Our team of researchers lead groundbreaking clinical studies aimed at improving the health of people throughout the world.
The Division of Clinical and Translational Research (DoCTR) is the home for patient-oriented research in the Department of Anesthesiology. Numerous translational and clinical research projects are currently led by faculty members in the division, in a wide variety of research areas. These include drug disposition, pharmacogenomics, perioperative myocardial infarction, intraoperative awareness, postoperative cognitive dysfunction, biomarkers, cardiovascular monitoring, coagulation, and functional brain imaging. All investigators have clinical research programs, and some also have laboratory-based translational programs.
Frequently Asked Questions
Are you curious about joining a clinical study? Explore our clinical study FAQs to learn more about clinical studies in DoCTR.
Active Clinical Studies
A list of ongoing clinical studies in the Department of Anesthesiology can be found below and on ClinicalTrials.gov.*
* the above link may display studies that have similar keywords but are not run in DoCTR.
If you would like to volunteer or receive more information about a particular study listed below, please send a request to volunteer@wustl.edu, note which study or studies you may be interested in and how you can be contacted, and one of our research coordinators will contact you with more information.
Principal Investigator | Title |
---|---|
Enyo Ablordeppey, MD, MPH | Ultrasound guided central venous catheter verification |
Enyo Ablordeppey, MD, MPH | A Qualitative Study of US guided CVC confirmation practices |
Enyo Ablordeppey, MD, MPH | Feasibility of volume assessment by echocardiography before and after dialysis in chronic renal failure patients. |
Enyo Ablordeppey, MD, MPH | Efficacy and acceptability of DRAUP |
Enyo Ablordeppey, MD, MPH | Utilization of point of care cardiothoracic ultrasound to guide fluid resuscitation in emergency department patients with sepsis |
Enyo Ablordeppey, MD, MPH | Low frequency, high complexity: skill retention following proficiency-based transesophageal echocardiography simulation training |
Enyo Ablordeppey, MD, MPH | Adapting and testing a deimplementation program in the Intensive Care Unit: Aim 1 |
Enyo Ablordeppey, MD, MPH | Decreasing Urinary Catheters in Kidney Injury: Aim 1-qualitative analysis |
Enyo Ablordeppey, MD, MPH | Decreasing Urinary Catheters in Kidney Injury: quantitative analysis |
Enyo Ablordeppey, MD, MPH / Scott Markowitz, MD, MSOL | Cultural Survey: Diversity, Equity, and Inclusion; wellness and engagement |
Enyo Ablordeppey, MD, MPH | Anesthesiology Residency DEI Curriculum Surve |
Enyo Ablordeppey, MD, MPH | Diversity in the Advanced Practice Critical Care Workforce |
Enyo Ablordeppey, MD, MPH | Subclavian vein cannulation under Ultrasound Guidance with Advanced Retention: an implementation science approach |
Cognition in the Anesthesiology Control Tower and Operating Room CO-ACT-OR | |
Observational Pilot Study of Post-Surgical Discharge Care Transition | |
Subjective Assessment of the ASAP Training Program | |
Designing a Tele-Critical Care Consult Service to Prevent Avoidable Intensive Care Unit Admissions | |
Joanna Abraham, PhD | TELE-TOC: Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients – Aim 1 |
Joanna Abraham, PhD | EnhanCed Handoff (ECHO) |
Joanna Abraham, PhD | Standardizing Intraoperative Handoffs among Anesthesia Providers |
Joanna Abraham, PhD | The INCLUDE (Improving meNtal healthCare for oLder sUrgical racially minoritizeD patiEnts) study |
Joanna Abraham, PhD | General Public and Patient Perspectives and Attitudes towards Use of Artificial Intelligence in Perioperative Care |
Jacob AuBuchon, MD | The Comfort Ability Workshop: Improving Pain Treatment for Children and Their Families |
Michael S. Avidan, MBBCh | SATISFY-SOS: Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys |
Michael S. Avidan, MBBCh | The Prevention of Delirium and Complications Associated with Surgical Treatments (PODCAST) Study: Protocol for an International Multicenter Randomized Controlled Trial |
Michael S. Avidan, MBBCh | CPAP Adherence and Postoperative Delirium in Patients with OSA |
Michael S. Avidan, MBBCh | Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) Study: a Pragmatic, Randomized Clinical Trial |
Michael S. Avidan, MBBCh | Perioperative Risk Factors for All-Cause Unplanned Readmission within 30 Days After Surgery – a Sub-study of the SATISFY-SOS Observational Trial |
Michael S. Avidan, MBBCh | Creation of a merged registry of patients in the NSQIP and SATISFY-SOS registries at BJH/Washington University |
Michael S. Avidan, MBBCh | Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia |
Michael S. Avidan, MBBCh | Ability of postoperative delirium to predict intermediate-term postoperative cognitive function in patients undergoing elective surgery at an academic medical center: protocol for a prospective study |
Michael S. Avidan, MBBCh | Validation of the 3D-CAM in a Surgical Population |
Michael S. Avidan, MBBCh | Relationship Between Immediate and Subsequent Postoperative Delirium |
Michael S. Avidan, MBBCh | Delirium on the Day of Surgery Is Related to Subsequent Postoperative Delirium |
Michael S. Avidan, MBBCh | Comparison of Patient-Reported Pain Between Delirious and Non-Delirious Patients |
Michael S. Avidan, MBBCh | Association between Delirium and Patient Reported-Outcomes 30-Days Following Major Surgery |
Michael S. Avidan, MBBCh | Patients self-report of delirium in the post-operative period |
Michael S. Avidan, MBBCh | Detection of Delirium in the Postoperative Period by Family and Caregivers |
Michael S. Avidan, MBBCh | Protocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the Post Anesthesia Care Unit |
Michael S. Avidan, MBBCh | Protocol for the Effectiveness of an Anesthesiology Control Tower System in Improving Perioperative Quality Metrics and Clinical Outcomes: the TECTONICS randomized, pragmatic trial |
Michael S. Avidan, MBBCh | Benzodiazepine-free Cardiac Anesthesia for reduction of Postoperative Delirium |
Michael S. Avidan, MBBCh | Comparing Methods of Delirium Detection |
Michael S. Avidan, MBBCh | An international, Bayesian platform adaptive, randomized, placebo-controlled trial assessing the effectiveness of candidate interventions in preventing COVID-19 disease in adults |
Michael S. Avidan, MBBCh | The effects of prior exposure to the Measles, Mumps, and Rubella vaccine on innate and adaptive immune responses to a SARS-CoV-2 mRNA vaccine |
Michael S. Avidan, MBBCh | Public perceptions on trial comparing total intravenous versus inhalational anesthesia for major surgery |
Michael S. Avidan, MBBCh | Behavioral Activation and Medication Optimization for Perioperative Mental Health Feasibility Study |
Michael S. Avidan, MBBCh | Evaluation of the Impact of an Anesthesiology Control Tower on Teamwork and Decision-Making Within the Operating Room |
Michael S. Avidan, MBBCh | Feasibility pilot trial for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) Trial |
Michael S. Avidan, MBBCh | Protocol for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) Trial |
Michael S. Avidan, MBBCh | Optimizing Screening Questions for Intraoperative Awareness |
Michael S. Avidan, MBBCh | Protocol for a pilot interventional study evaluating the efficiency and safety of a telemedicine solution for the Post-Anesthesia Care Unit |
Arbi Ben Abdallah, PhD, DES | Test-retest Reliability of Self-reported Outcomes by Surgical Patients |
Arbi Ben Abdallah, PhD, DES | Patient Health-Related Well-Being Before and After Surgery: A Latent Transition Analysis Approach |
Kelly Chilson, MD | Anesthetic management of children undergoing Potts shunt for medically refractory pulmonary hypertension |
Meaghan Creed, PhD | Characterizing value-based decision making in patients with neuropathic pain: A Pilot |
Lara Crock, MD, PhD | The role of the microbiome in the development of persistent post-surgical pain |
Lara Crock, MD, PhD | The role of microbiome in the severity and persistence of complex regional pain syndrome |
Anne Drewry, MD | Immunological Phenotyping of Febrile and Afebrile Critically Ill Septic Patients |
Anne Drewry, MD | Stratifying Patient Immune Endotypes in Sepsis (SPIES Study) |
Bradley Fritz, MD, MSCI | Protocol for the Perioperative Outcome Risk Assessment with Computer Learning Enhancement (Periop ORACLE) Randomized Study |
Bradley Fritz, MD, MSCI | Development an validation of a machine learning model predicting short intensive care unit stay |
Bradley Fritz, MD, MSCI | Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial |
Bradley Fritz, MD, MSCI | External Validation of an ICU Delirium Prediction Model |
Bradley Fritz, MD, MSCI | Feasibility Evaluation of a Tele-Critical Care Consult Service |
Bradley Fritz, MD, MSCI | Active Telemedicine Feedback to Enhance Compliance with a Spontaneous Awakening and Breathing Trial Protocol in Mechanically Ventilated Patients |
Bradley Fritz, MD, MSCI | Prevalence and Predictors of Cognitive Dysfunction after Surgery: A Retrospective Cohort Study |
Brian Fuller, MD | Memories among critically ill patients requiring mechanical ventilation in the emergency department |
Brian Fuller, MD | Awareness With Paralysis and Post-Traumatic Stress Disorder Among Mechanically Ventilated Emergency Department Survivors: the ED-AWARENESS-2 |
Robert Gereau, PhD | Determining the Pathogenicity of Autoantibodies in Small Fiber Neuropathy |
Robert Gereau, PhD | INTERCEPT: Integrated Research Center for Human Pain Tissues; Subproject Title: Human Tissues Core/Core B: Tissue Procurement and Processing |
Robert Gereau, PhD | Multi-omic profiling of traumatic nerve injury in humans to reveal mechanisms of degeneration, regeneration and pain |
Burel Goodin, PhD | Racial and Socioeconomic Differences in Chronic Low Back Pain |
Stephen Gregory, MD | A retrospective observational trial evaluating the prevalence and effect of preoperative cognitive dysfunction in a cohort of elderly patients undergoing elective surgery |
Stephen Gregory, MD | Financial Impact of a Pilot Program in Preoperative Nutritional Optimization |
Stephen Gregory, MD | Feasibility pilot trial for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) Trial |
Stephen Gregory, MD | Protocol for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) Trial |
Ryan Guffey, MD | PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery |
Ryan Guffey, MD | Encouraging Rational Use of Volatile Anesthetics |
Ryan Guffey, MD | Knowledge of perioperative multimodal analgesia after implementation of a standardized generic multimodal analgesia framework |
Simon Haroutounian, PhD, MSc | Intravenous lidocaine for preventing painful oxaliplatin-induced peripheral neuropathy (OIPN) |
Simon Haroutounian, PhD, MSc | Cognitive Flexibility Training for the Prevention of Persistent Post-Surgical Pain (COFLEX-PPSP): Feasibility Study |
Simon Haroutounian, PhD, MSc | Investigation of pharmacokinetics and pharmacodynamics of epidural methadone in healthy volunteers |
Simon Haroutounian, PhD, MSc | Cognitive Flexibility Training for Persistent Pain: MR imaging pilot (COFLEX-i) |
Simon Haroutounian, PhD, MSc | Effects of Pgp transporter inhibition on CNS biodistribution of ondansetron in healthy volunteers |
Simon Haroutounian, PhD, MSc | Chemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY) |
Simon Haroutounian, PhD, MSc | Brain-computer interface intervention for chronic upper extremity pain: a pilot study |
Simon Haroutounian, PhD, MSc | Administration of ondansetron with P-glycoprotein inhibitor tariquidar in patients with neuropathic pain |
Simon Haroutounian, PhD, MSc | P-5 Personalized Prediction of Persistent Postsurgical Pain |
Simon Haroutounian, PhD, MSc | P-5 Personalized Prediction of Persistent Postsurgical Pain: A Pilot Study |
Simon Haroutounian, PhD, MSc | Optimizing the use of ketamine to reduce chronic postsurgical pain |
Simon Haroutounian, PhD, MSc | Genetic, molecular, and phenotypic biomarkers of postoperative outcomes: Ancillary studies to P5 (Personalized Prediction of Persistent Postsurgical Pain) project |
Simon Haroutounian, PhD, MSc | Behavioral Activation and Medication Optimization For Improving Perioperative Mental Health In Older Adults Undergoing Cardiac Surgery |
Simon Haroutounian, PhD, MSc | Comparing Analgesic Regimen Effectiveness and Safety for surgery (CARES) Trial |
Simon Haroutounian, PhD, MSc | Opioids and postanesthesia recovery: A retrospective chart review |
Simon Haroutounian, PhD, MSc | Patient and clinician perspectives on biomarker for the prediction of chemotherapy-induced peripheral neuropathy (CIPN) |
Mohammed Helwani, MD, MSP | Metoprolol to Reduce Perioperative Myocardial Injury |
Mohammed Helwani, MD, MSP | Intra-Individual Transpulmonary Variation in Cardiac Biomarker Concentrations |
Mohammed Helwani, MD, MSP | Anesthesia Related Complications in Transesophageal Echocardiography Procedures |
Mohammed Helwani, MD, MSP | Effect of benzodiazepine on extubation time in post cardiac surgery patients |
Katherine Holzer, PhD, LCSW | Perspectives of individuals with chronic pain on patient engagement in clinical pain research |
Richard Hotchkiss, MD | Cellular Mechanisms of Sepsis and Organ Failure |
Richard Hotchkiss, MD | Potential Immuno-Adjuvant Therapy in Sepsis |
Richard Hotchkiss, MD | Red Blood Cell Danger Associated Molecular Patterns in Trauma |
Danish Jaffer | Machine Learning Using Cardiotocography and Other Intrapartum Elements in Predicting Fetal Outcomes |
York Jiao, MD | Prediction of surgical case duration from historical EHR data |
York Jiao, MD | Time Burden of Regional Blocks Performed Under General Anesthesia in the Pediatric Population |
York Jiao, MD | Multicenter perioperative outcomes group (MPOG) performance site |
Jessica Justmann, MD | Complex Regional Pain Syndrome in Children: Assessing PROMIS Score Outcomes Following Longitudinal Outpatient Treatment |
Mohammad Mehdi Kafashan | Correlating electroconvulsive therapy response to electroencephalographic ictal complexes and postictal markers |
Mohammad Mehdi Kafashan | Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy |
Muthuraj Kanakaraj, MD | Postoperative vasopressor usage: a prospective international observational study |
Ivan Kangrga, MD, PhD | Pulmonary function tests and perioperative complications in adult liver transplant recipients |
Thomas Kannampallil, PhD | Predicting Post-Surgical Pain Outcomes from Acute Pain Trajectories |
Thomas Kannampallil, PhD | Integrating Real Time Clinical Activity to Predict Physician Burnout |
Thomas Kannampallil, PhD | Characterizing anesthesiology provider EHR work habits and relation to process-based quality of care metrics |
Thomas Kannampallil, PhD | Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor (SPEAC) for Adults with Emotional Distress |
Thomas Kannampallil, PhD | Prediction of intraoperative blood product utilization |
Thomas Kannampallil, PhD | A Quasi-Experimental Study on the Effects of COVID-19 on Medication Errors |
Thomas Kannampallil, PhD | Assessing the Effect of Telemedicine on Physician EHR Work, Cognition, and Process Outcomes (ASPIRE) |
Thomas Kannampallil, PhD | IGNITE (Integrating real-time clinical activity and behavioral responses for characterizing cognitive load and errors) |
Thomas Kannampallil, PhD | Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older |
Thomas Kannampallil, PhD | Assessing the Impact of EHR-based Workload on Nurse Turnover |
Thomas Kannampallil, PhD | IGNITE (Integrating real-time clinical activity and behavioral responses for characterizing cognitive load and errors) |
Paul Kerby, MD | Protocol for a proof-of-concept study evaluating Systematic QUality Improvement with Realtime Event Support |
Christopher King, MD, PhD | Telemedicine Notifications with Machine Learning for Postoperative Care |
Christopher King, MD, PhD | Prediction models for increased length of stay and readmission after ambulatory surgery: A retrospective study |
Christopher King, MD, PhD | Developing Interfaces for Machine Learning for Postoperative Care |
Christopher King, MD, PhD | Machine Learning for Postoperative Care |
Christopher King, MD, PhD | Effect of Group-specific Performance Information on User Perception of AI |
Christopher King, MD, PhD | Understanding clinical use cases for Machine Learning Using Cardiotocography and Other Intrapartum Elements in Predicting Fetal Outcomes |
Christopher King, MD, PhD | Deep Learning to Jointly Align, Impute, and Transform EHR Databases |
Anand Lakshminarasimhachar, MD | Optimisation of perioperatice cardiovascular management to improve surgical outcomes II trial |
Anand Lakshminarasimhachar, MD | Effect on plasma acid base status of patients undergoing oncological surgery with Hyperthermic Intraperitoneal Chemotherapy |
Sunny Lou, MD, PhD | Metrics for EHR Secure Chat Use |
Sunny Lou, MD, PhD | Intelligent Clinical Decision Support for Perioperative Blood Management |
Sunny Lou, MD, PhD | Validation and refinement of a machine learning model for surgical transfusion risk |
Sunny Lou, MD, PhD | Characterizing the effect of secure messaging on clinician workflow and efficiency |
Gregory Miller, MD | A randomized controlled trial to compare hydromorphone vs fentanyl in children undergoing tonsillectomy surgery |
David Monks, MBChB | The pharmacokinetics of Oxytocin (PK-OXT) in pregnant women undergoing cesarean delivery – a feasibility pilot study |
David Monks, MBChB | Postpartum depression after Cesarean delivery: Ketamine as a preventative intervention. A feasibility pilot-study |
David Monks, MBChB | Perinatal SMILES (Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms) |
Rachel Moquin, EdD | Faculty Education Workshop Series |
Rachel Moquin, EdD | Pediatric Anesthesiology Curriculum Study |
Rachel Moquin, EdD | Anesthesiology Subspecialty Fellow Education Project |
Rachel Moquin, EdD | Novel Intern Curriculum Study |
Rachel Moquin, EdD | Developing Expertise in Clinical Education Program Evaluation |
Rachel Moquin, EdD | Take 2 for the Team: Cultivating a Culture of Gratitude |
Jeremiah Morrissey, PhD | Urine Proteome of Patients Undergoing Surgery |
Jeremiah Morrissey, PhD | New non-invasive methods for real-time monitoring of organ function |
Jeremiah Morrissey, PhD | Biomarker correlates of radiologic imaging |
Jeremiah Morrissey, PhD | Urine Proteome of Surgical Patients and Healthy Volunteers |
Jeremiah Morrissey, PhD | Nanotech biomarkers for renal cancer intervention: clinical validation and utility |
Jeremiah Morrissey, PhD | Metal-organic Framework as Protective Coating for Cancer Biospecimen Preservation |
Jeremiah Morrissey, PhD | Development and validation of an ultrasensitive, fast plasmon-enhanced assay for human IgG/IgM/IgA to COVID-19 infection. |
Hadas Nahman-Averbuch, PhD | The effect of puberty on pain sensitivity |
Hadas Nahman-Averbuch, PhD | Migraine onset in adolescent girls |
Hadas Nahman-Averbuch, PhD | Hormonal Effects of Puberty-Related Alterations on Pain in Adolescents with Migraine |
Hadas Nahman-Averbuch, PhD | Relationship between sex hormones, postoperative pain and opioid use: the role of immune factors |
Hadas Nahman-Averbuch, PhD | The mechanisms underlying endometriosis pain |
Sydney Nykiel-Bailey, DO | Pediatric Difficult Intubation (PeDI) Registry – Improving Safety and Quality of Airway Management in Children with Difficult Airways |
Sydney Nykiel-Bailey, DO | Assessment of Novel Anesthesiology Residency DEI Curriculum |
Sydney Nykiel-Bailey, DO | What roles do educators play in graduate medical education |
Ben Palanca, MD, PhD | Diffuse Optical Tomography of Surgical Patients Undergoing General Anesthesia |
Ben Palanca, MD, PhD | Postoperative Delirium: Brain Vulnerability and Recovery |
Ben Palanca, MD, PhD | Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies |
Ben Palanca, MD, PhD | Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography (P-DROWS-E) |
Ben Palanca, MD, PhD | Closed Loop Acoustic Stimulation during Sedation with Dexmedetomidine (CLASS-D) |
Ben Palanca, MD, PhD | Precision targeting of propofol-induced electroencephalographic slow waves: a novel paradigm for treatment-resistant major depressive disorder – Phase I |
Ben Palanca, MD, PhD | Safety of Anesthesia Volunteer Experiments |
Arvind Palanisamy, MD | Prevention of Transient Tachypnea of the Newborn with Prophylactic Phenylephrine Infusion During Elective Cesarean Delivery |
Arvind Palanisamy, MD | Understanding host-pathogen interaction in the respiratory mucosa during pregnancy |
Arvind Palanisamy, MD | Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section |
Bethany Pennington, PharmD | Patients’ Perspectives and Preferences towards Inhaled & Total Intravenous Anesthesia |
Bethany Pennington, PharmD | Perioperative use of potentially inappropriate centrally acting medications in older patients with and without antidepressant use |
Bethany Pennington, PharmD | Stakeholders’ Perspectives of the Acceptability of THRIVE Study Procedures and Experiences in Participation: An Exploratory Qualitative Study |
Stephen Ristvedt, PhD | Promoting Uptake of a Usual Source of Care among African American Men |
Stephen Ristvedt, PhD | Community-Based Study of Uptake of a Usual Source of Care by African Amerian Men |
Stephen Ristvedt, PhD | The Role of Sense of Purpose among Patients with Chronic Pain |
Benjamin Sanofsky, MD | Decreasing Emergence Delirium with Personalized Music |
Preet Mohinder Singh, MD | Human Imaging Studies with Butterfly Ultrasound Devices |
Pratik Sinha, MBChB, PhD | PREcision-based Critical Care In SEpsis (PRECCISE) Study |
Pratik Sinha, MBChB, PhD | Longitudinal Kinetics of Molecular Phenotypes |
S. Kendall Smith, MD, PhD | Longitudinal Assessment of Leadership, Career Development and Wellness Culture in Anesthesiology Residency |
S. Kendall Smith, MD, PhD | Multi-Omics To End Delirium (MENDEL) Study |
Loc Thang, MD, PhD | Analysis of Failed Spinal Cord Stimulator Implantation After Successful Trials in The Treatment of Intractable Chronic Pain |
Loc Thang, MD, PhD | Pain Rotation Tutorial Curriculum Project |
Loc Thang, MD, PhD | Efficacy of Pain Relief and Functional Improvement with Continuous Radiofrequency Ablation of the Shoulder |
Loc Thang, MD, PhD | A Retrospective Review Study of the Use of Lidocaine Infusion in Patients in Sickle Cell Crisis |
Brian Torres, CRNA | Alleviation of Certified Registered Nurse Anesthetist (CRNA) Preceptor Burnout |
Brian Wessman, MD | End of Life Care in the Emergency Department: A cross sectional observational study |
Brian Wessman, MD | Palliative Care and Rapid Emergency Screening (P-CaRES): Impact of ED Screening in Elderly Patients |