Our team of researchers lead groundbreaking clinical studies aimed at improving the health of people throughout the world.

The Division of Clinical and Translational Research (DoCTR) is the home for patient-oriented research in the Department of Anesthesiology. Numerous translational and clinical research projects are currently led by faculty members in the division, in a wide variety of research areas. These include drug disposition, pharmacogenomics, perioperative myocardial infarction, intraoperative awareness, postoperative cognitive dysfunction, biomarkers, cardiovascular monitoring, coagulation, and functional brain imaging. All investigators have clinical research programs, and some also have laboratory-based translational programs.

Frequently Asked Questions

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Active Clinical Studies

A list of ongoing clinical studies in the Department of Anesthesiology can be found below and on ClinicalTrials.gov.*

* the above link may display studies that have similar keywords but are not run in DoCTR.

If you would like to volunteer or receive more information about a particular study listed below, please send a request to volunteer@wustl.edu, note which study or studies you may be interested in and how you can be contacted, and one of our research coordinators will contact you with more information.

Principal InvestigatorTitleStatus
Enyo Ablordeppey, MD, MPHUltrasound guided central venous catheter verificationOpen
Enyo Ablordeppey, MD, MPHFeasibility of volume assessment by echocardiography before and after dialysis in chronic renal failure patients.Open
Enyo Ablordeppey, MD, MPHA Qualitative Study of US guided CVC confirmation practicesOpen
Enyo Ablordeppey, MD, MPHEfficacy and acceptability of DRAUPOpen
Cognition in the Anesthesiology Control Tower and Operating Room CO-ACT-OROpen
Exploratory Study of Care Transition and Handoff Workflows across the Perioperative Care ContinuumOpen

Umeshkumar Athiraman, MD

Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy PatientsActive

Jacob AuBuchon, MD

Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric PatientsPENDING IRB
Jacob AuBuchon, MDThe Comfort Ability Workshop: Improving Pain Treatment for Children and Their FamiliesActive
Michael S. Avidan, MBBChCreation of a merged registry of patients in the NSQIP and SATISFY-SOS registries at BJH/Washington UniversityOpen
Michael S. Avidan, MBBChAbility of postoperative delirium to predict intermediate-term postoperative cognitive function in patients undergoing elective surgery at an academic medical center: protocol for a prospective studyActive
Michael S. Avidan, MBBChPerioperative glycemia management in patients undergoing craniotomy for brain tumor resection: an international survey of neuroanesthesiologists’ perceptions and practicesActive
Michael S. Avidan, MBBChAnesthesiology Control Tower: Forecasting Algorithms to Support Treatments (ACTFAST)Active
Michael S. Avidan, MBBChDelirium on the Day of Surgery Is Related to Subsequent Postoperative DeliriumOpen
Michael S. Avidan, MBBChComparison of Patient-Reported Pain Between Delirious and Non-Delirious PatientsActive
Michael S. Avidan, MBBChExploring the Role of Mental Health Interventions for Geriatric Patients within Surgical SettingActive
Michael S. Avidan, MBBChProtocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the Post Anesthesia Care UnitActive
Michael S. Avidan, MBBChProtocol for the Effectiveness of an Anesthesiology Control Tower System in Improving Perioperative Quality Metrics and Clinical Outcomes: the TECTONICS randomized, pragmatic trialActive
Michael S. Avidan, MBBChPractical training of anesthesia clinicians in electroencephalogram-based determination of hypnotic depth of general anesthesiaActive
Michael S. Avidan, MBBChBenzodiazepine-free Cardiac Anesthesia for reduction of Postoperative DeliriumActive
Michael S. Avidan, MBBChSocial work intervention with older surgery patients, feasibility studyActive
Michael S. Avidan, MBBChCROWN CORONATION: COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTIONActive/recruiting
Arbi Ben Abdallah, PhD, DESPatient Health-Related Well-Being Before and After Surgery: A Latent Transition Analysis ApproachActive
Amber Benhardt, MDComparing the Performance of Residents in Obstetric Anesthesia after the Implementation of Anesthesia ToolboxActive
Kelly Chilson, MDThe Pediatric Heparin-Alternative Multi-Institutional Quality improvement ProjectActive
Lara Crock, MD, PhDThe role of microbiome in the severity and persistence of complex regional pain syndromeActive
Bakul Dave, MD, MSProduct Surveillance Registry: PainActive
Anne Drewry, MDImmunological Phenotyping of Febrile and Afebrile Critically Ill Septic PatientsActive
Anne Drewry, MDCore Warming of COVID-19 Patients Undergoing Mechanical Ventilation: a randomized, single center pilot studyPENDING IRB
Julie Drobish, MDRetrospective and ongoing assessment of pediatric liver transplant managementActive
Brian Fuller, MDAn Assessment of Awareness in Mechanically Ventilated Patients Admitted from the Emergency Department: The ED-AWARE StudyActive
Brian Fuller, MDBIS Monitoring in Mechanically Ventilated ED Patients: an Observational StudyActive
Brian Fuller, MDThe ED-SED Pilot: a Multicenter, Before-After Study to Improve Sedation in the Emergency DepartmentActive
Stephen Gregory, MDA retrospective observational trial evaluating the prevalence and effect of preoperative cognitive dysfunction in a cohort of elderly patients undergoing elective surgeryActive
Ryan Guffey, MDPeri-Operative Epidural Management Study (POEM study) SurveyActive
Simon Haroutounian, PhD, MScIntravenous lidocaine for preventing painful oxaliplatin-induced peripheral neuropathy (OIPN)Active
Simon Haroutounian, PhD, MScCognitive Flexibility Training for the Prevention of Persistent Post-Surgical Pain (COFLEX-PPSP): Feasibility StudyActive
Simon Haroutounian, PhD, MScEffects of Pgp transporter inhibition on CNS biodistribution of ondansetron in healthy volunteersActive
Simon Haroutounian, PhD, MScChemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY)Active
Simon Haroutounian, PhD, MScEEG Signature of Pain and Pain Relief: A Pilot Exploratory studyActive
Simon Haroutounian, PhD, MScBrain-computer interface intervention for chronic upper extremity pain: a pilot studyActive
Simon Haroutounian, PhD, MScIncidence and characterization of peripheral and cranial nerve neuropathy in patients diagnosed with COVID-19Active
Daniel Helsten, MDMulticenter perioperative outcomes group (MPOG) performance siteActive
Mohammed Helwani, MD, MSPCardiac Surgery in Jehovah’s Witness patients: Single Academic Center ExperienceActive
Richard Hotchkiss, MDCellular Mechanisms of Sepsis and Organ FailureActive
Richard Hotchkiss, MDPotential Immuno-Adjuvant Therapy in SepsisActive
Richard Hotchkiss, MDInternational, multicenter, randomized, double-blinded, placebo-controlled study of Recombinant Interleukin-7 (CYT107) to restore absolute lymphocyte counts (ALC) in patients with Sepsis (IRIS-7 C & D Bridge Studies)Active
York Jiao, MDPrediction of surgical case duration from historical EHR dataActive
Jessica Justmann, MDCognitive changes associated with initiation of gabapentin treatment in adults with chronic painActive
Mohammad Mehdi KafashanCorrelating electroconvulsive therapy response to electroencephalographic ictal complexes and postictal markersPENDING IRB
Ivan Kangrga, MDPulmonary function tests and perioperative complications in adult liver transplant recipientsActive
Thomas Kannampallil, PhDPredicting Post-Surgical Pain Outcomes from Acute Pain TrajectoriesActive
Thomas Kannampallil, PhDEffect of Intraoperative Pediatric Anesthesia Handoffs on Surgical OutcomesActive
Thomas Kannampallil, PhDMental Health Related Quality of LifeActive
Thomas Kannampallil, PhDAssessing Physician Trainee Wellness during a Pandemic (ASPIRE)Active
Christopher King, MD, PhDTelemedicine Notifications with Machine Learning for Postoperative CareActive
Anand Lakshminarasimhachar, MDOptimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) TrialActive
Anand Lakshminarasimhachar, MDEffect on plasma acid base status of patients undergoing oncological surgery with Hyperthermic Intraperitoneal ChemotherapyActive
Ellen Lockhart, MDSleep Apnea and Fetal Growth RestrictionActive
David Monks, MBChBPostpartum depression after Cesarean delivery: Ketamine as a preventative intervention. A feasibility pilot-studyPENDING
Michael Montana, MD, PhDHuman Brain Adaptation to Chronic Pain and Its Effects on Opioid UseActive
Michael Montana, MD, PhDPharmacokinetics and Safety of Anesthetics and Analgesics in Children and AdolescentsActive
Michael Montana, MD, PhDIdentification of the Causes of Persistent and Profound Pediatric Intraoperative Hypoxemia to Advance Health Care Professional Education and Improve Patient SafetyActive
Michael Montana, MD, PhDA randomized controlled trial to compare hydromorphone vs fentanyl in children undergoing tonsillectomy surgeryActive
Jeremiah Morrissey, PhDNanotech biomarkers for renal cancer intervention: clinical validation and utilityActive
Jeremiah Morrissey, PhDDevelopment and validation of an ultrasensitive, fast plasmon-enhanced assay for human IgG/IgM/IgA to COVID-19 infection.Active
David Murray, MDAnalysis of Perioperative Quality Data from Electronic Records: Strategies to Improve Anesthetic SafetyActive
David Murray, MDDifficult Airway Service (DAS)- A review since inceptionActive
Guido Musch, MD, MBAPRIME-AIR STUDY- An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary ComplicationsActive
Amjad Musleh, MDEarly Vasopressors in Septic Shock and the Prevention of Renal Replacement TherapyActive
Amjad Musleh, MDLung Compliance in COVID+ Ventilated PatientsActive
Sydney Nykiel-Bailey, DOPediatric Difficult Intubation (PeDI) Registry – Improving Safety and Quality of Airway Management in Children with Difficult AirwaysActive
Ben Palanca, MD, PhD
Christian Guay, MD
Closed Loop Acoustic Stimulation during Sedation with Dexmedetomidine (CLASS-D)Active
Arvind Palanisamy, MDPrevention of Transient Tachypnea of the Newborn with Prophylactic Phenylephrine Infusion During Elective Cesarean DeliveryActive
Arvind Palanisamy, MDThe SOAP COVID-19 Delivery RegistryActive
Anshuman Sharma, MD, MBAComparison of Ultrasonic Evaluation of the Pupillary Light Reflex with Dark Adapted PupillometryActive
Anshuman Sharma, MD, MBAA Retrospective Assessment of Opioid Use and Acute Pain Following Pediatric TonsillectomyActive
Anshuman Sharma, MD, MBAAnesthetic Implications for Surgical Palliation of Medically Refractory pulmonary Hypertension in Pediatric PatientsActive
Kendall Smith, MD, PhDLongitudinal Assessment of Leadership, Career Development and Wellness Culture in Anesthesiology ResidencyActive
Douglas Thompson, MDPediatric Craniofacial Surgery Perioperative RegistryActive
Brian Wessman, MDEnd of Life Care in the Emergency Department: A cross sectional observational studyActive
Brian Wessman, MDFeasibility Assessment of an ED to ICU team based Transition of Care ToolActive
Brian Wessman, MDLocal Practice Patterns of Vasopressor Use in the Emergency DepartmentActive