston B, Cleeland C, Coyle N, Deleon-Casasola OA, Eilers JG, Ferrell B, Janjan NA, Karver SB, Levy MH, Lynch M, Moryl N, Murphy BA, Nesbit SA, Oakes L, Obbens EA, Paice JA, Rabow MW, Syrjala KL, Urba S, Weinstein SM. Adult cancer pain. J Natl Compr Canc Netw 2010;8:1046-86.
95. Tang QY, Zhang Z, Xia XM, Lingle CJ. Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin) 2010;4:22-41.
96. Thors L, Burston JJ, Alter BJ, McKinney MK, Cravatt BF, Ross RA, Pertwee RG, Gereau RWt, Wiley JL, Fowler CJ. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. Br J Pharmacol 2010;160:549-60.
97. Unsinger J, Kazama H, McDonough JS, Griffith TS, Hotchkiss RS, Ferguson TA. Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol 2010;184:6766-72.
98. Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol 2010;184:3768-79.
99. Vretzakis G, Kleitsaki A, Stamoulis K, Bareka M, Georgopoulou S, Karanikolas M, Giannoukas A. Intra-operative intravenous fluid restriction reduces perioperative red blood cell transfusion in elective cardiac surgery, especially in transfusion-prone patients: a prospective, randomized controlled trial. J Cardiothorac Surg 2010;5:7.
100. Xiang C, Zhang KH, Yin J, Arends JJ, Erzurumlu RS, Jacquin MF, Chen ZF. The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway. Mol Cell Neurosci 2010;44:394-403.
101. Zhou Y, Tang QY, Xia XM, Lingle CJ. Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. J Gen Physiol 2010;135:481-94.
102. Zhou Y, Xia X, Lingle CJ. Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+. Mol Pharmacol 2010;78:952-60.
103. Ziporin SJ, Ifune CK, MacConmara MP, Geraghty PJ, Choi ET. A case of external iliac arteriovenous fistula and high-output cardiac failure after endovenous laser treatment of great saphenous vein. J Vasc Surg 2010;51:715-9.

Department Publications 2009

1. Adesanya, A. O., E. Rosero, C. Wyrick, M. H. Wall and G. P. Joshi (2009). “Assessing the predictive value of the bispectral index vs patient state index on clinical assessment of sedation in postoperative cardiac surgery patients.” J Crit Care 24(3): 322-8.
2. Akk, G., D. F. Covey, A. S. Evers, J. H. Steinbach, C. F. Zorumski and S. Mennerick (2009). “The influence of the membrane on neurosteroid actions at GABA(A) receptors.” Psychoneuroendocrinology.
3. Akk, G., P. Li, J. Bracamontes and J. H. Steinbach (2009). “Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.” Molecular Pharmacology 75(6): 1400-11.
4. Anderson, L. L., X. Mao, B. A. Scott and C. M. Crowder (2009). “Survival from hypoxia in C. elegans by inactivation of aminoacyl-tRNA synthetases.” Science 323(5914): 630-3.
5. Avidan, M. S., B. J. Palanca, D. Glick, E. Jacobsohn, A. Villafranca, M. O’Connor and G. A. Mashour (2009). “Protocol for the BAG-RECALL clinical trial: a prospective, multi-center, randomized, controlled trial to determine whether a bispectral index-guided protocol is superior to an anesthesia gas-guided protocol in reducing intraoperative awareness with explicit recall in high risk surgical patients.” BMC Anesthesiol 9(1): 8.
6. Avidan, M. S., A. C. Searleman, M. Storandt, K. Barnett, A. Vannucci, L. Saager, C. Xiong, E. A. Grant, D. Kaiser, J. C. Morris and A. S. Evers (2009). “Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness.” Anesthesiology 111(5): 964-70.
7. Bhatt, M., R. M. Kennedy, M. H. Osmond, B. Krauss, J. D. McAllister, J. M. Ansermino, L. M. Evered and M. G. Roback (2009). “Consensus-based recommendations for standardizing terminology and reporting adverse events for emergency department procedural sedation and analgesia in children.” Ann Emerg Med 53(4): 426-435 e4.
8. Bracamontes, J. R. and J. H. Steinbach (2009). “Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.” Molecular Pharmacology 75(4): 973-81.
9. Brahmamdam, P., E. Watanabe, J. Unsinger, K. C. Chang, W. Schierding, A. S. Hoekzema, T. T. Zhou, J. S. McDonough, H. Holemon, J. D. Heidel, C. M. Coopersmith, J. E. McDunn and R. S. Hotchkiss (2009). “Targeted delivery of siRNA to cell death proteins in sepsis.” Shock 32(2): 131-9.
10. Byrnes, M. C., D. J. Schuerer, M. E. Schallom, C. S. Sona, J. E. Mazuski, B. E. Taylor, W. McKenzie, J. M. Thomas, J. S. Emerson, J. L. Nemeth, R. A. Bailey, W. A. Boyle, T. G. Buchman and C. M. Coopersmith (2009). “Implementation of a mandatory checklist of protocols and objectives improves compliance with a wide range of evidence-based intensive care unit practices.” Critical Care Medicine 37(10): 2775-81.
11. Cavallone, L. F. (2009). “Dreaming of patients’ satisfaction.” Minerva Anestesiol 75(6): 355-6.
12. Chen, R., C. A. Furman, M. Zhang, M. N. Kim, R. W. t. Gereau, M. Leitges and M. E. Gnegy (2009). “Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice.” Journal of Pharmacology and Experimental Therapeutics 328(3): 912-20.
13. Chiechio, S., M. Zammataro, M. E. Morales, C. L. Busceti, F. Drago, R. W. t. Gereau, A. Copani and F. Nicoletti (2009). “Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.” Molecular Pharmacology 75(5): 1014-20.
14. Chisari, M., D. K. Saini, J. H. Cho, V. Kalyanaraman and N. Gautam (2009). “G protein subunit dissociation and translocation regulate cellular response to receptor stimulation.” PLoS One 4(11): e7797.
15. Crawford, D. C., K. L. Moulder, R. W. t. Gereau, G. M. Story and S. Mennerick (2009). “Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons.” PLoS One 4(12): e8166.
16. Crowder, C. M. (2009). “Cell biology. Ceramides–friend or foe in hypoxia?” Science 324(5925): 343-4.
17. Dalal, P. G., D. Murray, A. H. Messner, A. Feng, J. McAllister and D. Molter (2009). “Pediatric laryngeal dimensions: an age-based analysis.” Anesthesia and Analgesia 108(5): 1475-9.
18. Despotis, G., M. Avidan and C. Eby (2009). “Prediction and management of bleeding in cardiac surgery.” J Thromb Haemost 7 Suppl 1: 111-7.
19. Ellett, A. E., J. C. Shields, C. Ifune, N. Roa and A. Vannucci (2009). “A near miss: a nitrous oxide-carbon dioxide mix-up despite current safety standards.” Anesthesiology 110(6): 1429-31.
20. Fagley, R. E., A. Woodbury, A. Visuara and M. Wall (2009). “Rocuronium-induced coronary vasospasm–“Kounis syndrome”.” Int J Cardiol 137(2): e29-32.
21. Finkel, K. J., A. C. Searleman, H. Tymkew, C. Y. Tanaka, L. Saager, E. Safer-Zadeh, M. Bottros, J. A. Selvidge, E. Jacobsohn, D. Pulley, S. Duntley, C. Becker and M. S. Avidan (2009). “Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center.” Sleep Med 10(7): 753-8.
22. Goudet, C., V. Magnaghi, M. Landry, F. Nagy, R. W. t. Gereau and J. P. Pin (2009). “Metabotropic receptors for glutamate and GABA in pain.” Brain Res Rev 60(1): 43-56.
23. Hager, H., G. Mandadi, D. Pulley, J. C. Eagon, E. Mascha, B. Nutter and A. Kurz (2009). “A comparison of noninvasive blood pressure measurement on the wrist with invasive arterial blood pressure monitoring in patients undergoing bariatric surgery.” Obes Surg 19(6): 717-24.
24. Hamouda, A. K., X. Jin, M. Sanghvi, S. Srivastava, A. Pandhare, P. K. Duddempudi, J. H. Steinbach and M. P. Blanton (2009). “Photoaffinity labeling the agonist binding domain of alpha4beta4 and alpha4beta2 neuronal nicotinic acetylcholine receptors with [(125)I]epibatidine and 5[(125)I]A-85380.” Biochimica Et Biophysica Acta 1788(9): 1987-95.
25. Henrichs, B. M., M. S. Avidan, D. J. Murray, J. R. Boulet, J. Kras, B. Krause, R. Snider and A. S. Evers (2009). “Performance of certified registered nurse anesthetists and anesthesiologists in a simulation-based skills assessment.” Anesthesia and Analgesia 108(1): 255-62.
26. Hotchkiss, R. S., C. M. Coopersmith, J. E. McDunn and T. A. Ferguson (2009). “The sepsis seesaw: tilting toward immunosuppression.” Nature Medicine 15(5): 496-7.
27. Hotchkiss, R. S., A. Strasser, J. E. McDunn and P. E. Swanson (2009). “Cell death.” New England Journal of Medicine 361(16): 1570-83.
28. Ji, R. R., R. W. t. Gereau, M. Malcangio and G. R. Strichartz (2009). “MAP kinase and pain.” Brain Res Rev 60(1): 135-48.
29. Jin, X., D. F. Covey and J. H. Steinbach (2009). “Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue.” Journal of Physiology 587(Pt 5): 981-97.
30. Jorgensen, H. F., Z. F. Chen, M. Merkenschlager and A. G. Fisher (2009). “Is REST required for ESC pluripotency?” Nature 457(7233): E4-5; discussion E7.
31. Jorgensen, H. F., A. Terry, C. Beretta, C. F. Pereira, M. Leleu, Z. F. Chen, C. Kelly, M. Merkenschlager and A. G. Fisher (2009). “REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.” Development 136(5): 715-21.
32. Kashiwagi, H., J. E. McDunn, P. O. Simon, Jr., P. S. Goedegebuure, S. Vangveravong, K. Chang, R. S. Hotchkiss, R. H. Mach and W. G. Hawkins (2009). “Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma.” J Transl Med 7: 24.
33. Kertai, M. D., T. Tiszai-Szucs, K. S. Varga, C. Hermann, G. Acsady and J. Gal (2009). “Intraoperative use of packed red blood cell transfusion and mortality in patients undergoing abdominal or thoracoabdominal aortic aneurysm surgery.” J Cardiovasc Surg (Torino) 50(4): 501-8.
34. Kharasch, E. D., C. Hoffer, D. Whittington, A. Walker and P. S. Bedynek (2009). “Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir.” Anesthesiology 110(3): 660-72.
35. Kharasch, E. D., G. N. Subbarao, K. R. Cromack, D. A. Stephens and M. D. Saltarelli (2009). “Sevoflurane formulation water content influences degradation by Lewis acids in vaporizers.” Anesthesia and Analgesia 108(6): 1796-802.
36. Kharasch, E. D., A. Walker, D. Whittington, C. Hoffer and P. S. Bedynek (2009). “Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.” Drug Alcohol Depend 101(3): 158-68.
37. Lanier, W. L. and E. D. Kharasch (2009). “Contemporary clinical opioid use: opportunities and challenges.” Mayo Clin Proc 84(7): 572-5.
38. Li, P., A. K. Bandyopadhyaya, D. F. Covey, J. H. Steinbach and G. Akk (2009). “Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.” Br J Pharmacol 158(5): 1322-9.
39. Li, Z. F., Z. D. Wang, Y. Y. Ji, S. Zhang, C. Huang, J. Li and X. M. Xia (2009). “Induction of apoptosis and cell cycle arrest in human HCC MHCC97H cells with Chrysanthemum indicum extract.” World J Gastroenterol 15(36): 4538-46.
40. Li, Z. F., X. M. Xia, C. Huang, S. Zhang, J. Zhang and A. J. Zhang (2009). “Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis.” Hepatobiliary Pancreat Dis Int 8(2): 201-8.
41. Liu, Q., Z. Tang, L. Surdenikova, S. Kim, K. N. Patel, A. Kim, F. Ru, Y. Guan, H. J. Weng, Y. Geng, B. J. Undem, M. Kollarik, Z. F. Chen, D. J. Anderson and X. Dong (2009). “Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.” Cell 139(7): 1353-65.
42. Mabon, M. E., X. Mao, Y. Jiao, B. A. Scott and C. M. Crowder (2009). “Systematic identification of gene activities promoting hypoxic death.” Genetics 181(2): 483-96.
43. Mabon, M. E., B. A. Scott and C. M. Crowder (2009). “Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway.” PLoS One 4(11): e7937.
44. Mashour, G. A., R. K. Esaki, K. K. Tremper, D. B. Glick, M. O’Connor and M. S. Avidan (2009). “A Novel Classification Instrument for Intraoperative Awareness Events.” Anesthesia and Analgesia.
45. Mashour, G. A., K. K. Tremper and M. S. Avidan (2009). “Protocol for the “Michigan Awareness Control Study”: A prospective, randomized, controlled trial comparing electronic alerts based on bispectral index monitoring or minimum alveolar concentration for the prevention of intraoperative awareness.” BMC Anesthesiol 9: 7.
46. McDunn, J. E. and R. S. Hotchkiss (2009). “Leukocyte phenotyping to stratify septic shock patients.” Crit Care 13(2): 127.
47. McDunn, J. E., J. T. Muenzer, B. Dunne, A. Zhou, K. Yuan, A. Hoekzema, C. Hilliard, K. C. Chang, C. G. Davis, J. McDonough, C. Hunt, P. Grigsby, D. Piwnica-Worms and R. S. Hotchkiss (2009). “An anti-apoptotic peptide improves survival in lethal total body irradiation.” Biochemical and Biophysical Research Communications 382(4): 657-62.
48. Montana, M. C., L. F. Cavallone, K. K. Stubbert, A. D. Stefanescu, E. D. Kharasch and R. W. t. Gereau (2009). “The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.” Journal of Pharmacology and Experimental Therapeutics 330(3): 834-43.
49. Morales, M. E. and R. W. Gereau (2009). “The effects of tail biopsy for genotyping on behavioral responses to nociceptive stimuli.” PLoS One 4(7): e6457.
50. Nagele, P., B. Zeugswetter, C. Eberle, M. Hupfl, M. Mittlbock and M. Fodinger (2009). “A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia.” Pharmacogenet Genomics 19(5): 325-9.
51. Okazaki, M., S. Sugimoto, J. Lai, C. G. Kornfeld, R. S. Hotchkiss, S. B. Richardson, W. Li, F. H. Kreisel, H. J. Huang, G. A. Patterson, A. S. Krupnick, A. E. Gelman and D. Kreisel (2009). “Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient.” Transplant Proc 41(1): 385-7.
52. Pal, N. and R. Mehra (2009). “Unusual right atrium indentation: poststernum closure.” Journal of Cardiothoracic and Vascular Anesthesia 23(5): 751-2.
53. Palanca, B. J., G. A. Mashour and M. S. Avidan (2009). “Processed electroencephalogram in depth of anesthesia monitoring.” Current Opinion in Anaesthesiology 22(5): 553-9.
54. Parsons, A. J. and J. Alfa (2009). “Carotid dissection: a complication of internal jugular vein cannulation with the use of ultrasound.” Anesthesia and Analgesia 109(1): 135-6.
55. Peck-Palmer, O. M., J. Unsinger, K. C. Chang, J. S. McDonough, H. Perlman, J. E. McDunn and R. S. Hotchkiss (2009). “Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.” Shock 31(4): 359-66.
56. Pickrell, J. E., K. Hosaka, D. L. Jackson, M. Heima, E. Kharasch and P. M. Milgrom (2009). “Expanded studies of the pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.” J Clin Psychopharmacol 29(5): 426-31.
57. Racz, K., T. Tiszai-Szucs, J. Gal and D. M. Kertai (2009). “[Preoperative revascularization in high-risk patients undergoing vascular surgery].” Orv Hetil 150(8): 341-52.
58. Saccone, N. L., J. C. Wang, N. Breslau, E. O. Johnson, D. Hatsukami, S. F. Saccone, R. A. Grucza, L. Sun, W. Duan, J. Budde, R. C. Culverhouse, L. Fox, A. L. Hinrichs, J. H. Steinbach, M. Wu, J. P. Rice, A. M.Goate and L. J. Bierut (2009). “The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.” Cancer Res 69(17): 6848-56.
59. Saini, D. K., M. Chisari and N. Gautam (2009). “Shuttling and translocation of heterotrimeric G proteins and Ras.” Trends Pharmacol Sci 30(6): 278-86.
60. Scherrer, G., N. Imamachi, Y. Q. Cao, C. Contet, F. Mennicken, D. O’Donnell, B. L. Kieffer and A. I. Basbaum (2009). “Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.” Cell 137(6): 1148-59.
61. Shu, H. J., L. N. Eisenman, C. Wang, A. K. Bandyopadhyaya, K. Krishnan, A. Taylor, A. M. Benz, B. Manion, A. S. Evers, D. F. Covey, C. F. Zorumski and S. Mennerick (2009). “Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors.” Molecular Pharmacology 76(4): 754-65.
62. Simon, P. O., Jr., J. E. McDunn, H. Kashiwagi, K. Chang, P. S. Goedegebuure, R. S. Hotchkiss and W. G. Hawkins (2009). “Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.” Int J Cancer 125(4): 942-51.
63. Sona, C. S., J. E. Zack, M. E. Schallom, M. McSweeney, K. McMullen, J. Thomas, C. M. Coopersmith, W. A. Boyle, T. G. Buchman, J. E. Mazuski and D. J. Schuerer (2009). “The impact of a simple, low-cost oral care protocol on ventilator-associated pneumonia rates in a surgical intensive care unit.” Journal of Intensive Care Medicine 24(1): 54-62.
64. Stromberg, P. E., C. A. Woolsey, A. T. Clark, J. A. Clark, I. R. Turnbull, K. W. McConnell, K. C. Chang, C. S. Chung, A. Ayala, T. G. Buchman, R. S. Hotchkiss and C. M. Coopersmith (2009). “CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis.” Faseb J 23(6): 1817-25.
65. Stucky, C. L., A. E. Dubin, N. A. Jeske, S. A. Malin, D. D. McKemy and G. M. Story (2009). “Roles of transient receptor potential channels in pain.” Brain Res Rev 60(1): 2-23.
66. Sun, L., Y. Xiong, X. Zeng, Y. Wu, N. Pan, C. J. Lingle, A. Qu and J. Ding (2009). “Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells.” Biophysical Journal 97(7): 1832-42.
67. Sun, Y. G., N. G. Gracias, J. K. Drobish, M. R. Vasko, R. W. Gereau and Z. F. Chen (2009). “The c-kit signaling pathway is involved in the development of persistent pain.” Pain 144(1-2): 178-86.
68. Sun, Y. G., Z. Q. Zhao, X. L. Meng, J. Yin, X. Y. Liu and Z. F. Chen (2009). “Cellular basis of itch sensation.” Science 325(5947): 1531-4.
69. Tang, Q. Y., X. H. Zeng and C. J. Lingle (2009). “Closed-channel block of BK potassium channels by bbTBA requires partial activation.” Journal of General Physiology 134(5): 409-36.
70. Turnbull, I. R., A. T. Clark, P. E. Stromberg, D. J. Dixon, C. A. Woolsey, C. G. Davis, R. S. Hotchkiss, T. G. Buchman and C. M. Coopersmith (2009). “Effects of aging on the immunopathologic response to sepsis.” Critical Care Medicine 37(3): 1018-23.
71. Unsinger, J., H. Kazama, J. S. McDonough, R. S. Hotchkiss and T. A. Ferguson (2009). “Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury.” J Leukoc Biol 85(3): 382-90.
72. Unsinger, J., J. S. McDonough, L. D. Shultz, T. A. Ferguson and R. S. Hotchkiss (2009). “Sepsis-induced human lymphocyte apoptosis and cytokine production in “humanized” mice.” J Leukoc Biol 86(2): 219-27.
73. Vannucci, A., V. Krejci and I. Kangrga (2009). “Performance of Vigileo and LiDCOplus cardiac output monitors during a prolonged cardiac arrest and resuscitation.” Eur J Anaesthesiol 26(10): 885-7.
74. Vannucci, A., V. Krejci and I. Kangrga (2009). “Validation of a new cardiac output monitor.” Liver Transpl 15(11): 1650; author reply 1651-2.
75. Waldrop, W. B., D. J. Murray, J. R. Boulet and J. F. Kras (2009). “Management of anesthesia equipment failure: a simulation-based resident skill assessment.” Anesthesia and Analgesia 109(2): 426-33.
76. Wang, J. C., C. Cruchaga, N. L. Saccone, S. Bertelsen, P. Liu, J. P. Budde, W. Duan, L. Fox, R. A. Grucza, J. Kern, K. Mayo, O. Reyes, J. Rice, S. F. Saccone, N. Spiegel, J. H. Steinbach, J. A. Stitzel, M. W. Anderson, M. You, V. L. Stevens, L. J. Bierut and A. M. Goate (2009). “Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.” Hum Mol Genet 18(16): 3125-35.
77. Watanabe, E., J. T. Muenzer, W. G. Hawkins, C. G. Davis, D. J. Dixon, J. E. McDunn, D. J. Brackett, M. R. Lerner, P. E. Swanson and R. S. Hotchkiss (2009). “Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study.” Lab Invest 89(5): 549-61.
78. Yang, C. T., X. H. Zeng, X. M. Xia and C. J. Lingle (2009). “Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function.” PLoS One 4(7): e6135.
79. Zhang, Z., X. H. Zeng, X. M. Xia and C. J. Lingle (2009). “N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels.” Journal of General Physiology 133(3): 263-82.

Department Publications 2008

1. Akk, G., P. Li, J. Bracamontes, D. E. Reichert, D. F. Covey and J. H. Steinbach (2008). “Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.” Mol Pharmacol 74(3): 614-27.
2. Akk, G., S. Mennerick and J. H. Steinbach (2008). “Actions of anesthetics on excitatory transmitter-gated channels.” Handb Exp Pharmacol(182): 53-84.
3. Alter, B. J. and R. W. t. Gereau (2008). “Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity.” Neuron 57(5): 629-31.
4. Avidan, M. S., L. Zhang, B. A. Burnside, K. J. Finkel, A. C. Searleman, J. A. Selvidge, L. Saager, M. S. Turner, S. Rao, M. Bottros, C. Hantler, E. Jacobsohn and A. S. Evers (2008). “Anesthesia awareness and the bispectral index.” N Engl J Med 358(11): 1097-108.
5. Boulet, J. R., D. Murray, J. Kras and J. Woodhouse (2008). “Setting performance standards for mannequin-based acute-care scenarios: an examinee-centered approach.” Simul Healthc 3(2): 72-81.
6. Boyle, W. A. and M. Leone (2008). “Vasopressin in septic shock.” N Engl J Med 358(25): 2736; author reply 2737-8.
7. Bracamontes, J. R. and J. H. Steinbach (2008). “Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors.” J Biol Chem 283(38): 26128-36.
8. Carrasquillo, Y. and R. W. t. Gereau (2008). “Hemispheric lateralization of a molecular signal for pain modulation in the amygdala.” Mol Pain 4: 24.
9. Cattano, D., A. Vannucci, A. Nicolini, C. Nania, S. Buzzigoli and C. Eby (2008). “Varicella fulminant hepatitis in an adult patient with Factor V Leiden mutation and trisomy 8 related myelodysplastic syndrome.” J Clin Virol 43(1): 134-5.
10. Cattano, D., P. Williamson, K. Fukui, M. Avidan, A. S. Evers, J. W. Olney and C. Young (2008). “Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain.” Can J Anaesth 55(7): 429-36.
11. Clark, J. A., A. T. Clark, R. S. Hotchkiss, T. G. Buchman and C. M. Coopersmith (2008). “Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis.” Shock 30(1): 36-42.
12. Coles, R. and E. D. Kharasch (2008). “Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.” Pharm Res 25(6): 1405-11.
13. Crowder, C. M. (2008). “Does natural selection explain the universal response of metazoans to volatile anesthetics?” Anesth Analg 107(3): 862-3.
14. Cruz-Orengo, L., A. Dhaka, R. J. Heuermann, T. J. Young, M. C. Montana, E. J. Cavanaugh, D. Kim and G. M. Story (2008). “Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.” Mol Pain 4: 30.
15. Dalal, P. G., D. Murray, A. Feng, D. Molter and J. McAllister (2008). “Upper airway dimensions in children using rigid video-bronchoscopy and a computer software: description of a measurement technique.” Paediatr Anaesth 18(7): 645-53.
16. Ekins, S., M. Iyer, M. D. Krasowski and E. D. Kharasch (2008). “Molecular characterization of CYP2B6 substrates.” Curr Drug Metab 9(5): 363-73.
17. Freeman, B. D., C. Kennedy, T. E. Robertson, C. M. Coopersmith, M. Schallom, C. Sona, L. Cracchiolo, D. J. Schuerer, W. A. Boyle and T. G. Buchman (2008). “Tracheostomy protocol: experience with development and potential utility.” Crit Care Med 36(6): 1742-8.
18. Grundling, M., C. Lehmann, D. Saeger, S. Bohnenstengel, D. Pavlovic, V. Bac, T. Usichenko, K. Meissner, M. Wendt, O. Hung, M. Murphy, S. Whynot and U. Lindequist (2008). “Response of the rat intestinal microcirculation to experimental endotoxemia is attenuated by ampicillin but not by its derivative KKP723.” Clin Hemorheol Microcirc 38(3): 163-70.
19. Guillory, R. K. and O. L. Gunter (2008). “Ultrasound in the surgical intensive care unit.” Curr Opin Crit Care 14(4): 415-22.
20. Hodges, M. R., G. J. Tattersall, M. B. Harris, S. D. McEvoy, D. N. Richerson, E. S. Deneris, R. L. Johnson, Z. F. Chen and G. B. Richerson (2008). “Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons.” J Neurosci 28(10): 2495-505.
21. Holzmann-Pazgal, G., D. Hopkins-Broyles, A. Recktenwald, M. Hohrein, P. Kieffer, C. Huddleston, S. Anshuman and V. Fraser (2008). “Case-control study of pediatric cardiothoracic surgical site infections.” Infect Control Hosp Epidemiol 29(1): 76-9.
22. Hupfl, M., I. Schmatzer, A. Buzath, H. Burger, K. Horauf, G. Ihra, P. Marhofer and P. Nagele (2008). “The effects of aminophylline on bispectral index during inhalational and total intravenous anaesthesia.” Anaesthesia 63(6): 583-7.
23. Jacquin, M. F., J. J. Arends, C. Xiang, L. A. Shapiro, C. E. Ribak and Z. F. Chen (2008). “In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning.” J Neurosci 28(14): 3577-85.
24. Jia, B. and C. M. Crowder (2008). “Volatile anesthetic preconditioning present in the invertebrate Caenorhabditis elegans.” Anesthesiology 108(3): 426-33.
25. Katona, B. W., K. Krishnan, Z. Y. Cai, B. D. Manion, A. Benz, A. Taylor, A. S. Evers, C. F. Zorumski, S. Mennerick and D. F. Covey (2008). “Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.” Eur J Med Chem 43(1): 107-13.
26. Kertai, M. D. (2008). “Preoperative coronary revascularization in high-risk patients undergoing vascular surgery: a core review.” Anesth Analg 106(3): 751-8.
27. Kertai, M. D., C. M. Westerhout, K. S. Varga, G. Acsady and J. Gal (2008). “Dihydropiridine calcium-channel blockers and perioperative mortality in aortic aneurysm surgery.” Br J Anaesth 101(4): 458-65.
28. Kharasch, E. D. (2008). “Adverse drug reactions with halogenated anesthetics.” Clin Pharmacol Ther 84(1): 158-62. Kharasch, E. D. (2008). “Mutations in a molecule: the virtues of antagonism.” Mayo Clin Proc 83(10): 1083-6.
29. Kharasch, E. D., P. S. Bedynek, S. Park, D. Whittington, A. Walker and C. Hoffer (2008). “Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.” Clin Pharmacol Ther 84(4): 497-505.
30. Kharasch, E. D., P. S. Bedynek, A. Walker, D. Whittington and C. Hoffer (2008). “Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.” Clin Pharmacol Ther 84(4): 506-12.
31. Kharasch, E. D., D. Mitchell and R. Coles (2008). “Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.” J Clin Pharmacol 48(4): 464-74.
32. Kharasch, E. D., D. Mitchell, R. Coles and R. Blanco (2008). “Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.” Antimicrob Agents Chemother 52(5): 1663-9.
33. Kiekkas, P., K. S. Filos, M. Karanikolas, D. Aretha and G. I. Baltopoulos (2008). “Relationships between fever and outcome in intensive care unit patients.” Crit Care Med 36(11): 3127-8.
34. Lehmann, C., R. Scheibe, M. Schade, K. Meissner, M. Grundling, T. Usichenko, M. Wendt, O. Hung, S. Whynot, M. Murphy and D. Pavlovic (2008). “Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia.” Can J Anaesth 55(3): 155-62.
35. Levy, J. H. and G. J. Despotis (2008). “Transfusion and hemostasis in cardiac surgery.” Transfusion 48(1 Suppl): 1S.
36. Li, P. and G. Akk (2008). “The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor.” Br J Pharmacol 155(5): 783-94.
37. Li, P., D. E. Reichert, A. D. Rodriguez, B. D. Manion, A. S. Evers, V. A. Eterovic, J. H. Steinbach and G. Akk (2008). “Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate.” Br J Pharmacol 153(3): 598-608.
38. Lingle, C. J. (2008). “Mg2+-dependent regulation of BK channels: importance of electrostatics.” J Gen Physiol 131(1): 5-11.
39. Luhmann, S. J., M. Schootman, P. L. Schoenecker, J. E. Gordon and C. Schrock (2008). “Use of femoral nerve blocks in adolescents undergoing patellar realignment surgery.” Am J Orthop 37(1): 39-43.
40. McDunn, J. E., J. T. Muenzer, L. Rachdi, K. C. Chang, C. G. Davis, W. M. Dunne, D. Piwnica-Worms, E. Bernal-Mizrachi and R. S. Hotchkiss (2008). “Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.” Faseb J 22(2): 561-8.
41. Meissner, K., T. Iber, J. P. Roesner, C. Mutz, H. E. Wagner, C. Layher, U. Bartels, M. Grundling, T. I. Usichenko, M. Wendt, C. Lehmann and D. Pavlovic (2008). “Successful transtracheal lung ventilation using a manual respiration valve: an in vitro and in vivo study.” Anesthesiology 109(2): 251-9.
42. Militante, J., B. W. Ma, G. Akk and J. H. Steinbach (2008). “Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies.” Mol Pharmacol 74(3): 764-76.
43. Nagele, P., B. Zeugswetter, C. Wiener, H. Burger, M. Hupfl, M. Mittlbock and M. Fodinger (2008). “Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia.” Anesthesiology 109(1): 36-43.
44. Okubadejo, G. O., M. R. Talcott, R. E. Schmidt, A. Sharma, A. A. Patel, R. B. Mackey, A. H. Guarino, C. J. Moran and K. D. Riew (2008). “Perils of intravascular methylprednisolone injection into the vertebral artery. An animal study.” J Bone Joint Surg Am 90(9): 1932-8.
45. Peck-Palmer, O. M., J. Unsinger, K. C. Chang, C. G. Davis, J. E. McDunn and R. S. Hotchkiss (2008). “Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.” J Leukoc Biol 83(4): 1009-18.
46. Peterson, L. R., P. F. Soto, P. Herrero, B. S. Mohammed, M. S. Avidan, K. B. Schechtman, C. Dence and R. J. Gropler (2008). “Impact of gender on the myocardial metabolic response to obesity.” JACC Cardiovasc Imaging 1(4): 424-33.
47. Pezet, M., M. P. Jacob, B. Escoubet, D. Gheduzzi, E. Tillet, P. Perret, P. Huber, D. Quaglino, R. Vranckx, D. Y. Li, B. Starcher, W. A. Boyle, R. P. Mecham and G. Faury (2008). “Elastin haploinsufficiency induces alternative aging processes in the aorta.” Rejuvenation Res 11(1): 97-112.
48. Puyo, C. A., S. M. Tricomi and T. E. Dahms (2008). “Early biochemical markers of inflammation in a swine model of endotracheal intubation.” Anesthesiology 109(1): 88-94.
49. Rajan, S., D. Vyas, A. T. Clark, C. A. Woolsey, J. A. Clark, R. S. Hotchkiss, T. G. Buchman and C. M. Coopersmith (2008). “Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.” Shock 29(4): 483-9.
50. Robertson, C. M., E. E. Perrone, K. W. McConnell, W. M. Dunne, B. Boody, T. Brahmbhatt, M. J. Diacovo, N. Van Rooijen, L. A. Hogue, C. L. Cannon, T. G. Buchman, R. S. Hotchkiss and C. M. Coopersmith (2008). “Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.” J Surg Res 150(2): 278-85.
51. Samokhvalov, V., B. A. Scott and C. M. Crowder (2008). “Autophagy protects against hypoxic injury in C. elegans.” Autophagy 4(8): 1034-41.
52. Scaglione, J. B., I. Jastrzebska, K. Krishnan, P. Li, G. Akk, B. D. Manion, A. Benz, A. Taylor, N. P. Rath, A. S. Evers, C. F. Zorumski, S. Mennerick and D. F. Covey (2008). “Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes.” J Med Chem 51(5): 1309-18.
53. Schwulst, S. J., J. T. Muenzer, K. C. Chang, T. S. Brahmbhatt, C. M. Coopersmith and R. S. Hotchkiss (2008). “Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.” J Am Coll Surg 206(2): 335-42.
54. Schwulst, S. J., J. T. Muenzer, O. M. Peck-Palmer, K. C. Chang, C. G. Davis, J. S. McDonough, D. F. Osborne, A. H. Walton, J. Unsinger, J. E. McDunn and R. S. Hotchkiss (2008). “Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis.” Shock 30(2): 127-34.
55. Steinbach, J. H. (2008). “Pharmacology: Unready for action.” Nature 454(7205): 704-5. Sun, Y. G., Y. J. Gao, Z. Q. Zhao, B. Huang, J. Yin, G. A. Taylor and Z. F. Chen (2008). “Involvement of P311 in the affective, but not in the sensory component of pain.” Mol Pain 4: 23.
56. Sun, Y. M., M. Cooper, S. Finch, H. H. Lin, Z. F. Chen, B. P. Williams and N. J. Buckley (2008). “Rest-mediated regulation of extracellular matrix is crucial for neural development.” PLoS One 3(11): e3656.
57. Szekely, A., E. Sapi, T. Breuer, M. D. Kertai, G. Bodor, P. Vargha and A. Szatmari (2008). “Aprotinin and renal dysfunction after pediatric cardiac surgery.” Paediatr Anaesth 18(2): 151-9.
58. Tempelhoff, R. (2008). “An optic nerve at risk and a prolonged surgery in the prone position: time to reconsider?” Anesthesiology 108(5): 775-6.
59. Tempelhoff, R. and J. Yoder (2008). “Monitoring the brain: lack of tools or lack of will?” Crit Care Med 36(6): 1983-4.
60. Totah, R. A., P. Sheffels, T. Roberts, D. Whittington, K. Thummel and E. D. Kharasch (2008). “Role of CYP2B6 in stereoselective human methadone metabolism.” Anesthesiology 108(3): 363-74.
61. Ulrich, H., G. Akk, A. A. Nery, C. A. Trujillo, A. D. Rodriguez and V. A. Eterovic (2008). “Mode of cembranoid action on embryonic muscle acetylcholine receptor.” J Neurosci Res 86(1): 93-107.
62. Velissaris, D., M. Karanikolas, A. Kalogeropoulos, E. Solomou, P. Polychronopoulos, K. Thomopoulos and C. Labropoulou-Karatza (2008). “Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy.” World J Gastroenterol 14(26): 4190-5.
63. Zeng, X., X. M. Xia and C. J. Lingle (2008). “Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits.” J Gen Physiol 132(1): 115-29.

Department Publications 2007

1. Akk, G., D. F. Covey, A. S. Evers, J. H. Steinbach, C. F. Zorumski and S. Mennerick (2007). “Mechanisms of neurosteroid interactions with GABA(A) receptors.” Pharmacol Ther 116(1): 35-57.
2. Akk, G., P. Li, B. D. Manion, A. S. Evers and J. H. Steinbach (2007). “Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.” Mol Pharmacol 71(2): 461-72.
3. Avidan, M. S., S. Z. Ali, H. Tymkew, E. Jacobsohn, C. J. De Wet, L. L. Hill and M. Pasque (2007). “Mild hypercapnia after uncomplicated heart surgery is not associated with hemodynamic compromise.” J Cardiothorac Vasc Anesth 21(3): 371-4.
4. Baniwal, S., S. Meru and B. Biswas (2007). “Osteochondroma of the glenoid fossa–a case report.” Br J Oral Maxillofac Surg 45(7): 579-81.
5. Bordet, T., B. Buisson, M. Michaud, C. Drouot, P. Galea, P. Delaage, N. P. Akentieva, A. S. Evers, D. F. Covey, M. A. Ostuni, J. J. Lacapere, C. Massaad, M. Schumacher, E. M. Steidl, D. Maux, M. Delaage, C. E. Henderson and R. M. Pruss (2007). “Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.” J Pharmacol Exp Ther 322(2): 709-20.
6. Carrasquillo, Y. and R. W. t. Gereau (2007). “Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception.” J Neurosci 27(7): 1543-51.
7. Chang, K. C., J. Unsinger, C. G. Davis, S. J. Schwulst, J. T. Muenzer, A. Strasser and R. S. Hotchkiss (2007). “Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis.” Faseb J 21(3): 708-19.
8. Chiechio, S., A. Copani, R. W. t. Gereau and F. Nicoletti (2007). “Acetyl-L-carnitine in neuropathic pain: experimental data.” CNS Drugs 21 Suppl 1: 31-8; discussion 45-6.
9. Chisari, M., D. K. Saini, V. Kalyanaraman and N. Gautam (2007). “Shuttling of G protein subunits between the plasma membrane and intracellular membranes.” J Biol Chem 282(33): 24092-8.
10. Christoforou, E., E. Akbudak, A. Ozcan, M. Karanikolas and N. V. Tsekos (2007). “Performance of interventions with manipulator-driven real-time MR guidance: implementation and initial in vitro tests.” Magn Reson Imaging 25(1): 69-77.
11. Chu, W., J. Rothfuss, A. d’Avignon, C. Zeng, D. Zhou, R. S. Hotchkiss and R. H. Mach (2007). “Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.” J Med Chem 50(15): 3751-5.
12. Dasgupta, N., A. M. Patel, B. A. Scott and C. M. Crowder (2007). “Hypoxic preconditioning requires the apoptosis protein CED-4 in C. elegans.” Curr Biol 17(22): 1954-9.
13. Despotis, G. J., L. Zhang and D. M. Lublin (2007). “Transfusion risks and transfusion-related pro-inflammatory responses.” Hematol Oncol Clin North Am 21(1): 147-61.
14. Eidelman, A., T. White and R. A. Swarm (2007). “Interventional therapies for cancer pain management: important adjuvants to systemic analgesics.” J Natl Compr Canc Netw 5(8): 753-60.
15. Eisenman, L. N., H. J. Shu, G. Akk, C. Wang, B. D. Manion, G. J. Kress, A. S. Evers, J. H. Steinbach, D. F. Covey, C. F. Zorumski and S. Mennerick (2007). “Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.” Nat Neurosci 10(4): 523-30.
16. Evers, A. S. and R. D. Miller (2007). “Can we get there if we don’t know where we’re going?” Anesthesiology 106(4): 651-2.
17. Frieling, H., K. S. Lauer, M. Grundling, T. Usichenko, K. Meissner, T. Kanellopoulou, C. Lehmann, M. Wendt and D. Pavlovic (2007). “Peritoneal instillation of taurolidine or polihexanide modulates intestinal microcirculation in experimental endotoxemia.” Int J Colorectal Dis 22(7): 807-17.
18. Gal, J., A. Grattan, M. D. Kertai, A. Smith, A. D. Shaw, D. Royston and B. J. Riedel (2007). “Coronary revascularization in transition from on-pump to off-pump: the effect of the off-pump coronary artery bypass on medium-term outcome.” J Cardiovasc Surg (Torino) 48(1): 67-72.
19. Gandhi, M. J., R. A. Pierce, L. Zhang, M. R. Moon, G. J. Despotis and N. Moazami (2007). “Use of activated recombinant factor VII for severe coagulopathy post ventricular assist device or orthotopic heart transplant.” J Cardiothorac Surg 2: 32.
20. Guarino, A. H. and J. C. Myers (2007). “An assessment protocol to guide opioid prescriptions for patients with chronic pain.” Mo Med 104(6): 513-6.
21. Guo, C., H. Y. Qiu, Y. Huang, H. Chen, R. Q. Yang, S. D. Chen, R. L. Johnson, Z. F. Chen and Y. Q. Ding (2007). “Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.” Development 134(2): 317-25.
22. Harris, C. B., M. J. Krauss, C. M. Coopersmith, M. Avidan, P. A. Nast, M. H. Kollef, W. C. Dunagan and V. J. Fraser (2007). “Patient safety event reporting in critical care: a study of three intensive care units.” Crit Care Med 35(4): 1068-76.
23. Hiltebrand, L. B., G. Pestel, H. Hager, J. Ratnaraj, G. H. Sigurdsson and A. Kurz (2007). “Perioperative fluid management: comparison of high, medium and low fluid volume on tissue oxygen pressure in the small bowel and colon.” Eur J Anaesthesiol 24(11): 927-33.
24. Hu, H. J., B. J. Alter, Y. Carrasquillo, C. S. Qiu and R. W. t. Gereau (2007). “Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons.” J Neurosci 27(48): 13181-91.
25. Kashiwagi, H., J. E. McDunn, P. S. Goedegebuure, M. C. Gaffney, K. Chang, K. Trinkaus, D. Piwnica-Worms, R. S. Hotchkiss and W. G. Hawkins (2007). “TAT-Bim induces extensive apoptosis in cancer cells.” Ann Surg Oncol 14(5): 1763-71.
26. Kashiwagi, H., J. E. McDunn, P. O. Simon, Jr., P. S. Goedegebuure, J. Xu, L. Jones, K. Chang, F. Johnston, K. Trinkaus, R. S. Hotchkiss, R. H. Mach and W. G. Hawkins (2007). “Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy.” Mol Cancer 6: 48.
27. Kentner, R., P. Safar, W. Behringer, X. Wu, J. Henchir, L. Ma, C. J. Hsia and S. A. Tisherman (2007). “Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats.” Resuscitation 72(2): 295-305.
28. Kowark, P., R. Huneke, E. Jungling, R. Rossaint and A. Luckhoff (2007). “Oxygen tension modulates inhibition of L-type calcium currents by isoflurane in human atrial cardiomyocytes.” Anesthesiology 106(4): 715-22.
29. Lehmann, C., F. Feyerherd, T. Feyerherd, M. Fogliata, M. Grundling, T. I. Usichenko, K. Meissner, M. Wendt and D. Pavlovic (2007). “Ketamine does not affect intestinal microcirculation in pentobarbital-anaesthetized rats during experimental endotoxaemia.” Lab Anim 41(1): 55-62.
30. Li, P., J. Bracamontes, B. W. Katona, D. F. Covey, J. H. Steinbach and G. Akk (2007). “Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor.” Mol Pharmacol 71(6): 1582-90.
31. Li, P., H. J. Shu, C. Wang, S. Mennerick, C. F. Zorumski, D. F. Covey, J. H. Steinbach and G. Akk (2007). “Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.” J Physiol 584(Pt 3): 789-800.
32. Li, W., X. Jin, D. F. Covey and J. H. Steinbach (2007). “Neuroactive steroids and human recombinant rho1 GABAC receptors.” J Pharmacol Exp Ther 323(1): 236-47. Lingle, C. J. (2007). “Gating rings formed by RCK domains: keys to gate opening.” J Gen Physiol 129(2): 101-7.
33. Lockhart, E. M. and C. L. Baysinger (2007). “Intracranial venous thrombosis in the parturient.” Anesthesiology 107(4): 652-8; quiz 687-8.
34. McConnell, K. W., J. T. Muenzer, K. C. Chang, C. G. Davis, J. E. McDunn, C. M. Coopersmith, C. A. Hilliard, R. S. Hotchkiss, P. W. Grigsby and C. R. Hunt (2007). “Anti-apoptotic peptides protect against radiation-induced cell death.” Biochem Biophys Res Commun 355(2): 501-7.
35. Metz, L. B., N. Dasgupta, C. Liu, S. J. Hunt and C. M. Crowder (2007). “An evolutionarily conserved presynaptic protein is required for isoflurane sensitivity in Caenorhabditis elegans.” Anesthesiology 107(6): 971-82.
36. Minkovich, L., G. Djaiani, R. Katznelson, F. Day, L. Fedorko, J. Tan, J. Carroll, D. Cheng and J. Karski (2007). “Effects of alveolar recruitment on arterial oxygenation in patients after cardiac surgery: a prospective, randomized, controlled clinical trial.” J Cardiothorac Vasc Anesth 21(3): 375-8.
37. Mizobuchi, M., J. Morrissey, J. L. Finch, D. R. Martin, H. Liapis, T. Akizawa and E. Slatopolsky (2007). “Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats.” J Am Soc Nephrol 18(6): 1796-806.
38. Murray, D. and C. Enarson (2007). “Communication and teamwork: essential to learn but difficult to measure.” Anesthesiology 106(5): 895-6.
39. Murray, D. J., J. R. Boulet, M. Avidan, J. F. Kras, B. Henrichs, J. Woodhouse and A. S. Evers (2007). “Performance of residents and anesthesiologists in a simulation-based skill assessment.” Anesthesiology 107(5): 705-13.
40. Noordzij, P. G., E. Boersma, F. Schreiner, M. D. Kertai, H. H. Feringa, M. Dunkelgrun, J. J. Bax, J. Klein and D. Poldermans (2007). “Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery.” Eur J Endocrinol 156(1): 137-42.
41. Noordzij, P. G., D. Poldermans, O. Schouten, F. Schreiner, H. H. Feringa, M. Dunkelgrun, M. D. Kertai and E. Boersma (2007). “Beta-blockers and statins are individually associated with reduced mortality in patients undergoing noncardiac, nonvascular surgery.” Coron Artery Dis 18(1): 67-72.
42. Okubadejo, G. O., K. H. Bridwell, L. G. Lenke, J. M. Buchowski, D. D. Fang, C. R. Baldus, C. H. Nielsen and C. C. Lee (2007). “Aprotinin may decrease blood loss in complex adult spinal deformity surgery, but it may also increase the risk of acute renal failure.” Spine 32(20): 2265-71.
43. Ott, E., C. D. Mazer, I. C. Tudor, L. Shore-Lesserson, S. A. Snyder-Ramos, B. A. Finegan, P. Mohnle, C. B. Hantler, B. W. Bottiger, R. D. Latimer, W. S. Browner, J. Levin and D. T. Mangano (2007). “Coronary artery bypass graft surgery–care globalization: the impact of national care on fatal and nonfatal outcome.” J Thorac Cardiovasc Surg 133(5): 1242-51.
44. Pal, N., N. Makhija, U. Kiran and S. Pal (2007). “Posttracheostomy subcutaneous emphysema: a management plan.” Paediatr Anaesth 17(3): 298-300.
45. Parrino, J., R. S. Hotchkiss and M. Bray (2007). “Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections.” Emerg Infect Dis 13(2): 191-8.
46. Poldermans, D., O. Schouten, R. Vidakovic, J. J. Bax, I. R. Thomson, S. E. Hoeks, H. H. Feringa, M. Dunkelgrun, P. de Jaegere, A. Maat, M. R. van Sambeek, M. D. Kertai and E. Boersma (2007). “A clinical randomized trial to evaluate the safety of a noninvasive approach in high-risk patients undergoing major vascular surgery: the DECREASE-V Pilot Study.” J Am Coll Cardiol 49(17): 1763-9.
47. Pratap, A., N. Kaur, V. C. Shakya, G. Sapkota, S. Tanveer-ur Rahman, B. K. Biswas, C. S. Agrawal and S. Adhikary (2007). “Triple tube therapy: a novel enteral feeding technique for short bowel syndrome in low-income countries.” J Pediatr Surg 42(3): 470-3.
48. Pratap, A., V. C. Shakya, B. K. Biswas, A. Sinha, A. Tiwari, C. S. Agrawal and S. Adhikary (2007). “Single-stage transanal endorectal pull-through for Hirschsprung’s disease: perspective from a developing country.” J Pediatr Surg 42(3): 532-5.
49. Saini, D. K., V. Kalyanaraman, M. Chisari and N. Gautam (2007). “A family of G protein betagamma subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation.” J Biol Chem 282(33): 24099-108.
50. Schena, S., T. Wildes, M. A. Beardslee, J. M. Lasala, R. J. Damiano, Jr. and J. S. Lawton (2007). “Successful management of unremitting spasm of the nongrafted right coronary artery after off-pump coronary artery bypass grafting.” J Thorac Cardiovasc Surg 133(6): 1649-50.
51. Schuerer, D. J., J. E. Zack, J. Thomas, I. B. Borecki, C. S. Sona, M. E. Schallom, M. Venker, J. L. Nemeth, M. R. Ward, L. Verjan, D. K. Warren, V. J. Fraser, J. E. Mazuski, W. A. Boyle, T. G. Buchman and C. M. Coopersmith (2007). “Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial.” Surg Infect (Larchmt) 8(4): 445-54.
52. Schwulst, S. J., C. G. Davis, C. M. Coopersmith and R. S. Hotchkiss (2007). “Adoptive transfer of dying cells causes bystander-induced apoptosis.” Biochem Biophys Res Commun 353(3): 780-5.
53. Steinbach, J. H. (2007). “A slip ‘twixt the cup and the lip: a new way to impair function of transmitter-gated channels.” J Physiol 581(Pt 1): 3.
54. Steiner, M. E. and G. J. Despotis (2007). “Transfusion algorithms and how they apply to blood conservation: the high-risk cardiac surgical patient.” Hematol Oncol Clin North Am 21(1): 177-84.
55. Sun, Y. G. and Z. F. Chen (2007). “A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.” Nature 448(7154): 700-3.
56. Swarm, R., D. L. Anghelescu, C. Benedetti, B. Boston, C. Cleeland, N. Coyle, O. A. Deleon-Casasola, A. Eidelman, J. G. Eilers, B. Ferrell, S. A. Grossman, N. A. Janjan, M. H. Levy, M. Lynch, G. S. Montana, S. Nesbit, L. Oakes, E. A. Obbens, J. Paice, K. L. Syrjala, S. Urba and S. M. Weinstein (2007). “Adult cancer pain.” J Natl Compr Canc Netw 5(8): 726-51.
57. Wagner, T. H., A. M. Drewry, S. Macmillan, W. M. Dunne, K. C. Chang, I. E. Karl, R. S. Hotchkiss and J. P. Cobb (2007). “Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo.” Am J Physiol Regul Integr Comp Physiol 292(4): R1751-9.
58. Wang, C. Z., M. Shi, L. L. Yang, R. Q. Yang, Z. G. Luo, M. F. Jacquin, Z. F. Chen and Y. Q. Ding (2007). “Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11.” Mol Cell Neurosci 35(2): 368-76.
59. Yuki, K., K. Chilson, K. C. Odegard and J. A. DiNardo (2007). “Trendelenburg position, simulated Valsalva maneuver, and liver compression do not alter the size of the right internal jugular vein in patients with a bidirectional Glenn shunt.” Anesth Analg 105(2): 365-8.
60. Zeng, C., S. Vangveravong, J. Xu, K. C. Chang, R. S. Hotchkiss, K. T. Wheeler, D. Shen, Z. P. Zhuang, H. F. Kung and R. H. Mach (2007). “Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy.” Cancer Res 67(14): 6708-16.
61. Zeng, X. H., G. R. Benzinger, X. M. Xia and C. J. Lingle (2007). “BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism.” J Neurosci 27(17): 4707-15.
62. Zhang, Q., Y. Q. Cao and R. W. Tsien (2007). “Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles.” Proc Natl Acad Sci U S A 104(45): 17843-8.
63. Zhao, Z. Q., S. Chiechio, Y. G. Sun, K. H. Zhang, C. S. Zhao, M. Scott, R. L. Johnson, E. S. Deneris, K. J. Renner, R. W. t. Gereau and Z. F. Chen (2007). “Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs.” J Neurosci 27(22): 6045-53.
64. Zhao, Z. Q., Y. J. Gao, Y. G. Sun, C. S. Zhao, R. W. t. Gereau and Z. F. Chen (2007). “Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward.” Proc Natl Acad Sci U S A 104(36): 14519-24.

Department Publications 2006

1. Akgoz, M., V. Kalyanaraman, et al. (2006). “G protein betagamma complex translocation from plasma membrane to Golgi complex is influenced by receptor gamma subunit interaction.” Cell Signal.
2. Azpiazu, I., M. Akgoz, et al. (2006). “G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type.” Cell Signal 18(8): 1190-200.
3. Azpiazu, I. and N. Gautam (2006). “A G protein gamma subunit peptide stabilizes a novel muscarinic receptor state.” Biochem Biophys Res Commun 341(4): 904-10.
4. Bateman, R. J., L. Y. Munsell, et al. (2006). “Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo.” Nat Med 12(7): 856-61.
5. Benzinger, G. R., X. M. Xia, et al. (2006). “Direct observation of a preinactivated, open state in BK channels with beta2 subunits.” J Gen Physiol 127(2): 119-31.
6. Birnbaum, J., O. V. Hein, et al. (2006). “Effects of coagulation factor XIII on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation in experimental endotoxemia.” Crit Care 10(1): R29.
7. Cao, Y. Q. (2006). “Voltage-gated calcium channels and pain.” Pain 126(1-3): 5-9.
8. Cattano, D. (2006). “cTrach: a valuable aid for daily practice in bariatric surgery.” British Journal of Anaesthesia.
9. Cattano, D. and F. Giunta (2006). “Combine anesthesia and integration of mechanisms. Mixing flavour for a better recipe.” British Journal of Anaesthesia.
10. Cattano, D., F. Giunta, et al. (2006). “Forceps dilatational percutaneous tracheostomy: safe and short.” Anaesth Intensive Care 34(4): 523.
11. Cattano, D., B. Pesetti, et al. (2006). “cTrach: the size 6 could be better.” British Journal of Anaesthesia.
12. Chalasani, J., T. Davis, et al. (2006). “Thoracolumbar epidural abscess after combined spinal-epidural for labor and tubal ligtation.” SOAP.
13. Chiechio, S., A. Copani, et al. (2006). “Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine.” Mol Pain 2: 20.
14. Chiechio, S., A. Copani, et al. (2006). ” L-Acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies.” Current Neuropharmacology 4: 233-237.
15. Dalal, P. G., D. Murray, et al. (2006). “Sedation and anesthesia protocols used for magnetic resonance imaging studies in infants: provider and pharmacologic considerations.” Anesth Analg 103(4): 863-8.
16. Erzurumlu, R. S., Z. F. Chen, et al. (2006). “Molecular determinants of the face map development in the trigeminal brainstem.” Anat Rec A Discov Mol Cell Evol Biol 288(2): 121-34.
17. Fang, H., S. Patanavanich, et al. (2006). “Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate.” J Biol Chem 281(29): 20011-7.
18. Grube, M., H. E. Meyer zu Schwabedissen, et al. (2006). “Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).” Circulation 113(8): 1114-22.
19. Guarino, A. H. (2006). “Observational study of dural punctures: a retrospective review of the rate of dural punctures as a complication of lumbar epidural steriod injections.” Practical Pain Management(October): 22-28.
20. Guarino, A. H. and M. Cornell (2006). “Breakthrough pain in non-cancer patients.” Practical Pain Management(April 2006): 12-16.
21. Guarino, A. H., C. M., et al. (2006). “Observational study of the effects of infliximab on low back pain.” Proceedings of the NASS 21st Annual Meeting 6: 53S.
22. Guarino, A. H., J. Myers, et al. (2006). “A descriptive case series: oral transmucosal fentanyl use in patients with noncancerous pain.” J Opioid Manag 2(2): 81-7.
23. Hager, H., D. Reddy, et al. (2006). “Hypercapnia improves tissue oxygenation in morbidly obese surgical patients.” Anesth Analg 103(3): 677-81.
24. Hotchkiss, R. S., K. W. McConnell, et al. (2006). “TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.” J Immunol 176(9): 5471-7.
25. Hotchkiss, R. S. and D. W. Nicholson (2006). “Apoptosis and caspases regulate death and inflammation in sepsis.” Nat Rev Immunol 6(11): 813-22.
26. Hu, H. J., Y. Carrasquillo, et al. (2006). “The kv4.2 potassium channel subunit is required for pain plasticity.” Neuron 50(1): 89-100.
27. Jacobsohn, E., M. Avidan, et al. (2006). “Case report: inferior vena-cava right atrial anastomotic stenosis after bicaval orthotopic heart transplation.” Canadian Journal of Anaesthesia 53(10): 1039-1043.
28. Jacobsohn, E., D. A. Fessler, et al. (2006). “Morbidity and mortality associated with accidentally entrapped pulmonary artery catheters during cardiac surgery: a case series.” J Cardiothorac Vasc Anesth 20(3): 371-5.
29. Jin, X. and R. W. t. Gereau (2006). “Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha.” J Neurosci 26(1): 246-55.
30. Karim, F., H. J. Hu, et al. (2006). “Impaired Inflammatory Pain and Thermal Hyperalgesia in Mice Expressing Neuron-Specific Dominant Negative Mitogen Activated Protein Kinase Kinase (MEK).” Mol Pain 2(1): 2.
31. Kashiwagi, H., J. E. McDunn, et al. (2006). “Novel, selective sigma-2 receptor ligands induce apoptosis in pancreas cancer.” ASGO GI.
32. Kishi, M. and J. H. Steinbach (2006). “Role of the agonist binding site in up-regulation of neuronal nicotinic alpha4beta2 receptors.” Mol Pharmacol 70(6): 2037-44.
33. Kjaer, K., M. Comerford, et al. (2006). “Oral sodium citrate increases nausea amongst elective Cesarean delivery patients.” Can J Anaesth 53(8): 776-80.
34. Krejci, V., L. Hiltebrand, et al. (2006). “Decreasing gut wall glucose as an early marker of impaired intestinal perfusion.” Crit Care Med 34(9): 2406-14.
35. Krejci, V., L. B. Hiltebrand, et al. (2006). “Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis.” Crit Care Med 34(5): 1456-63.
36. Kwan, K. Y., A. J. Allchorne, et al. (2006). “TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.” Neuron 50(2): 277-89.
37. Lehmann, C., V. H. Bac, et al. (2006). “Metronidazole improves intestinal microcirculation in septic rats independently of bacterial burden.” Clin Hemorheol Microcirc 34(3): 427-38.
38. Lehmann, C., K. Meissner, et al. (2006). “Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat.” Crit Care 10(6): R157.
39. Leone, M. and W. A. Boyle (2006). “Decreased vasopressin responsiveness in vasodilatory septic shock-like conditions.” Crit Care Med 34(4): 1126-30.
40. Li, M. Z., J. S. Wang, et al. (2006). “Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.” Dev Biol 292(2): 555-64.
41. Li, P., D. F. Covey, et al. (2006). “Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.” Mol Pharmacol 69(6): 2015-26.
42. Li, P., D. F. Covey, et al. (2006). “Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analogue on recombinant {alpha}1{beta}2{gamma}2 GABAA receptors.” Mol Pharmacol.
43. Li, W., D. F. Covey, et al. (2006). “Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action.” Mol Pharmacol 69(6): 1779-82.
44. Lingle, C. J. (2006). “Empirical considerations regarding the use of ensemble-variance analysis of macroscopic currents.” J Neurosci Methods 158(1): 121-32.
45. Macpherson, L. J., S. W. Hwang, et al. (2006). “More than cool: promiscuous relationships of menthol and other sensory compounds.” Mol Cell Neurosci 32(4): 335-43.
46. McCann, C. M., J. Bracamontes, et al. (2006). “The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors.” Proc Natl Acad Sci U S A 103(13): 5149-54.
47. McDunn, J. E., A. Burykin, et al. (2006). “Plasticity of the human innate immune response to acute infection during critical illness: development of riboleukogram.” Critical Care Medicine 34: A47.
48. Meissner, K., B. Heydrich, et al. (2006). “The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart.” J Histochem Cytochem 54(2): 215-21.
49. Meyer zu Schwabedissen, H. E., M. Grube, et al. (2006). “Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).” Drug Metab Dispos 34(4): 524-33.
50. Muenzer, J. T., C. G. Davis, et al. (2006). “Pneumonia after cecal ligation and puncture: a clinically relevant “two-hit” model of sepsis.” Shock 26(6): 565-70.
51. Munir, M. A., R. Rastogi, et al. (2006). “Fluoroscopy and safety of spinal interventional procedures.” Anesth Analg 102(5): 1586; author reply 1587.
52. Murray, D. (2006). “Clinical skills in acute care: a role for simulation training.” Crit Care Med 34(1): 252-3.
53. Nagele, P., H. Schochl, et al. (2006). “Who else, if not us? the role of anesthesiology in prehospital emergency medicine in Austria – in German.” AIC News 56: 8-10.
54. Nagele, P. and M. Strickner (2006). “Considering a new focus for Austrian Army Medicine – in German.” OMZ [Austrian Military Journal]: 729-733.
55. Niedhart, D. J., H. A. Kaiser, et al. (2006). “Intrapatient reproducibility of the BISxp monitor.” Anesthesiology 104(2): 242-8.
56. Ordodi, V. L., V. Paunescu, et al. (2006). “A pressure-controlled rat ventilator with electronically preset respirations.” Artif Organs 30(12): 965-8.
57. Ordodi, V. L., V. Paunescu, et al. (2006). “Improved electrodes for electrical defibrillation of rats.” J Am Assoc Lab Anim Sci 45(6): 54-7.
58. Pavlovic, D., H. Frieling, et al. (2006). “Thermostatic tissue platform for intravital microscopy: ‘the hanging drop’ model.” J Microsc 224(Pt 2): 203-10.
59. Rebelo, S., Z. F. Chen, et al. (2006). “Involvement of DRG11 in the development of the primary afferent nociceptive system.” Mol Cell Neurosci 33(3): 236-46.
60. Rosemeier, F., C. J. De Wet, et al. (2006). “Severe acute tricuspid regurgitation after the withdrawal of an entrapped pulmonary artery catheter.” J Cardiothorac Vasc Anesth 20(6): 910-1.
61. Saager, L., K. Barnett, et al. (2006). “Cognitive deterioration following major surgery or major illness.” Anesthesiology 105: A1181.
62. Scaglione, J. B., B. D. Manion, et al. (2006). “Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.” J Med Chem 49(15): 4595-605.
63. Scherrer, G., P. Tryoen-Toth, et al. (2006). “Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.” Proc Natl Acad Sci U S A 103(25): 9691-6.
64. Schwulst, S. J., M. H. Grayson, et al. (2006). “Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis.” J Immunol 177(1): 557-65.
65. Stamenkovic, D. M. and M. Hassid (2006). “Dexmedetomidine for fiberoptic intubation of a patient with severe mental retardation and atlantoaxial instability.” Acta Anaesthesiol Scand 50(10): 1314-5.
66. Story, G. M. (2006). “The emerging role of TRP channels in mechanisms of temperature and pain sensation.” Current Neuropharmacology 4: 183-196.
67. Story, G. M. and R. W. t. Gereau (2006). “Numbing the Senses: Role of TRPA1 in Mechanical and Cold Sensation.” Neuron 50(2): 177-80.
68. Taylor, B. E., M. E. Schallom, et al. (2006). “Efficacy and safety of an insulin infusion protocol in a surgical ICU.” J Am Coll Surg 202(1): 1-9.
69. Troung, R. M., N. Scaccia, et al. (2006). “Thoracolumbar epidural abscess after combined spinal-epidural for labor and tubal ligtation.” SOAP.
70. Unsinger, J., J. M. Herndon, et al. (2006). “The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.” J Immunol 177(11): 7968-73.
71. Weber, N. C., J. Stursberg, et al. (2006). “Xenon preconditioning differently regulates p44/42 MAPK (ERK 1/2) and p46/54 MAPK (JNK 1/2 and 3) in vivo.” Br J Anaesth 97(3): 298-306.
72. Weber, N. C., O. Toma, et al. (2006). “Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1.” Eur J Pharmacol 539(1-2): 1-9.
73. Zhang, X., X. Zeng, et al. (2006). “Slo3 K+ channels: voltage and pH dependence of macroscopic currents.” J Gen Physiol 128(3): 317-36.
74. Zhang, X., X. Zeng, et al. (2006). “pH-regulated Slo3 K+ channels: properties of unitary currents.” J Gen Physiol 128(3): 301-15.
75. Zhang, Z., Y. Zhou, et al. (2006). “A limited access compartment between the pore domain and cytosolic domain of the BK channel.” J Neurosci 26(46): 11833-43.
76. Zhao, Z. Q., M. Scott, et al. (2006). “Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity.” J Neurosci 26(49): 12781-8.

Department Publications 2005

1. Akk, G., L. S. Milescu, et al. (2005). “Activation of heteroliganded mouse muscle nicotinic receptors.” J Physiol 564(Pt 2): 359-76.
2. Akk, G. and J. H. Steinbach (2005). “Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site.” J Neurosci 25(8): 1992-2001.
3. Akk, G., H. J. Shu, et al. (2005). “Neurosteroid access to the GABAA receptor.” J Neurosci 25(50): 11605-13.
4. Alagarsamy, S., J. Saugstad, et al. (2005). “NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin.” Neuropharmacology 49 Suppl 1: 135-45.
5. Avidan, M. S., J. H. Levy, et al. (2005). “Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass.” J Thorac Cardiovasc Surg 130(1): 107-13.
6. Avidan, M. S., J. H. Levy, et al. (2005). “A phase III, double-blind, placebo-controlled, multicenter study on the efficacy of recombinant human antithrombin in heparin-resistant patients scheduled to undergo cardiac surgery necessitating cardiopulmonary bypass.” Anesthesiology 102(2): 276-84.
7. Azpiazu, I., M. Akgoz, et al. (2005). “G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type.” Cell Signal.
8. Chaobal, H. N. and E. D. Kharasch (2005). “Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.” Clin Pharmacol Ther 78(5): 529-39.
9. Checchia, P. A., J. McCollegan, et al. (2005). “The effect of surgical case volume on outcome after the Norwood procedure.” J Thorac Cardiovasc Surg 129(4): 754-9.
10. Chen, X. K., L. C. Wang, et al. (2005). “Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC.” Nat Neurosci 8(9): 1160-8.
11. Cohen, M. S., S. E. Finkelstein, et al. (2005). “Outpatient minimally invasive parathyroidectomy using local/regional anesthesia: a safe and effective operative approach for selected patients.” Surgery 138(4): 681-7; discussion 687-9.
12. D’Angelo, R., B. Philip, et al. (2005). “A randomized, double-blind, close-ranging, pilot study of intravenous granisetron in the prevention of postoperative nausea and vomiting in patients abdominal hysterectomy.” Eur J Anaesthesiol 22(10): 774-9.
13. Degler, S. M., R. D. Dowling, et al. (2005). “Awake intubation using an intubating laryngeal mask airway in a parturient with spina bifida.” Int J Obstet Anesth 14(1): 77-8.
14. Dembo, G., S. B. Park, et al. (2005). “Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.” Anesthesiology 102(2): 409-15.
15. Despotis, G., M. Avidan, et al. (2005). “Off-label use of recombinant factor VIIA concentrates after cardiac surgery.” Ann Thorac Surg 80(1): 3-5.
16. Ding, Y. Q., J. Y. Kim, et al. (2005). “Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord.” Development 132(9): 2047-56.
17. Ding, Y. Q., C. X. Xiang, et al. (2005). “Generation and characterization of the PKCgamma-Cre mouse line.” Genesis 43(1): 28-33.
18. Dunston, J. A., T. Reimschisel, et al. (2005). “A neurological phenotype in nail patella syndrome (NPS) patients illuminated by studies of murine Lmx1b expression.” Eur J Hum Genet 13(3): 330-5.
19. Faury, G., T. M. Wynnychenko, et al. (2005). “Decreased circulating elastin peptide levels in humans with sepsis.” Pathol Biol (Paris) 53(7): 443-7.
20. Gereau, R. W. t. (2005). “Neurofibromatosis pain is in the membrane. Focus on “sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability”.” J Neurophysiol 94(6): 3659-60.
21. Guarino, A. H. and N. Wright (2005). “Pneumocephalus: a case study.” Pain Physician 8: 239-241.
22. Guarino, A. H. and M. Cornell (2005). “Opioids as an option in MS patients with chronic pain.” International Journal of MS Care 7(1): 10-15.
23. Hidaka, T., I. Tsuneyoshi, et al. (2005). “Marked synergism between vasopressin and angiotensin II in a human isolated artery.” Crit Care Med 33(11): 2613-20.
24. Hogue, C. W., Jr., L. L. Creswell, et al. (2005). “Epidemiology, mechanisms, and risks: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery.” Chest 128(2 Suppl): 9S-16S.
25. Hooten, W. M., M. Karanikolas, et al. (2005). “Postoperative pain management following bilateral lung volume reduction surgery for severe emphysema.” Anaesth Intensive Care 33(5): 591-6.
26. Hotchkiss, R. S., S. B. Osmon, et al. (2005). “Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways.” J Immunol 174(8): 5110-8.
27. Hupfl, M., A. Duma, et al. (2005). “Over-the-head cardiopulmonary resuscitation improves efficacy in basic life support performed by professional medical personnel with a single rescuer: a simulation study.” Anesth Analg 101(1): 200-5, table of contents.
28. Jacobsohn, E., T. W. Lee, et al. (2005). “Low-dose intrathecal morphine does not delay early extubation after cardiac surgery.” Can J Anaesth 52(8): 848-57.
29. Jacobsohn, E., C. De Wet, et al. (2005). “Use of the Patient State Index (PSI) to assist in the diagnosis of perioperative neurological injury and brain death.” J Clin Monit Comput 19(3): 219-22.
30. Javadi, P., T. G. Buchman, et al. (2005). “Iron dysregulation combined with aging prevents sepsis-induced apoptosis.” J Surg Res 128(1): 37-44.
31. Kailasam, R., C. A. Palin, et al. (2005). “Atrial fibrillation after cardiac surgery: an evidence-based approach to prevention.” Semin Cardiothorac Vasc Anesth 9(1): 77-85.
32. Kharasch, E. D., A. Walker, et al. (2005). “Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.” J Clin Pharmacol 45(1): 79-88.
33. Kharasch, E. D., D. Whittington, et al. (2005). “Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.” Clin Pharmacokinet 44(7): 731-51.
34. Kharasch, E. D., A. Walker, et al. (2005). “Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.” J Clin Pharmacol 45(10): 1187-97.
35. Kharasch, E. D., K. E. Thummel, et al. (2005). “CYP3A Probes Can Quantitatively Predict the In Vivo Kinetics of Other CYP3A Substrates and Can Accurately Assess CYP3A Induction and Inhibition.” Mol Interv 5(3): 151-3.
36. Kharasch, E. D., J. L. Schroeder, et al. (2005). “Influence of sevoflurane on the metabolism and renal effects of compound A in rats.” Anesthesiology 103(6): 1183-8.
37. Klees, T. M., P. Sheffels, et al. (2005). “Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.” Anesthesiology 102(3): 550-6.
38. Klees, T. M., P. Sheffels, et al. (2005). “Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.” Drug Metab Dispos 33(3): 303-11.
39. Leone, M., A. Charvet, et al. (2005). “Terlipressin: a new therapeutic for calcium-channel blockers overdose.” J Crit Care 20(1): 114-115.
40. McDonald, S. B., M. Renna, et al. (2005). “Preoperative use of enoxaparin increases the risk of postoperative bleeding and re-exploration in cardiac surgery patients.” J Cardiothorac Vasc Anesth 19(1): 4-10.
41. McDonald, S. B., E. Jacobsohn, et al. (2005). “Parasternal block and local anesthetic infiltration with levobupivacaine after cardiac surgery with desflurane: the effect on postoperative pain, pulmonary function, and tracheal extubation times.” Anesth Analg 100(1): 25-32.
42. Milescu, L. S., G. Akk, et al. (2005). “Maximum likelihood estimation of ion channel kinetics from macroscopic currents.” Biophys J 88(4): 2494-515.
43. Murray, D. J., J. R. Boulet, et al. (2005). “A simulation-based acute skills performance assessment for anesthesia training.” Anesth Analg 101(4): 1127-34, table of contents.
44. Murray, D. (2005). “Clinical simulation: measuring the efficacy of training.” Curr Opin Anaesthesiol 18(6): 645-8.
45. Nagele, P., J. B. Mendel, et al. (2005). “Volatile Anesthetics Bind Rat Synaptic Snare Proteins.” Anesthesiology 103(4): 768-778.
46. Nast, P. A., M. Avidan, et al. (2005). “Reporting and classification of patient safety events in a cardiothoracic intensive care unit and cardiothoracic postoperative care unit.” J Thorac Cardiovasc Surg 130(4): 1137.
47. Schreiber, T. and W. Boyle (2005). “Lung injury caused by mechanical ventilation.” Contemporary Critical Care 3(6): 1-11.
48. Stanko, L. K., E. Jacobsohn, et al. (2005). “Transthoracic echocardiography: impact on diagnosis and management in tertiary care intensive care units.” Anaesth Intensive Care 33(4): 492-6.
49. Textoris, J., M. Leone, et al. (2005). “[Selective digestive decontamination: the light as changed from red to green].” Ann Fr Anesth Reanim 24(4): 366-76.
50. Willson, D. F., N. J. Thomas, et al. (2005). “Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial.” Jama 293(4): 470-6.
51. Yi, X., A. J. Cook, et al. (2005). “Cervicogenic headache in patients with presumed migraine: missed diagnosis or misdiagnosis?” J Pain 6(10): 700-3.
52. Zeng, X. H., X. M. Xia, et al. (2005). “Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.” J Gen Physiol 125(3): 273-86.
53. Zeng, C. M., B. D. Manion, et al. (2005). “Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.” J Med Chem 48(8): 3051-9.

Department Publications 2004

1. Adwanikar, H., F. Karim, et al. (2004). “Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation.” Pain 111(1-2): 125-35.
2. Akata, T., T. Kanna, et al. (2004). “Reliability of fingertip skin-surface temperature and its related thermal measures as indices of peripheral perfusion in the clinical setting of the operating theatre.” Anaesth Intensive Care 32(4): 519-29.
3. Akk, G., J. Bracamontes, et al. (2004). “Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital.” J Physiol 556(Pt 2): 387-99.
4. Akk, G., J. R. Bracamontes, et al. (2004). “Neuroactive steroids have multiple actions to potentiate GABAA receptors.” J Physiol 558(Pt 1): 59-74.
5. Altuntas, T. G., S. B. Park, et al. (2004). “Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).” Chem Res Toxicol 17(3): 435-45.
6. Amar, D., W. Shi, et al. (2004). “Clinical prediction rule for atrial fibrillation after coronary artery bypass grafting.” J Am Coll Cardiol 44(6): 1248-53.
7. Avidan, M. S., E. L. Alcock, et al. (2004). “Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery.” Br J Anaesth 92(2): 178-86.
8. Azpiazu, I. and N. Gautam (2004). “A fluorescence resonance energy transfer-based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell.” J Biol Chem 279(26): 27709-18.
9. Bhave, G. and R. W. t. Gereau (2004). “Posttranslational mechanisms of peripheral sensitization.” J Neurobiol 61(1): 88-106.
10. Bommhardt, U., K. C. Chang, et al. (2004). “Akt decreases lymphocyte apoptosis and improves survival in sepsis.” J Immunol 172(12): 7583-91.
11. Braun, E. B., C. A. Palin, et al. (2004). “Vasopressin during spinal anesthesia in a patient with primary pulmonary hypertension treated with intravenous epoprostenol.” Anesth Analg 99(1): 36-7.
12. Coopersmith, C. M., J. E. Zack, et al. (2004). “The impact of bedside behavior on catheter-related bacteremia in the intensive care unit.” Arch Surg 139(2): 131-6.
13. Crowder, C. M. (2004). “Ethanol targets: a BK channel cocktail in C. elegans.” Trends Neurosci 27(10): 579-82.
14. Dai, Y., K. Iwanaga, et al. (2004). “In vitro metabolism of cyclosporine A by human kidney CYP3A5.” Biochem Pharmacol 68(9): 1889-902.
15. Dale, O., P. Sheffels, et al. (2004). “Bioavailabilities of rectal and oral methadone in healthy subjects.” Br J Clin Pharmacol 58(2): 156-62.
16. Darbandi-Tonkabon, R., B. D. Manion, et al. (2004). “Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia.” J Pharmacol Exp Ther 308(2): 502-11.
17. De Wet, C. J., D. G. Affleck, et al. (2004). “Inhaled prostacyclin is safe, effective, and affordable in patients with pulmonary hypertension, right heart dysfunction, and refractory hypoxemia after cardiothoracic surgery.” J Thorac Cardiovasc Surg 127(4): 1058-67.
18. Ding, Y. Q., J. Yin, et al. (2004). “Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.” Development 131(15): 3693-703.
19. Efron, P. A., K. Tinsley, et al. (2004). “Increased lymphoid tissue apoptosis in baboons with bacteremic shock.” Shock 21(6): 566-71.
20. Fatheree, R. S. and B. L. Leighton (2004). “Acute respiratory distress syndrome after an exothermic Baralyme-sevoflurane reaction.” Anesthesiology 101(2): 531-3.
21. Hantler, C., G. J. Despotis, et al. (2004). “Guidelines and alternatives for neuraxial anesthesia and venous thromboembolism prophylaxis in major orthopedic surgery.” J Arthroplasty 19(8): 1004-16.
22. Hashiguchi, K., T. Morioka, et al. (2004). “[Postoperative transient hemiplegia after resection of the medial frontal tumor involving the supplementary motor area: report of two cases].” No Shinkei Geka 32(9): 947-53.
23. Hawasli, A. H., O. Saifee, et al. (2004). “Resistance to volatile anesthetics by mutations enhancing excitatory neurotransmitter release in Caenorhabditis elegans.” Genetics 168(2): 831-43.
24. Hill, L. L., D. L. Chen, et al. (2004). “Neutrophils and neutrophil products do not mediate pulmonary hemodynamic effects of endotoxin on oleic acid-induced lung injury.” Anesth Analg 98(2): 452-7, table of contents.
25. Hill, L. L., C. J. De Wet, et al. (2004). “Peripartum substitution of inhaled for intravenous prostacyclin in a patient with primary pulmonary hypertension.” Anesthesiology 100(6): 1603-5.
26. Hiltebrand, L. B., V. Krejci, et al. (2004). “Effects of dopamine, dobutamine, and dopexamine on microcirculatory blood flow in the gastrointestinal tract during sepsis and anesthesia.” Anesthesiology 100(5): 1188-97.
27. Hotchkiss, R. S. and I. E. Karl (2004). “Endothelial cell apoptosis in sepsis: a case of habeas corpus?” Crit Care Med 32(3): 901-2.
28. Javadi, P., T. G. Buchman, et al. (2004). “High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis.” Crit Care Med 32(5): 1178-85.
29. Kharasch, E. D. (2004). “Perioperative COX-2 inhibitors: knowledge and challenges.” Anesth Analg 98(1): 1-3.
30. Kharasch, E. D., C. Hoffer, et al. (2004). “The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.” Br J Clin Pharmacol 57(5): 600-10.
31. Kharasch, E. D., C. Hoffer, et al. (2004). “Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate.” Anesthesiology 101(3): 738-43.
32. Kharasch, E. D., C. Hoffer, et al. (2004). “Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.” Clin Pharmacol Ther 76(3): 250-69.
33. Kharasch, E. D., A. Walker, et al. (2004). “Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.” Clin Pharmacol Ther 76(5): 452-66.
34. Kharasch, E. D., D. Whittington, et al. (2004). “Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.” Anesthesiology 101(3): 729-37.
35. Leone, M., F. Garnier, et al. (2004). “Catheter-associated urinary tract infections in intensive care units.” Microbes Infect 6(11): 1026-32.
36. Leone, M., S. Rousseau, et al. (2004). “Target concentrations of remifentanil with propofol to blunt coughing during intubation, cuff inflation, and tracheal suctioning.” Br J Anaesth 93(5): 660-3.
37. Markovitz, B. P. (2004). “The wired pediatric intensive care unit today: what is your patient’s URL?” Pediatr Crit Care Med 5(5): 493-4.
38. Mennerick, S., Y. He, et al. (2004). “Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.” Mol Pharmacol 65(5): 1191-7.
39. Morioka, T., K. Hashiguchi, et al. (2004). “[Surgical treatment for temporal lobe epilepsy in patients over age 50 years].” No To Shinkei 56(4): 326-32.
40. Murray, D. J., J. R. Boulet, et al. (2004). “Acute care skills in anesthesia practice: a simulation-based resident performance assessment.” Anesthesiology 101(5): 1084-95.
41. Nagele, P., M. Hupfl, et al. (2004). “Epidemiology and outcome of pediatric trauma treated by an emergency-physician-staffed advanced life-support unit.” Wien Klin Wochenschr 116(11-12): 398-403.
42. Nagele, P., L. B. Metz, et al. (2004). “Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans.” Proc Natl Acad Sci U S A 101(23): 8791-6.
43. Ratnaraj, J., B. Kabon, et al. (2004). “Supplemental oxygen and carbon dioxide each increase subcutaneous and intestinal intramural oxygenation.” Anesth Analg 99(1): 207-11.
44. Ren, X. R., G. L. Ming, et al. (2004). “Focal adhesion kinase in netrin-1 signaling.” Nat Neurosci 7(11): 1204-12.
45. Rosemeier, F., J. B. Shumway, et al. (2004). “Successful pregnancy and cesarean delivery 22 years after separation in an ischiopagus tetrapus conjoined twin.” Anesthesiology 100(6): 1601-3.
46. Saleh, M., J. P. Vaillancourt, et al. (2004). “Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.” Nature 429(6987): 75-9.
47. Sheffels, P., J. L. Schroeder, et al. (2004). “Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.” Chem Res Toxicol 17(9): 1177-89.
48. Taguchi, A., J. Ratnaraj, et al. (2004). “Effects of a circulating-water garment and forced-air warming on body heat content and core temperature.” Anesthesiology 100(5): 1058-64.
49. Taylor, B. E., W. Y. Huey, et al. (2004). “Treatment of hypophosphatemia using a protocol based on patient weight and serum phosphorus level in a surgical intensive care unit.” J Am Coll Surg 198(2): 198-204.
50. Tempelhoff, R. (2004). “Ischemic optic neuropathy: “whodunit?”” Can J Anaesth 51(4): 286-9.
51. Turnbull, I. R., T. G. Buchman, et al. (2004). “Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium.” Shock 22(4): 364-8.
52. Turnbull, I. R., P. Javadi, et al. (2004). “Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels.” Shock 21(2): 121-5.
53. Whittington, D., P. Sheffels, et al. (2004). “Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.” J Chromatogr B Analyt Technol Biomed Life Sci 809(2): 313-21.
54. Wizorek, J. J., C. M. Coopersmith, et al. (2004). “Sequence makes a difference: paradoxical effects of stress in vivo.” Shock 22(3): 229-33.
55. Wu, X. S., J. Y. Sun, et al. (2004). “Isoflurane inhibits transmitter release and the presynaptic action potential.” Anesthesiology 100(3): 663-70.
56. Xia, X. M., X. Zhang, et al. (2004). “Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains.” J Neurosci 24(24): 5585-91.
57. Yang, D. and R. W. t. Gereau (2004). “Group II metabotropic glutamate receptors inhibit cAMP-dependent protein kinase-mediated enhancemednt of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons.” Neurosci Lett 357(3): 159-62.

Department Publications 2003

1. Akk, G. and J. H. Steinbach (2003). “Low doses of ethanol and a neuroactive steroid positively interact to modulate GABAA receptor function.” J Physiol 546: 641-646.
2. Akk, G. and J. H. Steinbach (2003). “Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium.” J Physiol 551: 155-168.
3. Akk, G. and J. H. Steinbach (2003). “Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function.” J Physiol 546(Pt 3): 641-6.
4. Albanese, J., M. Leone, et al. (2003). “Decompressive craniectomy for severe traumatic brain injury: Evaluation of the effects at one year.” Crit Care Med 31: 2535-2540.
5. Ali, S., B. D. Freeman, et al. (2003). “Abdominal compartment syndrome in a patient resulting from pneumothorax.” Intensive Care Med 29: 1614.
6. Ali, S. Z., A. Taguchi, et al. (2003). “Effect of supplemental pre-operative fluid on postoperative nausea and vomiting.” Anaesthesia 58: 780-784.
7. Altuntas, T. G., R. A. Zager, et al. (2003). “Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.” Toxicol Appl Pharmacol 193(1): 55-65.
8. Arkilic, C. F., A. Taguchi, et al. (2003). “Supplemental perioperative fluid administration increases tissue oxygen pressure.” Surgery 133(1): 49-55.
9. Avidan, M. S., A. Harvey, et al. (2003). Peri-operative Care, Anaesthesia, Pain Management and Intensive Care. London, Churchill-Livingstone.
10. Bhave, G., H. J. Hu, et al. (2003). “Protein kinase C sensitizes but does not activate the capsaicin receptor TRPV1.” Proc Natl Acad Sci 100(21): 12480-12485.
11. Bhave, G. and R. W. Gereau (2003). “Growing Pains: The cytoskeleton as a critical regulator of pain plasticity.” Neuron 39: 577-589.
12. Bhave, G., B. Nadin, et al. (2003). “Membrane topology of a metabotropic glutamate receptor.” J Biol Chem 278(32): 30294-30301.
13. Boulet, J. R., D. J. Murray, et al. (2003). “Reliability and validity of a simulation-based acute care skills assessment for medical students and residents.” Anesthesiology 99(6): 1270-1280.
14. Cassell, J., T. G. Buchman, et al. (2003). “Surgeons, intensivists and the covenant of care: administrative models and values affecting care at the end of life.” Crit Care Med 31(5): 1551-1559.
15. Cheng, M. A., S. G. Soriano, et al. (2003). “Society of the Neurosurigal Anesthesia and Critical Care (SNACC) Newsletter: Report of the 2002 annual meeting, Orlando, Florida.” J Neurosurg Anesthesiol 15: 165-167.
16. Cole, J. W., D. J. Murray, et al. (2003). “Aprotinin reduces blood loss during spinal surgery in children.” Spine 28(21): 2482-2485.
17. Cole, J. W., D. J. Murray, et al. (2003). “Aprotinin reduces blood loss during spinal surgery in children.” Spine 28(21): 2482-5.
18. Coopersmith, C. M., P. E. Stromberg, et al. (2003). “Sepsis from pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest.” Crit Care Med 31(6): 1630-1637.
19. Coopersmith, C. M., D. M. Amiot, et al. (2003). “Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from pseudomonas aeruginosa pneumonia.” Shock 19(5): 408-414.
20. Dalal, P., F. Reynolds, et al. (2003). “Assessing bupivacaine 10 mg/fentanyl 20 microg as an intrathecal test dose.” Int J Obstet Anesth 12(4): 250-5.
21. Darbandi-Tonkabon, R., W. R. Hastings, et al. (2003). “Photoaffinity labeling with a neuroactive steroid analogue: 6-azi-pregnanolone labels VDAC-1 in rat brain.” J Biol Chem 278: 13196-13206.
22. Delmas, A., M. Leone, et al. (2003). “Indications of vasopressin in the management of septic shock.” Ann Fr Anesth Reanim 22: 600-608.
23. Ding, Y. Q., J. Yin, et al. (2003). “Formation of whisker-related PrV-based lemnical pathway requires a paired homeodomain transcription factor, Drg11.” J Neurosci 23: 7246-7254.
24. Ding, Y. Q., U. Marklund, et al. (2003). “Lmx1b is essential for the development of serotonergic neurons.” Nat Neurosci 6: 933-938.
25. Edler, A. E., D. J. Murray, et al. (2003). “Blood loss during posterior spinal fusion surgery in patients with neuromuscular disease: Is there an increased risk?” Paediatr Anaesth 13: 818-822.
26. Emery, M. G., J. M. Fisher, et al. (2003). “CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.” Hepatology 38(2): 428-35.
27. Evers, A. S. (2003). “Recipient of the 2003 Award for Excellence in Research.” American Society of Anesthesiologists Newsletter 67(8): 19-20.
28. Evers, A. S. (2003). “Recipient of the 2003 Excellence in Research Award.” Anesthesiology 99(4): 777-778.
29. Evers, A. S. and D. D. Koblin (2003). Inhalational Anesthetics. Anesthetic Pharmacology: Physiologic Principals and Clincal Practice. A. S. Evers and M. Maze, Elsevier Science Co.: 369-393.
30. Evers, A. S. and M. Maze, Eds. (2003). Anesthetic Pharmacology: Physiologic Priniciples and Clinical Practice, Elsevier Science Co.
31. Faury, G., M. Pezet, et al. (2003). “Development adaptation of the mouse cardiovascular system to elastin haploinsufficiency.” J Clin Invest 112(9): 1419-1428.
32. Fitzgibbon, D., D. Morgan, et al. (2003). “Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients.” Pain 106(3): 309-15.
33. Freeman, B. D., B. A. Zehnbauer, et al. (2003). “A meta-analysis of controlled trials of anticoagulant therapies in patients with sepsis.” Shock 20(1): 5-9.
34. Gadalla, F., S. H. Lee, et al. (2003). “Injecting saline through the epidural needle decreases the I.V. epidural catheter placement rate during combined spinal-epidural labour analgesia.” Can J Anesth(50): 382-385.
35. Gautam, N. (2003). “A conformational switch regulates receptor-G protein interaction.” Structure (Camb) 11: 359-360.
36. Gottschalk, L. A., R. J. Bechtel, et al. (2003). “Computerized content analysis of conversational interactions.” Comput Inform Nurs 21(5): 249-258.
37. Grayson, M. H., R. S. Hotchkiss, et al. (2003). “Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.” Am J Physiol Heart Circ Physiol 284: H2213-H2226.
38. Halpern, S. H. and B. L. Leighton (2003). “Misconceptions about neuraxial analgesia.” Anesthesiol Clin North America 21: 59-70.
39. Hiltebrand, L., V. Krejci, et al. (2003). “Redistribution of microcirculatory blood flow within the intestinal wall during sepsis and general anesthesia.” Anesthesiology 98(3): 658-669.
40. Hiltebrand, L. B., V. Krejci, et al. (2003). “Redistribution of microcirculatory blood flow within the intestinal wall during sepsis and general anesthesia.” Anesthesiology 98(3): 658-69.
41. Hogue Jr, C. W., R. Lillie, et al. (2003). “Gender influence on cognitive function after cardiac surgery.” Ann Thorac Surg 76(4): 1119-1125.
42. Hogue Jr, C. W., C. J. deWet, et al. (2003). “The importance of prior stroke for the adjusted risk of neurologic injury after cardiac surgery for women and men.” Anesthesiology 98(4): 823-829.
43. Hotchkiss, R. S. and I. E. Karl (2003). “Advances in the pathophysiology and treatment of sepsis.” N Engl J Med 348: 138-150.
44. Hotchkiss, R. S., K. C. Chang, et al. (2003). “Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.” Proc Natl Acad Sci 100: 6724-6729.
45. Hotchkiss, R. S., K. W. Tinsley, et al. (2003). “Role of apoptotic cell death in sepsis.” Scand J Infect Dis 35: 1-8.
46. Hu, H. J., K. S. Glauner, et al. (2003). “ERK integrates PKA and PKC signaling in superficial dorsal horn neurons I: Modulation of a-type K+ currents.” J Neurophysiol 90: 1671-1679.
47. Hu, H. J. and R. W. Gereau (2003). “ERK integrates PKA and PKC signaling in superficial dorsal horns neurons II: Modulation of neuronal excitability.” J of Neurophysiol 90: 1680-1688.
48. Husain, K. D., P. E. Stromberg, et al. (2003). “Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival.” Shock 20(5): 437-443.
49. Husain, K. D. and C. M. Coopersmith (2003). “Role of intestinal epithelial apoptosis on survival.” Curr Opin Crit Care 9: 159-163.
50. Husain, K. D. and C. M. Coopersmith (2003). “Intestinal apoptosis in shock and sepsis.” Advances in Sepsis 3: 2-7.
51. Ibrahim, A. E., J. Feldman, et al. (2003). “Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.” Anesthesiology 98(4): 853-61.
52. Jones, S. B., C. W. Whitten, et al. (2003). “The influence of crystalloid and colloid replacement on hemodynamics and hemostasis during acute normovolemic hemodilution.” Anesth Analg 96: 363-368.
53. Karanikolas, M. and R. Swarm (2003). “Cancer pain management: Part II-anesthetic techniques.” Contemp Oncol 2(10): 1-8.
54. Kharasch, E. D., C. Hoffer, et al. (2003). “Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.” Clin Pharmacol Ther 74(6): 543-54.
55. Kharasch, E. D., C. Hoffer, et al. (2003). “Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.” Clin Pharmacol Ther 73(3): 199-208.
56. Krejci, V., L. B. Hiltebrand, et al. (2003). “Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock.” Crit Care Med 31(1): 203-10.
57. Lee, T. W., H. P. Grocott, et al. (2003). “High spinal anesthesia for cardiac surgery: Effects on beta-adrenergic receptors stress response and hemodynamics.” Anesthesiology 98(2): 499-510.
58. Leighton, B. L. (2003). “The impact of neuraxial analgesia on the progress and outcome of labor.” Techniques in Regional Anesthesia & Pain Management 7: 197-203.
59. Leone, M., J. Albanese, et al. (2003). “Pulmonary contusion in severe head trauma patients: Impact on gas exchange and outcome.” Chest 124: 2261-2266.
60. Leone, M., J. Albanese, et al. (2003). “Long-term epidemiological survey of candida species: Comparison of isolates found in intensive care unit and in conventional wards.” J Hosp Infect 55: 169-174.
61. Leone, M., J. Albanese, et al. (2003). “Long-term (6-year) effect of selective digestive decontamination on antimicrobial resistance in intensive care, multiple-trauma patients.” Crit Care Med 31: 2090-2095.
62. Leone, M., J. Albanese, et al. (2003). “Ceftriaxone (1 g intravenously) penetration into abdominal tissues when administered as antibiotic prophylaxis during nephrectomy.” J Chemother 15: 139-142.
63. Leone, M., J. Albanese, et al. (2003). “Risk factors of nosocomial catheter-associated urinary tract infection in a polyvalent intensive care unit.” Intensive Care Med 29: 1077-1080.
64. Leone, M., F. Garnier, et al. (2003). “Comparison of effectiveness of two urinary drainage systems in intensive care unit: A prospective, randomized clinical trial.” Intensive Care Med 29: 551-554.
65. Leone, M., A. Bourgoin, et al. (2003). “Empirical antimicrobial therapy of septic shock patients: Adequacy and impact on the outcome.” Crit Care Med 31: 462-467.
66. Leone, M., A. Bourgoin, et al. (2003). “Which therapeutic prospects in the septic syndrome?” Ann Fr Anesth Reanim 22: 798-808.
67. Leone, M., F. Garcin, et al. (2003). “Activiation of adhesion molecules in patients with septic shock.” Ann Fr Anesth Reanim 22: 721-729.
68. Liauw, J., G. D. Wang, et al. (2003). “NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice.” Sheng Li Xue Bao 55: 373-380.
69. Markovitz, B. P. (2003). “Pediatric Critical Care BP. Small trials and drug safety:  When will we learn?” Medicine 4(1): 129.
70. Markovitz, B. P. (2003). “What’s new about PubMed?” J Intensive Care Med 18: 286-287.
71. Markovitz, B. P. (2003). “What’s happening with open access journals?” J Intensive Care Med 18: 163.
72. Markovitz, B. P. (2003). “Small trials and drug safety:  When will we learn?” Pediatr Crit Care Med 4(1): 129.
73. Markovitz, B. P. (2003). “Continuous propofol infusion of 142 critically ill children.” Pediatrics 112: 146-161.
74. McIlroy, D. R. and E. D. Kharasch (2003). “Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia.” Anesth Analg 96(6): 1572-7, table of contents.
75. Mitchell, L. M. and B. L. Leighton (2003). “Warmed diluent speeds dantrolene reconstitution.” Can J Anesth 50(2): 127-130.
76. Moazami, N. and L. L. Hill (2003). “Case Report: Right ventricular dysfunction in patients with acute inferior MI: Role of RV mechanical support.” Thorac Cardiovasc Surg 51: 1-2.
77. Morioka, T., T. Kawamura, et al. (2003). “Temporal lobe epilepsy associated with cystic lesion in the temporal lobe and middle cranial fossa.” No to Shinkei. Brain and Nerve (Tokyo) 55(6): 511-516.
78. Nagele, P. (2003). “Misuse of standard error of the mean (SEM) when reporting variability of a sample. A critical evaluation of four anaesthesia journals.” Br J Anaesth 90(4): 514-6.
79. Neugebauer, V., W. Li, et al. (2003). “Synaptic plasticity in the amygdala in prolonged pain: Differential roles of mGluR1 and mGluR5.” J Neurosci 23: 52-63.
80. Panchal, S. and B. L. Leighton (2003). Pregnancy-Induced Hypertension. Yao and Artusio’s Anesthesiology Problem-Oriented Patient Management. S. Panchal and B. L. Leighton. Philadelphia, Lippincott, Williams & Wilkins: 807-825.
81. Paradiso, K. G. and J. H. Steinbach (2003). “Nicotine is highly effective at producing desensitization of alpha4beta2 neuronal nicotinic receptors.” J Physiol 553: 857-871.
82. Pleym, H., O. Spigset, et al. (2003). “Gender differences in drug effects: implications for anesthesiologists.” Acta Anaesthesiol Scand 47(3): 241-59.
83. Robinson, D. A. and M. Zhuo (2003). “Pharmacological interventions at the spinal cord.  Intrathecal injections.” Methods in Mol Med 84: 217-222.
84. Rosemeier, F., M. Avidan, et al. (2003). “Postoperative cognitive dysfunction: overinterpretation of data?” Anesthesiology 98: 1294.
85. Rossaint, R., M. Reyle-Hahn, et al. (2003). “Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery.” Anesthesiology 98(1): 6-13.
86. Schootman, M., T. G. Buchman, et al. (2003). “National estimates of hospitalization charges for the acute care of traumatic brain injuries.” Brain Inj 17(11): 983-990.
87. Schrock, C. R. and M. B. Jones (2003). “The dose of caudal epidural analgesia and duration of postoperative analgesia.” Paediatr Anaesth 13: 403-408.
88. Schrock, C. R. and B. J. Jones (2003). “Effect of volume of caudal anesthetic on duration of analgesia.” Paediatr Anaesth 13: 403-408.
89. Spracklin, D. K., M. E. Emery, et al. (2003). “Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.” Acta Anaesthesiol Scand 47(6): 765-70.
90. Stamenkovic, D., T. Randjelovic, et al. (2003). “[Mediastinitis caused by tonsillitis ].” Acta Chir Iugosl 50(2): 127-30.
91. Steinbach, J. H. and L. G. Wu (2003). Synaptic transmission at the neuromuscular junction. Anesthetic Pharmacology: Physiologic Principles and Clinical Practice. A. S. Evers and M. Maze, Harcourt Health Sciences.
92. Tao, Y. X., G. Rumbaugh, et al. (2003). “Impared NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein.” J Neurosci 23: 6703-6712.
93. Tempelhoff, R. (2003). “Should neuroanesthesia be regulated?” J Neurosurg Anesth 15: 333.
94. Tinsley, K. W., M. H. Grayson, et al. (2003). “Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells.” Eur J Immunol 171: 909-914.
95. Tsuneyoshi, I., D. Zhang, et al. (2003). “Ca2+- and myosin phosphorylation-independent relaxation by halothane in K+-depolarized rat mesenteric arteries.” Anesthesiology 99: 656-665.
96. Tsuneyoshi, I. and W. A. Boyle (2003). “Vasopressin: New uses for an old drug.” Contemp Crit Care 1(6): 1-12.
97. Turnbull, I. R., J. J. Wizorek, et al. (2003). “Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.” Shock 19(4): 310-313.
98. Upadhya, G. A., S. A. Topp, et al. (2003). “Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells.” Hepatology 37(2): 313-323.
99. Wang, H., E. Shimizu, et al. (2003). “Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain.” Proc Natl Acad Sci 100: 4287-4292.
100. Wei, F., X. M. Xia, et al. (2003). “Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: A microelectroporation study in adult rodents.” J Neurosci 23(23): 8402-8409.
101. Whittington, D. and E. D. Kharasch (2003). “Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spectrometry.” J Chromatogr B Analyt Technol Biomed Life Sci 796(1): 95-103.
102. Wizorek, J. J., I. R. Turnbull, et al. (2003). “Iron overload prior to cecal ligation and puncture increases mortality.” Shock 20(1): 52-55.
103. Xia, X. M., J. P. Ding, et al. (2003). “Inactivation of BK channels by the NH2  terminus of the beta2 auxiliary subunit:  An essential role of a terminal peptide segment of three hydrophobic residues.” J Gen Physiol 121(2): 125-148.
104. Yang, D. and R. W. Gereau (2003). “Peripheral group II mGluRs mediate endogenous anti-allodynia in inflammation.” Pain 106: 411-417.
105. Yao, C., K. L. Kunze, et al. (2003). “Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19.” Drug Metab Dispos 31(5): 565-71.
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107. Zeng, Z. H., X. M. Xia, et al. (2003). “Redox-sensitive extracellular gates to K+ permeation formed by auxiliary beta subunits of calcium-activated potassium channels.” Nat Struct Biol 10(6): 448-454.
108. Zhang, J. and J. H. Steinbach (2003). “Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates.” Brain Res 959: 98-102.
109. Zhuo, M. (2003). “Synaptic and molecular mechanisms of glutamatergic synapses in pain and memory.” Sheng Li Xue Bao 55: 1-8.
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Department Publications 2002

1. Akgoz, M., I. Azpiazu, et al. (2002). “Role of the G protein subunit in complex modulation of Phospholipase C-function.” Journal of Biological Chemistry 277(22): 19573-19578.
2. Akk, G. (2002). “Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the mouse muscle nicotinic acetylcholine receptor.” J Physiol 544: 695-705.
3. Akk, G. and J. H. Steinbach (2002). “Do barbiturates affect how GABA_A receptors open or how they close? In: Molecular and Basic Mechanisms of Anesthesia. B.W. Urban, M. Barann (Eds.).” Pabst Science Publishers, Lengerich: 143-150
4. Azpiazu, I. and N. Gautam (2002). “Role of G protein beta gamma complex in receptor-G protein interaction.” Methods Enzymol 344: 112-125
5. Azpiazu, I. and N. Gautam (2002). “Analysis of receptor interaction with the G protein betagamma complex.” Methods in Enzymol 344: 112-125
6. Bruemmer-Smith, S., M. S. Avidan, et al. (2002). “Glucose, insulin and potassium for heart protection during cardiac surgery.” British Journal of Anaesthesia 88: 489-495
7. Bui, J., G. J. Despotis, et al. (2002). “Fatal thrombosis immediately after administration of activated prothrombin complex concentrates in a patient on ECMO who had received activated recombinant Factor II.” J Thorac Cardiovasc Surg 124: 852-854
8. Cheng, M. A. and R. Tempelhoff (2002). “Postoperative visual loss, still no answers yet (letter).” Anesthesiology 96: 1531
9. Cheng, M. A. and R. Tempelhoff (2002). “Causes of elevated intraocular pressure during prone spine surgery: In reply (letter).” Anesthesiology 97: 760
10. Cobb, J. P., J. M. Laramie, et al. (2002). “Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays.” Critical Care Medicine 30(12): 2711-2721
11. Cole, J. W., D. J. Murray, et al. (2002). “Emergence Behavior Scores in Children: Midazolam Premedication Increases Emergence Agitation.” Paediatric Anaesthesia 12: 442-447
12. Coopersmith, C. M., T. L. Rebmann, et al. (2002). “Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit.” Critical Care Medicine 30: 59-64
13. Coopersmith, C. M., T. L. Rebmann, et al. (2002). “Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit.” Crit Care Med 30: 59-64
14. Coopersmith, C. M., P. E. Stromberg, et al. (2002). “Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis.” JAMA 287: 1716-1721
15. Coopersmith, C. M. (2002). “Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice.” Crit Care Med 30: 195-201
16. Ding, J. P. and C. J. Lingle (2002). “Steady-state and closed-state inactivation properties of inactivating BK channels.” Biophysical Journal 82: 2448-2465
17. Hamasaki, J., I. Tsuneyoshi, et al. (2002). “Dual alpha2-adrenergic agonist and alpha1-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries.” Anesth Analg 94: 1434-1440
18. Hill, L. L., C. J. De Wet, et al. (2002). “Management of atrial fibrillation after cardiac surgery-part II: prevention and treatment.” J Cardiothorac Vasc Anesth 16: 626
19. Hotchkiss, R. S., K. W. Tinsley, et al. (2002). “Depletion of dendritic cells, but not macrophages, in patients with sepsis.” J Immunol 168: 2493-2500
20. Hotchkiss, R. S., K. W. Tinsley, et al. (2002). “Endothelial cell apoptosis in sepsis.” Crit Care Med 30: S225-228
21. Huettner, J. E., G. A. Kerchner, et al. (2002). “Glutamate and the presynaptic control of spinal sensory transmission.” Neuroscientist. 8(2): 89-92
22. Jazaycri, A., D. N. Contreras, et al. (2002). “Diagnosis and management of abdominal pregnancy after transabdominal amino-infusion performed to evaluate elevated maternal serum alpha feto-protein.” Journal of Reproductive Medicine
23. Kerchner, G. A., T. J. Wilding, et al. (2002). “Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.” Journal of Neuroscience. 22(18): 8010-7
24. Kerchner, G. A. and M. Zhuo (2002). “Presynaptic suppression of dorsal horn inhibitory transmission by mu-opioid receptors.” Journal of Neurophysiology. 88(1): 520-2
25. Koster, A., G. J. Despotis, et al. (2002). “The Plasma Supplemented Modified ACT Provides Improved Monitoring of Heparinization during Cardiopulmonary Bypass.” Anesth Analg 95: 26-30
26. Lemmer, J. H. and G. J. Despotis (2002). “Antithrombin III concentrate to treat heparin-resistance in cardiac surgical patients.” Journal of Thorarcic and Cardiovascular Surgery 123: 217-7
27. Lemmer, J. H. and G. J. Despostis (2002). “Antithrombin III concentrate to treat heparin-resistance in cardiac surgical patients.” J Thorac Cardiovasc Surg 123: 213-217
28. Levy, J. H., G. J. Despotis, et al. (2002). “Recombinant Human Transgenic Antithrombin in Cardiac Surgery: A Dose-finding Study.” Anesthesiology 96: 1095-1102
29. Li, Y. C., J. Kong, et al. (2002). “1,25-dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system.” J. Clin. Invest 110: 229-238
30. Markovitz, B. P. (2002). “Does magnesium sulfate have a role in the management of pediatric status asthmaticus?” Archives of Diseases in Childhood 86: 381-382
31. Markovitz, B. P. (2002). “The Balkanization of Online Medical Literature, Part I: The Problem.” J Intensive Care Med 17: 199
32. Markovitz, B. P. (2002). “The Balkanization of Online Medical Literature, Part II: Attempted Solutions.” J Intensive Care Med 17: 260
33. Markovitz, B. P. and A. G. Randolph (2002). “Corticosteroids for the Prevention of Reintubation and Post-extubation Stridor in Pediatric Patients: A Meta-Analysis.” Pediatric Critical Care Medicine 3: 223-226
34. McDonald, S., R. Saleem, et al. (2002). “Excessive blood loss after hirudin anticoagulation for cardiac surgery.” Anesthesiology 97: 509-512
35. Murray, D. J., J. Boulet, et al. (2002). “An Acute Care Skills Evaluation for Graduating Medical Students: A Pilot Study Using Clinical Simulation.” Med Educ 36(9): 833-841
36. Murray, D. J., J. W. Cole, et al. (2002). “Sevoflurane versus Halothane: Effect of Oxycodone Premedication on Emergence Behavior in Children.” Paediatric Anaesthesia 12: 308-312
37. Murray, D. J., J. Boulet, et al. (2002). “An Acute Care Skills Evaluation for Graduating Medical Students: A Pilot Using Clinical Simulation.” Medical Education 36: 833-841
38. Owens, W. D. (2002). “Anesthesia Foundation Receives Bequest From Dorothy Thompson Larson, M.D.” ASA Newsletter 66(8): 19
39. Ratnaraj, J., A. Todorov, et al. (2002). “The effects of decreasing endotracheal tube cuff pressures during neck retraction for cervical spine surgery.” J Neurosurg Spine 97: 176-179
40. Ratnaraj, J., A. Todorov, et al. (2002). “Effects of decreasing endotracheal tube cuff pressures during neck retraction for anterior cervical spine surgery.” J Neurosurg 97 (2 Suppl): 176-179
41. Robinson, D. A., F. Wei, et al. (2002). “Oxytocin mediates stress-induced analgesia.” Journal of Physiology 540: 593-606
42. Rosemeier, F. and L. Bottros (2002). “Combined Spinal Epidural Anesthesia for Cesarean Section in a Pregnant Separated Conjoined Twin: Case Report at the MARC.” Anesthesiology
43. Scott, B. A., M. S. Avidan, et al. (2002). “Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.” Science 296(5577): 2388-2391
44. Seegers, H., R. W. Gross, et al. (2002). “Calcium-independent phospholipase A2-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine.” J Pharmacol Exp Ther 302: 918-923
45. Taguchi, A., N. Sharma, et al. (2002). “Auricular Acupuncture to Reduce Anesthesia Requirement.” Anaesthesia 57(12): 1156-1163
46. Van Swinderen, B., L. B. Metz, et al. (2002). “A C. elegans pheromone antagonizes volatile anesthetic action through a Go-coupled pathway.” Genetics 161: 109-119
47. Wang, Y. W., J. P. Ding, et al. (2002). “Consequences of the stoichiometry of Slo1 α and auxiliary β subunits on functional properties of BK-type Ca²⁺ -activated K⁺channels.” Journal of Neuroscience 22: 1550-1561
48. Wang, G. D. and M. Zhuo (2002). “Synergistic enhancement of glutamate-mediated responses by serotonin and forskolin in adult mouse spinal dorsal horn neurons.” Journal of Neurophysiology 87: 732-739
49. Wang, Y. W., J. P. Ding, et al. (2002). “Consequences of the stoichiometry of Slo1 (alpha) and auxiliary (beta) subunits on functional properties of BK-type Ca2+-activated K+ channels.” The Journal of Neuroscience 22(5): 1550-1561
50. Wei, F., C. S. Qiu, et al. (2002). “Calcium calmodulin-dependent protein kinase IV is required for fear memory.” Nature Neuroscience. 5(6): 573-9
51. Wei, F., S. J. Kim, et al. (2002). “Elimination of inflammation related allodynia but not acute pain in mice lacking calmodulin stimulated adenylyl cyclases.” Neuron 36: 713-726
52. Xia, X. M., X. H. Zeng, et al. (2002). “Multiple regulatory sites in large-conductance calcium-activated potassium channels.” Nature 418(6900): 880-884
53. Xia, X. M., X. H. Zeng, et al. (2002). “Multiple regulatory sites in large-conductance calcium-activated potassium channels.” Nature 418: 880-884
54. Yu, F., Z. Guan, et al. (2002). “Further identification of NSF* as an epilepsy related gene.” Brain Research. Molecular Brain Research. 99(2): 141-4
55. Zhuo, M. and G. F. Gebhart (2002). “Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat.” Gastroenterology 122: 1007-1019
56. Zhuo, M., J. N. Sengupta, et al. (2002). “Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat.” Journal of Neurophysiology 87: 2225-2236
57. Zhuo, M. and G. F. Gebhart (2002). “Biphasic modulation of a visceral nociceptive reflex from the rostroventral medial medulla in the rat.” Gastroenterology 122: 1007-1019
58. Zou, W., J. Zeng, et al. (2002). “Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells.” Journal of Neuroscience Research. 67(6): 837-43.

Department Publications 2001

1. Akk, G. (2001). “Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the aY93 and aW149 residues.” Journal of Physiology 535: 729-740.
2. Akk, G., J. Bracamontes, et al. (2001). “Pregnenolone sulfate block of GABAA receptors: mechanism and involvement of a residue in the M2 regions of the a subunit.” Journal of Physiology 532: 673-684.
3. Apostolidou, I., N. Skubas, et al. (2001). “Occurrence of myocardial ischemia immediately following coronary revascularization using radial arterial conduit.” Journal of Cardiothoracic and Vascular Anesthesia 15: 433-438.
4. Avidan, M. S., N. Meehan, et al. (2001). “Changes in brain natriuretic peptide concentrations following open cardiac surgery with cardioplegic cardiac arrest.” Clinica Chimica Acta 303: 127-32.
5. Azpiazu, I. and N. Gautam (2001). “G protein Gamma subunit interaction with a receptor regulates receptor stimulated nucleotide exchange.” Journal of Biological Chemistry 276(45): 41742-41747.
6. Browne, S. H., J. Kang, et al. (2001). “Kinetic and pharmacological properties of GABAA receptors in single thalamic neurons and GABAA subunit expression.” Journal of Neurophysiology 86: 2312-2322.
7. Bruemmer-Smith, S., F. Stueber, et al. (2001). “Protective Functions of Intracellular Heat-Shock-Proteins (HSP) 70- expression in Patients with Severe Sepsis, review article.” Intensive Care Medicine 27: 1835-1841.
8. Chang-Fogg, V., I. Azpiazu, et al. (2001). “Roll of the gamma subunit prenyl moiety in G-protein betagamma complex interaction with phospholipase C-beta.” Journal of Biological Chemistry 276(45): 41797-41802.
9. Chen, Z. F., S. Rebelo, et al. (2001). “The paired homeodomain protein DRG11 controls the projection of nociceptive sensory afferent fibers to the dorsal spinal cord.” Neuron 31: 59-79.
10. Cheng, M. A., A. Todorov, et al. (2001). “The effect of prone positioning on intraocular pressure in anesthetized patients.” Anesthesiology 95: 1351-1355.
11. Cheng, D., M. F. Newman, et al. (2001). “The efficacy and resource utilization of remifentanil and fentanyl in fast-track coronary artery bypass graft surgery: a prospective randomized, double-blinded controlled, multi-center trial.” Anesthesia Analog 92: 1094-1102.
12. Cobb, J. P., B. H. Brownstein, et al. (2001). “Injury in the era of genomics.” Shock 15: 165-170.
13. Cobb, J. P., B. H. Brownstein, et al. (2001). “Injury in the era of genomics.” Shock 15: 165-170. Crowder, C. M., E. J. Westover, et al. (2001). Enantiospecificity of cholesterol function in vivo.
14. Crowder, C. M. and A. Evers (2001). General anesthetics. The Pharmacological Basis of Therapeutics, 10th Edition. J. Hardman and L. Limbird. New York, McGraw-Hill Companies, Inc.: 337-365.
15. Cullen, D., C. D. Morris, et al. (2001). “Warfarin therapy does not increase bleeding in patients undergoing heart transplantation.” Ann Thorac Surg 72: 714-718.
16. Davila-Roman, V. and C. W. Hogue Jr (2001). “Safety and efficacy of intraarterial thrombolysis for perioperative stroke after cardiac operation. Editorial.” Ann Thorac Surg 72: 1938-9.
17. Despostis, G. J. and C. W. Hogue Jr (2001). “Mechanisms and Attenuation of Hemostatic Activation During Extracorporeal Circulation.” Ann Thorac Surg 72: S1821-S1831.
18. Despotis, G. J. and C. W. Hogue Jr (2001). “Mechanisms and attenuation of hemostatic activation during extracorporeal circulation.” Ann Thorac Surg 72: S1821-31.
19. Despotis, G. J., R. Saleem, et al. (2001). “The relationship between hirudin and plasma-modified ACT: implications for patients with heparin induced thrombocytopenia undergoing cardiac surgery.” Anesthesia Analog 93: 28-32.
20. Evers, A. S. (2001). Cellular and molecular mechanisms of anesthesia. Clinical Anesthesia. P. G. Barash, B. F. Cullen and R. K. Stoelting. Philadelphia, PA, Lippincott Raven. 7: 46-53.
21. Foster, K., G. J. Despotis, et al. (2001). “Point-of-care testing: cost issues and impact on hospital operations.” Clinicals in Laboratory Medicine 21: 269-84.
22. Freeman, B. D., K. Isabella, et al. (2001). “A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients.” Critical Care Medicine 29: 926-930.
23. Gaut, J. P., G. C. Yeh, et al. (2001). “Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.” Proc Natl Acad Sci USA 98: 11961-11966.
24. Gaut, J. P., G. C. Yeh, et al. (2001). “Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.” PNAS 98: 11961-11966.
25. Goodnough, L. R. and G. J. Despotis (2001). “Transfusion Medicine: Support of patients undergoing cardiac surgery.” Am J Cardiovasc Drugs 1: 337-351.
26. Grayson, M. H., D. D. Chaplin, et al. (2001). “Fluorescent intravital microscopy of the murinespleen.” J Immunol Methods 256: 55-63.
27. Grayson, M. H., D. D. Chaplin, et al. (2001). “Fluorescent intravital microscopy of the murinespleen.” J Immunol Methods 256: 55-63.
28. Heerdt, P., G. A. Blessios, et al. (2001). “Flow dependency of error in thermodilution measurement of cardiac output during acute tricuspid regurgitation.” J Cardiothorac Vasc Anesth 15: 183-7.
29. Hill, L. L., M. Kattapuram, et al. (2001). “Management of atrial fibrillation after cardiac surgery: Part I. Pathophysiology and risk factors.” J Thorac Cardiovasc Anesth.
30. Hogue Jr, C. W., B. Barzilai, et al. (2001). “Sex differences in neurologic outcomes and mortality after cardiac surgery: a society of thoracic surgery national database report.” Circulation 103: 2133-7.
31. Hogue Jr, C. W., T. M. Sundt III, et al. (2001). “Cardiac and neurologic complications identifyrisk for mortality for both men and women undergoing coronary artery bypass graft surgery.” Anesthesiology 95: 1074-8.
32. Hotchkiss, R. S., K. W. Tinsley, et al. (2001). “Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans.” Journal of Immunology 166: 6952-6963.
33. Hotchkiss, R. S. and I. E. Karl (2001). “The Fas death pathway as a mechanism of multiple organ dysfunction syndrome: not so fast.” Crit Care Med 29: 901-902 (Editorial Comment).
34. Hotchkiss, R. S. and I. E. Karl (2001). “Cytokine blockade in sepsis–Are two better than one?” Crit Care Med 29: 671-672 (Editorial Comment).
35. Hotchkiss, R. S., W. M. Dunne, et al. (2001). “Lymphocyte but not Bronchial Epithelial Apoptosis.” Science 294: 1783.
36. Hotchkiss, R. S., W. M. Dunne, et al. (2001). “Lymphocyte but not Bronchial Epithelial Apoptosis.” Science 294: 1783a-1783b.
37. Hou, Y., V. Chang, et al. (2001). “G protein b subunit types different interact with a muscarinic receptor, but not adenylyl cyclase type II or phospholipase C-b2/3.” Biol Chem 276: 19982-19988.
38. Howie, M., D. Cheng, et al. (2001). “A randomized double-blind multicenter comparison of remifentanil versus fentanyl with isoflurane/propofol for early extubation after CABG surgery.” Anesthesia Analog 92: 1084-93.
39. Huang, J., A. Taguchi, et al. (2001). “Preoperative Oral Rofecoxib Does Not Decrease Postoperative Pain or Morphine Consumption in Patients after Radical Prostatectomy.” J Clin Anesth 13(2): 94-97.
40. Jellish, W. S., M. A. Theard, et al. (2001). “The effects of clonidine premedication and scalp infiltration of lidocaine on hemodynamic responses to laryngoscopy and skull pin head -holder insertion during skull base procedures.” Skull Base 11(3): 169-76.
41. Jellish, W. S., M. A. Theard, et al. (2001). “The effects of clonidine premedication and scalp infiltration of lidocaine on hemodynamic responses to laryngoscopy and skull pin head-holder insertion during skull base procedures.” Skull Base 11: 169-76.
42. Kalauokalani, D. A., K. J. Sherman, et al. (2001). “Acupuncture for chronic low back pain: Diagnosis and treatment patterns among acupuncturists evaluating the same patient.” Southern Medical Journal 94: 486-492.
43. Kalauokalani, D. A., D. C. Cherkin, et al. (2001). “Lessons from a trial of acupuncture and massage for low back pain: Patient expectations and treatment effects.” Spine 26: 1418-1424.
44. Kerchner, G. A., T. J. Wilding, et al. (2001). “Presynaptic kainate receptors regulate spinal sensory transmission.” Journal of Neuroscience 21: 59-66.
45. Kerchner, G. A., F. Wei, et al. (2001). “DO ‘smart’ mice feel more pain, or are they just better learners?” Nature Neuroscience 4: 453-454.
46. Kerchner, G. A., G. D. Wang, et al. (2001). “Direct presynaptic regulation of GABA/Glycine release by kainate receptors in the dorsal horn: an inotropic mechanism.” Neuron 32: 477-488.
47. Labarca, C., J. Schwarz, et al. (2001). “Point mutant mice with hypersensitive [a] 4 nicotinic receptors show dopaminergic deficits and increased anxiety.” Proceedings of the National Academy of Sciences of the United States of America 98: 2786-2791.
48. Li, P. and M. Zhuo (2001). “Cholinergic, noradrenergic and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat.” Brain Research Bulletin 54: 639-647.
49. Li, P. and M. Zhuo (2001). “Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.” Brain Research Bulletin 55: 521-531.
50. Lingle, C., X. H. Zeng, et al. (2001). “Inactivation of BK channels mediated by the N-terminus of the b3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.” Journal of General Physiology 117: 583-606.
51. Markovitz, B. (2001). “Intensive care on the Web: Evidence-based medicine resources.” J of Intensive Care Med 16: 200.
52. Markovitz, B. (2001). “Intensive care on the Web: Bioethics resources.” J of Intensive Care Med 16: 246.
53. Markovitz, B. (2001). “Intensive care resources on the web: let’s play doctor!” J of Intensive Care Med 16: 100-101.
54. Murray, D. J. (2001). “The efficacy of antifibrinolytics in the reduction of blood loss during complex adult reconstructive spinal surgery (point of view).” SPINE 26: 1156-1157.
55. Murray, D. J. and J. McAllister (2001). “Foreign body aspiration: A presenting sign of juvenile myasthenia gravis.” Anesthesiology 95: 555-557.
56. Owens, W. D. (2001). “American Society of Anesthesiologists physical status classificationsystem is not a risk classification system.” Anesthesiology 94: 378.
57. Paradiso, K., J. Zhang, et al. (2001). “The terminus of the human nicotinic a4b2 receptor forms a binding site required for potentiation by an estrogenic steroid.” Journal of Neuroscience 21: 6564-6568.
58. Renna, M., J. Handy, et al. (2001). “Does Dementia affect the Bispectral Index?” Anesthesiology 95: A286.
59. Skubas, N., B. Barzilai, et al. (2001). “Atrial fibrillation after CABG surgery is unrelated to cardiac abnormalities detected by transesophageal echocardiography.” Anes Analg 93: 14-9.
60. Steinbach, J. H. and G. Akk (2001). “Modulation of GABAA receptor channel gating by pentobarbital.” Journal of Physiology 537: 715-733.
61. Sun, Q. Q., G. Akk, et al. (2001). “Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons.” Journal of Physiology 531: 81-94.
62. Sun, J. Y. and L. G. Wu (2001). “Fast kinetics of exocytosis revealed by simultaneous measurements of presynaptic capacitance and postsynaptic currents at a central synapse.” Neuron 30: 171-182.
63. Swarm, R., M. Karanikolas, et al. (2001). “Pain management in the perioperative period.” Current Problems in Surgery.
64. Taguchi, A., C. Arkilic, et al. (2001). “The efficacy of vital heat warming in post-anesthetic volunteers.” Anesthesia and Analgesia 92: 261-266.
65. Taguchi, A., N. Sharma, et al. (2001). “Selective Postoperative Inhibition of Gastrointestinal Opioid Receptors.” NEJM 345(13): 935-940.
66. Taguchi, A., C. F. Arkilic, et al. (2001). “Negative Pressure Rewarming vs. Forced Air Warming in Hypothermic Postanesthetic Volunteers.” Anesth Analg 92: 261-266.
67. Tsuneyoshi, I., H. Yamada, et al. (2001). “Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock.” Critical Care Medicine 29: 487-493.
68. Van Swinderen, B., L. Shebester, et al. (2001). “Gao regulates of volatile anesthetic action in Caenorhabditis. elegans.” Genetics 158: 643-55.
69. Wei, F., G. D. Wang, et al. (2001). “Genetic enhancement of inflammatory pain by forebrain NR2B over expression.” Nature Neuroscience 4: 164-169.
70. Wei, A. and M. Zhuo (2001). “Potentiation of synaptic responses in the anterior cingulate cortex following digital amputation in rat.” Journal of Physiology 532: 823-833.
71. Weigle, C. G. M., B. Markovitz, et al. (2001). “The internet, the electronic medical record, the pediatric intensive care unit, and everything.” Critical Care Medicine 29: [suppl]:N166-N176.
72. Wu, X. and L. G. Wu (2001). “Activation of protein kinase C enhances the release probability of the release machinery downstream of the binding between Ca2+ and its sensor.” Journal of Neuroscience 21: 7928-7936.
73. Zeng, X. H., J. P. Ding, et al. (2001). “Gating properties conferred on BK channels by the b3b auxiliary subunit in the absence of its N- and C-termini.” Journal of General Physiology 117: 607-628.
74. Zhang, X., C. R. Solaro, et al. (2001). “Allosteric regulation of BK channel gating by Ca2+ and Mg2+ through a nonselective, low affinity divalent cation site.” Journal of General Physiology 118: 607-635.
75. Zhuo, M. (2001). “No pain, no gains.” The Scientific World: 204-206.

Department Publications 2000

1. Akk, G. and J. H. Steinbach (2000). “Activation and block of recombinant GABA(A) receptors by pentobarbital: a single-channel study.” British Journal of Pharmacology 130: 249-258
2. Akk, G. and J. H. Steinbach (2000). “Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision.” Journal of Physiology 527: 405-417
3. Arkilic, C. F., O. Akca, et al. (2000). “Temperature monitoring and management during neuraxial anesthesia.” Anesthesia and Analgesia 91: 662-666
4. Avidan, M. S., N. Jones, et al. (2000). “The implications of HIV for the anesthetist and the intensivist.” Anaesthesia 55: 344-354
5. Avidan, M. S., A. Harvey, et al. (2000). “Tracheal intubation via the intubating laryngeal mask by inexperienced personnel.” British Journal of Anaesthesia 84: 538-539
6. Banoub, M., U. Rao, et al. (2000). “Recurrent postoperative stridor requiring tracheostomy in a patient with spas dysphonia.” Anesthesiology 92: 893-895
7. Boyle, W. A., L. S. Parvathaneni, et al. (2000). “INOS gene deficiency modulates mesenteric microvascular responsiveness in mice challenged with endotoxin.” Circulation Research 87: 18-24
8. Calejesan, A. A., S. J. Kim, et al. (2000). “Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex.” European Journal of Pain 4: 83-96
9. Chen, Z. F., T. Guenther, et al. (2000). “Genetic ablation of parathyroid glands by targeted mutation of Glial cells missing2 reveals an auxiliary source of parathyroid hormone secretion.” Nature 406: 199-203
10. Cheng, M. A., W. Sigurdson, et al. (2000). “Visual loss following spine surgery: a survey.” Neurosurgery 46: 625-631
11. Cheung, A. T. and C. W. Hogue, Jr. (2000). “Dysphagia after cardiac surgery: How safe is TEE?” Annals of Thoracic Surgery 69: 486-490
12. Choyce, A., M. S. Avidan, et al. (2000). “Comparison of laryngeal mask and intubating laryngeal mask insertion by the naive intubator.” British Journal of Anaesthesia 84: 103-105
13. Covey, D. F., D. Nathan, et al. (2000). “Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid A receptor modulation and anesthesia.” Journal of Pharmacology and Experimental Therapeutics 293: 1009-1016
14. Covey, D. F., M. Han, et al. (2000). “Neurosterroid Analogues. 8. Structure-activity studies of N-acylated 17a-Aza-D-homosteroid analogues of the anesthetic steroids (3alpha5alpha)- and (3alpha,5beta)-3- hydroxypregnan-20-one.” Journal of Medicinal Chemistry 43: 3201-3204
15. Despotis, G. J., R. Saleem, et al. (2000). “Clinical evaluation of a new, point-of-care hemocytometer.” Critical Care Medicine 28: 1185-1190
16. Despotis, G. J., L. T. Goodnough, et al. (2000). “Management approaches to platelet-related, microvascular bleeding in cardiothorcic surgery.” Annals of Thoracic Surgery 70: S20-S32
17. DiCarlo, J. V., X. Pastor, et al. (2000). “The shadow URL: Standardizing citations for electronically published materials.” Journal of the American Medical Informatics Association 7: 149-151
18. Evers, A. S., D. F. Covey, et al. (2000). “Enantioselectivity of steroid anesthetic action.” Progress in Anesthetic Mechanism 6: 372-381
19. Fehr, J. J., C. A. Hirshman, et al. (2000). “Cellular signaling by the potent bronchoconstrictor endothelin-1 in airway smoth muscle.” Critical Care Medicine 28: 1884-1888
20. Feng, J., Z. Yan, et al. (2000). “Regulation of the formation and function of dendritic spines by spinophilin.” Proceedings of the National Academy of Sciences of the United States of America 16: 9287-9292
21. Freeman, B. D., A. G. Reaume, et al. (2000). “The role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis.” Critical Care Medicine 28: 1701-1708
22. Goodnough, L. R., G. J. Despotis, et al. (2000). “A randomized trial of acute normovolemic hemodilution compared to preoperative autologous blood donation in total hip arthroplasty.” Transfusion 40: 1054-57
23. Greif, R., O. Akca, et al. (2000). “Supplemental perioperative oxygen to reduce the incidence of surgical wound infection.” New England Journal of Medicine 342: 161-167
24. Groves, P. and M. S. Avidan (2000). The parturient with co-existing disease. Anaesthesia for Obstetric and Gynaecology: 201-238
25. Hill, L. L. and R. G. Pearl (2000). Pain/sedation management in the ICU. Perioperative Pain Management and Regional Anesthesia for the Trauma Patient. W. Saunders Ho, N., J. A. Liauw, et al. (2000). “Impaired synaptic plasticity and CREB activation in CaMKIV/Gr-deficient mice.” Journal of Neuroscience 20: 6459-6472
26. Hogue, C. W., Jr. and M. L. Hyder (2000). “Atrial fibrillation after cardiac surgery: risks, mechanisms and prophylaxis.” Annals of Thoracic Surgery 69: 300-306
27. Hogue, C. W., Jr., K. S. Filos, et al. (2000). “Sinus nodal function and risk for atrials fibrillation risk after coronary artery bypass graft surgery.” Anesthesiology 92: 1286-1292
28. Hotchkiss, R. S., K. W. Tinsley, et al. (2000). “p53-dependent and -independent pathways of apoptotic cell death in sepsis.” Journal of Immunology 164: 3675-3680
29. Hotchkiss, R. S., K. C. Chang, et al. (2000). “Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte.” Nature Immunology 1: 496-501
30. Hotchkiss, R., R. E. Schmieg Jr, et al. (2000). “Rapid onset of intestinal epithelial and lymphoccyte apoptotic cell death in patients with trauma and shock.” Critical Care Medicine 28: 3207-3217
31. Hou, Y., I. Azpiazu, et al. (2000). “Selective role of G protein gamma subunits in receptor interaction.” Journal of Biological Chemistry 275: 38961-38964
32. Jacob, A. K., R. S. Hotchkiss, et al. (2000). “Injection of iron compounds followed by induction of the stress response causes tissue injury and apoptosis.” Shock 14: 460-464
33. Karanikolas, M. and R. Swarm (2000). “Current trends in perioperative pain management.” Anesthesiology Clinics of North America 18: 575-599
34. Lenhardt, R., H. W. Hopf, et al. (2000). “Perioperative collagen deposition in elderly and young men and women.” Archives of Surgery 134: 71-74
35. Lincoff, M. A., G. J. Despotis, et al. (2000). “Perioperative hemorrhage and complications are not increased by abciximab among patients who require emergency coronary artery bypass grafting: Results from the EPILOG and EPISTENT randomized trials.” Annals of Thoracic Surgery 70: 516-526
36. Loeser, J. D. and D. A. Kalauokalani (2000). Regional Pains. Bonica’s Management of Pain. J. D. Loeser, S. H. Butler, C. R. Chapman and D. C. Turk. Philadelphia, PA, Lippincott Williams & Wilkins: 825-830
37. Macaulay, B. D., M. Barton, et al. (2000). “Prehydration and combined spinal epidural labor analgesia.” Anesthesiology Markovitz, B. P. (2000). “Biomedicine on the Net: Where to start?” Journal of Intensive Care Medicine 15: 59
38. Markovitz, B. P. (2000). “Biomedicine’s electronic publishing paradigm shift: copyright policy and PubMed Central.” Journal of the American Medical Informatics Association 7: 222-229
39. Markovitz, B. P. (2000). “Who’s journal is it anyway? A new journal, a new paradigm?” Pediatric Critical Care Medicine 1: 186-187
40. Markovitz, B. P. (2000). “Intensive care resources on the Web: version 1.0.” Journal of Intensive Care Medicine 15: 270
41. Markovitz, B. P. (2000). “Intensive care resources on the Web: Interactive tools.” Journal of Intensive Care Medicine 15: 333
42. Markovitz, B. P. (2000). “Complex ethical issues in transplantation.” Pediatric Pulmonology S20: 169-170
43. Markovitz, B. P. (2000). “Intensive care resources on the Web: Let’s play doctor!” Journal of Intensive Care Medicine 16: 100-101
44. Nagamine, J., L. L. Hill, et al. (2000). “Combined therapy with zaprinast and inhaled nitric oxide abolishes hypoxic pulmonary hypertension.” Critical Care Medicine 28: 2420-2424
45. Norris, M. C. (2000). “Are combined spinal-epidural catheters reliable?” International Journal of Obstetrics Anesthesia 9: 3-6
46. Paradiso, K., K. Sabey, et al. (2000). “Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells.” Molecular Pharmacology 58: 341-351
47. Plattner, O., O. Akca, et al. (2000). “The influence of two surgical bandage systems on wound tissue oxygen tension.” Archives of Surgery 135: 818-822
48. Prakriya, M. and C. J. Lingle (2000). “Activation of BK channels in rat chromaffin cells requires summation of Ca2+ influx from multiple Ca2+ channels.” Journal of Neurophysiology 84: 1123-1135
49. Rauh, M. J., A. J. Margheritz, et al. (2000). “High school cross country running injuries: A longitudinal study.” Clinical Journal of Sport Medicine 10: 110-116
50. Saleem, R., M. Bigham, et al. (2000). “The effect of epsilon-aminocaproic acid on hemoSTATUS and kaolin activated clotting time measurements.” Anesthesia and Analgesia 90: 1281-1285
51. Schaefer, M. L., S. T. Wong, et al. (2000). “Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.” Journal of Neuroscience 20: 4809-4820
52. Schmieg Jr, R. E., K. W. Tinsley, et al. (2000). “Rapid onset of hepatocyte apoptosis in a patient with trauma.” Journal of Trauma 49: 542-546
53. Serafini, R., J. Bracamontes, et al. (2000). “Structural domains of the GABA(A) beta3 subunit involved in the actions of pentobarbital.” Journal of Physiology 524: 649-676
54. Siddiqui, A. U., T. G. Buchman, et al. (2000). “Pulmonary embolism as a consequence of applying sequential compression device on legs in patient asymptomatic of deep vein thrombosis.” Anesthesiology 92: 880-882
55. Steinbach, J. H., J. Bracamontes, et al. (2000). “Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane spanning region.” Molecular Pharmacology 58: 11-17
56. Steinbach, J. H. (2000). “How to force conformity on transmitter-gated channels.” Journal of General Physiology 116: 445-448
57. Tinsley, K. W., S. L. Cheng, et al. (2000). “Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis.” Shock 13: 1-7
58. Todorovic, S. M., E. Perez-Reyes, et al. (2000). “Anticonvulsants, but not general anestshetics, have differential blocking effects on different T-type current variants.” Molecular Pharmacology 58: 98-108
59. Tong, G. L., G. S. Varner, et al. (2000). “Measurement of the total cross section for hadronic production by e(+)e(-) annihilation at energies between 2.6-5 GeV.” Physiological Review Letters 84: 594-597
60. van Swinderen, B., D. F. Lemmel, et al. (2000). “Genes regulating neurotransmitter release control volatile anesthetic sensitivity in C. elegans.” Progress in Anesthetic Mechanism 6: 330-342
61. Wei, F., Z. C. Xu, et al. (2000). “Role of Egr1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation.” Journal of Cell Biology 149: 1325-1333
62. Wei, F., G. D. Wang, et al. (2000). “Genetic enhancement of persistent pain by forebrain NR2B overexpression.” Nature Neuroscience 4: 164-169
63. Winkler, M., O. Akca, et al. (2000). “Very mild hypothermia increase blood loss during regional anesthesia.” Anesthesia and Analgesia 91: 978-984
64. Xia, X. M., J. P. Ding, et al. (2000). “Rectification and rapid activation at low Ca2+ of Ca2+ -activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.” Journal of Neuroscience 20: 4890-4903
65. Zhuo, M., D. M. Holtaman, et al. (2000). “Role of tissue-type plasminogen activator receptor LRP in hippocampal long-term potentiation.” Journal of Neuroscience 20: 542-549
66. Zhuo, M. (2000). “Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurons.” Progress in Brain Research 129: 101-113.

Department Publications 1999

1. Akca, O., A. Podolsky, et al. (1999). “Comparable postoperative pulmonary atelectasis in patients given 30% or 80% oxygen during and for two hours after colon resection.” Anesthesiology 91: 991-998
2. Akca, O., M. Melischek, et al. (1999). “Postoperative pain and subcutaneous oxygen tension (research letter).” Lancet 354: 41-42
3. Algra, L. J., S. T. Fogel, et al. (1999). “Anesthesia for reduction of uterine incarceration: report of two cases.” International Journal of Obstetrics Anesthesia 8: 142-143
4. Anderson, S. A., S. K. Song, et al. (1999). “Sepsis increases brain intracellular free calcium in brain.” J of Neurochem 72: 2617-2620
5. Apostolidou, I., G. J. Despotis, et al. (1999). “Anti-ischemic effects of intravenous nicardipine and nitroglycerin following coronary artery bypass surgery.” Annals of Thoracic Surgery 67: 417-422
6. Apostolidou, I., N. J. Skubas, et al. (1999). “Effects of nicardipine and nitroglycerin on perioperative myocardial ischemia in patients undergoing coronary artery bypass surgery.” Seminars in Thoracic and Cardiovascular Surgery 11: 77-83
7. Azpiazu, I., H. Cruzblanca, et al. (1999). “A G protein y subunit specific peptide inhibits muscarinic receptor signaling.” Journal of Biological Chemistry 274: 35305-35308
8. Bach, M. E., H. Son, et al. (1999). “Aged-related defects in late-phase hippocampal LTP correlate with defects in spatial memory.” Proceedings of the National Academy of Sciences of the United States of America 96: 5280-5285
9. Bell, B., H. Xing, et al. (1999). “KSR-1 binds to G protein By subunits and inhibits By induced MAP kinase activation.” Journal of Biological Chemistry 274: 7982-7986
10. Cheng, M. A. and R. Tempelhoff (1999). “Anaesthesia and epilespsy.” Current Opinion in Anaesthesiology 12: 523-528
11. Choo-Kang, L. R., J. J. Fehr, et al. (1999). “Cerebral edema and priapism in an adolescent with acute lymphoblastic leukemia.” Pediatric Emergency Care 15(2): 110-112
12. Cobb, J. P., R. S. Hotchkiss, et al. (1999). “Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice.” Surgery 126: 438-442
13. Dalman, F. C. and K. L. O’Malley (1999). “kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons.” Journal of Neuroscience 19: 5750-5757
14. Despotis, G. J. and C. W. Hogue (1999). “Cardiac anesthesia and management of bleeding during CABG: a primer for cardiologists and an update for the cardiothoracic team.” American Journal of Cardiology 83: 15B-30B
15. Despotis, G. J. and C. W. Hogue JR (1999). “Pathophysiology, prevention and treatment of bleeding after cardiac surgery: a primer for cardiologist and an upate for the cardiothoracic team.” American Journal of Cardiology 83: 15B-30B
16. Despotis, G. J., V. Levine, et al. (1999). “Use of point-of-care test inidentification of patients who can benefit from Desmopressin during cardiac surgery: A randomized, controlled trial.” Lancet 354: 106-110
17. Despotis, G. J., L. T. Goodnough, et al. (1999). “Serious adverse events in normal platelet pheresis donors: A multivariate analysis in a hospital-based program.” Vox Sang 77: 24-32
18. Despotis, G. J. and J. H. Joist (1999). “Anticoagulation and anticoagulation reversal with cardiac surgery involving cardiopulmonary bypass: an update.” Journal of Cardiothoracic and Vascular Anesthesia 13: 18-29
19. Despotis, G. J., N. Skubas, et al. (1999). “Optimal management of excessive bleeding and transfusion with cardiac surgery.” Seminars in Thoracic and Cardiovascular Surgery 11: 81-104
20. Despotis, G. J., G. Gravlee, et al. (1999). “Anticoagulation monitoring during cardiac surgery: A review of current and emerging techniques.” Anesthesiology 91: 1122-1151
21. Downes, G. B., D. J. Gilbert, et al. (1999). “Chromosomal mapping of five mouse G protein y subunits.” Genomics 57: 173-176
22. Downes, G. and N. Gautam (1999). “The G protein subunit gene families.” Genomics 62: 544-552
23. Ebach, D. R., R. P. Foglia, et al. (1999). “Experience with procedural sedation in a pediatric burn center.” Pediatric Surgery 34(6): 955-958
24. Evers, A. S. and J. H. Steinbach (1999). “Double edged swords: volatile anesthetics both enhance and inhibit ligand-gated ion channels.” Anesthesiology 90: 1-3
25. Fleischmann, E., O. Akca, et al. (1999). “Onset time, recovery duration, and drug cost with four different methods of inducing general anesthesia.” Anesthesia and Analgesia 88: 930-935
26. Goodnough, L. T., S. Ali, et al. (1999). “Economic impact of donor platelet count and platelet yield in apheresis products: relevance for emerging issues in platelet transfusion therapy.” Vox Sang 76: 43-49
27. Goodnough, L. T., K. Merkel, et al. (1999). “A randomized trial of acute normovolemic hemodilution compared to preoperative autologous blood donation in total knee arthroplasty.” Vox Sang 77: 11-16
28. Hageman, J. and B. P. Markovitz (1999). “Critical Appraisal of Bulow,SM, Nir,M, Levin, E, et al. Prednisolone treatment of respiratory syncytial virus infection: a randomized controlled trial of 147 infants.”
29. Hogue, C. W., Jr (1999). “Con: Pharmacologic prophylaxis should be used in all patients having cardiac surgery.” Journal of Cardiothoracic and Vascular Anesthesia 13: 101-104
30. Hogue, C. W., Jr, B. Barzilai, et al. (1999). “Stroke reduction: diagnosis and management of the atherosclerotic ascending aorta during cardiac surgery.” Seminars in Cardioracic and Vascular Anesthesia 3: 1-9
31. Hogue, C. W., Jr, S. F. Murphy, et al. (1999). “Risk factors for early or delayed stroke after cardiac surgery.” Circulation 100: 642-647
32. Hogue, C. W., Jr, T. Stamos, et al. (1999). “Acute myocardial infarction during lung volume reduction surgery.” Anesthesia and Analgesia 88: 332-334
33. Hotchkiss, R. S., P. F. Swanson, et al. (1999). “Overexpression of BCL-2 in transgenic mice decreases apoptosis and improves survival in sepsis.” Journal of Immunology 162: 4148-4156
34. Hotchkiss, R. S., P. E. Swanson, et al. (1999). “Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction.” Critical Care Medicine 27: 1230-1251
35. Hotchkiss, R. S., K. W. Tinsley, et al. (1999). “Prevention of lymphocyte cell death in sepsis improves survival in mice.” Proceedings of the National Academy of Sciences of the United States of America 96: 14541-14546
36. Jayasinghe, C. and N. Blass (1999). “Pain management in critically ill obstetric patient.” Critical Care Clinics Kay, A., A. Alfonso, et al. (1999). “Imaging synaptic activity in intact brain and slices with FMI-43 in c.elegans, lamprey and rat.” Neuron 24: 809-817
37. Kerchner, G. A., P. Li, et al. (1999). “Speaking out of turn: a role of silent synapses in pain.” Life 48: 251-256
38. Kim, S. J., A. A. Calejesan, et al. (1999). “Sex differences in late behavioral response to subcutaneous formalin injection in mice.” Brain Research 829: 185-189
39. Krucylak, C. P. (1999). Anesthetic considerations for pediatric thoracoscopic procedures. Minimal Access Cardiothoracic Surgery.
40. Philadelphia, WB Saunders Company Lappas, D. G., N. J. Skubas, et al. (1999). “Prevalence of left ventricular diastolic filling abnormalities in adult cardiac surgical patients: an intraoperative echocardiographic study.” Seminars in Thoracic and Cardiovascular Surgery 11: 125-133
41. Lee, D. E., S. J. Kim, et al. (1999). “Comparison of behavioral responses to noxious cold and heat in mice.” Brain Research 845: 117-121
42. Levy, F. H. and B. P. Markovitz (1999). “A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.”
43. Li, P., T. J. Wilding, et al. (1999). “Kainate receptor-mediated sensory synaptic transmission in mammalian spinal cord.” Nature 397: 161-164
44. Li, Z. W., J. P. Ding, et al. (1999). “RINm5f cells express inactivating BK channels, while HIT cells express noninactivating BK channels.” Journal of Neurophysiology 81: 611-624
45. Li, D. Y., G. Faury, et al. (1999). “Relation between outer and luminal diameter.” American Journal of Physiology 277: H1745-H1753
46. Li, P., G. A. Kerchner, et al. (1999). “AMPA receptor-PDZ protein interaction mediate synaptic plasticity in spinal cord.” Nature Neuroscience 2: 972-977
47. Liang, B. A., M. A. Cheng, et al. (1999). “Efforts at intubation: cervical injury in an emergency circumstance?” Journal of Clinical Anesthesia 11: 349-352
48. Luhmann, J. D., R. M. Kennedy, et al. (1999). “Continuous flow delivery of nitrous oxide and oxygen: a safe and cost effective technique for inhalation analgesia and sedation of pediatric patients.” Pediatric Emergency Care 15: 388-392
49. Markovitz, B. P. and P. Johnson (1999) Markovitz, B. P. (1999). “Y2K.” Journal of Intensive Care Medicine 14: 248
50. Markovitz, B. P. (1999). “Severity scoring and the practice of evidence based medicine in the ICU.” Current Opinion in Critical Care 5(3): 167-172
51. Markovitz, B. P. (1999). “Intensivists guide to the medical internet: part I.” Journal of Intensive Care Medicine 14: 291
52. McAllister, J. and K. Gnauck (1999). Rapid sequence intubation of the pediatric patient: fundamentals of practice. Pediatric Clinics of North America: 46(6):1249-1283
53. Motoyama, K., I. E. Karl, et al. (1999). “Ca2+ agonists on calcium signaling in perfused rat liver – determination via laser scanning confocal microscopy.” American Journal of Physiology 276: R575-R585
54. Murray, D. J., B. Pennell, et al. (1999). “Variability of PT and aPTT tests in diagnosis of increased surgical bleeding.” Transfusion 39: 56-62
55. Murray, D. J. (1999). “Hemodilution as a method to reduce transusion requirements in scoliosis surgery.” SPINE 24: 223-224
56. Murray, D. J. (1999). “Desmopressin.” SPINE 24: 882 Nakashima, Y. M., A. Pereverzev, et al. (1999). “Blockade of Ba(2+) current through human a1e channels by two steroid analogs, (+)-ACN and (+)-ECN.” Neuropharmacology 38: 843-855
57. Norris, M. C. (1999). Obstetric Anesthesia. Philadelphia, Lippincott-Williams & Wilkins Norris, M. C., D. Ferrenbach, et al. (1999). “Does epinephrine improve the diagnostic accuracy of aspiration during labor epidural analgeisa?” Anesthesia and Analgesia 88: 1073-1076
58. Norris, M. C. (1999). “Analgesia and the outcome of labor.” Rev Mex Anest 22: 254-260
59. Norris, M. C., D. Ferrenbach, et al. (1999). “Ventilatory effects of intrathecal bupivacaine or sufentanil in laboring women.” Anesthesiology 91(3A)
60. North, R. B. and A. H. Guarino (1999). “Spinal cord stimulation for the failed back surgery syndrome: technical advances, patient selection and outcome.” Neuromodulation 2(3)
61. Owens, W. D. (1999). “Experience: the wisdom to recognize our previous follies.” American Society of Anesthesiologists Newsletter 63: 5-8
62. Owens, W. D. (1999). “Moving toward the dream.” NYSSA Sphere 51: 25-28
63. Panzer, O., N. Ghafzanfari, et al. (1999). “Shivering and shivering-like tremor during labor with and without epidural analgesia.” Anesthesiology 90: 1609-1616
64. Prakriya, M. and C. J. Lingle (1999). “Activation of BK channels during brief depolarizations or action potential waveforms requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cells.” Journal of Neurophysiology 81: 2267-2278
65. Sabey, K., K. Paradiso, et al. (1999). “Ligand binding and activation of rat nicotinic a4B2 receptors stably expressed in HEK293 cells.” Molecular Pharmacology 55: 58-66
66. Sessler, D. I., A. Kurz, et al. (1999). “Hypothermia reduces resistance to surgical wound infections.” American Journal of Surgery 65(12): 1193-1196
67. Skubas, N. J., G. J. Despotis, et al. (1999). “Preoperative use of enoxaparin and tirofiban: possible association with increased bleeding post-bypass.” Anesthesiology 91: 869-872
68. Tang, Y. P., E. Shimizu, et al. (1999). “Genetic enhancement of learning and memory in mice.” Nature 401: 63-69
69. van Swinderen, B., O. Saifee, et al. (1999). “A neomorphic syntaxin mutation blocks volatile-anesthetic action in caenorbhabditis elegans.” Proceedings of the National Academy of Sciences of the United States of America 96: 2479-2484
70. Wei, F., P. Li, et al. (1999). “Loss of synaptic depression in mammalian anterior cingulate cortex after amputation.” Journal of Neuroscience 19(21): 9346-9354
71. Wissler, R. N. and M. C. Norris (1999). Neuraxial analgesia for labor part I: techniques. Obstetric Anesthesia. M. C. Norris. Philadelphia, Lippincott-Williams & Wilkins: 293-315
72. Wu, L. G. and J. G. G. Borst (1999). “The reduced release probability of releasable vesicles during recovery from short-term synaptic depression.” Neuron 23: 821-832
73. Wu, L. G., R. E. Westenbroek, et al. (1999). “Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses.” Journal of Neuroscience 19: 726-736
74. Wu, L. G. and W. J. Betz (1999). “Spatial variability in release at the frog neuromuscular junction measured with FMI-43.” Canadian Journal of Physiology and Pharmacology 77: 672-678
75. Xia, X. M., J. P. Ding, et al. (1999). “Molecular basis for the inactivation of Ca2+ – and voltage dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.” Journal of Neuroscience 19(13): 5255-5264
76. Zhuo, M., W. Zhang, et al. (1999). “A selective role of calcineurin Aa in synaptic depotentiation in hippocampus.” Proceedings of the National Academy of Sciences of the United States of America 96: 4650-4655.

Department Publications 1998

1. Adkins, D., S. Ali, et al. (1998). “Granulocyte collection efficiency and yield are enhanced using higher interface offset during apheresis of donors given granulocyte-colony stimulating factor.” Transfusion 38: 557-564
2. Arkoosh, V. A., M. Cooper, et al. (1998). “Intrathecal sufentanil dose response in nulliparous patients.” Anesthesiology 89: 364-370
3. Bucur, S. Z., J. Levy, et al. (1998). “The use of antithrombin 3 concentrate in congenital and acquired deficiency states.” Transfusion 36: 481-497
4. Caamano, C. A., M. I. Morano, et al. (1998). “A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stbilization and receptor signaling.” Journal of Biological Chemistry 32: 20473-20480
5. Calejesan, A. A., M. H.-C. Ch’ang, et al. (1998). “Spinal serotonergic receptors mediate facilitation of a nociceptive reflex by subcutaneous formalin injection into the hindpaw in rats.” Brain Research 798: 46-54
6. Cole, J. W., S. M. Rothman, et al. (1998). “High-dose magnesium for neuroprotection in infants undergoing cardiac surgery – how safe is it?” Anesthesia and Analgesia 86: S395
7. Crowder, C. M. (1998). “Mapping anesthesia genes: why and how?” Anesthesiology 88: 293-296
8. DeMeester, S. L., T. G. Buchman, et al. (1998). “Pyrrolidine dithiocarbamate activates the heat shock response and thereby induces apoptosis in primed endothelial cells.” Shock 10: 1-6
9. DeMeester, S. L., J. P. Cobb, et al. (1998). “Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis.” Surgery 124: 362-371
10. Ding, J. P., Z. W. Li, et al. (1998). “Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and noninactivation subunits.” Biophysical Journal 74: 268-289
11. Downes, G. B., N. G. Copeland, et al. (1998). “Structure and mapping of the G protein y3 subunit gene and a divergently transcribed novel gene, Gng31g.” Genomics 53: 220-230
12. Eberle, R. L., M. C. Norris, et al. (1998). “The effect of maternal position on fetal heart rate during epidural or itrathecal labor analgesia.” American Journal of Obstetrics and Gynecology 179: 150-155
13. Feng, G., J. H. Steinbach, et al. (1998). “Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse.” Journal of Neuroscience 18: 4166-4176
14. Garcia, D. E., B. Li, et al. (1998). “G-protein beta-subunit specificity in the fast membrane-delimited inhibition of Ca2+ channels.” Journal of Neuroscience 18: 9163-9170
15. Gautam, N., G. Downes, et al. (1998). “The G protein By complex.” Cellular Signalling 10: 447-455
16. Guarino, A. H. (1998). “Clarification of sympathetically mediated pain.” New England Journal of Medicine 338: 334-335
17. Hogue, C. W., P. P. Domitrovich, et al. (1998). “RR interval dynamics prior to atrial fibrillation in patients after coronary artery bypass graft surgery.” Circulation 1998 98: 429-434
18. Hogue, C. W., Jr, L. T. Goodnough, et al. (1998). “Perioperative myocardial ischemic episodes are related to hematocrit level in patients undergoing radical prostatectomy.” Transfusion 38: 924-931
19. Huffnagle, S. L., M. C. Norris, et al. (1998). “The influence of epidural needle bevel orientation on spread of sensory blockade in the laboring parturient.” Anesthesia and Analgesia 87: 326-330
20. Ikeda, T., F. Tayefeh, et al. (1998). “Local radiant heating increases subcutaneous oxygen tension.” American Journal of Surgery 175: 33-37
21. Jevtovic-Todorovic, V., S. M. Todorovic, et al. (1998). “Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.” Nature Medicine 4(4): 460-463
22. Jevtovic-Todorovic, V., D. F. Wozniak, et al. (1998). “Clonidine potentiates the neuropathic pain relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects.” Brain Research 781: 202-211
23. Jevtovic-Todorovic, V., S. Mennerick, et al. (1998). “Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.” Nature Medicine 4: 460-463
24. Kalyanaraman, S., N. G. Copeland, et al. (1998). “Structure and chromosomal localization of mouse G protein subunit Gamma4 gene.” Genomics 49: 147-151
25. Kim, S. J., K. S. Thomas, et al. (1998). “Macromolecular syntheses contributes to nociceptive response to subcutaneous formalin injection in mice.” Neuropharmacology 37: 1091-1093
26. Kisselev, O., Y. C. Fann, et al. (1998). “Light-activated rhodopsin induces structural binding motif in G-protein alpha subunit.” Proceedings of the National Academy of Sciences of the United States of America 95: 4270-4275
27. Kovacs, A., M. R. Courtois, et al. (1998). “Reversal of hypocalcemia and decreased afterload in sepsis – effect on myocardial systolic and idastolic function.” American Journal of Respiratory Critical Care Medicine 158: 1990-1998
28. ‘Kurz, A., M. Greher, et al. (1998). “Heat loss during major orthopedic surgery.” Anesthesia and Analgesia 53 (Supp 2): 43-45
29. Larson, M. D., A. Kurz, et al. (1998). “Lidocaine does not depress reflex dilation of the pupil.” Regional Anesthesia and Pain Medicine 22: 461-465
30. Lenhardt, R., C. Negishi, et al. (1998). “Paralysis only slightly reduces the febrile response to interleukin-2 administration during isoflurane anesthesia.” Anesthesiology 89: 648-656
31. Li, P. and M. Zhuo (1998). “Silent glutamatergic synapses and nociception in mammalian spinal cord.” Nature 393: 695-698
32. Li, P., A. A. Calejesan, et al. (1998). “ATP P2x receptors and sensory transmission between primary afferent fibers and spinal dorsal horn neurons in rats.” Journal of Neurophysiology 80: 3356-3360
33. Li, D. Y., G. Faury, et al. (1998). “Novel arterial pathology in mice and humans hemizygous for elastin.” Journal of Clinical Investigation 102: 1783-1787
34. Maconochie, D. J. and J. H. Steinbach (1998). “The channel opening rate of adult and fetal type mouse muscle nicotinic receptors, activated by acetylcholine.” Journal of Physiology 506: 53-72
35. Markovitz, B. P. (1998). “Electronic Journals: time for a new paradigm in biomedical communication.” Journal of Intensive Care Medicine 13: 158-167
36. Markovitz, B. and L. May (1998). “Three patients, two hearts.” Hastings Center Report 28(5): 8-9
37. Markovitz, B. (1998). “Electronic Journals: Time for a New Paradigm in Biomedical Communication.” J of Intensive Care Med 13: 158-167
38. Mennerick, S., V. Jevtovic-Todorovic, et al. (1998). “Effects of nitrous oxide (laughing gas) on excitatory and inhibitory synaptic transmission in hippocampal cultures.” Journal of Neuroscience 18(23): 9716-9726
39. Mennerick, S., V. Jevtovic-Todorovic, et al. (1998). “Effects of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures.” Journal of Neuroscience 18(23): 9716-9726
40. Murray, D. J. (1998). “A sudden increase in expired nitrogen: diagnosis and management of a bronchial-gastric fistula.” Anesthesiology 88: 539-541
41. Murray, D. J. (1998). “Clinical simulation – technical novelty or innovation in education?” Anesthesiology 89: 1-2
42. Nadler, R. B., T. G. Monk, et al. (1998). “Simultaneous bilateral percutaneous nephrolithotomy with subarachnoid spinal anesthesia.” Journal of Endourology 12(1): 27-31
43. Nakashima, Y., S. M. Todorovic, et al. (1998). “The anesthetic steroid, (+)-ACN, blocks N-, Q-, and R-, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat.” Molecular Pharmacology 54: 559-568
44. Nakashima, Y., S. M. Todorovic, et al. (1998). “Properties of Ca2+ currents arising from human a1E and a1EB3 constructs expressed in HEK293 cells: physiology, pharmacology, and comparison to native T-type currents.” Neuropharmacology 37: 957-972
45. Nakashima, Y. M., A. Pereverzev, et al. (1998). “Blockade of Ba2+ current through human a1E channels by two steroid analogs, (+)-ACN and (+)-ECN.” Neuropharmacology 37: 957-972
46. Negishi, C., R. Lenhardt, et al. (1998). “Desflurane reduces the febrile response to interleukin-2 administration.” Anesthesiology 88: 1162-1169
47. Newcomer, J. W., N. B. Farber, et al. (1998). “Ketamine-induced NMDA receptor hypofunction as a model of memory impairment in schizophrenia.” Neuropsychopharmocology 20: 106-118
48. Newcomer, J. W., N. B. Farber, et al. (1998). “Ketamine-induced NMDA receptor hypofunction as a model of memory impairment in schizophrenia.” Neuropsychopharmocology 20: 106-118
49. Noda, S., M. J. Buckmaster, et al. (1998). “Intraabdominal hemorrhage during combined coronary artery bypass and carotid endarterectomy.” Annals of Thoracic Surgery 66: 557-558
50. Norris, M. C., S. T. Fogel, et al. (1998). “Intrathecal sufentanil (5 vs. 10 mg) for labor analgesia: efficacy and side effects.” Regional Anesthesia and Pain Medicine 23: 252-257
51. Norris, M. C., S. T. Fogel, et al. (1998). “Labor epidural analgesia without an intravascular “test dose”.” Anesthesiology 88(6): 1495-1501
52. Norris, M. C. (1998). “Labour analgesia: what are the (new) options?” Canadian Journal of Anaesthesia 45: R138-R143
53. Owens, W. D. (1998). “Correct the wrongs and move on toward the dream.” American Society of Anesthesiologists Newsletter 62: 8-10
54. Rajek, A., R. Lenhardt, et al. (1998). “Tissue heat content and distribution during and after cardiopulmonary bypass at 31 degrees C and 27 degrees C.” Anesthesiology 88: 1511-1518
55. Skubas, N. J., C. W. Hogue Jr, et al. (1998). Anesthesia for electrophysiologic procedures. Cardiac Anesthesia. J. A. Kaplan, D. L. Reich and S. N. Konstadt. Philadelphia, W B Saunders Company: 861-899
56. Son, H., Y.-F. Lu, et al. (1998). “The specific role of cCMPin hippocampal LTP.” Learning & Memory 5: 231-245
57. Stix, M., C. W. Hogue JR, et al. (1998). Anticoagulation for cardiopulmonary bypass. Complications in anesthesia. J. L. Atlee. Philadelphia, W B Saunders Company: 295-298
58. Todorovic, S. M. and C. J. Lingle (1998). “Pharmacological properties of T-type Ca3+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents.” Journal of Neurophysiology 79: 240-252
59. Todorovic, S. M., M. Prakriya, et al. (1998). “Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid lacking GABA-modulatory activity.” Molecular Pharmacology 54: 918-927
60. van Swinderen, B., A. Galifianakis, et al. (1998). “Common genetic determinants of halothane and isoflurane potencies in caenorhabditis elegans.” Anesthesiology 89: 1509-1517
61. van Swinderen, B. and C. M. Crowder (1998). “A quantitative genetic approach towards volatile anesthetic mechanisms in C. elegans.” Toxicology Letters 100-101: 309-317
62. Waddle, J. P., A. S. Evers, et al. (1998). “Inappropriate length of stay in the post anesthesia care unit: quantification and assessment of contributing factors.” Anesthesia and Analgesia 87: 628-633
63. Weigle, C. G. M., B. P. Markovitz, et al. (1998). “What does the internet offer pediatric intensive care?” Balliere’s Clinical Pediatrics 6(1): 133-150
64. Zhuo, M. (1998). “NMDA receptor-dependent long term hyperalgesia after tail amputation.” European Journal of Pharmacology 349: 211-220
65. Zhuo, M., J. T. Laitinen, et al. (1998). “Tests of the roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus.” Learning & Memory 5: 467-480

Department Publications 1997

1. Akata, T. and W. A. Boyle (1997). “Is guanosine-5′-triphosphate involved in calcium-activation of contractile proteins in vascular smooth muscle?” Japanese Journal of Pharmacology 57: 1-12
2. Birmingham, P. J., M. J. Tobin, et al. (1997). “Twenty-four hour pharmacokinetics of rectal acetaminophen in children.” Anesthesiology 87: 244-252
3. Boyle, W. A., S. Muralidharan, et al. (1997). “Vascular actions of “caged” phenylephrine analogs depend on the structure and site of attachment of the 2-nitrobenzyl group.” Journal of Photochemistry and Photobiology B 41: 233-244
4. Cheng, M. A., M. A. Theard, et al. (1997). “Beyond barbiturates: intravenous anesthetics and neuroprotection.” Critical Care Clinics 13: 185-189
5. Cheng, M. A., M. A. Theard, et al. (1997). “Anesthetic technique for carotid endarterectomy: a survey.” Journal of Neurosurgical Anesthesiology 9: 211-216
6. Cheng, M. A., M. A. Theard, et al. (1997). “Anesthesia for carotid endarterectomy: a survey.” Journal of Neurosurgical Anesthesiology 9: 211-216
7. Cole, J. W., D. J. Murray, et al. (1997). “Emergence delirium in pediatric patients: a common postoperative problem.” Anesthesia and Analgesia 84: S422
8. Cole, J. W. and G. E. Hirshberg (1997). “Invited commentary on bilateral pulmonary edema following left modified blalock-taussig shunt.” Journal of Cardiothoracic and Vascular Anesthesia 11(5): 657-660
9. DeMeester, S. L., T. G. Buchman, et al. (1997). “Heat shock induces 1-B and prevents stress-induced endothelial cell apoptosis.” Archives of Surgery 132: 1283-1287
10. Despotis, G., V. Levine, et al. (1997). “A comparison between continuous infusion versus standard bolus administration of heparin based on monitoring in cardiac surgery.” Blood Coagulation and Fibrinolysis 8: 419-430
11. Despotis, G. J., J. H. Joist, et al. (1997). “Monitoring hemostasis with cardiac surgery: The impact of point-of-care testing on blood loss and transfusion outcomes.” Clinical Chemistry 43: 1684-1696
12. Despotis, G. J., V. Levine, et al. (1997). “Antithrombin III during cardiac surgery: Effect on response of activated clotting time to heparin and relationship to markers of hemostatic activation.” Anesthesia and Analgesia 85: 498-506
13. Despotis, G. J., V. Levine, et al. (1997). “The relationship between leukocyte count and patient risk for excessive blood loss after cardiac surgery.” Critical Care Medicine 25: 1338-1346
14. Despotis, G. J., S. Ikonomakou, et al. (1997). “Effects of platelets, white blood cells and antiplatelet agent c7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood.” Thrombosis Research 86: 205-219
15. Despotis, G. J., V. Levine, et al. (1997). “Hemofiltration increases heparin concentration during cardiopulmonary bypass.” Anesthesia and Analgesia 84: 479-483
16. Despotis, G. J., J. H. Joist, et al. (1997). “Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements.” Journal of Thorarcic and Cardiovascular Surgery 113: 611-613
17. Despotis, G. J., V. Levine, et al. (1997). “Multiple episodes of thrombosis with biventricular support devices with inadequate anticoagulation and evidence of accelerated intravascular coagulation.” Journal of Thorarcic and Cardiovascular Surgery 113: 419-422
18. Evers, A. S. and J. H. Steinbach (1997). “Supersensitive sites in the central nervous system.” Anesthesiology 86: 760-762
19. Ferouz, F., M. C. Norris, et al. (1997). “Baricity, needle direction and intrathecal sufentanil labor analgesia.” Anesthesiology 86: 592-598
20. Ferouz, F., M. C. Norris, et al. (1997). “Risk of respiratory arrest after intrathecal sufentanil.” Anesthesia and Analgesia 85: 1088-1090
21. Giambarella, U., T. Yamatsuji, et al. (1997). “G protein betagamma complex-mediated apoptosis by familial Altzheimer’s disease mutant of APP.” EMBO Journal 1997: 4897-4907
22. Goodnough, L. T., G. J. Despotis, et al. (1997). “Erythropoietin therapy in patients undergoing cardiac surgery.” Annals of Thoracic Surgery 64: 1579-1580
23. Guarino, A. H. and P. S. Staats (1997). “Diagnostic neural blockade.” Pain Digest
24. Hiramatsu, M., R. S. Hotchkiss, et al. (1997). “Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung and gut by an endotoxin and TNF-independent pathway.” Shock 7: 247-253
25. Hogue, C. W. (1997). Atrial septal defects, repair of. Essence of anesthesia practice. M. F. Roizen and L. A. Fleisher. Philadelphia, W B Saunders Company: 347
26. Hogue Jr, C. W. and V. G. Davila-Roman (1997). “Detection of myocardial ischemia by transesophageal echocardiography determined changes in left ventricular area in patients undergoing coronary artery bypass surgery.” Journal of Clinical Anesthesia 9: 388-393
27. Hotchkiss, R. S. and I. E. Karl (1997). “Ca2+, a regulator of the inflammatory response: the good, the bad, and the possibilities.” Shock 7: 308-310
28. Hotchkiss, R. S., P. E. Swanson, et al. (1997). “Apoptosis in lymphoid and parenchmal cells during sepsis-findings in normal and T & B cell deficient mice.” Critical Care Medicine 25: 1298-1307
29. Hotchkiss, R. S., W. M. Bowling, et al. (1997). “Calcium antagonists inhibit oxidative burst and nitrate formation in LPS-stimulated rat peritoneal macrophages.” Shock 8: 170-178
30. Hu, Y., L. L. Wittmer, et al. (1997). “Neurotsteroid analogues. Part 5-1. Enantiomers of neuroactive steroids and benz[e]indenes: Total synthesis, electrophysiological effects on GABA-A receptor function and anesthetic actions in tadpoles.” Journal of the Chemical Society Perkin Transactions 1 24: 3665-3671
31. Jellish, W. S., H. Riche, et al. (1997). “Etomidate and thiopental EEG-based anesthetic induction: Comparisons between different titrated levels of electrophysiologic cortical depression and response to laryngoscopy.” Journal of Clinical Anesthesia 9: 36-41
32. Jevtovic-Todorovic, V., C. O. Kirby, et al. (1997). “Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate/retrosplenial cortex.” Journal of Cerebral Blood Flow and Metabolism 17: 168-174
33. Kavalali, E. T., M. Zhuo, et al. (1997). “Dendritic Ca2+ channels characterized by recordings from isolated hippocampus dendritic segments.” Neuron 18: 651-663
34. Keller, C. A., K. S. Naunheim, et al. (1997). “Hemodynamics and gas exchange following single lung transplant and unilateral thoracoscopic lung reduction.” Journal of Heart and Lung Transplantation 16: 199-208
35. Kem, W. R., V. M. Mahnir, et al. (1997). “Anabaseine is a potent agonist on muscle and neuronal alph-bungarotoxin-sensitive nicotinic receptors.” Journal of Pharmacology and Experimental Therapeutics 283: 979-992
36. Kofke, W. A., R. Tempelhoff, et al. (1997). “Anesthesia for epileptic patients, status epilepticus and epilepsy surgery.” Journal of Neurosurgical Anesthesiology 9: 349-372
37. Krucylak, C. P. and J. D. McAllister (1997). “Intubating the newborn.” Anesthesia Analog 85: 167-171
38. Liopyris, P., G. J. Despotis, et al. (1997). “The effects of nicardipine and nitroglycerin on cardiac arrhythmias and heart rate variability during cardiac surgery.” Anesthesiology 87
39. Missias, A. C., J. Mudd, et al. (1997). “Deficient development and maintenance of postsynaptic specializations in mutant mice lacking an “adult” acetylcholine receptor subunit.” Development 24: 5075-5086
40. Monk, T. G., L. T. Goodnough, et al. (1997). “Acute normovolemic hemodilution can replace preoperative blood donation as a standard of care for autologous blood procurement in radical prostatectomy.” Anesthesia and Analgesia 85: 953-958
41. Morley-Forster, P., J. McAllister, et al. (1997). “Does thiopental delaly recovery in children premedicated with midazolam.” Pediatric Anesthesia 7: 279-285
42. Mulroy, M. F., M. C. Norris, et al. (1997). “Safety steps for epidural injection of local anesthetics: review of the literature and recommendations.” Anesthesia and Analgesia 85: 1346-1356
43. Murray, D. J., W. J. Brosnahan, et al. (1997). “Heparin detection by the activated coagulation time: a comparison of the sensitivity of coagulation tests to heparin.” Journal of Cardiothoracic and Vascular Anesthesia 11: 24-28
44. Murray, D. J., R. B. Forbes, et al. (1997). “Transfusion management in pediatric and adolescent scoliosis surgery: efficacy of autologous donation in pediatric patients.” SPINE 22: 2735-2740
45. Murray, D. J. (1997). “Coagulopathy: current perioperative evaluation and management.” Anesthesia Today 8: 1-6
46. Niehoff, J. M. (1997). Diaphragmatic hernia (congenital). Essence of anesthesia practice. M. S. Roizen and L. A. Fleisher.
47. Philadelphia, WB Saunders Co Norris, M. C. (1997). “Combined spinal-epidural anesthesia for urological and lower extremity vascular procedures.” Techniques in Regional Anesthesia & Pain Management 1: 131-136
48. Norris, M. C., V. A. Arkoosh, et al. (1997). “Maternal and fetal effects of isoproterenol in the gravid ewe.” Anesthesia and Analgesia 85: 389-394
49. Parker, R. K., B. Holtmann, et al. (1997). “Patient-controlled epidural analgesia: interactions between nalbuphine and hyropmorphone.” Anesthesia and Analgesia 84: 757-763
50. Randolph, A. G. and B. Markovitz (1997). “Resources for applying evidence based medicine in the Pediatric Intensive Care Unit (PICU).” Journal of Intensive Care Medicine 12: 316-320
51. Saito, M., C. Nelson, et al. (1997). “A cysteine-rich domain defined by a novel exon in a Slo variant in rat adrenal chromaffin cells and PC12 cells.” Journal of Biological Chemistry 272: 11710-11717
52. Schornack, P. A., S.-K. Song, et al. (1997). “Inhibition of ion transport in septic rat heart: 133Cs+ as an NMR active K+ analog.” American Journal of Physiology 272: C1635-C1641
53. Schornack, P. A., S.-K. Song, et al. (1997). “Quantification of ion transport in perfused rat heart: 133Cs as an NMR active K+ analog.” American Journal of Physiology 272: C1618-C1634
54. Skubas, N., G. J. Despotis, et al. (1997). “The effects of nicardipine on perioperative blood loss during cardiac surgery.” Anesthesia and Analgesia 84: SCA 115
55. Solaro, C. R., J. P. Ding, et al. (1997). “The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open channel blockers.” Biophysical Journal 73: 819-830
56. Starsnic, M. A., D. M. Guarnieri, et al. (1997). “Efficacy and financial benefit of an anesthesiologist-directed university preadmission evaluation center.” Journal of Clinical Anesthesia 9: 299-305
57. Tempelhoff, R., M. A. Cheng, et al. (1997). Chapter 26: Anesthetic considerations for carotid endarterectomy. Cerebrovascular Disease. H. H. Batjer. New York, Raven Press Co: 327-339
58. Tempelhoff, R. (1997). “The new inhalational anesthetics: desflurane and sevoflurane,are not valuable additions to the practice of neuroanesthesia.” Journal of Neurosurgical Anesthesiology 9: 69-71
59. Theard, M. A., R. Tempelhoff, et al. (1997). “Convection versus conduction cooling for induction of mild hypothermia for neurovascular procedures in adults.” Journal of Neurosurgical Anesthesiology 9: 250-255
60. Todorovic, S. M. (1997). “Cationic modulation of 5-HT2 and 5-HT3 receptors in rat sensory neurons: the role of K+, Ca2+ and Mg2+.” Brain Research 765: 291-300
61. Ueno, S., J. Bracamontes, et al. (1997). “Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAa receptor.” Journal of Neuroscience 17: 625-634
62. Van Swinderen, B., R. H. Ebert, et al. (1997). “Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans.” Proceedings of the National Academy of Sciences of the United States of America 94: 8232-8237
63. Yan, K. and N. Gautam (1997). “Structural determinants for interaction with three different effectors on the G protein β subunit.” Journal of Biological Chemistry 272: 2056-2059
64. Zhuo, M. and G. F. Gebhart (1997). “Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat.” Journal of Neurophysiology 78: 746-758

Department Publications 1996

1. Akata, T., K. Kodama, et al. (1996). “Protamine relaxes vascular smooth muscle by directly reducing cytosolic fee calcium concentrations in smal resistance arteries.” Journal of Anesthesia 10: 252-259
2. Akata, T. and W. A. Boyle (1996). “Dual actions of halothane on intracellular calcium stores of vascular smooth muscle.” Anesthesiology 84: 580-595
3. Apostolidou, I., N. Skubas, et al. (1996). “Effect of nicardipine and nitroglycerine on intrapulmonary shunt after coronary artery bypass surgery.” Journal of Anesthesia 82 (4S) 122
4. Apostolidou, I., G. J. Despotis, et al. (1996). “Antiischemic effects of intravenous nicardipine and nitroglycerin following coronary artery bypass surgery.” Anesthesia and Analgesia 82: SCA 43
5. Apostolidou, I., G. J. Despotis, et al. (1996). “Cost Comparison of nicardipine and nitroglycerin infusion in cardiac surgery.” Anesthesiology 85
6. Bauman, N., T. Oyos, et al. (1996). “Post-operative care following single stage laryngotracheoplasty.” Annals of Otology, Rhinology, and Laryngology 105: 317-322
7. Bowdle, T. A., E. M. Camporesi, et al. (1996). “A multicenter evaluation of remifentanil for early postoperative analgesia.” Anesthesia and Analgesia 83: 1292-1297
8. Cheng, M. A., R. Tempelhoff, et al. (1996). “Large-dose propofol alone in adult epileptic patients: electrocorticographic results.” Anesthesia and Analgesia 83: 169-174
9. Cobb, J. P., R. S. Hotchkiss, et al. (1996). “Mechanisms of cell injury and death.” British Journal of Anaesthesia 77: 3-10
10. Crowder, C. M., L. D. Shebester, et al. (1996). “Behavioral effects of volatile anesthetics in Caenorhabditis elegans.” Anesthesiology 85: 901-912
11. Crowder, C. M., R. Tempelhoff, et al. (1996). “Comparison with brain surface and core temperatures in neurosurgical patients during mild hypothermia.” Journal of Neurosurgery 85: 98-103
12. Crowder, C. M., R. Tempelhoff, et al. (1996). “Jugular bulb temperature: Comparison with brain surface and core temperatures in neurosurgical patients during mild hypothermia.” J Neurosurg 85: 98-103
13. Despotis, G. J., V. Levine, et al. (1996). “Evaluation of a new, point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients.” Anesthesiology 85: 1311-1323
14. Despotis, G. J., V. Levine, et al. (1996). “Recurrent thrombosis of biventricular support devices associated with accelerated intravascular coagulation and increased heparin requirements.” Journal of Thorarcic and Cardiovascular Surgery 112: 538-540
15. Despotis, G. J., J. H. Joist, et al. (1996). “More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT.” Thrombosis and Haemostasis 76: 902-908
16. Despotis, G. J., A. Alsoufiev, et al. (1996). “Comparison of CBC results from a new, on-site hemocytometer to a laboratory-based hemocytometer.” Critical Care Medicine 24: 1163-1167
17. Despotis, G. J., K. S. Filos, et al. (1996). “Aprotinin prolongs activated and non-activated whole blood clotting time and potentiates the effects of heparin in vitro.” Anesthesia and Analgesia 82: 1126-1131
18. Despotis, G. J., A. Alsoufiev, et al. (1996). “The response of kaolin ACT to heparin: Evaluation with an automated assay and higher heparin doses.” Annals of Thoracic Surgery 61: 795-799
19. Despotis, G. J., K. S. Filos, et al. (1996). “Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: A multivariate analysis in cardiac surgical patients.” Anesthesia and Analgesia 82: 13-21
20. Despotis, G. J., K. S. Filos, et al. (1996). “Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: a multivariate analysis in cardiac surgical patients.” Anesthesia and Analgesia 82: 13-21
21. Despotis, G. J., A. Alsoufiev, et al. (1996). “Comparison of CBC results from a new, on-site hemocytometer to a laboratory-based hemocytometer.” Critical Care Medicine 24: 1163-1167
22. Dunteman, E., M. Karanikolas, et al. (1996). “Transnasal butorphanol for the treatment of opioid-induced pruritus, unresponsive to antihistamines.” Journal of Pain and Symptom Management 12(4): 255-260
23. Dunteman, E., S. Turner, et al. (1996). “Pseudo-spinal headache.” Regional Anesthesia 21: 358-360
24. Eberle, R. L. and M. C. Norris (1996). “Labour analgesia: A risk/benefit analysis.” Drug Safety 14: 239-251
25. Fletcher, G. H. and J. H. Steinbach (1996). “Ability of nondepolarizing neuromuscular blocking drugs to act as partial agonists at fetal and adult mouse muscle nicotinic receptors.” Molecular Pharmacology 49: 938-947
26. Hogue, C. W., V. G. Davila-Roman, et al. (1996). “Transesophageal trial pacing in anesthetized patients with coronary artery disease: hemodynamic improvements versus the risk of myocardial ischemia.” Anesthesiology 85: 69-76
27. Hogue, C. W., V. G. Davila-Roman, et al. (1996). “Hemodynamic improvements versus the risk of myocardial ischemia: transesophageal atrial pacing in anesthetized patients with coronary artery disease.” Anesthesiology 85: 69-76
28. Hogue, C. W., T. A. Bowdle, et al. (1996). “Multicenter evaluation of the safety and efficacy of total intravenous anesthesia with remifentanil and propofol for elective inpatient surgery.” Anesthesia and Analgesia 83: 279-285
29. Hogue, C. W. (1996). “Mechanism of hemodynamic improvement by dual-chamber pacing for severe left ventricular dysfunction: an acute Doppler and catheterization hemodynamic study.” Journal of the American College of Cardiology 25: 281-288
30. Hogue, C. W. (1996). “(2)Mechanism of hemodynamic improvement by dual-chamber pacing for severe left ventricular dysfunction: an acute Doppler and catheterization hemodynamic study.” The Cardiovascular & Thoracic Journal Club Journal 1: 24-26
31. Hogue, C. W. (1996). “Relation between heart rate variability and spontaneous and induced ventricular arrhythmias in patients with coronary artery disease.” The Cardiovascular & Thoracic Journal Club Journal 1: 28-32
32. Hogue, C. W. (1996). “Commentary: Arrhythmias and conduction distrubances after coronary artery bypass graft surgery: epidemiology, management, and prognosis.” The Cardiovascular & Thoracic Journal Club Journal 1: 152-154
33. Hotchkiss, R. S. and I. E. Karl (1996). “Calcium in endotoxemia and Sepsis: A regulator of the inflammatory response and a two-edged sword.” New Horizons 4: 58-71
34. Huang, Y. Y., M. E. Bach, et al. (1996). “Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late phase LTP in both schaffer collateral and mossy fiber pathways.” Proceedings of the National Academy of Sciences of the United States of America 93: 8699-8704
35. Huffnagle, H. J., M. C. Norris, et al. (1996). “Ilioinguinal Iliohypogastric nerve blocks – before or after a cesarean section?” Anesthesia and Analgesia 82: 8-12
36. Jellish, W. S., Z. Thalgi, et al. (1996). “Recovery from mivacurium-induced neurmuscular blockade is not affected by anticonvulsant therapy.” Journal of Neurosurgery 8: 4-8
37. Kenagy, D. N., B. R. Cole, et al. (1996). “One patient’s experience with mycophenolic acid.” Pediatric Nephrology 10: 546-547
38. Kinsella, S. M. and M. C. Norris (1996). “Advance prediction of hypotension risk at cesarean delivery under spinal anesthesia.” International Journal of Obstetrics Anesthesia 5: 3-7
39. Krucylak, P. E., L. J. Baudendistel, et al. (1996). “Anesthetic management of patients undergoing unilateral VATS lung reduction for treatment of end-stage emphysema.” Journal of Cardiothoracic and Vascular Anesthesia 10: 850-853
40. Leighton, B. L., V. A. Arkoosh, et al. (1996). “The dermatomal spread of epidural bupivacaine with and without prior intrathecal sufentanil.” Anesthesia and Analgesia 83: 526-529
41. Norris, M. C., J. E. Honet, et al. (1996). “A comparison of meperidine and lidocaine for spinal anesthesia for postpartum tubal ligation.” Regional Anesthesia 21: 84-88
42. Prakriya, M., C. R. Solaro, et al. (1996). “Ca2+ elevations detected by BK channels during Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular stores in rat chromaffin cells.” Journal of Neuroscience 16: 4344-4359
43. Shear, J. M. and T. G. Monk (1996). ENT laryngoscopy, bronchoscopy, and laryngectomy. Geriatric Anesthesiology.
44. C. McLesky. Baltimore, Williams and Wilkins Ueno, S., J. M. Zempel, et al. (1996). “Difference in the expression of GABAA receptors between functionall innervated and non-innervated granule neurons in neonatal rat cerebellar cultures.” Brain Research 714: 49-56
45. Ueno, S., C. Zorumski, et al. (1996). “Endogenous subunits can cause ambiguities in the pharmacology of exogenous GABAA receptors expressed in HEK293 cells.” Molecular Pharmacology 50: 931-938
46. Unheim, K. S., C. A. Keller, et al. (1996). “Unilateral VATS lung reduction.” Annals of Thoracic Surgery 61: 1092-1098
47. Wade, S. M., M. K. Scribner, et al. (1996). “Structural requirements for G activation by receptor-derived peptides: activation and modulation domains of the alpha 2-adrenergic receptor, 3c region.” Molecular Pharmacology 50(2): 351-358
48. Wang J, L., S. Kalyanaraman, et al. (1996). “Bombesin and thrombin affect discrete pools of intracellular calcium through different G proteins.” Journal of Biological Chemistry 320: 87-91
49. Williams, L. E., W. M. Hart, et al. (1996). “Optic nerve injury: Role of the anesthesiologist? In response to Roth S and Roizen M [letter].” Anesthesia and Analgesia 82: 435-436
50. Wittmer, L. L., Y. Hu, et al. (1996). “Enantioselectivity of steroid-induced GABA-A receptor modulation and anesthesia.” Molecular Pharmacology 50: 1581-1586
51. Yan, K., V. Kalyanaraman, et al. (1996). “Differential ability to form the G protein by complex among members of the β and γ subunit families.” Journal of Biological Chemistry 271: 7141-7146
52. Yan, K. and N. Gautam (1996). “A domain on the G protein β subunit interacts with both adenylyl cyclase 2 and the muscarinic atrial potassium channel.” Journal of Biological Chemistry 271: 17597-17600

Department Publications 1995

1. Abboud, N. (1995). “Hypothermic cardiopulmonary bypass and circulatory arrest for operations on the descending thoracic and thoracoabdominal aorta.” Annals of Thoracic Surgery 60: 67-77
2. Akata, T., M. Nakashima, et al. (1995). “Effects of volatile anesthetics on acetylcholine-induced relaxation in the rabbit mesenteric resistance artery.” Anesthesiology 82: 188-204
3. Akata, T. and W. A. Boyle (1995). “Effects of volatile anesthetics on contractile proteins in small splanchnic resistance arteries.” Anesthesiology 82: 700-712
4. Boyle, W. A. and G. M. Maher (1995). “Endothelium-independent vasoconstricting and vasodilating actions of halothane on rat mesenteric resistance blood vessels.” Anesthesiology 82: 221-235
5. Chang, P., D. J. Murray, et al. (1995). “Analysis of changes in coagulation factors after post-operative blood loss in burn and non-burn patients.” Journal of Burn Care and Rehabilitation 231: 432-436
6. Chao, C. K. S., P. W. Grigsby, et al. (1995). “Brachytherapy-related complications for medically inoperable stage 1 endometrial carcinoma.” International Journal of Radiation Oncology, Biology, Physics 31: 37-42
7. Chen, Q., G. H. Fletcher, et al. (1995). “Selection of stably transfected cells expressing a high level of fetal nicotinic receptors.” Journal of Neuroscience Research 40: 606-612
8. Chen, J., Y. Zhang, et al. (1995). “Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating.” Biophysical Journal 69: 849-859
9. Despotis, G. J., A. Alsoufiev, et al. (1995). “Aprotinin prolongs whole blood APTT but not whole blood PT in patients undergoing cardiac surgery.” Anesthesia and Analgesia 81: 919-924
10. Despotis, G. J., C. W. Hogue Jr., et al. (1995). “Effect of heparin on whole blood APPT using a portable, whole blood coagulation monitor.” Critical Care Medicine 23: 1674-1679
11. Despotis, G. J., J. H. Joist, et al. (1995). “Effect of Aprotinin on ACT, whole blood and plasma heparin measurements.” Annals of Thoracic Surgery 59: 106-111
12. Despotis, G. J., J. H. Joist, et al. (1995). “The impact of heparin concentration and activated clotting time monitoring on blood conservation: A prospective, randomized evaluation in patients undergoing cardiac operations.” Journal of Thorarcic and Cardiovascular Surgery 110: 46-54
13. Despotis, G. J., J. H. Joist, et al. (1995). “The impact of heparin concentration and activated clotting time monitoring on blood conservation: A prospective, randomized evaluation in patients undergoing cardiac operations.” Journal of Thorarcic and Cardiovascular Surgery 110: 46-54
14. Despotis, G. J., C. W. Hogue, et al. (1995). “Effect of heparin on whole blood partial thromboplastin time using a portable, whole blood coagulation monitor.” Critical Care Medicine 28: 1674-1679
15. Despotis, G. J., M. Karanikolas, et al. (1995). “A pressure gradient across the pulmonary artery anastomosis during lung transplantation.” Annals of Thoracic Surgery 60: 630-634
16. Dunteman, E. D. and R. A. Swarm (1995). “Atypical facial “neuralgia”.” Anesthesia and Analgesia 80: 188-190
17. Evers, A. S., B. W. Dubois, et al. (1995). “Saturable binding of volatile anesthetics to proteins studied by 19F-NMR spectroscopy and photoaffinity labeling.” Progress in Anesthetic Mechanism 3 (July): 151-157
18. Foroughi, V., P. E. Krucylak, et al. (1995). “A techincally simple means for administration of continuous positive airway pressure during one-lung ventilation using a univent tube [letter].” Anesthesia and Analgesia 81: 656
19. Goodnough, L. T., G. J. Despotis, et al. (1995). “On the need for improved transfusion indicators in cardiac surgery.” Annals of Thoracic Surgery 60: 473-480
20. Goodnough, L. T. and G. J. Despotis (1995). “Establishing practice guidelines for surgical blood management.” American Journal of Surgery 170:6A
21. Herrington, J., C. R. Solaro, et al. (1995). “The suppression of Ca2+ and voltage-dependent K+ current during mAChR activation in rat adrenal chromaffin cells.” Journal of Physiology 485: 297-318
22. Hogue, C. W., G. D. Lappas, et al. (1995). “Swallowing dysfunction after cardiac surgery: associated outcomes and risk factors including intraoperative transesophageal echocardiography.” Journal of Thorarcic and Cardiovascular Surgery 110: 517-522
23. Hogue, C., V. Davila-Roman, et al. (1995). “Alterations in heart rate variability in patients undergoing dobutamine stress echocardiography, including patients with neurocardiogenic hypotension.” American Heart Journal 130: 1203-1209
24. Hogue, C. W. (1995). “Commentary: Relation between heart rate variability and spontaneous and induced ventricular arrhythmias in patient with coronary artery disease.” Journal of the American College of Cardiology 25: 437-443
25. Hogue, C. W. (1995). “Commentary: Arrhythmias and conduction distrubances after coronary artery bypass graft surgery: epidemiology, management, and prognosis.” American Heart Journal 129: 799-808
26. Hotchkiss, R. S., D. F. Osborne, et al. (1995). “Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-a, interleukin-1b, and interleukin-1a in a mouse model of endotoxin.” Shock 3: 337-342
27. Jevtovic-Todorovic, V., M. Ishimaru, et al. (1995). “Isoflurane, halothane, and propofol protect against MK-801 neurotoxicity in rat brain.” Society for Neuroscience Abstracts 21: 73
28. Kalyanaraman, K., V. Kalyanaraman, et al. (1995). “A brain specific G protein y subunit.” Biochemical and Biophysical Research Communications 216: 126-132
29. Kisselev, O. G., A. N. Pronin, et al. (1995). “Receptor – G protein coupling is established by a potential conformational switch in the By-complex.” Proceedings of the National Academy of Sciences of the United States of America 92: 9102-9106
30. Kisselev, O., M. Ermolaeva, et al. (1995). “Efficient interaction with a receptor requires a specific type of prenyl group on the G protein y subunit.” Journal of Biological Chemistry 270: 25356-25358
31. Kouchoukos, N. T., B. B. Daily, et al. (1995). “Hypothermic bypass and circulatory arrest for operations on the descending thoracic and thoracoabdominal aorta.” Annals of Thoracic Surgery 60: 67-77
32. Lowell, J. A., T. S. Sutton, et al. (1995). “Stability of cerebral perfusion pressure and ICP during orthotopic liver transplantation with preservation of the IVC and temporary portacaval slunt.” Hepatology: 22S-496A
33. Maconochie, D. J., G. H. Fletcher, et al. (1995). “The conductance of the muscle nicotinic receptor channel changes rapidly upon gating.” Biophysical Journal 68: 483-490
34. Maconochie, D. J. and J. H. Steinbach (1995). “Block by acetylcholine of mouse muscle nicotinic receptors, stably expressed in fibroblasts.” Journal of General Physiology 106: 113-147
35. McCobb, D. P., N. L. Fowler, et al. (1995). “A human calcium-activated potassium channel gene expressed in vascular smooth muscle.” American Journal of Physiology 269: H767-H777
36. Murray, D. J., B. Pennell, et al. (1995). “Packed red cells in acute blood loss: Dilutional coagulopathy as a cause of surgical bleeding.” Anesthesia and Analgesia 80: 336-342
37. Murray, D. J., C. Schmid, et al. (1995). “Anesthesia for magnetic resonance imaging in children: A low incidence of post-procedure vomiting.” Journal of Clinical Anesthesia 7: 323-326
38. Otto, A. (1995). “Comparison of the effects of isoflurane and desflurane on somatosensory evoked potential measurements during scoliosis surgery.” Accepted at the International Anesthesia Research Society in November, 1995
39. Otto, A. and S. Nkanga (1995). “Doing educational research: an action research approach.” Educational Action Research 3(3)
40. Otto, A. (1995). “Cultural understandings: reflections on OTP teaching.” American Society of Anesthesiologists Newsletter 59(4): 11-14
41. Sicard, G., J. Reilly, et al. (1995). “Transabdominal versus retroperitoneal incision for abdominal aortic surgery: Report of a prospective randomized trial.” Journal of Vascular Surgery 174-183: 1995
42. Solaro, C. R., M. Prakriya, et al. (1995). “Inactivating and non-inactivating Ca2+ and voltage-dependent K+ current in rat adrenal chromaffin cell.” Journal of Neuroscience 15: 6110-6123
43. Song, S.-K., R. S. Hotchkiss, et al. (1995). “Determination of intracellular calcium in vivo via fluorine-19 Nuclear Magnetic Resonance spectroscopy.” American Journal of Physiology 269: C318-C322
44. Steinbach, J. H. and Q. Chen (1995). “Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors.” Journal of Neuroscience 15: 230-240
45. Sutton, T., C. Weiss, et al. (1995). “Stability of cerebral perfusion pressure and ICP in orthotopic liver transplantation with preservation of the IVC and temporary porta-caval shunt.” Hepatology 22(S4): 1995
46. Sutton, T., J. Lowell, et al. (1995). “A new technique to maintain cerebral perfusion pressure in patients with fulminant hepatic failure during liver transplantation.” Critical Care Medicine
47. Tempelhoff, R., M. A. Cheng, et al. (1995). “Cerebral protection: role of intravenous anaesthetic agents.” Annales Francaisses D Anesthesie Et De Reanimation 14: 129-133
48. Tempelhoff, R., M. A. Cheng, et al. (1995). “Protection cerebrale et agents anesthetiques intraveineux.” Annales Francaisses D Anesthesie Et De Reanimation 14: 129-133
49. Tempelhoff, R., M. A. Cheng, et al. (1995). “Cerebral protection: role of intravenous anaesthetic agents.” Annales Francaises D Anesthesie Et De Reanimation 14: 129-133
50. Tian, L., S. Coffin, et al. (1995). “The effect of hypothermia or heparin anticoagulation as measured by ACT and factor Xa inhibition.” Journal of Extracorporeal Technology 27: 192-196
51. Williams, L. E., W. M. Hart, et al. (1995). “Postoperative ischemic optic neuropathy.” Anesthesia and Analgesia 80: 1018-1029
52. Zempel, J. M. and J. H. Steinbach (1995). “Neonatal rat cerebellar granule and Purkinje neurons in culture express different GABAA receptors.” European Journal of Neuroscience 7: 1895-1905

Department Publications 1994

1. Blake, B. P., P. Q. Bessey, et al. (1994). “Hyperthermia induces IL-1a but does not decrease release of IL-1a or TNF-a after endotoxin.” Lymphokine Cytokine Research 13: 271-275
2. Brundidge, P. K., M. Leavell, et al. (1994). “EEG-based anesthetic management of a patient with documented experience of intra-anesthetic awareness.” Journal of Clinical Anesthesia 6: 496-499
3. Despotis, G. J., A. L. Summerfield, et al. (1994). “In vitro reversal of heparin-effect with heparinase: Evaluation with whole blood PT and APTT in cardiac surgical patients.” Anesthesia and Analgesia 79: 670-674
4. Despotis, G. J., J. E. Grishaber, et al. (1994). “The effect of an intraoperative transfusion algorithm on physician transfusion behavior in cardiac surgery.” Transfusion 34: 290-296
5. Despotis, G. J., A. L. Summerfield, et al. (1994). “Comparison of activated coagulation time and whole blood heparin measurements to laboratory plasma anti-Xa heparin concentration in cardiac surgical patients.” Journal of Thorarcic and Cardiovascular Surgery 108: 1076-1082
6. Despotis, G. J., S. A. Santoro, et al. (1994). “Prospective evaluation and clinical utility of on-site coagulation monitoring in patients undergoing cardiac operation.” Journal of Thorarcic and Cardiovascular Surgery 107: 271-279
7. Despotis, G. J., S. A. Santoro, et al. (1994). “On-site PT, aPTT and platelet count: A comparison between whole blood and laboratory assays with coagulation factor analysis in patients presenting for cardiac surgery.” Anesthesiology(80): 338-351
8. Evers, A. S. and M. D. Hossain (1994). “Volatile anesthetic effects on inositol trisphosphate-gated intracellular calcium stores in GH3 cells.” Advances in Pharmacology 31: 343-350
9. Gallagher, C. and N. Gautam (1994). “Design of oligonucleotide probes for molecular cloning of β and γ subunits.” Methods in Enzymology 237: 482-498
10. Goodnough, L. T., M. S. Bodner, et al. (1994). “Blood transfusion and blood conservation: cost and utilization issues.” American Journal of Medical Quality 9(4): 172-183
11. Goodnough, L. T., M. S. Bodner, et al. (1994). “Blood conservation and blood salvage.” Journal of Intensive Care Medicine 9: 86-97
12. Heesen, B. J., R. S. Hotchkiss, et al. (1994). “Sepsis decreases phenylephrine- and KCl-induced aortic ring contraction and decreases the frequency of oscillations in active wall tension.” Shock 2: 106-112
13. Herrington, J. and C. Lingle (1994). “Multiple components of voltage-dependent potassium current in normal rat anterior pituitary cells.” Journal of Neurophysiology 72: 719-729
14. Hogue, C. W., P. K. Stein, et al. (1994). “Alterations in temporal patterns of heart rate variability after coronary artery surgery.” Anesthesiology 81: 1356-1364
15. Hogue, C. W. (1994). “Effectiveness of low levels of nonventilated lung continuous positive airway pressure in improving arterial oxygenation during one-lung ventilation.” Anesthesia and Analgesia 79: 364-367
16. Hogue, C. W., M. R. Rosenbloom, et al. (1994). “Comparison of cardiac output measurement by continuous thermodilution with electromagnetometry in adult cardiac surgical patients.” Journal of Cardiothoracic and Vascular Anesthesia 8: 631-635
17. Hossain, D. and A. S. Evers (1994). “Volatile anesthetic-induced efflex of calcium from IP3-gated stores in clonal (GH3) pituitary cells.” Anesthesiology 80: 1379-1389