Our team of researchers lead groundbreaking clinical studies aimed at improving the health of people throughout the world.

The Division of Clinical and Translational Research (DoCTR) is the home for patient-oriented research in the Department of Anesthesiology. Numerous translational and clinical research projects are currently led by faculty members in the division, in a wide variety of research areas. These include drug disposition, pharmacogenomics, perioperative myocardial infarction, intraoperative awareness, postoperative cognitive dysfunction, biomarkers, cardiovascular monitoring, coagulation, and functional brain imaging. All investigators have clinical research programs, and some also have laboratory-based translational programs.

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Active Clinical Studies

A list of ongoing clinical studies in the Department of Anesthesiology can be found below and on ClinicalTrials.gov.*

* the above link may display studies that have similar keywords but are not run in DoCTR.

If you would like to volunteer or receive more information about a particular study listed below, please send a request to volunteer@wustl.edu, note which study or studies you may be interested in and how you can be contacted, and one of our research coordinators will contact you with more information.

Principal InvestigatorTitle
Enyo Ablordeppey, MD, MPHUltrasound guided central venous catheter verification
Enyo Ablordeppey, MD, MPHIncorporating critical care ultrasound training into a critical medicine fellowship curriculum
Enyo Ablordeppey, MD, MPHA Qualitative Study of US guided CVC confirmation practices
Enyo Ablordeppey, MD, MPHFeasibility of volume assessment by echocardiography before and after dialysis in chronic renal failure patients
Enyo Ablordeppey, MD, MPHEfficacy and acceptability of DRAUP
Enyo Ablordeppey, MD, MPHUtilization of point of care cardiothoracic ultrasound to guide fluid resuscitation in emergency department patients with sepsis
Enyo Ablordeppey, MD, MPHLow frequency, high complexity: skill retention following proficiency-based transesophageal echocardiography simulation trining
Enyo Ablordeppey, MD, MPHAdapting and testing a deimplementation program in the Intensive Care Unit: Aim 1
Etiology of Medication Ordering: An Exploratory Investigation of Error Generation and Correction
Cognition in the Anesthesiology Control Tower and Operating Room CO-ACT-OR
Exploratory Study of Care Transition and Handoff Workflows across the Perioperative Care Continuum
Observational Pilot Study of Post-Surgical Discharge Care Transition
Gathering Design Requirements for a Machine Learning-Integrated Postoperative Risk-Based Handoff Report
Enhanced Handoff
Telehealth Education Leveraging Electronic Transitions of Care for COPD patients – Aim 1
Jacob AuBuchon, MDThe Comfort Ability Workshop: Improving Pain Treatment for Children and Their Families
Michael S. Avidan, MBBChSATISFY-SOS: Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Michael S. Avidan, MBBChThe Prevention of Delirium and Complications Associated with Surgical Treatments (PODCAST) Study: Protocol for an International Multicenter Randomized Controlled Trial
Michael S. Avidan, MBBChReconstructing Consciousness and Cognition
Michael S. Avidan, MBBChCPAP Adherence and Postoperative Delirium in Patients with OSA
Michael S. Avidan, MBBChProtocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) Study: a Pragmatic, Randomized Clinical Trial
Michael S. Avidan, MBBChPerioperative Risk Factors for All-Cause Unplanned Readmission within 30 Days After Surgery – a Sub-study of the SATISFY-SOS Observational Trial
Michael S. Avidan, MBBChCreation of a merged registry of patients in the NSQIP and SATISFY-SOS registries at BJH/Washington University
Michael S. Avidan, MBBChCognitive Recovery After Electroconvulsive Therapy and General Anesthesia
Michael S. Avidan, MBBChAbility of postoperative delirium to predict intermediate-term postoperative cognitive function in patients undergoing elective surgery at an academic medical center: protocol for a prospective study
Michael S. Avidan, MBBChAnesthesiology Control Tower: Feedback Alerts to Supplement Treatments (ACTFAST)
Michael S. Avidan, MBBChQuality of Life, Pain, and Functionality Following Surgery: The Impact of Complications
Michael S. Avidan, MBBChAnesthesiology Control Tower: Forecasting Algorithms to Support Treatments (ACTFAST)
Michael S. Avidan, MBBChValidation of the 3D-CAM in a Surgical Population
Michael S. Avidan, MBBChRelationship Between Immediate and Subsequent Postoperative Delirium
Michael S. Avidan, MBBChIntrapatient Reproducibility of the Triple Low Condition
Michael S. Avidan, MBBChDelirium on the Day of Surgery Is Related to Subsequent Postoperative Delirium
Michael S. Avidan, MBBChPerioperative glycemia management in patients undergoing craniotomy for brain tumor resection: an international survey of neuroanesthesiologists’ perceptions and practices
Michael S. Avidan, MBBChComparison of Patient-Reported Pain Between Delirious and Non-Delirious Patients
Michael S. Avidan, MBBChAssociation between Delirium and Patient Reported-Outcomes 30-Days Following Major Surgery
Michael S. Avidan, MBBChPatients self-report of delirium in the post-operative period
Michael S. Avidan, MBBChDetection of Delirium in the Postoperative Period by Family and Caregivers
Michael S. Avidan, MBBChProtocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the Post Anesthesia Care Unit
Michael S. Avidan, MBBChProtocol for the Effectiveness of an Anesthesiology Control Tower System in Improving Perioperative Quality Metrics and Clinical Outcomes: the TECTONICS randomized, pragmatic trial
Michael S. Avidan, MBBChPractical training of anesthesia clinicians in electroencephalogram-based determination of hypnotic depth of general anesthesia
Michael S. Avidan, MBBChBenzodiazepine-free Cardiac Anesthesia for reduction of Postoperative Delirium
Michael S. Avidan, MBBChComparing Methods of Delirium Detection
Michael S. Avidan, MBBChAn international, Bayesian platform adaptive, randomized, placebo-controlled trial assessing the effectiveness of candidate interventions in preventing COVID-19 disease in adults
Michael S. Avidan, MBBChThe effects of prior exposure to the Measles, Mumps, and Rubella vaccine on innate and adaptive immune responses to a SARS-CoV-2 mRNA vaccine
Michael S. Avidan, MBBChPublic perceptions on trial comparing total intravenous versus inhalational anesthesia for major surgery
Michael S. Avidan, MBBChBehavioral Activation and Medication Optimization for Perioperative Mental Health Feasibility Study
Michael S. Avidan, MBBChEvaluation of the Impact of an Anesthesiology Control Tower on Teamwork and Decision-Making Within the Operating Room
Arbi Ben Abdallah, PhD, DESTest-retest Reliability of Self-reported Outcomes by Surgical Patients
Arbi Ben Abdallah, PhD, DESPatient Health-Related Well-Being Before and After Surgery: A Latent Transition Analysis Approach
Amber Benhardt, MDComparing the Performance of Residents in Obstetric Anesthesia after the Implementation of Anesthesia Toolbox
Amber Benhardt, MDAnesthesiology Subspecialty Fellow Education Project
Adithya Bhat, MDEvaluating the effectiveness of interdisciplinary simulation training on difficult aireway management: creating a center of airway excellence at Barnes_Jewish Hospital
Zhoufeng Chen, MDClinical Comparison of Maintenance Anesthetic agents
Lara Crock, MD, PhDThe role of microbiome in the severity and persistence of complex regional pain syndrome
Bakul Dave, MD, MSProduct Surveillance Registry: Pain
Anne Drewry, MDPilot Randomized Trial of External Warming in Critically Ill Adult Septic Patients
Anne Drewry, MDImmunological Phenotyping of Febrile and Afebrile Critically Ill Septic Patients
Anne Drewry, MDWorking toward the advancement of recovery using modulated therapeutic hyperthermia in sepsis – Pilot
Julie Drobish, MDRetrospective and ongoing assessment of pediatric liver transplant management
Bradley Fritz, MD, MSCIUser-centered design of a machine learning display interface for an anesthesiology telemedicine suite
Bradley Fritz, MD, MSCIEffect of race and socioeconomic status on participation in a remote monitoring program for patients with COVID-19
Bradley Fritz, MD, MSCIProtocol for the Perioperative Outcome Risk Assessment with Computer Learning Enhancement (Periop ORACLE) Randomized Study
Bradley Fritz, MD, MSCIDevelopment an validation of a machine learning model predicting short intensive care unit stay
Brian Fuller, MDAn Assessment of Awareness in Mechanically Ventilated Patients Admitted from the Emergency Department: The ED-AWARE Study
Brian Fuller, MDThe ED-SED Pilot: a Multicenter, Before-After Study to Improve Sedation in the Emergency Department
Robert Gereau, PhDDetermining the Pathogenicity of Autoantibodies in Small Fiber Neuropathy
Stephen Gregory, MDA retrospective observational trial evaluating the prevalence and effect of preoperative cognitive dysfunction in a cohort of elderly patients undergoing elective surgery
Ryan Guffey, MDPECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery
Ryan Guffey, MDEncouraging Rational Use of Volatile Anesthetics
Ryan Guffey, MDPeri-Operative Epidural Management Study (POEM study) Survey
Ryan Guffey, MDRisk of N95 Fit Failure with Reuse: A prospective trial
Simon Haroutounian, PhD, MScPredicting individual response to analgesic treatment in painful diabetic neuropathy
Simon Haroutounian, PhD, MScPersistent Postsurgical Pain (PPSP) following Cystectomy: A survey and sensory examination
Simon Haroutounian, PhD, MScIntravenous lidocaine for preventing painful oxaliplatin-induced peripheral neuropathy (OIPN)
Simon Haroutounian, PhD, MScCognitive Flexibility Training for the Prevention of Persistent Post-Surgical Pain (COFLEX-PPSP): Feasibility Study
Simon Haroutounian, PhD, MScInvestigation of pharmacokinetics and pharmacodynamics of epidural methadone in healthy volunteers
Simon Haroutounian, PhD, MScA new method for identifying sensory changes in painful chemotherapy-induced peripheral neuropathy (CIPN): a feasibility study
Simon Haroutounian, PhD, MScCognitive Flexibility Training for Persistent Pain: MR imaging pilot (COFLEX-i)
Simon Haroutounian, PhD, MScEffects of Pgp transporter inhibition on CNS biodistribution of ondansetron in healthy volunteers
Simon Haroutounian, PhD, MScChemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY)
Simon Haroutounian, PhD, MScEEG Signature of Pain and Pain Relief: A Pilot Exploratory study
Simon Haroutounian, PhD, MScBrain-computer interface intervention for chronic upper extremity pain: a pilot study
Simon Haroutounian, PhD, MScIncidence and characterization of peripheral and cranial nerve neuropathy in patients diagnosed with COVID-19
Simon Haroutounian, PhD, MScPerioperative Cognitive Flexibility Training for the Prevention of Persistent Pain after Thoracic Surgery
Simon Haroutounian, PhD, MScPatient Perspective on Perioperative Cognitive Training to Prevent Persistent Pain After Thoracic Surgery
Simon Haroutounian, PhD, MScAdministration of ondansetron with P-glycoprotein inhibitor tariquidar in patients with neuropathic pain
Simon Haroutounian, PhD, MScP-5 Personalized Prediction of Persistent Postsurgical Pain
Simon Haroutounian, PhD, MScIncidence of peripheral neuropathy among patients with colorectal cancer receiving oxaliplatin/5-FU based therapy: A retrospective chart review.
Simon Haroutounian, PhD, MScP-5 Personalized Prediction of Persistent Postsurgical Pain: A Pilot Study
Daniel Helsten, MDMulticenter perioperative outcomes group (MPOG) performance site
Daniel Helsten, MDEscalations of Care Following Colonoscopies With and Without Anesthesia Assistance
Daniel Helsten, MDEarly Extubation Failure After Head and Neck Surgery
Mohammed Helwani, MD, MSPPharmacogenetics of Adverse Outcomes After Nitrous Oxide Anesthesia
Mohammed Helwani, MD, MSPMetoprolol to Reduce Perioperative Myocardial Injury
Mohammed Helwani, MD, MSPIntra-Individual Transpulmonary Variation in Cardiac Biomarker Concentrations
Mohammed Helwani, MD, MSPCardiac Surgery in Jehovah’s Witness patients: Single Academic Center Experience
Mohammed Helwani, MD, MSPA Multi-disciplinary Protocol to Minimize Mechanical Ventilation Time Post Cardiac Surgery
Alexander Hincker, MDSleep Apnea and Fetal Growth Restriction
Richard Hotchkiss, MDCellular Mechanisms of Sepsis and Organ Failure
Richard Hotchkiss, MDPotential Immuno-Adjuvant Therapy in Sepsis
Richard Hotchkiss, MDRed Blood Cell Danger Associated Molecular Patterns in Trauma
Richard Hotchkiss, MDInternational, multicenter, randomized, double-blinded, placebo-controlled study of Recombinant Interleukin-7 (CYT107) to restore absolute lymphocyte counts (ALC) in patients with Sepsis (IRIS-7 C & D Bridge Studies)
Richard Hotchkiss, MDStratifying Patient Immune Endotypes in Sepsis (SPIES Study)
York Jiao, MDPrediction of surgical case duration from historical EHR data
Jessica Justmann, MDComplex Regional Pain Syndrome in Children: Assessing PROMIS Score Outcomes Following Longitudinal Outpatient Treatment
Mohammad Mehdi KafashanCorrelating electroconvulsive therapy response to electroencephalographic ictal complexes and postictal markers
Muthuraj Kanakaraj, MDPostoperative vasopressor usage: a prospective international observational study
Ivan Kangrga, MDPulmonary function tests and perioperative complications in adult liver transplant recipients
Thomas Kannampallil, PhDEffects of surgical complications on post-surgical cognitive abilities
Thomas Kannampallil, PhDPredicting Post-Surgical Pain Outcomes from Acute Pain Trajectories
Thomas Kannampallil, PhDDeveloping Models of Psychological Stress from Smartwatch Sensors
Thomas Kannampallil, PhDEffect of Intraoperative Pediatric Anesthesia Handoffs on Surgical Outcomes
Thomas Kannampallil, PhDMental Health Related Quality of Life
Thomas Kannampallil, PhDAssessing Physician Trainee Wellness during a Pandemic (ASPIRE)
Thomas Kannampallil, PhDCharacterizing anesthesiology provider EHR work habits and relation to process-based quality of care metrics
Thomas Kannampallil, PhDStudy of a PST-Trained Voice-Enabled Artificial Intelligence Counselor (SPEAC) for Adults with Emotional Distress
Thomas Kannampallil, PhDPrediction of intraoperative blood product utilization
Thomas Kannampallil, PhDA Quasi-Experimental Study on the Effects of COVID-19 on Medication Errors
Thomas Kannampallil, PhDAssessing the Effect of Telemedicine on Physician EHR Work, Cognition, and Process Outcomes
Christopher King, MD, PhDTelemedicine Notifications with Machine Learning for Postoperative Care
Christopher King, MD, PhDPrediction models for increased length of stay and readmission after ambulatory surgery: A retrospective study
Christopher King, MD, PhDDeveloping Interfaces for Machine Learning for Postoperative Care
Christopher King, MD, PhDMachine Learning for Postoperative Care
Helga Komen, MDMethadone in Ambulatory Surgery
Anand Lakshminarasimhachar, MDOptimisation of perioperatice cardiovascular management to improve surgical outcomes II trial
Anand Lakshminarasimhachar, MDEffect on plasma acid base status of patients undergoing oncological surgery with Hyperthermic Intraperitoneal Chemotherapy
David Monks, MBChBThe pharmacokinetics of Oxytocin (PK-OXT) in pregnant women undergoing cesarean delivery – a feasibility pilot study
David Monks, MBChBPostpartum depression after Cesarean delivery: Ketamine as a preventative intervention. A feasibility pilot-study
Michael Montana, MD, PhDOpioid Sensitivity in Adults with Treated and Untreated Obstructive Sleep Apnea
Michael Montana, MD, PhDPharmacokinetics and Safety of Anesthetics and Analgesics in Children and Adolescents
Michael Montana, MD, PhDIdentification of the Causes of Persistent and Profound Pediatric Intraoperative Hypoxemia to Advance Health Care Professional Education and Improve Patient Safety
Michael Montana, MD, PhDA randomized controlled trial to compare hydromorphone vs fentanyl in children undergoing tonsillectomy surgery
David Moquin, MDThe Flipped Classroom Approach in a Pediatric Anesthesia Fellowship Curriculum
Jeremiah Morrissey, PhDUrine Proteome of Patients Undergoing Surgery
Jeremiah Morrissey, PhDNew non-invasive methods for real-time monitoring of organ function
Jeremiah Morrissey, PhDBiomarker correlates of radiologic imaging
Jeremiah Morrissey, PhDUrine Proteome of Surgical Patients and Healthy Volunteers
Jeremiah Morrissey, PhDNanotech biomarkers for renal cancer intervention: clinical validation and utility
Jeremiah Morrissey, PhDDevelopment and validation of an ultrasensitive, fast plasmon-enhanced assay for human IgG/IgM/IgA to COVID-19 infection.
Amjad Musleh, MDLung Compliance in COVID+ Ventilated Patients
Sydney Nykiel-Bailey, DOPediatric Difficult Intubation (PeDI) Registry – Improving Safety and Quality of Airway Management in Children with Difficult Airways
Uchenna Ofoma, MD, MSAssociations between Hospital Intensive Care Unit Telemedicine Adoption and Rates of Survival for In-Hospital Cardiac Arrest – An Effectiveness Study
Ben Palanca, MD, PhDDiffuse Optical Tomography of Surgical Patients Undergoing General Anesthesia
Ben Palanca, MD, PhDPostoperative Delirium: Brain Vulnerability and Recovery
Ben Palanca, MD, PhDInhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies
Ben Palanca, MD, PhD
Christian Guay, MD
Closed Loop Acoustic Stimulation during Sedation with Dexmedetomidine (CLASS-D)
Ben Palanca, MD, PhDPrecision targeting of propofol-induced electroencephalographic slow waves: a novel paradigm for treatment-resistant major depressive disorder – Phase I
Ben Palanca, MD, PhDSafety of Anesthesia Volunteer Experiments
Arvind Palanisamy, MDPrevention of Transient Tachypnea of the Newborn with Prophylactic Phenylephrine Infusion During Elective Cesarean Delivery
Arvind Palanisamy, MDUnderstanding host-pathogen interaction in the respiratory mucosa during pregnancy
Chris Palmer, MC, FCCMCOVID-19 Virtual Post Intensive Care Syndrome (CoV-PICS) Clinic: Modern, Covenient and Practical Recovery Care
Stephen Ristvedt, PhDPromoting Uptake of a Usual Source of Care among African American Men
Stephen Ristvedt, PhDCommunity-Based Study of Uptake of a Usual Source of Care by African Amerian Men
Charles Schrock, MDRetrospective assessment of opioid use, pain, and recovery following strabismus surgery in children
Pratik Sinha, MBChB, PhDClinical Phenotyping of COVID-19 and Other Viral Pneumonias using Unsupervised Machine Learning
Pratik Sinha, MBChB, PhDMolecular Phenotyping of COVID-19 Patients Requiring Hospital Admission Using Latent Class Analysis.
Pratik Sinha, MBChB, PhDPREcision-based Critical Care In SEpsis (PRECCISE) Study
Kendall Smith, MD, PhDLongitudinal Assessment of Leadership, Career Development and Wellness Culture in Anesthesiology Residency
Loc Thang, MD, PhDAnalysis of Failed Spinal Cord Stimulator Implantation After Successful Trials in The Treatment of Intractable Chronic Pain
Loc Thang, MD, PhDPain Rotation Tutorial Curriculum Project
Brian TorresAlleviation of Certified Registered Nurse Anesthetist (CRNA) Preceptor Burnout
Brian Wessman, MDEnd of Life Care in the Emergency Department: A cross sectional observational study
Brian Wessman, MDFeasibility Assessment of an ED to ICU team based Transition of Care Tool
Brian Wessman, MDLocal Practice Patterns of Vasopressor Use in the Emergency Department
Brian Wessman, MDPalliative Care and Rapid Emergency Screening (P-CaRES): Impact of ED Screening in Elderly Patients
Troy Wildes, MDChanges In diastolic dysfunction with the onset of volatile anesthesia in patients undergoing coronary artery bypass grafting as determined by a load-independent efficiency index derived from the parameterized Doppler analysis of left ventricular filling.
Troy Wildes, MDProtocol for a proof-of-concept study evaluating Systematic Quality Improvement with Realtime Event Support