Our team of researchers lead groundbreaking clinical studies aimed at improving the health of people throughout the world.

The Division of Clinical and Translational Research (DoCTR) is the home for patient-oriented research in the Department of Anesthesiology. Numerous translational and clinical research projects are currently led by faculty members in the division, in a wide variety of research areas. These include drug disposition, pharmacogenomics, perioperative myocardial infarction, intraoperative awareness, postoperative cognitive dysfunction, biomarkers, cardiovascular monitoring, coagulation, and functional brain imaging. All investigators have clinical research programs, and some also have laboratory-based translational programs.

Frequently Asked Questions

Are you curious about joining a clinical study? Explore our clinical study FAQs to learn more about clinical studies in DoCTR.

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Active Clinical Studies

A list of ongoing clinical studies in the Department of Anesthesiology can be found below and on ClinicalTrials.gov.*

* the above link may display studies that have similar keywords but are not run in DoCTR.

If you would like to volunteer or receive more information about a particular study listed below, please send a request to volunteer@wustl.edu, note which study or studies you may be interested in and how you can be contacted, and one of our research coordinators will contact you with more information.

Principal InvestigatorTitle
Enyo Ablordeppey, MD, MPHUltrasound guided central venous catheter verification
Enyo Ablordeppey, MD, MPHFeasibility of volume assessment by echocardiography before and after dialysis in chronic renal failure patients.
Enyo Ablordeppey, MD, MPHA Qualitative Study of US guided CVC confirmation practices
Enyo Ablordeppey, MD, MPHEfficacy and acceptability of DRAUP
Cognition in the Anesthesiology Control Tower and Operating Room CO-ACT-OR
Exploratory Study of Care Transition and Handoff Workflows across the Perioperative Care Continuum

Umeshkumar Athiraman, MD

Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients

Jacob AuBuchon, MD

Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric Patients
Jacob AuBuchon, MDThe Comfort Ability Workshop: Improving Pain Treatment for Children and Their Families
Michael S. Avidan, MBBChCreation of a merged registry of patients in the NSQIP and SATISFY-SOS registries at BJH/Washington University
Michael S. Avidan, MBBChAbility of postoperative delirium to predict intermediate-term postoperative cognitive function in patients undergoing elective surgery at an academic medical center: protocol for a prospective study
Michael S. Avidan, MBBChPerioperative glycemia management in patients undergoing craniotomy for brain tumor resection: an international survey of neuroanesthesiologists’ perceptions and practices
Michael S. Avidan, MBBChAnesthesiology Control Tower: Forecasting Algorithms to Support Treatments (ACTFAST)
Michael S. Avidan, MBBChDelirium on the Day of Surgery Is Related to Subsequent Postoperative Delirium
Michael S. Avidan, MBBChComparison of Patient-Reported Pain Between Delirious and Non-Delirious Patients
Michael S. Avidan, MBBChExploring the Role of Mental Health Interventions for Geriatric Patients within Surgical Setting
Michael S. Avidan, MBBChProtocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the Post Anesthesia Care Unit
Michael S. Avidan, MBBChProtocol for the Effectiveness of an Anesthesiology Control Tower System in Improving Perioperative Quality Metrics and Clinical Outcomes: the TECTONICS randomized, pragmatic trial
Michael S. Avidan, MBBChPractical training of anesthesia clinicians in electroencephalogram-based determination of hypnotic depth of general anesthesia
Michael S. Avidan, MBBChBenzodiazepine-free Cardiac Anesthesia for reduction of Postoperative Delirium
Michael S. Avidan, MBBChSocial work intervention with older surgery patients, feasibility study
Michael S. Avidan, MBBChCROWN CORONATION: COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION
Arbi Ben Abdallah, PhD, DESPatient Health-Related Well-Being Before and After Surgery: A Latent Transition Analysis Approach
Amber Benhardt, MDComparing the Performance of Residents in Obstetric Anesthesia after the Implementation of Anesthesia Toolbox
Kelly Chilson, MDThe Pediatric Heparin-Alternative Multi-Institutional Quality improvement Project
Lara Crock, MD, PhDThe role of microbiome in the severity and persistence of complex regional pain syndrome
Bakul Dave, MD, MSProduct Surveillance Registry: Pain
Anne Drewry, MDImmunological Phenotyping of Febrile and Afebrile Critically Ill Septic Patients
Anne Drewry, MDCore Warming of COVID-19 Patients Undergoing Mechanical Ventilation: a randomized, single center pilot study
Julie Drobish, MDRetrospective and ongoing assessment of pediatric liver transplant management
Brian Fuller, MDAn Assessment of Awareness in Mechanically Ventilated Patients Admitted from the Emergency Department: The ED-AWARE Study
Brian Fuller, MDBIS Monitoring in Mechanically Ventilated ED Patients: an Observational Study
Brian Fuller, MDThe ED-SED Pilot: a Multicenter, Before-After Study to Improve Sedation in the Emergency Department
Stephen Gregory, MDA retrospective observational trial evaluating the prevalence and effect of preoperative cognitive dysfunction in a cohort of elderly patients undergoing elective surgery
Ryan Guffey, MDPeri-Operative Epidural Management Study (POEM study) Survey
Simon Haroutounian, PhD, MScIntravenous lidocaine for preventing painful oxaliplatin-induced peripheral neuropathy (OIPN)
Simon Haroutounian, PhD, MScCognitive Flexibility Training for the Prevention of Persistent Post-Surgical Pain (COFLEX-PPSP): Feasibility Study
Simon Haroutounian, PhD, MScEffects of Pgp transporter inhibition on CNS biodistribution of ondansetron in healthy volunteers
Simon Haroutounian, PhD, MScChemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY)
Simon Haroutounian, PhD, MScEEG Signature of Pain and Pain Relief: A Pilot Exploratory study
Simon Haroutounian, PhD, MScBrain-computer interface intervention for chronic upper extremity pain: a pilot study
Simon Haroutounian, PhD, MScIncidence and characterization of peripheral and cranial nerve neuropathy in patients diagnosed with COVID-19
Daniel Helsten, MDMulticenter perioperative outcomes group (MPOG) performance site
Mohammed Helwani, MD, MSPCardiac Surgery in Jehovah’s Witness patients: Single Academic Center Experience
Mohammed Helwani, MD, MSPEFFECT OF SPINAL VERSUS GENERAL ANESTHESIA ON CARDIAC AND RENAL BIOMARKER LEVELS IN HIP AND KNEE ARTHROPLASTY SURGERY
Richard Hotchkiss, MDCellular Mechanisms of Sepsis and Organ Failure
Richard Hotchkiss, MDPotential Immuno-Adjuvant Therapy in Sepsis
Richard Hotchkiss, MDInternational, multicenter, randomized, double-blinded, placebo-controlled study of Recombinant Interleukin-7 (CYT107) to restore absolute lymphocyte counts (ALC) in patients with Sepsis (IRIS-7 C & D Bridge Studies)
York Jiao, MDPrediction of surgical case duration from historical EHR data
Jessica Justmann, MDCognitive changes associated with initiation of gabapentin treatment in adults with chronic pain
Mohammad Mehdi KafashanCorrelating electroconvulsive therapy response to electroencephalographic ictal complexes and postictal markers
Ivan Kangrga, MDPulmonary function tests and perioperative complications in adult liver transplant recipients
Thomas Kannampallil, PhDPredicting Post-Surgical Pain Outcomes from Acute Pain Trajectories
Thomas Kannampallil, PhDEffect of Intraoperative Pediatric Anesthesia Handoffs on Surgical Outcomes
Thomas Kannampallil, PhDMental Health Related Quality of Life
Thomas Kannampallil, PhDAssessing Physician Trainee Wellness during a Pandemic (ASPIRE)
Thomas Kannampallil, PhDINTEGRATING REAL TIME CLINICAL ACTIVITY TO PREDICT PHYSICIAN BURNOUT
Christopher King, MD, PhDTelemedicine Notifications with Machine Learning for Postoperative Care
Anand Lakshminarasimhachar, MDOptimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) Trial
Anand Lakshminarasimhachar, MDEffect on plasma acid base status of patients undergoing oncological surgery with Hyperthermic Intraperitoneal Chemotherapy
Ellen Lockhart, MDSleep Apnea and Fetal Growth Restriction
David Monks, MBChBPostpartum depression after Cesarean delivery: Ketamine as a preventative intervention. A feasibility pilot-study
Michael Montana, MD, PhDHuman Brain Adaptation to Chronic Pain and Its Effects on Opioid Use
Michael Montana, MD, PhDPharmacokinetics and Safety of Anesthetics and Analgesics in Children and Adolescents
Michael Montana, MD, PhDIdentification of the Causes of Persistent and Profound Pediatric Intraoperative Hypoxemia to Advance Health Care Professional Education and Improve Patient Safety
Michael Montana, MD, PhDA randomized controlled trial to compare hydromorphone vs fentanyl in children undergoing tonsillectomy surgery
Jeremiah Morrissey, PhDNanotech biomarkers for renal cancer intervention: clinical validation and utility
Jeremiah Morrissey, PhDMETAL-ORGANIC FRAMEWORK AS PROTECTIVE COATING FOR CANCER BIOSPECIMEN PRESERVATION
Jeremiah Morrissey, PhDDevelopment and validation of an ultrasensitive, fast plasmon-enhanced assay for human IgG/IgM/IgA to COVID-19 infection.
David Murray, MDAnalysis of Perioperative Quality Data from Electronic Records: Strategies to Improve Anesthetic Safety
David Murray, MDDifficult Airway Service (DAS)- A review since inception
Guido Musch, MD, MBAPRIME-AIR STUDY- An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications
Amjad Musleh, MDEarly Vasopressors in Septic Shock and the Prevention of Renal Replacement Therapy
Amjad Musleh, MDLung Compliance in COVID+ Ventilated Patients
Sydney Nykiel-Bailey, DOPediatric Difficult Intubation (PeDI) Registry – Improving Safety and Quality of Airway Management in Children with Difficult Airways
Ben Palanca, MD, PhDPROGNOSTICATING DELIRIUM RECOVERY OUTCOMES USING WAKEFULNESS AND SLEEP ELECTROENCEPHALOGRAPHY (P-DROWS-E)
Ben Palanca, MD, PhD
Christian Guay, MD
Closed Loop Acoustic Stimulation during Sedation with Dexmedetomidine (CLASS-D)
Arvind Palanisamy, MDPrevention of Transient Tachypnea of the Newborn with Prophylactic Phenylephrine Infusion During Elective Cesarean Delivery
Arvind Palanisamy, MDThe SOAP COVID-19 Delivery Registry
Anshuman Sharma, MD, MBAComparison of Ultrasonic Evaluation of the Pupillary Light Reflex with Dark Adapted Pupillometry
Anshuman Sharma, MD, MBAA Retrospective Assessment of Opioid Use and Acute Pain Following Pediatric Tonsillectomy
Anshuman Sharma, MD, MBAAnesthetic Implications for Surgical Palliation of Medically Refractory pulmonary Hypertension in Pediatric Patients
Kendall Smith, MD, PhDLongitudinal Assessment of Leadership, Career Development and Wellness Culture in Anesthesiology Residency
Douglas Thompson, MDPediatric Craniofacial Surgery Perioperative Registry
Brian Wessman, MDEnd of Life Care in the Emergency Department: A cross sectional observational study
Brian Wessman, MDFeasibility Assessment of an ED to ICU team based Transition of Care Tool
Brian Wessman, MDLocal Practice Patterns of Vasopressor Use in the Emergency Department