Our team of researchers lead groundbreaking clinical studies aimed at improving the health of people throughout the world.

The Division of Clinical and Translational Research (DoCTR) is the home for patient-oriented research in the Department of Anesthesiology. Numerous translational and clinical research projects are currently led by faculty members in the division, in a wide variety of research areas. These include drug disposition, pharmacogenomics, perioperative myocardial infarction, intraoperative awareness, postoperative cognitive dysfunction, biomarkers, cardiovascular monitoring, coagulation, and functional brain imaging. All investigators have clinical research programs, and some also have laboratory-based translational programs.

Frequently Asked Questions

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Active Clinical Studies

A list of ongoing clinical studies in the Department of Anesthesiology can be found below and on ClinicalTrials.gov.*

* the above link may display studies that have similar keywords but are not run in DoCTR.

If you would like to volunteer or receive more information about a particular study listed below, please send a request to volunteer@wustl.edu, note which study or studies you may be interested in and how you can be contacted, and one of our research coordinators will contact you with more information.

Principal Investigator Title Status
Enyo Ablordeppey, MD, MPH Ultrasound guided central venous catheter verification Open
Enyo Ablordeppey, MD, MPH Feasibility of volume assessment by echocardiography before and after dialysis in chronic renal failure patients. Open
Enyo Ablordeppey, MD, MPH A Qualitative Study of US guided CVC confirmation practices Open
Enyo Ablordeppey, MD, MPH Efficacy and acceptability of DRAUP Open
Cognition in the Anesthesiology Control Tower and Operating Room CO-ACT-OR Open
Exploratory Study of Care Transition and Handoff Workflows across the Perioperative Care Continuum Open

Umeshkumar Athiraman, MD

Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients Active

Jacob AuBuchon, MD

Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric Patients PENDING IRB
Jacob AuBuchon, MD The Comfort Ability Workshop: Improving Pain Treatment for Children and Their Families Active
Michael S. Avidan, MBBCh Creation of a merged registry of patients in the NSQIP and SATISFY-SOS registries at BJH/Washington University Open
Michael S. Avidan, MBBCh Ability of postoperative delirium to predict intermediate-term postoperative cognitive function in patients undergoing elective surgery at an academic medical center: protocol for a prospective study Active
Michael S. Avidan, MBBCh Perioperative glycemia management in patients undergoing craniotomy for brain tumor resection: an international survey of neuroanesthesiologists’ perceptions and practices Active
Michael S. Avidan, MBBCh Anesthesiology Control Tower: Forecasting Algorithms to Support Treatments (ACTFAST) Active
Michael S. Avidan, MBBCh Delirium on the Day of Surgery Is Related to Subsequent Postoperative Delirium Open
Michael S. Avidan, MBBCh Comparison of Patient-Reported Pain Between Delirious and Non-Delirious Patients Active
Michael S. Avidan, MBBCh Exploring the Role of Mental Health Interventions for Geriatric Patients within Surgical Setting Active
Michael S. Avidan, MBBCh Protocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the Post Anesthesia Care Unit Active
Michael S. Avidan, MBBCh Protocol for the Effectiveness of an Anesthesiology Control Tower System in Improving Perioperative Quality Metrics and Clinical Outcomes: the TECTONICS randomized, pragmatic trial Active
Michael S. Avidan, MBBCh Practical training of anesthesia clinicians in electroencephalogram-based determination of hypnotic depth of general anesthesia Active
Michael S. Avidan, MBBCh Benzodiazepine-free Cardiac Anesthesia for reduction of Postoperative Delirium Active
Michael S. Avidan, MBBCh Social work intervention with older surgery patients, feasibility study Active
Michael S. Avidan, MBBCh An international, multi-site, Bayesian platform adaptive,randomised, double-blind, placebo-controlled trial assessing the effectiveness of varied doses of oral Chloroquine in preventing or reducing the severity of COVID-19 disease in healthcare workers Active/not yet recruiting
Arbi Ben Abdallah, PhD, DES Patient Health-Related Well-Being Before and After Surgery: A Latent Transition Analysis Approach Active
Amber Benhardt, MD Comparing the Performance of Residents in Obstetric Anesthesia after the Implementation of Anesthesia Toolbox Active
Kelly Chilson, MD The Pediatric Heparin-Alternative Multi-Institutional Quality improvement Project Active
Lara Crock, MD, PhD The role of microbiome in the severity and persistence of complex regional pain syndrome Active
Bakul Dave, MD, MS Product Surveillance Registry: Pain Active
Anne Drewry, MD Immunological Phenotyping of Febrile and Afebrile Critically Ill Septic Patients Active
Anne Drewry, MD Core Warming of COVID-19 Patients Undergoing Mechanical Ventilation: a randomized, single center pilot study PENDING IRB
Julie Drobish, MD Retrospective and ongoing assessment of pediatric liver transplant management Active
Brian Fuller, MD An Assessment of Awareness in Mechanically Ventilated Patients Admitted from the Emergency Department: The ED-AWARE Study Active
Brian Fuller, MD BIS Monitoring in Mechanically Ventilated ED Patients: an Observational Study Active
Brian Fuller, MD The ED-SED Pilot: a Multicenter, Before-After Study to Improve Sedation in the Emergency Department Active
Stephen Gregory, MD A retrospective observational trial evaluating the prevalence and effect of preoperative cognitive dysfunction in a cohort of elderly patients undergoing elective surgery Active
Ryan Guffey, MD Peri-Operative Epidural Management Study (POEM study) Survey Active
Simon Haroutounian, PhD, MSc Intravenous lidocaine for preventing painful oxaliplatin-induced peripheral neuropathy (OIPN) Active
Simon Haroutounian, PhD, MSc Cognitive Flexibility Training for the Prevention of Persistent Post-Surgical Pain (COFLEX-PPSP): Feasibility Study Active
Simon Haroutounian, PhD, MSc Effects of Pgp transporter inhibition on CNS biodistribution of ondansetron in healthy volunteers Active
Simon Haroutounian, PhD, MSc Chemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY) Active
Simon Haroutounian, PhD, MSc EEG Signature of Pain and Pain Relief: A Pilot Exploratory study Active
Simon Haroutounian, PhD, MSc Brain-computer interface intervention for chronic upper extremity pain: a pilot study Active
Simon Haroutounian, PhD, MSc Incidence and characterization of peripheral and cranial nerve neuropathy in patients diagnosed with COVID-19 Active
Daniel Helsten, MD Multicenter perioperative outcomes group (MPOG) performance site Active
Mohammed Helwani, MD, MSP Cardiac Surgery in Jehovah’s Witness patients: Single Academic Center Experience Active
Mohammed Helwani, MD, MSP EFFECT OF SPINAL VERSUS GENERAL ANESTHESIA ON CARDIAC AND RENAL BIOMARKER LEVELS IN HIP AND KNEE ARTHROPLASTY SURGERY Active
Richard Hotchkiss, MD Cellular Mechanisms of Sepsis and Organ Failure Active
Richard Hotchkiss, MD Potential Immuno-Adjuvant Therapy in Sepsis Active
Richard Hotchkiss, MD International, multicenter, randomized, double-blinded, placebo-controlled study of Recombinant Interleukin-7 (CYT107) to restore absolute lymphocyte counts (ALC) in patients with Sepsis (IRIS-7 C & D Bridge Studies) Active
York Jiao, MD Prediction of surgical case duration from historical EHR data Active
Jessica Justmann, MD Cognitive changes associated with initiation of gabapentin treatment in adults with chronic pain Active
Mohammad Mehdi Kafashan Correlating electroconvulsive therapy response to electroencephalographic ictal complexes and postictal markers PENDING IRB
Ivan Kangrga, MD Pulmonary function tests and perioperative complications in adult liver transplant recipients Active
Thomas Kannampallil, PhD Predicting Post-Surgical Pain Outcomes from Acute Pain Trajectories Active
Thomas Kannampallil, PhD Effect of Intraoperative Pediatric Anesthesia Handoffs on Surgical Outcomes Active
Thomas Kannampallil, PhD Mental Health Related Quality of Life Active
Thomas Kannampallil, PhD Assessing Physician Trainee Wellness during a Pandemic (ASPIRE) Active
Thomas Kannampallil, PhD INTEGRATING REAL TIME CLINICAL ACTIVITY TO PREDICT PHYSICIAN BURNOUT Active
Christopher King, MD, PhD Telemedicine Notifications with Machine Learning for Postoperative Care Active
Anand Lakshminarasimhachar, MD Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) Trial Active
Anand Lakshminarasimhachar, MD Effect on plasma acid base status of patients undergoing oncological surgery with Hyperthermic Intraperitoneal Chemotherapy Active
Ellen Lockhart, MD Sleep Apnea and Fetal Growth Restriction Active
David Monks, MBChB Postpartum depression after Cesarean delivery: Ketamine as a preventative intervention. A feasibility pilot-study PENDING
Michael Montana, MD, PhD Human Brain Adaptation to Chronic Pain and Its Effects on Opioid Use Active
Michael Montana, MD, PhD Pharmacokinetics and Safety of Anesthetics and Analgesics in Children and Adolescents Active
Michael Montana, MD, PhD Identification of the Causes of Persistent and Profound Pediatric Intraoperative Hypoxemia to Advance Health Care Professional Education and Improve Patient Safety Active
Michael Montana, MD, PhD A randomized controlled trial to compare hydromorphone vs fentanyl in children undergoing tonsillectomy surgery Active
Jeremiah Morrissey, PhD Nanotech biomarkers for renal cancer intervention: clinical validation and utility Active
Jeremiah Morrissey, PhD METAL-ORGANIC FRAMEWORK AS PROTECTIVE COATING FOR CANCER BIOSPECIMEN PRESERVATION Active
Jeremiah Morrissey, PhD Development and validation of an ultrasensitive, fast plasmon-enhanced assay for human IgG/IgM/IgA to COVID-19 infection. Active
David Murray, MD Analysis of Perioperative Quality Data from Electronic Records: Strategies to Improve Anesthetic Safety Active
David Murray, MD Difficult Airway Service (DAS)- A review since inception Active
Guido Musch, MD, MBA PRIME-AIR STUDY- An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications Active
Amjad Musleh, MD Early Vasopressors in Septic Shock and the Prevention of Renal Replacement Therapy Active
Amjad Musleh, MD Lung Compliance in COVID+ Ventilated Patients Active
Sydney Nykiel-Bailey, DO Pediatric Difficult Intubation (PeDI) Registry – Improving Safety and Quality of Airway Management in Children with Difficult Airways Active
Ben Palanca, MD, PhD PROGNOSTICATING DELIRIUM RECOVERY OUTCOMES USING WAKEFULNESS AND SLEEP ELECTROENCEPHALOGRAPHY (P-DROWS-E) Active
Ben Palanca, MD, PhD
Christian Guay, MD
Closed Loop Acoustic Stimulation during Sedation with Dexmedetomidine (CLASS-D) Active
Arvind Palanisamy, MD Prevention of Transient Tachypnea of the Newborn with Prophylactic Phenylephrine Infusion During Elective Cesarean Delivery Active
Arvind Palanisamy, MD The SOAP COVID-19 Delivery Registry Active
Anshuman Sharma, MD, MBA Comparison of Ultrasonic Evaluation of the Pupillary Light Reflex with Dark Adapted Pupillometry Active
Anshuman Sharma, MD, MBA A Retrospective Assessment of Opioid Use and Acute Pain Following Pediatric Tonsillectomy Active
Anshuman Sharma, MD, MBA Anesthetic Implications for Surgical Palliation of Medically Refractory pulmonary Hypertension in Pediatric Patients Active
Kendall Smith, MD, PhD Longitudinal Assessment of Leadership, Career Development and Wellness Culture in Anesthesiology Residency Active
Douglas Thompson, MD Pediatric Craniofacial Surgery Perioperative Registry Active
Brian Wessman, MD End of Life Care in the Emergency Department: A cross sectional observational study Active
Brian Wessman, MD Feasibility Assessment of an ED to ICU team based Transition of Care Tool Active
Brian Wessman, MD Local Practice Patterns of Vasopressor Use in the Emergency Department Active